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Protein

Cysteine proteinase 7

Gene

cprG

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei134By similarity1
Active sitei275By similarity1
Active sitei423By similarity1

GO - Molecular functioni

  • cysteine-type endopeptidase activity Source: GO_Central
  • cysteine-type peptidase activity Source: dictyBase

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Enzyme and pathway databases

ReactomeiR-DDI-2132295. MHC class II antigen presentation.
R-DDI-6798695. Neutrophil degranulation.

Protein family/group databases

MEROPSiC01.081.

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine proteinase 7 (EC:3.4.22.-)
Alternative name(s):
Proteinase 1
Gene namesi
Name:cprG
Synonyms:CP7
ORF Names:DDB_G0279187
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 3, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0279187. cprG.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
PropeptideiPRO_000002636618 – 111Activation peptideSequence analysisAdd BLAST94
ChainiPRO_0000026367112 – 460Cysteine proteinase 7Add BLAST349

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi131 ↔ 176By similarity
Disulfide bondi167 ↔ 210By similarity
Glycosylationi226N-linked (GlcNAc...)Sequence analysis1
Glycosylationi252N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi268 ↔ 445By similarity

Post-translational modificationi

Glycosylated; contains GlcNAc-alpha-1-P-Ser residues. Also N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Zymogen

Proteomic databases

PaxDbiQ94504.

Expressioni

Developmental stagei

Present in the vegetative phase and decreases with the start development.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0215005.

Structurei

3D structure databases

ProteinModelPortaliQ94504.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi276 – 433Gly/Ser-richAdd BLAST158

Sequence similaritiesi

Belongs to the peptidase C1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1543. Eukaryota.
COG4870. LUCA.
InParanoidiQ94504.
KOiK01365.
PhylomeDBiQ94504.

Family and domain databases

InterProiIPR025661. Pept_asp_AS.
IPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR013201. Prot_inhib_I29.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 2 hits.
PfamiPF08246. Inhibitor_I29. 1 hit.
PF00112. Peptidase_C1. 2 hits.
[Graphical view]
PRINTSiPR00705. PAPAIN.
SMARTiSM00848. Inhibitor_I29. 1 hit.
SM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q94504-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVLSALCVL LVSVATAKQQ LSEVEYRNAF TNWMIAHQRH YSSEEFNGRY
60 70 80 90 100
NIFKANMDYV NEWNTKGSET VLGLNVFADI SNEEYRATYL GTPFDASSLE
110 120 130 140 150
MTESDKIFDA SAQVDWRTQG AVTPIKNQGQ CGGCWSFSTT GATEGAQYLA
160 170 180 190 200
NGKKNLVSLS EQNLIDCSGS YGNNGCEGGL MTLAFEYIIN NKGIDTESSY
210 220 230 240 250
PYTAEDGKKC KFNPKNVAAQ LSSYVNVTSG SESDLAAKVT QGPTSVAIDA
260 270 280 290 300
SNQSFQLYVS GIYNEPACSS TQLDHGVLAV GFGTGSGSSG SHGGSQSQSA
310 320 330 340 350
GSDSQSAGSE SSQSESGSQS QSESGSQSQS QSGSQSFSGS LYSGSYSGSQ
360 370 380 390 400
SGSQSGNSGA AVKQTGAGSG SGSGSGSGSG SGSGSVSGSA SGSASGSASG
410 420 430 440 450
SSSGSNSNGG VYPTAGDYWI VKNSWGTSWG MDGYILMTKG NNNQCGIATM
460
ASRPTAVASL
Length:460
Mass (Da):47,166
Last modified:February 1, 1997 - v1
Checksum:i0D71CFA1BAC99B25
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U72746 mRNA. Translation: AAC47482.1.
AAFI02000030 Genomic DNA. Translation: EAL67742.2.
RefSeqiXP_641720.2. XM_636628.2.

Genome annotation databases

EnsemblProtistsiEAL67742; EAL67742; DDB_G0279187.
GeneIDi8621915.
KEGGiddi:DDB_G0279187.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U72746 mRNA. Translation: AAC47482.1.
AAFI02000030 Genomic DNA. Translation: EAL67742.2.
RefSeqiXP_641720.2. XM_636628.2.

3D structure databases

ProteinModelPortaliQ94504.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0215005.

Protein family/group databases

MEROPSiC01.081.

Proteomic databases

PaxDbiQ94504.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAL67742; EAL67742; DDB_G0279187.
GeneIDi8621915.
KEGGiddi:DDB_G0279187.

Organism-specific databases

dictyBaseiDDB_G0279187. cprG.

Phylogenomic databases

eggNOGiKOG1543. Eukaryota.
COG4870. LUCA.
InParanoidiQ94504.
KOiK01365.
PhylomeDBiQ94504.

Enzyme and pathway databases

ReactomeiR-DDI-2132295. MHC class II antigen presentation.
R-DDI-6798695. Neutrophil degranulation.

Miscellaneous databases

PROiQ94504.

Family and domain databases

InterProiIPR025661. Pept_asp_AS.
IPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR013201. Prot_inhib_I29.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 2 hits.
PfamiPF08246. Inhibitor_I29. 1 hit.
PF00112. Peptidase_C1. 2 hits.
[Graphical view]
PRINTSiPR00705. PAPAIN.
SMARTiSM00848. Inhibitor_I29. 1 hit.
SM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCYSP7_DICDI
AccessioniPrimary (citable) accession number: Q94504
Secondary accession number(s): Q54X57
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: February 1, 1997
Last modified: November 30, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.