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Q94561 (PSA5_ENTHI) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Proteasome subunit alpha type-5

EC=3.4.25.1
OrganismEntamoeba histolytica
Taxonomic identifier5759 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaArchamoebaeEntamoebidaeEntamoeba

Protein attributes

Sequence length247 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.

Catalytic activity

Cleavage of peptide bonds with very broad specificity.

Subunit structure

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Sequence similarities

Belongs to the peptidase T1A family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 247247Proteasome subunit alpha type-5
PRO_0000124122

Sequences

Sequence LengthMass (Da)Tools
Q94561 [UniParc].

Last modified January 1, 1998. Version 2.
Checksum: B39C01D3D56161BF

FASTA24727,247
        10         20         30         40         50         60 
MFMTKNENDH GVNTFSSEGR LFQVEYATEA MKLGSTVIGI QTKEGVVLAV EKRISSPLML 

        70         80         90        100        110        120 
GSSIEKIIEI DDHIGAAVSG LTADARTLID NARLEAQNHR FMYDEPINVE VVAQAISDLS 

       130        140        150        160        170        180 
LRFGEGSRKK KVMSRPFGVA LLIAGVDETG PRLFQTDPSG MFIEFYAKAT GAGTEAAQSI 

       190        200        210        220        230        240 
LHEKYNKSMT LREAEILALS TLKQVMEEKL NSKNVEVALV TVEKKKFEIM DTAFIENLIG 


EIKEELI 

« Hide

References

[1]"The Entamoeba histolytica proteasome alpha-subunit gene."
Ramos M.A., Stock R.P., Sanchez-Lopez R., Olvera F., Lizardi P.M., Alagon A.
Mol. Biochem. Parasitol. 84:131-135(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 30459 / HM-1:IMSS.
[2]"Entamoeba histolytica contains a gene encoding a homologue to the 54 kDa subunit of the signal recognition particle."
Ramos M.A., Mercado G.C., Salgado L.M., Sanchez-Lopez R., Stock R.P., Lizardi P.M., Alagon A.
Mol. Biochem. Parasitol. 88:225-235(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-20.
Strain: ATCC 30459 / HM-1:IMSS.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF386797 Genomic DNA. Translation: AAL50554.1.

3D structure databases

ProteinModelPortalQ94561.
SMRQ94561. Positions 9-242.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ94561.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGCOG0638.

Family and domain databases

Gene3D3.60.20.10. 1 hit.
InterProIPR029055. Ntn_hydrolases_N.
IPR000426. Proteasome_asu_N.
IPR023332. Proteasome_suA-type.
IPR001353. Proteasome_sua/b.
[Graphical view]
PfamPF00227. Proteasome. 1 hit.
PF10584. Proteasome_A_N. 1 hit.
[Graphical view]
SMARTSM00948. Proteasome_A_N. 1 hit.
[Graphical view]
SUPFAMSSF56235. SSF56235. 1 hit.
PROSITEPS00388. PROTEASOME_ALPHA_1. 1 hit.
PS51475. PROTEASOME_ALPHA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePSA5_ENTHI
AccessionPrimary (citable) accession number: Q94561
Entry history
Integrated into UniProtKB/Swiss-Prot: December 8, 2000
Last sequence update: January 1, 1998
Last modified: June 11, 2014
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries