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Protein

Cysteine proteinase 6

Gene

cprF

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei136By similarity1
Active sitei276By similarity1
Active sitei394By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease

Protein family/group databases

MEROPSiC01.081

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine proteinase 6 (EC:3.4.22.-)
Gene namesi
Name:cprF
Synonyms:CP6
ORF Names:DDB_G0279185
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 3, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0279185 cprF

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
PropeptideiPRO_000031251420 – 113Activation peptideSequence analysisAdd BLAST94
ChainiPRO_0000312515114 – 434Cysteine proteinase 6Add BLAST321

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi133 ↔ 178By similarity
Disulfide bondi169 ↔ 211By similarity
Glycosylationi227N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi269 ↔ 416By similarity
Glycosylationi305N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Zymogen

Proteomic databases

PaxDbiQ94503

Expressioni

Developmental stagei

Present in the vegetative phase and decreases with the start development.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0215002

Structurei

3D structure databases

ProteinModelPortaliQ94503
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi277 – 381Gly/Ser-richAdd BLAST105

Sequence similaritiesi

Belongs to the peptidase C1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1543 Eukaryota
COG4870 LUCA
InParanoidiQ94503
KOiK01365
OMAiRNEETYE
PhylomeDBiQ94503

Family and domain databases

InterProiView protein in InterPro
IPR025661 Pept_asp_AS
IPR000169 Pept_cys_AS
IPR025660 Pept_his_AS
IPR013128 Peptidase_C1A
IPR000668 Peptidase_C1A_C
IPR013201 Prot_inhib_I29
PANTHERiPTHR12411 PTHR12411, 1 hit
PfamiView protein in Pfam
PF08246 Inhibitor_I29, 1 hit
PF00112 Peptidase_C1, 2 hits
PRINTSiPR00705 PAPAIN
SMARTiView protein in SMART
SM00848 Inhibitor_I29, 1 hit
SM00645 Pept_C1, 1 hit
PROSITEiView protein in PROSITE
PS00640 THIOL_PROTEASE_ASN, 1 hit
PS00139 THIOL_PROTEASE_CYS, 1 hit
PS00639 THIOL_PROTEASE_HIS, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q94503-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVLSALCVL LVSVATAKQQ LSELQYRNAF TNWMIAHQRH YSSEEFNGRF
60 70 80 90 100
NIFKANMDYI NEWNTKGSET VLGLNVFADI TNEEYRATYL GTPFDASSLE
110 120 130 140 150
MTPSEKVFGG VQANSVDWRA KGAVTPIKNQ GECGGCWSFS ATGATEGAQY
160 170 180 190 200
IANGDSDLTS VSEQQLIDCS GSYGNNGCEG GLMTLAFEYI INNGGIDTES
210 220 230 240 250
SYPFTANTEK CKYNPSNIGA ELSSYVNVTS GSESDLAAKV TQGPTSVAID
260 270 280 290 300
ASQPSFQFYS SGIYNEPACS STQLDHGVLA VGFGSGSSGS QSQSAGSQSQ
310 320 330 340 350
SSNNNWSESS QSQDSNSWSQ SSQSQSSQDS NSWSQSSQSQ GSNSFTGAGT
360 370 380 390 400
GSGSGSVSGS GSASGSSSFS GSSNGGNSNS GDYPTDGNYW IVKNSWGLDW
410 420 430
GINGYILMSK DKDNQCGIAT MASIPQAIPK SKWN
Length:434
Mass (Da):45,765
Last modified:February 1, 1997 - v1
Checksum:i4F2297D8BDF7AFBD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U72745 mRNA Translation: AAC47481.1
AAFI02000030 Genomic DNA Translation: EAL67741.1
RefSeqiXP_641725.1, XM_636633.1

Genome annotation databases

EnsemblProtistsiEAL67741; EAL67741; DDB_G0279185
GeneIDi8621921
KEGGiddi:DDB_G0279185

Similar proteinsi

Entry informationi

Entry nameiCYSP6_DICDI
AccessioniPrimary (citable) accession number: Q94503
Secondary accession number(s): Q54X52
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: February 1, 1997
Last modified: March 28, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health