Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Fatty acid desaturase

Gene

Desat1

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cofactori

Fe cationUniRule annotation

GO - Molecular functioni

GO - Biological processi

  • cuticle hydrocarbon biosynthetic process Source: FlyBase
  • glucose homeostasis Source: FlyBase
  • male mating behavior Source: FlyBase
  • mating behavior, sex discrimination Source: FlyBase
  • pheromone biosynthetic process Source: FlyBase
  • positive regulation of cell size Source: FlyBase
  • positive regulation of imaginal disc growth Source: FlyBase
  • positive regulation of multicellular organism growth Source: FlyBase
  • regulation of autophagy Source: FlyBase
  • regulation of lipid metabolic process Source: FlyBase
  • response to starvation Source: FlyBase
  • response to sucrose Source: FlyBase
  • triglyceride homeostasis Source: FlyBase
  • unsaturated fatty acid biosynthetic process Source: InterPro

Keywordsi

Molecular functionOxidoreductaseUniRule annotationSAAS annotation
Biological processFatty acid biosynthesisUniRule annotation, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

ReactomeiR-DME-75105 Fatty acyl-CoA biosynthesis

Names & Taxonomyi

Protein namesi
Submitted name:
Fatty acid desaturaseImported
Gene namesi
Name:Desat1Imported
Synonyms:desat1Imported
ORF Names:CG5887Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0086687 Desat1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei70 – 90HelicalSequence analysisAdd BLAST21
Transmembranei102 – 123HelicalSequence analysisAdd BLAST22
Transmembranei217 – 239HelicalSequence analysisAdd BLAST23
Transmembranei245 – 264HelicalSequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PRIDEiQ94541

Expressioni

Gene expression databases

BgeeiFBgn0086687
ExpressionAtlasiQ94541 baseline and differential

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini97 – 305FA_desaturaseInterPro annotationAdd BLAST209

Domaini

The histidine box domains may contain the active site and/or be involved in metal ion binding.UniRule annotation

Sequence similaritiesi

Belongs to the fatty acid desaturase type 1 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG1600 Eukaryota
COG1398 LUCA
OrthoDBiEOG091G0B5S

Family and domain databases

CDDicd03505 Delta9-FADS-like, 1 hit
InterProiView protein in InterPro
IPR009160 Acyl-CoA_deSatase_haem/ster-bd
IPR015876 Acyl-CoA_DS
IPR005804 FA_desaturase_dom
PANTHERiPTHR11351 PTHR11351, 1 hit
PfamiView protein in Pfam
PF00487 FA_desaturase, 1 hit
PIRSFiPIRSF000345 OLE1, 1 hit
PRINTSiPR00075 FACDDSATRASE

Sequencei

Sequence statusi: Complete.

Q94541-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPNAQAGAQ SISDSLIAAA SAAADAGQSP TKLQEDSTGV LFECDVETTD
60 70 80 90 100
GGLVKDITVM KKAEKRLLKL VWRNIIAFGY LHLAALYGAY LMVTSAKWQT
110 120 130 140 150
CILAYFLYVI SGLGITAGAH RLWAHRSYKA KWPLRVILVI FNTIAFQDAA
160 170 180 190 200
YHWARDHRVH HKYSETDADP HNATRGFFFS HVGWLLCKKH PEVKAKGKGV
210 220 230 240 250
DLSDLRADPI LMFQKKYYMI LMPIACFIIP TVVPMYAWGE SFMNAWFVAT
260 270 280 290 300
MFRWCFILNV TWLVNSAAHK FGGRPYDKFI NPSENISVAI LAFGEGWHNY
310 320 330 340 350
HHVFPWDYKT AEFGKYSLNF TTAFIDFFAK IGWAYDLKTV STDIIKKRVK
360 370 380
RTGDGTHATW GWGDVDQPKE EIEDAVITHK KSE
Length:383
Mass (Da):43,377
Last modified:February 1, 1997 - v1
Checksum:i6DDB775615CB94C6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73160 mRNA Translation: AAB17283.1

Similar proteinsi

Entry informationi

Entry nameiQ94541_DROME
AccessioniPrimary (citable) accession number: Q94541
Entry historyiIntegrated into UniProtKB/TrEMBL: February 1, 1997
Last sequence update: February 1, 1997
Last modified: May 23, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health