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Protein

Protein DETOXIFICATION 47, chloroplastic

Gene

DTX47

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Functions as a multidrug and toxin extrusion transporter in the export of salicylic acid (SA) from the chloroplast to the cytoplasm (PubMed:23757404). Plays an essential function in plant defense via the pathogen-induced salicylic acid (SA) accumulation (PubMed:11826312, PubMed:24594657). Acts also as a key component of the Age-related resistance (ARR) pathway (PubMed:11884688, PubMed:19694953, PubMed:24594657).5 Publications

GO - Molecular functioni

GO - Biological processi

  • defense response Source: TAIR
  • defense response to bacterium Source: TAIR
  • innate immune response Source: UniProtKB
  • negative regulation of defense response Source: TAIR
  • response to nematode Source: TAIR
  • response to salicylic acid Source: UniProtKB
  • salicylic acid biosynthetic process Source: UniProtKB

Keywordsi

Biological processImmunity, Innate immunity, Plant defense, Transport

Protein family/group databases

TCDBi2.A.66.1.11 the multidrug/oligosaccharidyl-lipid/polysaccharide (mop) flippase superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Protein DETOXIFICATION 47, chloroplastic1 Publication
Short name:
AtDTX471 Publication
Alternative name(s):
Multidrug and toxic compound extrusion protein 47Curated
Short name:
MATE protein 47Curated
Protein ENHANCED DISEASE SUSCEPTIBILITY 51 Publication
Short name:
Protein EDS51 Publication
Protein IMPORTANT FOR THE ARR PATHWAY 11 Publication
Short name:
Protein IAP11 Publication
Protein SALICYLIC ACID INDUCTION DEFICIENT 11 Publication
Short name:
Protein SID11 Publication
Protein SUSCEPTIBLE TO CORONATINE-DEFICIENT PST DC3000 3
Short name:
Protein SCORD31 Publication
Gene namesi
Name:DTX471 Publication
Synonyms:EDS51 Publication, IAP11 Publication, SCORD31 Publication, SID11 Publication
Ordered Locus Names:At4g39030Imported
ORF Names:F19H22.130Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G39030
TAIRilocus:2120267 AT4G39030

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei107 – 127HelicalSequence analysisAdd BLAST21
Transmembranei135 – 155HelicalSequence analysisAdd BLAST21
Transmembranei181 – 201HelicalSequence analysisAdd BLAST21
Transmembranei228 – 248HelicalSequence analysisAdd BLAST21
Transmembranei256 – 276HelicalSequence analysisAdd BLAST21
Transmembranei278 – 298HelicalSequence analysisAdd BLAST21
Transmembranei319 – 339HelicalSequence analysisAdd BLAST21
Transmembranei342 – 362HelicalSequence analysisAdd BLAST21
Transmembranei406 – 426HelicalSequence analysisAdd BLAST21
Transmembranei443 – 463HelicalSequence analysisAdd BLAST21
Transmembranei472 – 492HelicalSequence analysisAdd BLAST21
Transmembranei497 – 517HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Chloroplast, Membrane, Plastid

Pathology & Biotechi

Disruption phenotypei

Enhanced susceptibility to several bacterial pathogens and alterations in PR-1 gene expression (PubMed:9090877). No salicylic acid (SA) accumulation after pathogen inoculation and more susceptibility to both virulent and avirulent forms of Pseudomonas syringae and Peronospora parasitica (PubMed:10449575, PubMed:24594657). Age-related resistance (ARR)-defective (PubMed:11884688, PubMed:19694953). Defect in stomatal response during bacterial infection (PubMed:21998587).6 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 30ChloroplastSequence analysisAdd BLAST30
ChainiPRO_000016425931 – 543Protein DETOXIFICATION 47, chloroplasticAdd BLAST513

