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Protein

Ras-related protein Rap-1

Gene

RAP1

Organism
Physarum polycephalum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 198GTPBy similarity
Nucleotide bindingi59 – 635GTPBy similarity
Nucleotide bindingi118 – 1214GTPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rap-1
Alternative name(s):
Pprap1
Gene namesi
Name:RAP1
OrganismiPhysarum polycephalum (Slime mold)
Taxonomic identifieri5791 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaMyxogastriaMyxogastromycetidaePhysariidaPhysaraceaePhysarum

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 185185Ras-related protein Rap-1PRO_0000082685Add
BLAST
Propeptidei186 – 1883Removed in mature formBy similarityPRO_0000281334

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei185 – 1851Cysteine methyl esterBy similarity
Lipidationi185 – 1851S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PRIDEiQ94694.

Expressioni

Developmental stagei

Highest levels in fruiting bodies, abundant in amoebae, moderately abundant in CL spherules but barely present in plasmodia and MCC spherules.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ94694.
SMRiQ94694. Positions 3-169.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi34 – 429Effector region

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi177 – 1815Lys-rich

Sequence similaritiesi

Belongs to the small GTPase superfamily. Ras family.Curated

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q94694-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLREFKIVV LGSGGVGKSA LTVQFVQGIF VEKYDPTIED SYRKQVEVDG
60 70 80 90 100
QQCMLEILDT AGTEQFTAMR DLYMKNGQGF VLVYSIIAMS TFNDLPDLRE
110 120 130 140 150
QILRVKDCDD VPMVLVGNKC DLAEQRVIST EQGDELARKF GGCAFLEASA
160 170 180
KNKINVEQIF YDLIRQINRK NPGPTNKKEK KSGGCILL
Length:188
Mass (Da):21,036
Last modified:February 1, 1997 - v1
Checksum:i72B3FC927EB648AE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15594 mRNA. Translation: AAC47511.1.
AF000653 Genomic DNA. Translation: AAB58345.1.
PIRiS65761.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15594 mRNA. Translation: AAC47511.1.
AF000653 Genomic DNA. Translation: AAB58345.1.
PIRiS65761.

3D structure databases

ProteinModelPortaliQ94694.
SMRiQ94694. Positions 3-169.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ94694.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification and sequence analysis of a rap gene from the true slime mold Physarum polycephalum."
    Kozlowski P., Trzcinska-Danielewicz J., Toczko K.
    Biochim. Biophys. Acta 1305:29-33(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: LU352.
  2. "Ppras1, ppras2 and pprap1 genes, members of a ras gene family from the true slime mold Physarum polycephalum are developmentally regulated."
    Kozlowski P., Trzcinska-Danielewicz J., Urbanczyk A., Toczko K.
    Cell Biol. Int. 21:441-445(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE.
    Strain: CL, LU352 and MCC.

Entry informationi

Entry nameiRAP1_PHYPO
AccessioniPrimary (citable) accession number: Q94694
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: February 1, 1997
Last modified: May 11, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.