Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

T-complex protein 1 subunit alpha

Gene

TCP-1A

Organism
Schistosoma mansoni (Blood fluke)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
T-complex protein 1 subunit alpha
Short name:
TCP-1-alpha
Alternative name(s):
CCT-alpha
Gene namesi
Name:TCP-1A
OrganismiSchistosoma mansoni (Blood fluke)
Taxonomic identifieri6183 [NCBI]
Taxonomic lineageiEukaryotaMetazoaPlatyhelminthesTrematodaDigeneaStrigeididaSchistosomatoideaSchistosomatidaeSchistosoma

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001283111 – 545T-complex protein 1 subunit alphaAdd BLAST545

Proteomic databases

PRIDEiQ94757.

Expressioni

Gene expression databases

ExpressionAtlasiQ94757. baseline.

Interactioni

Subunit structurei

Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ94757.
SMRiQ94757.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.Curated

Phylogenomic databases

eggNOGiKOG0360. Eukaryota.
COG0459. LUCA.
OrthoDBiEOG091G04HL.

Family and domain databases

CDDicd03335. TCP1_alpha. 1 hit.
Gene3Di1.10.560.10. 2 hits.
InterProiView protein in InterPro
IPR012715. Chap_CCT_alpha.
IPR017998. Chaperone_TCP-1.
IPR002194. Chaperonin_TCP-1_CS.
IPR002423. Cpn60/TCP-1.
IPR037290. Cpn60/TCP-1_sf.
IPR027409. GroEL-like_apical_dom_sf.
IPR027413. GROEL-like_equatorial_sf.
PANTHERiPTHR11353. PTHR11353. 1 hit.
PfamiView protein in Pfam
PF00118. Cpn60_TCP1. 1 hit.
PRINTSiPR00304. TCOMPLEXTCP1.
SUPFAMiSSF48592. SSF48592. 2 hits.
SSF52029. SSF52029. 1 hit.
SSF54849. SSF54849. 2 hits.
TIGRFAMsiTIGR02340. chap_CCT_alpha. 1 hit.
PROSITEiView protein in PROSITE
PS00750. TCP1_1. 1 hit.
PS00751. TCP1_2. 1 hit.
PS00995. TCP1_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q94757-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTLGGERTS GESVRKQNVL AACSFANFVK TSLGPVGLDK MLVDDVGDVT
60 70 80 90 100
ITNDGATILK LLDVEHPAAK ILVQLAQLQD EEVGDGTTSV VILAAALLKN
110 120 130 140 150
ADELISRFVH PTTVINGYRL ACREACKYIQ EHMAYDVNKL GKAGLINVAR
160 170 180 190 200
TAMSSKLINL DADMFSQMAV DALMAVEVSG GPKGPVYPIK AVNILKAHGR
210 220 230 240 250
SMSESMLIDG YALNCTAASQ QMPRIIKKAK IAFLDFSLQK VKMKLGVQVV
260 270 280 290 300
VKDPAQLEAI RQREADITKE RIQKILNAGA NVILTTGGID DLCMKYFVEV
310 320 330 340 350
NAMAVRRCKK VDLKNMAKAT GGQLIVSLAD MEGDEVFDPT KLGNAEEVSQ
360 370 380 390 400
ERICDDELII LRGPKVHPSA SIILRGANDF YVDEMERSLH DALLVVKRVL
410 420 430 440 450
ESKRIVPGAG ACETAVSIYL ENYALTLSSR EQLAIAEFAR AMLSIPKQLA
460 470 480 490 500
VNAGVDSTEL VARLRSCHNS SQSKPDQAHN KWWGLDLNNQ YVADCKEIGV
510 520 530 540
FEPLVSKIKS LKFATEAAIT ILRIDDLIKL KEEKQPDHDG DECGY
Length:545
Mass (Da):59,440
Last modified:February 1, 1997 - v1
Checksum:i992CCA919389E42C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U55769 mRNA. Translation: AAA99815.1.

Similar proteinsi

Entry informationi

Entry nameiTCPA_SCHMA
AccessioniPrimary (citable) accession number: Q94757
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: November 22, 2017
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families