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Protein

Isocitrate dehydrogenase [NAD] catalytic subunit 5, mitochondrial

Gene

IDH5

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Performs an essential role in the oxidative function of the citric acid cycle.By similarity

Catalytic activityi

Isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 1 Mg2+ or Mn2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei127SubstrateBy similarity1
Binding sitei137SubstrateBy similarity1
Binding sitei158SubstrateBy similarity1
Sitei165Critical for catalysisBy similarity1
Sitei212Critical for catalysisBy similarity1
Metal bindingi245Magnesium or manganeseBy similarity1
Binding sitei245SubstrateBy similarity1
Metal bindingi269Magnesium or manganeseBy similarity1
Metal bindingi273Magnesium or manganeseBy similarity1

GO - Molecular functioni

  • ATP binding Source: TAIR
  • isocitrate dehydrogenase (NAD+) activity Source: TAIR
  • magnesium ion binding Source: InterPro
  • NAD binding Source: InterPro
  • zinc ion binding Source: TAIR

GO - Biological processi

  • isocitrate metabolic process Source: TAIR
  • tricarboxylic acid cycle Source: TAIR

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandMagnesium, Manganese, Metal-binding, NAD

Enzyme and pathway databases

BioCyciMetaCyc:AT5G03290-MONOMER
BRENDAi1.1.1.41 399

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NAD] catalytic subunit 5, mitochondrial (EC:1.1.1.41)
Alternative name(s):
IDH-V
Isocitric dehydrogenase 5
NAD(+)-specific ICDH 5
Gene namesi
Name:IDH5
Ordered Locus Names:At5g03290
ORF Names:F12E4_20, MOK16.20
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G03290
TAIRilocus:2142604 AT5G03290

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 44MitochondrionSequence analysisAdd BLAST44
ChainiPRO_000027129145 – 374Isocitrate dehydrogenase [NAD] catalytic subunit 5, mitochondrialAdd BLAST330

Proteomic databases

PaxDbiQ945K7
PRIDEiQ945K7

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

ExpressionAtlasiQ945K7 baseline and differential
GenevisibleiQ945K7 AT

Interactioni

Subunit structurei

Heterooligomer of catalytic and regulatory subunits.

Protein-protein interaction databases

BioGridi17160, 2 interactors
IntActiQ945K7, 1 interactor
STRINGi3702.AT5G03290.1

Structurei

3D structure databases

ProteinModelPortaliQ945K7
SMRiQ945K7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0785 Eukaryota
COG0473 LUCA
HOGENOMiHOG000021113
InParanoidiQ945K7
KOiK00030
OMAiRGIKVWP
OrthoDBiEOG09360ECW
PhylomeDBiQ945K7

Family and domain databases

InterProiView protein in InterPro
IPR019818 IsoCit/isopropylmalate_DH_CS
IPR004434 Isocitrate_DH_NAD
IPR024084 IsoPropMal-DH-like_dom
PfamiView protein in Pfam
PF00180 Iso_dh, 1 hit
SMARTiView protein in SMART
SM01329 Iso_dh, 1 hit
TIGRFAMsiTIGR00175 mito_nad_idh, 1 hit
PROSITEiView protein in PROSITE
PS00470 IDH_IMDH, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q945K7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTMAANLARR LIGNRSTQIL GAVNSSSGAA SSVARAFCSS TTPITATLFP
60 70 80 90 100
GDGIGPEIAE SVKKVFTTAG VPIEWEEHYV GTEIDPRTQS FLTWESLESV
110 120 130 140 150
RRNKVGLKGP MATPIGKGHR SLNLTLRKEL NLYANVRPCY SLPGYKTRYD
160 170 180 190 200
DVDLITIREN TEGEYSGLEH QVVRGVVESL KIITRQASLR VAEYAFLYAK
210 220 230 240 250
THGRERVSAI HKANIMQKTD GLFLKCCREV AEKYPEITYE EVVIDNCCMM
260 270 280 290 300
LVKNPALFDV LVMPNLYGDI ISDLCAGLVG GLGLTPSCNI GEDGVALAEA
310 320 330 340 350
VHGSAPDIAG KNLANPTALL LSGVMMLRHL KFNEQAEQIH SAIINTIAEG
360 370
KYRTADLGGS STTTEFTKAI CDHL
Length:374
Mass (Da):40,625
Last modified:December 1, 2001 - v1
Checksum:i723D0150C360F7A1
GO

Sequence cautioni

The sequence BAB08389 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAB83285 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB005240 Genomic DNA Translation: BAB08389.1 Different initiation.
AL162751 Genomic DNA Translation: CAB83285.1 Different initiation.
CP002688 Genomic DNA Translation: AED90581.1
AF412100 mRNA Translation: AAL06553.1
AY099823 mRNA Translation: AAM20674.1
BT008460 mRNA Translation: AAP37819.1
PIRiT48350
RefSeqiNP_568113.1, NM_120407.6
UniGeneiAt.25268

Genome annotation databases

EnsemblPlantsiAT5G03290.1; AT5G03290.1; AT5G03290
GeneIDi831884
GrameneiAT5G03290.1; AT5G03290.1; AT5G03290
KEGGiath:AT5G03290

Similar proteinsi

Entry informationi

Entry nameiIDH5_ARATH
AccessioniPrimary (citable) accession number: Q945K7
Secondary accession number(s): Q9LZG1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: December 1, 2001
Last modified: April 25, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health