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Q94561

- PSA5_ENTHI

UniProt

Q94561 - PSA5_ENTHI

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Protein

Proteasome subunit alpha type-5

Gene
N/A
Organism
Entamoeba histolytica
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.

GO - Molecular functioni

  1. threonine-type endopeptidase activity Source: UniProtKB-KW

GO - Biological processi

  1. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Threonine protease

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit alpha type-5 (EC:3.4.25.1)
OrganismiEntamoeba histolytica
Taxonomic identifieri5759 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaArchamoebaeEntamoebidaeEntamoeba

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
  3. proteasome core complex, alpha-subunit complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 247247Proteasome subunit alpha type-5PRO_0000124122Add
BLAST

Proteomic databases

PRIDEiQ94561.

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ94561.
SMRiQ94561. Positions 9-242.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1A family.

Phylogenomic databases

eggNOGiCOG0638.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
InterProiIPR029055. Ntn_hydrolases_N.
IPR000426. Proteasome_asu_N.
IPR023332. Proteasome_suA-type.
IPR001353. Proteasome_sua/b.
[Graphical view]
PfamiPF00227. Proteasome. 1 hit.
PF10584. Proteasome_A_N. 1 hit.
[Graphical view]
SMARTiSM00948. Proteasome_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiPS00388. PROTEASOME_ALPHA_1. 1 hit.
PS51475. PROTEASOME_ALPHA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q94561-1 [UniParc]FASTAAdd to Basket

« Hide

MFMTKNENDH GVNTFSSEGR LFQVEYATEA MKLGSTVIGI QTKEGVVLAV    50
EKRISSPLML GSSIEKIIEI DDHIGAAVSG LTADARTLID NARLEAQNHR 100
FMYDEPINVE VVAQAISDLS LRFGEGSRKK KVMSRPFGVA LLIAGVDETG 150
PRLFQTDPSG MFIEFYAKAT GAGTEAAQSI LHEKYNKSMT LREAEILALS 200
TLKQVMEEKL NSKNVEVALV TVEKKKFEIM DTAFIENLIG EIKEELI 247
Length:247
Mass (Da):27,247
Last modified:January 1, 1998 - v2
Checksum:iB39C01D3D56161BF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF386797 Genomic DNA. Translation: AAL50554.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF386797 Genomic DNA. Translation: AAL50554.1 .

3D structure databases

ProteinModelPortali Q94561.
SMRi Q94561. Positions 9-242.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q94561.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi COG0638.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
InterProi IPR029055. Ntn_hydrolases_N.
IPR000426. Proteasome_asu_N.
IPR023332. Proteasome_suA-type.
IPR001353. Proteasome_sua/b.
[Graphical view ]
Pfami PF00227. Proteasome. 1 hit.
PF10584. Proteasome_A_N. 1 hit.
[Graphical view ]
SMARTi SM00948. Proteasome_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
PROSITEi PS00388. PROTEASOME_ALPHA_1. 1 hit.
PS51475. PROTEASOME_ALPHA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 30459 / HM-1:IMSS.
  2. "Entamoeba histolytica contains a gene encoding a homologue to the 54 kDa subunit of the signal recognition particle."
    Ramos M.A., Mercado G.C., Salgado L.M., Sanchez-Lopez R., Stock R.P., Lizardi P.M., Alagon A.
    Mol. Biochem. Parasitol. 88:225-235(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-20.
    Strain: ATCC 30459 / HM-1:IMSS.

Entry informationi

Entry nameiPSA5_ENTHI
AccessioniPrimary (citable) accession number: Q94561
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 8, 2000
Last sequence update: January 1, 1998
Last modified: June 11, 2014
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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