Reviewed,
UniProtKB/Swiss-Prot Q94523 (DHSA_DROME)
Last modified
February 9, 2010.
Version 107.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial EC=1.3.5.1 Alternative name(s): Flavoprotein subunit of complex II Short name=FP | ||||
| Gene names |
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| Organism | Drosophila melanogaster (Fruit fly) [Complete proteome] | ||||
| Taxonomic identifier | 7227 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora |
Protein attributes
| Sequence length | 661 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) By similarity. |
| Catalytic activity | Succinate + ubiquinone = fumarate + ubiquinol. |
| Cofactor | FAD By similarity. |
| Pathway | |
| Subunit structure | Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit By similarity. |
| Subcellular location | Mitochondrion inner membrane; Peripheral membrane protein; Matrix side By similarity. |
| Sequence similarities | Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Electron transport Transport Tricarboxylic acid cycle |
| Cellular component | Membrane Mitochondrion Mitochondrion inner membrane |
| Domain | Transit peptide |
| Ligand | FAD Flavoprotein |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transportInferred from electronic annotation. Source: UniProtKB-KW tricarboxylic acid cycleInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | extrinsic to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrial inner membraneInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | FAD binding Inferred from electronic annotation. Source: InterPro electron carrier activityInferred from electronic annotation. Source: InterPro succinate dehydrogenase (ubiquinone) activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Transit peptide | 1 – 41 | 41 | Mitochondrion Potential | ||||||
| Chain | 42 – 661 | 620 | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial | PRO_0000010340 | |||||
Regions | |||||||||
| Nucleotide binding | 88 – 103 | 16 | FAD By similarity | ||||||
Sites | |||||||||
| Active site | 337 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 293 | 1 | Substrate By similarity | ||||||
| Binding site | 305 | 1 | Substrate By similarity | ||||||
| Binding site | 404 | 1 | Substrate By similarity | ||||||
| Binding site | 449 | 1 | Substrate By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 96 | 1 | Tele-8alpha-FAD histidine By similarity | ||||||
Experimental info | |||||||||
| Sequence conflict | 207 | 1 | S → N in CAA70285. Ref.4 | ||||||
| Sequence conflict | 251 | 1 | I → L in CAA70285. Ref.4 | ||||||
| Sequence conflict | 503 | 1 | Q → L in CAA70285. Ref.4 | ||||||
| Sequence conflict | 520 | 1 | H → L in CAA70285. Ref.4 | ||||||
Sequences
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References
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AE013599 Genomic DNA. Translation: AAG22257.1. AE013599 Genomic DNA. Translation: AAN16127.1. AY051472 mRNA. Translation: AAK92896.1. Y09064 mRNA. Translation: CAA70285.1. Different initiation. |
| RefSeq | NP_477210.1. NP_725881.1. NP_725882.1. |
| UniGene | Dm.4591 |
3D structure databases | |
| SMR | Q94523. Positions 51-661. |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP-19386N. |
| IntAct | Q94523. 7 interactions. |
| STRING | Q94523. |
Genome annotation databases | |
| Ensembl | FBtr0086552; FBpp0085736; FBgn0017539; Drosophila melanogaster. [Genome view] FBtr0086553; FBpp0085737; FBgn0017539; Drosophila melanogaster. [Genome view] FBtr0086554; FBpp0085738; FBgn0017539; Drosophila melanogaster. [Genome view] |
| GeneID | 37228. |
| KEGG | dme:Dmel_CG17246. |
Organism-specific databases | |
| CTD | 37228. |
| FlyBase | FBgn0017539. Scs-fp. |
Phylogenomic databases | |
| eggNOG | inNOG07817. |
| InParanoid | Q94523. |
| OMA | ALGNSHE. |
| OrthoDB | EOG9C5CRB. |
| PhylomeDB | Q94523. |
Enzyme and pathway databases | |
| BioCyc | DMEL-XXX-02:DMEL-XXX-02-005521-MONOMER. DMEL-XXX-02:DMEL-XXX-02-005522-MONOMER. DMEL-XXX-02:DMEL-XXX-02-005523-MONOMER. |
| BRENDA | 1.3.5.1. 48. |
Gene expression databases | |
| ArrayExpress | Q94523. |
| GermOnline | CG17246. Drosophila melanogaster. |
Family and domain databases | |
| InterPro | IPR003953. FAD_bind2_N. IPR003952. FRD_SDH_FAD_BS. IPR015939. Fum_Rdtase/Succ_DH_flav-like_C. IPR004112. Fum_Rdtase/Succ_DH_flav_C. IPR011281. Succ_DH_flav_su_fwd. IPR014006. Succ_Dhase_frdA_Gneg. [Graphical view] |
| Pfam | PF00890. FAD_binding_2. 1 hit. PF02910. Succ_DH_flav_C. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR01816. sdhA_forward. 1 hit. TIGR01812. sdhA_frdA_Gneg. 1 hit. |
| PROSITE | PS00504. FRD_SDH_FAD_BINDING. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 802625. |
Entry information
| Entry name | DHSA_DROME | ||||||||
| Accession | Primary (citable) accession number: Q94523 Secondary accession number(s): A4UZP5, Q0E918, Q9I7G3 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Drosophila annotation project | ||||||||
Relevant documents
| Drosophila Drosophila: entries, gene names and cross-references to FlyBase |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