Proteomic databases

PaxDbiQ945F0

PTM databases

SwissPalmiQ945F0

Expressioni

Tissue specificityi

Preferentially expressed in the epidermal cells.1 Publication

Inductioni

By salicylic acid, UV-C light and pathogens.1 Publication

Gene expression databases

ExpressionAtlasiQ945F0 baseline and differential
GenevisibleiQ945F0 AT

Interactioni

Protein-protein interaction databases

BioGridi15338, 26 interactors
STRINGi3702.AT4G39030.1

Structurei

3D structure databases

ProteinModelPortaliQ945F0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili55 – 94Sequence analysisAdd BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi78 – 86Poly-Glu9

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1347 Eukaryota
COG0534 LUCA
HOGENOMiHOG000029977
InParanoidiQ945F0
OMAiIVSAYMM
OrthoDBiEOG093606HB
PhylomeDBiQ945F0

Family and domain databases

InterProiView protein in InterPro
IPR002528 MATE_fam
PfamiView protein in Pfam
PF01554 MatE, 1 hit
TIGRFAMsiTIGR00797 matE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q945F0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLIKSQRLTL FSPLLSKTRR IPVNSHQTLV AESVITRRTL GAITATPSFH
60 70 80 90 100
KNPVVIRRRI KLERVTRNCV RIDREIDEEE EEEEKERGDL VKQSIWEQMK
110 120 130 140 150
EIVKFTGPAM GMWICGPLMS LIDTVVIGQG SSIELAALGP GTVLCDHMSY
160 170 180 190 200
VFMFLSVATS NMVATSLAKQ DKKEAQHQIS VLLFIGLVCG LMMLLLTRLF
210 220 230 240 250
GPWAVTAFTR GKNIEIVPAA NKYIQIRGLA WPFILVGLVA QSASLGMKNS
260 270 280 290 300
WGPLKALAAA TIINGLGDTI LCLFLGQGIA GAAWATTASQ IVSAYMMMDS
310 320 330 340 350
LNKEGYNAYS FAIPSPQELW KISALAAPVF ISIFSKIAFY SFIIYCATSM
360 370 380 390 400
GTHVLAAHQV MAQTYRMCNV WGEPLSQTAQ SFMPEMLYGA NRNLPKARTL
410 420 430 440 450
LKSLMIIGAT LGLVLGVIGT AVPGLFPGVY THDKVIISEM HRLLIPFFMA
460 470 480 490 500
LSALPMTVSL EGTLLAGRDL KFVSSVMSSS FIIGCLTLMF VTRSGYGLLG
510 520 530 540
CWFVLVGFQW GRFGLYLRRL LSPGGILNSD GPSPYTVEKI KSI
Length:543
Mass (Da):59,528
Last modified:December 1, 2001 - v1
Checksum:iDF2EEFE0942A51C5
GO

Sequence cautioni

The sequence CAB38823 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAB80566 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF416569 mRNA Translation: AAL27003.1
AL035679 Genomic DNA Translation: CAB38823.1 Sequence problems.
AL161594 Genomic DNA Translation: CAB80566.1 Sequence problems.
CP002687 Genomic DNA Translation: AEE87009.1
AK175482 mRNA Translation: BAD43245.1
AK176074 mRNA Translation: BAD43837.1
AK176272 mRNA Translation: BAD44035.1
AK176334 mRNA Translation: BAD44097.1
RefSeqiNP_195614.2, NM_120063.6
UniGeneiAt.2846
At.66625

Genome annotation databases

EnsemblPlantsiAT4G39030.1; AT4G39030.1; AT4G39030
GeneIDi830058
GrameneiAT4G39030.1; AT4G39030.1; AT4G39030
KEGGiath:AT4G39030

Similar proteinsi

Entry informationi

Entry nameiDTX47_ARATH
AccessioniPrimary (citable) accession number: Q945F0
Secondary accession number(s): Q67ZP3, Q9SVJ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: December 1, 2001
Last modified: April 25, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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