Reviewed, UniProtKB/Swiss-Prot Q94524 (DYLT_DROME)

Names and origin

Protein names

Recommended name:
    Dynein light chain Tctex-type
Alternative name(s):
    TCTEX-1 protein homolog

Gene names

Name:	Dlc90F
Synonyms:	Tctex
ORF Names:	CG12363

Organism

Drosophila melanogaster (Fruit fly) [Complete proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	111 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Sequence similarities

Belongs to the dynein light chain Tctex-type family.

Ontologies

Keywords
Cellular component	Dynein Microtubule
Molecular function	Motor protein
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	spermatid development Inferred from mutant phenotype. Source: FlyBase
Cellular component	dynein complex Inferred from electronic annotation. Source: UniProtKB-KW microtubule Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	dynein intermediate chain binding Inferred from physical interaction. Source: FlyBase motor activity Inferred from electronic annotation. Source: UniProtKB-KW protein homodimerization activity Inferred from direct assay. Source: FlyBase
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
CG10187	Q9VCK5	1	EBI-158251,EBI-122056
ena	Q8T4F7	1	EBI-158251,EBI-466810
Fur2	P30432	1	EBI-158251,EBI-496684
Hsp67Bc	P22979	1	EBI-158251,EBI-165408
metl	Q86BS6-3	1	EBI-158251,EBI-220621
msb1l	Q9VIT3	1	EBI-158251,EBI-121559
Oli	Q9VJC1	1	EBI-158251,EBI-155586
rap	Q9W4H9	1	EBI-158251,EBI-124356
Tctex-1	Q9VH45	1	EBI-158251,EBI-155608
UbcD2	P52485	1	EBI-158251,EBI-149576

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 111

111

Dynein light chain Tctex-type

PRO_0000195155

Secondary structure

1

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111

Helix Strand Turn

Details...

Helix

14 – 27

14

Helix

34 – 53

20

Beta strand

58 – 69

12

Beta strand

75 – 83

9

Turn

85 – 87

3

Beta strand

89 – 96

8

Beta strand

98 – 110

13

Sequences

	Sequence		Length	Mass (Da)
	Q94524-1 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 544CC39F5B318137	FASTA	111	12,479
	10 20 30 40 50 60 MDDSREESQF IVDDVSKTIK EAIETTIGGN AYQHDKVNNW TGQVVENCLT VLTKEQKPYK 70 80 90 100 110 YIVTAMIMQK NGAGLHTASS CYWNNDTDGS CTVRWENKTM YCIVSVFGLA V

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of nuclear genes encoding mitochondrial proteins: isolation of a collection of D. melanogaster cDNAs homologous to sequences in the Human Gene Index database." Caggese C., Ragone G., Perrini B., Moschetti R., de Pinto V., Caizzi R., Barsanti P. Mol. Gen. Genet. 261:64-70(1999) [PubMed: 10071211] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Ovary.
[2]	"dtctex-1, the Drosophila melanogaster homolog of a putative murine t-complex distorter encoding a dynein light chain, is required for production of functional sperm." Caggese C., Moschetti R., Ragone G., Barsanti P., Caizzi R. Mol. Genet. Genomics 265:436-444(2001) [PubMed: 11405626] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[4]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION.
[5]	Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J.W., Champe M., Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., George R.A., Gonzalez M., Guarin H., Kronmiller B., Li P.W., Liao G., Miranda A. , Mungall C.J., Nunoo J., Pacleb J.M., Paragas V., Park S., Patel S., Phouanenavong S., Wan K.H., Yu C., Lewis S.E., Rubin G.M., Celniker S.E. Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Berkeley. Tissue: Embryo.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBLGenBankDDBJ

Y08968 mRNA. Translation: CAA70165.1.
AF123058 Genomic DNA. Translation: AAD30033.1.
AE014297 Genomic DNA. Translation: AAF55532.1.
AY069608 mRNA. Translation: AAL39753.1.

RefSeq

NP_477356.1.

UniGene

Dm.2045

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1YGT	X-ray	1.70	A	1-111	[»]
2PG1	X-ray	2.80	E/F/G/H	1-111	[»]

ModBase

Search...

Protein-protein interaction databases

DIP

DIP:17339N.

IntAct

Q94524. 32 interactions.

Proteomic databases

PRIDE

Q94524.

Genome annotation databases

Ensembl

FBgn0024432. Drosophila melanogaster. [Contig view]

GeneID

42199.

KEGG

dme:Dmel_CG12363.

NMPDR

fig|7227.3.peg.13430.

Organism-specific databases

FlyBase

FBgn0024432. Dlc90F.

Phylogenomic databases

OMA

Q94524. CIVSTFG.

Enzyme and pathway databases

BioCyc

DMEL-XXX-02:DMEL-XXX-02-012203-MON.

Gene expression databases

ArrayExpress

Q94524.

GermOnline

CG12363. Drosophila melanogaster.

Family and domain databases

InterPro

IPR005334. Tctex.
[Graphical view]

PANTHER

PTHR21255. Tctex. 1 hit.

Pfam

PF03645. Tctex-1. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

827633.

Entry information

Entry name

DYLT_DROME

Accession

Primary (citable) accession number: Q94524
Secondary accession number(s): Q9VE95

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	February 1, 1997
Last modified:	June 16, 2009
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Drosophila annotation project