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Protein

Cathepsin L 1

Gene

GSPATT00020990001

Organism
Paramecium tetraurelia
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in extracellular digestion.

Catalytic activityi

Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity toward protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei135PROSITE-ProRule annotation1
Active sitei265PROSITE-ProRule annotation1
Active sitei282PROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease

Names & Taxonomyi

Protein namesi
Recommended name:
Cathepsin L 1 (EC:3.4.22.15)
Gene namesi
ORF Names:GSPATT00020990001
OrganismiParamecium tetraurelia
Taxonomic identifieri5888 [NCBI]
Taxonomic lineageiEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaPeniculidaParameciidaeParamecium
Proteomesi
  • UP000000600 Componenti: Partially assembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
PropeptideiPRO_000002627325 – 109Activation peptide1 PublicationAdd BLAST85
ChainiPRO_0000026274110 – 314Cathepsin L 1Add BLAST205

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi132 ↔ 175By similarity
Disulfide bondi166 ↔ 207By similarity
Disulfide bondi259 ↔ 302By similarity

Keywords - PTMi

Disulfide bond, Zymogen

Structurei

3D structure databases

ProteinModelPortaliQ94714.
SMRiQ94714.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1543. Eukaryota.
COG4870. LUCA.
InParanoidiQ94714.

Family and domain databases

InterProiView protein in InterPro
IPR000169. Pept_cys_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR013201. Prot_inhib_I29.
PANTHERiPTHR12411. PTHR12411. 1 hit.
PfamiView protein in Pfam
PF08246. Inhibitor_I29. 1 hit.
PF00112. Peptidase_C1. 1 hit.
PRINTSiPR00705. PAPAIN.
SMARTiView protein in SMART
SM00848. Inhibitor_I29. 1 hit.
SM00645. Pept_C1. 1 hit.
PROSITEiView protein in PROSITE
PS00139. THIOL_PROTEASE_CYS. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q94714-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMLLGASLYL NNTQEVSDEI DTANLYANWK MKYNRRYTNQ RDEMYRYKVF
60 70 80 90 100
TDNLNYIRAF YESPEEATFT LELNQFADMS QQEFAQTYLS LKVPRTAKLN
110 120 130 140 150
AANSNFQYKG AEVDWTDNKK VKYPAVKNQG SCGSCWAFSA VGALEINTDI
160 170 180 190 200
ELNRKYELSE QDLVDCSGPY DNDGCNGGWM DSAFEYVADN GLAEAKDYPY
210 220 230 240 250
TAKDGTCKTS VKRPYTHVQG FKDIDSCDEL AQTIQERTVA VAVDANPWQF
260 270 280 290 300
YRSGVLSKCT KNLNHGVVLV GVQADGAWKI RNSWGSSWGE AGHIRLAGGD
310
TCGICAAPSF PILG
Length:314
Mass (Da):35,159
Last modified:February 1, 1997 - v1
Checksum:i56B4489D118FF097
GO

Sequence cautioni

The sequence CAK87348 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91754 mRNA. Translation: CAA62869.1.
CT868618 Genomic DNA. Translation: CAK87348.1. Different initiation.
PIRiS68783.
UniGeneiPte.18017.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91754 mRNA. Translation: CAA62869.1.
CT868618 Genomic DNA. Translation: CAK87348.1. Different initiation.
PIRiS68783.
UniGeneiPte.18017.

3D structure databases

ProteinModelPortaliQ94714.
SMRiQ94714.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG1543. Eukaryota.
COG4870. LUCA.
InParanoidiQ94714.

Family and domain databases

InterProiView protein in InterPro
IPR000169. Pept_cys_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR013201. Prot_inhib_I29.
PANTHERiPTHR12411. PTHR12411. 1 hit.
PfamiView protein in Pfam
PF08246. Inhibitor_I29. 1 hit.
PF00112. Peptidase_C1. 1 hit.
PRINTSiPR00705. PAPAIN.
SMARTiView protein in SMART
SM00848. Inhibitor_I29. 1 hit.
SM00645. Pept_C1. 1 hit.
PROSITEiView protein in PROSITE
PS00139. THIOL_PROTEASE_CYS. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCATL1_PARTE
AccessioniPrimary (citable) accession number: Q94714
Secondary accession number(s): A0DWD1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: February 1, 1997
Last modified: February 15, 2017
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.