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Protein
Submitted name:

Fatty acid desaturase

Gene

Desat1

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Cofactori

Fe cationUniRule annotation

GO - Molecular functioni

GO - Biological processi

  • cuticle hydrocarbon biosynthetic process Source: FlyBase
  • glucose homeostasis Source: FlyBase
  • male mating behavior Source: FlyBase
  • mating behavior, sex discrimination Source: FlyBase
  • pheromone biosynthetic process Source: FlyBase
  • positive regulation of cell size Source: FlyBase
  • positive regulation of imaginal disc growth Source: FlyBase
  • positive regulation of multicellular organism growth Source: FlyBase
  • regulation of autophagy Source: FlyBase
  • regulation of lipid metabolic process Source: FlyBase
  • response to starvation Source: FlyBase
  • response to sucrose Source: FlyBase
  • triglyceride homeostasis Source: FlyBase
  • unsaturated fatty acid biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationSAAS annotation

Keywords - Biological processi

Fatty acid biosynthesisUniRule annotation, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

ReactomeiR-DME-2426168. Activation of gene expression by SREBF (SREBP).
R-DME-75105. Fatty Acyl-CoA Biosynthesis.

Names & Taxonomyi

Protein namesi
Submitted name:
Fatty acid desaturaseImported
Gene namesi
Name:Desat1Imported
Synonyms:desat1Imported
ORF Names:CG5887Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0086687. Desat1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei70 – 90HelicalSequence analysisAdd BLAST21
Transmembranei102 – 123HelicalSequence analysisAdd BLAST22
Transmembranei217 – 239HelicalSequence analysisAdd BLAST23
Transmembranei245 – 264HelicalSequence analysisAdd BLAST20

GO - Cellular componenti

  • cytoplasmic vesicle Source: FlyBase
  • endoplasmic reticulum Source: FlyBase
  • integral component of membrane Source: UniProtKB-KW
  • lipid particle Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiQ94541.
PRIDEiQ94541.

Expressioni

Gene expression databases

BgeeiFBgn0086687.

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0082095.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini97 – 305FA_desaturaseInterPro annotationAdd BLAST209

Domaini

The histidine box domains may contain the active site and/or be involved in metal ion binding.UniRule annotation

Sequence similaritiesi

Belongs to the fatty acid desaturase type 1 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG1600. Eukaryota.
COG1398. LUCA.
OrthoDBiEOG091G0B5S.

Family and domain databases

CDDicd03505. Delta9-FADS-like. 1 hit.
InterProiIPR009160. Acyl-CoA_deSatase_haem/ster-bd.
IPR015876. Acyl-CoA_DS.
IPR005804. FA_desaturase_dom.
[Graphical view]
PANTHERiPTHR11351. PTHR11351. 1 hit.
PfamiPF00487. FA_desaturase. 1 hit.
[Graphical view]
PIRSFiPIRSF000345. OLE1. 1 hit.
PRINTSiPR00075. FACDDSATRASE.

Sequencei

Sequence statusi: Complete.

Q94541-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPNAQAGAQ SISDSLIAAA SAAADAGQSP TKLQEDSTGV LFECDVETTD
60 70 80 90 100
GGLVKDITVM KKAEKRLLKL VWRNIIAFGY LHLAALYGAY LMVTSAKWQT
110 120 130 140 150
CILAYFLYVI SGLGITAGAH RLWAHRSYKA KWPLRVILVI FNTIAFQDAA
160 170 180 190 200
YHWARDHRVH HKYSETDADP HNATRGFFFS HVGWLLCKKH PEVKAKGKGV
210 220 230 240 250
DLSDLRADPI LMFQKKYYMI LMPIACFIIP TVVPMYAWGE SFMNAWFVAT
260 270 280 290 300
MFRWCFILNV TWLVNSAAHK FGGRPYDKFI NPSENISVAI LAFGEGWHNY
310 320 330 340 350
HHVFPWDYKT AEFGKYSLNF TTAFIDFFAK IGWAYDLKTV STDIIKKRVK
360 370 380
RTGDGTHATW GWGDVDQPKE EIEDAVITHK KSE
Length:383
Mass (Da):43,377
Last modified:February 1, 1997 - v1
Checksum:i6DDB775615CB94C6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73160 mRNA. Translation: AAB17283.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73160 mRNA. Translation: AAB17283.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0082095.

Proteomic databases

PaxDbiQ94541.
PRIDEiQ94541.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

FlyBaseiFBgn0086687. Desat1.

Phylogenomic databases

eggNOGiKOG1600. Eukaryota.
COG1398. LUCA.
OrthoDBiEOG091G0B5S.

Enzyme and pathway databases

ReactomeiR-DME-2426168. Activation of gene expression by SREBF (SREBP).
R-DME-75105. Fatty Acyl-CoA Biosynthesis.

Miscellaneous databases

ChiTaRSidesat1. fly.

Gene expression databases

BgeeiFBgn0086687.

Family and domain databases

CDDicd03505. Delta9-FADS-like. 1 hit.
InterProiIPR009160. Acyl-CoA_deSatase_haem/ster-bd.
IPR015876. Acyl-CoA_DS.
IPR005804. FA_desaturase_dom.
[Graphical view]
PANTHERiPTHR11351. PTHR11351. 1 hit.
PfamiPF00487. FA_desaturase. 1 hit.
[Graphical view]
PIRSFiPIRSF000345. OLE1. 1 hit.
PRINTSiPR00075. FACDDSATRASE.
ProtoNetiSearch...

Entry informationi

Entry nameiQ94541_DROME
AccessioniPrimary (citable) accession number: Q94541
Entry historyi
Integrated into UniProtKB/TrEMBL: February 1, 1997
Last sequence update: February 1, 1997
Last modified: November 30, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.