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Protein

Nascent polypeptide-associated complex subunit alpha

Gene

Nacalpha

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May promote appropriate targeting of ribosome-nascent polypeptide complexes (By similarity). Required for correct localization of the osk/oskar protein to the posterior pole during embryonic development. The osk protein directs the recruitment of molecules responsible for posterior body patterning and germline formation in the embryo.By similarity1 Publication

GO - Biological processi

  • multicellular organism development Source: UniProtKB-KW
  • oogenesis Source: FlyBase
  • protein transport Source: UniProtKB-KW

Keywordsi

Molecular functionDevelopmental protein
Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Nascent polypeptide-associated complex subunit alpha
Short name:
NAC-alpha
Alternative name(s):
Alpha-NAC
Gene namesi
Name:Nacalpha
Synonyms:aic
ORF Names:CG8759
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0086904 Nacalpha

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001355861 – 217Nascent polypeptide-associated complex subunit alphaAdd BLAST217

Proteomic databases

PaxDbiQ94518
PRIDEiQ94518

Expressioni

Gene expression databases

BgeeiFBgn0086904
ExpressionAtlasiQ94518 baseline and differential
GenevisibleiQ94518 DM

Interactioni

Subunit structurei

Part of the nascent polypeptide-associated complex (NAC), consisting of Nac-alpha and bicaudal (bic).

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi62181, 82 interactors
IntActiQ94518, 20 interactors
STRINGi7227.FBpp0086971

Structurei

3D structure databases

ProteinModelPortaliQ94518
SMRiQ94518
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini70 – 135NAC-A/BPROSITE-ProRule annotationAdd BLAST66
Domaini177 – 217UBAAdd BLAST41

Sequence similaritiesi

Belongs to the NAC-alpha family.Curated

Phylogenomic databases

eggNOGiKOG2239 Eukaryota
COG1308 LUCA
GeneTreeiENSGT00440000033468
InParanoidiQ94518
KOiK03626
OMAiMANPRVE
OrthoDBiEOG091G0292
PhylomeDBiQ94518

Family and domain databases

Gene3Di2.20.70.30, 1 hit
InterProiView protein in InterPro
IPR016641 EGD2/NACA
IPR038187 NAC_A/B_dom_sf
IPR002715 Nas_poly-pep-assoc_cplx_dom
PANTHERiPTHR21713 PTHR21713, 1 hit
PfamiView protein in Pfam
PF01849 NAC, 1 hit
PIRSFiPIRSF015901 NAC_alpha, 1 hit
SMARTiView protein in SMART
SM01407 NAC, 1 hit
PROSITEiView protein in PROSITE
PS51151 NAC_AB, 1 hit

Sequencei

Sequence statusi: Complete.

Q94518-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPELTEIKSE AAPSTSAEAK PEDVRVEDDG SDSDSDGGMP GLEEAVAATT
60 70 80 90 100
QLGGGATGLP IDLVSKAKQS RGEKKARKIM LKLGLKQIQG VNRVTIRKSK
110 120 130 140 150
NILFVINNPD VYKNPHSDTY IVFGEAKIED LSQQAQVAAA EKFKAPEAAG
160 170 180 190 200
AADSVGATTS VAPIAEEDEE DVDDTGVDEK DIELVITQAN TTRAKAIKAL
210
KNNNNDIVNA IMELTML
Length:217
Mass (Da):23,021
Last modified:July 19, 2005 - v2
Checksum:i6E1BD9C91E1D7F93
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti47A → P in CAA70166 (PubMed:10071211).Curated1
Sequence conflicti110D → N in CAA70166 (PubMed:10071211).Curated1
Sequence conflicti204N → D in CAA70166 (PubMed:10071211).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08969 mRNA Translation: CAA70166.1
AF017783 Genomic DNA Translation: AAB97513.1
AE013599 Genomic DNA Translation: AAM68653.1
AE013599 Genomic DNA Translation: AAM68654.1
AY075332 mRNA Translation: AAL68199.1
RefSeqiNP_001286363.1, NM_001299434.1
NP_477216.1, NM_057868.4
NP_599139.1, NM_134312.3
NP_725229.1, NM_165950.2
UniGeneiDm.4630

Genome annotation databases

EnsemblMetazoaiFBtr0087858; FBpp0086971; FBgn0086904
FBtr0087859; FBpp0086972; FBgn0086904
FBtr0087860; FBpp0086973; FBgn0086904
FBtr0345195; FBpp0311394; FBgn0086904
GeneIDi36409
KEGGidme:Dmel_CG8759

Similar proteinsi

Entry informationi

Entry nameiNACA_DROME
AccessioniPrimary (citable) accession number: Q94518
Secondary accession number(s): A4UZF1, O16813, Q0E999
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: May 23, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

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