Q94741 (OPS1_SCHGR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Opsin-1

Gene names

Name:

Lo1

Organism

Schistocerca gregaria (Desert locust)

Taxonomic identifier

7010 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Orthopteroidea › Orthoptera › Caelifera › Acridomorpha › Acridoidea › Acrididae › Cyrtacanthacridinae › Schistocerca

Protein attributes

Sequence length	381 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal.
Subcellular location	Membrane; Multi-pass membrane protein.
Post-translational modification	Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region By similarity.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.

Ontologies

Keywords
Biological process	Sensory transduction Vision
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Ligand	Chromophore
Molecular function	G-protein coupled receptor Photoreceptor protein Receptor Retinal protein Transducer
PTM	Disulfide bond Glycoprotein Phosphoprotein
Gene Ontology (GO)
Biological_process	phototransduction Inferred from electronic annotation. Source: UniProtKB-KW protein-chromophore linkage Inferred from electronic annotation. Source: UniProtKB-KW visual perception Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW photoreceptor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 381	381	Opsin-1		PRO_0000197635
Regions
	Topological domain	1 – 53	53	Extracellular Potential
	Transmembrane	54 – 78	25	Helical; Name=1; Potential
	Topological domain	79 – 90	12	Cytoplasmic Potential
	Transmembrane	91 – 115	25	Helical; Name=2; Potential
	Topological domain	116 – 130	15	Extracellular Potential
	Transmembrane	131 – 150	20	Helical; Name=3; Potential
	Topological domain	151 – 169	19	Cytoplasmic Potential
	Transmembrane	170 – 193	24	Helical; Name=4; Potential
	Topological domain	194 – 217	24	Extracellular Potential
	Transmembrane	218 – 245	28	Helical; Name=5; Potential
	Topological domain	246 – 280	35	Cytoplasmic Potential
	Transmembrane	281 – 304	24	Helical; Name=6; Potential
	Topological domain	305 – 311	7	Extracellular Potential
	Transmembrane	312 – 336	25	Helical; Name=7; Potential
	Topological domain	337 – 381	45	Cytoplasmic Potential
Amino acid modifications
	Modified residue	323	1	N6-(retinylidene)lysine By similarity
	Glycosylation	24	1	N-linked (GlcNAc...) Potential
	Glycosylation	200	1	N-linked (GlcNAc...) Potential
	Disulfide bond	127 ↔ 204		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q94741 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 50D38FF9038D5BA3	FASTA	381	42,399
	10 20 30 40 50 60 MASASLISEP SFSAYWGGSG GFANQTVVDK VPPEMLYLVD PHWYQFPPMN PLWHGLLGFV 70 80 90 100 110 120 IGVLGVISVI GNGMVIYIFS TTKSLRTPSN LLVVNLAFSD FLMMFTMSAP MGINCYYETW 130 140 150 160 170 180 VLGPFMCELY ALFGSLFGCG SIWTMTMIAL DRYNVIVKGL SAKPMTNKTA MLRILFIWAF 190 200 210 220 230 240 SVAWTIMPLF GWNRYVPEGN MTACGTDYLT KDWVSRSYIL VYSFFVYLLP LGTIIYSYFF 250 260 270 280 290 300 ILQAVSAHEK QMREQRKKMN VASLRSAEAS QTSAECKLAK VALMTISLWF FGWTPYLIIN 310 320 330 340 350 360 FTGIFETMKI SPLLTIWGSL FAKANAVFNP IVYGISHPKY RAALEKKFPS LACASSSDDN 370 380 TSVASGATTV SDEKSEKSAS A

References

[1]	"Primary structure of locust opsins: a speculative model which may account for ultraviolet wavelength light detection." Towner P., Harris P., Wolstenholme A.J., Hill C., Worm K., Gartner W. Vision Res. 37:495-503(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	X80071 mRNA. Translation: CAA56377.1.
3D structure databases
ProteinModelPortal	Q94741.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR001760. Opsin. IPR001391. Opsin_lateye. IPR027430. Retinal_BS. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00238. OPSIN. PR00578. OPSINLTRLEYE.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. PS00238. OPSIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

OPS1_SCHGR

Accession

Primary (citable) accession number: Q94741

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	February 1, 1997
Last modified:	May 29, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)