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Protein

Cysteine proteinase 6

Gene

cprF

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei136 – 1361By similarity
Active sitei276 – 2761By similarity
Active sitei394 – 3941By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Enzyme and pathway databases

ReactomeiR-DDI-2132295. MHC class II antigen presentation.

Protein family/group databases

MEROPSiC01.081.

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine proteinase 6 (EC:3.4.22.-)
Gene namesi
Name:cprF
Synonyms:CP6
ORF Names:DDB_G0279185
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 3, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0279185. cprF.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Propeptidei20 – 11394Activation peptideSequence analysisPRO_0000312514Add
BLAST
Chaini114 – 434321Cysteine proteinase 6PRO_0000312515Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi133 ↔ 178By similarity
Disulfide bondi169 ↔ 211By similarity
Glycosylationi227 – 2271N-linked (GlcNAc...)Sequence analysis
Disulfide bondi269 ↔ 416By similarity
Glycosylationi305 – 3051N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Zymogen

Proteomic databases

PaxDbiQ94503.
PRIDEiQ94503.

Expressioni

Developmental stagei

Present in the vegetative phase and decreases with the start development.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0215002.

Structurei

3D structure databases

ProteinModelPortaliQ94503.
SMRiQ94503. Positions 389-426.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi277 – 381105Gly/Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1543. Eukaryota.
COG4870. LUCA.
InParanoidiQ94503.
OMAiNSWSQSS.
PhylomeDBiQ94503.

Family and domain databases

InterProiIPR025661. Pept_asp_AS.
IPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR013201. Prot_inhib_I29.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 2 hits.
PfamiPF08246. Inhibitor_I29. 1 hit.
PF00112. Peptidase_C1. 2 hits.
[Graphical view]
PRINTSiPR00705. PAPAIN.
SMARTiSM00848. Inhibitor_I29. 1 hit.
SM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q94503-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVLSALCVL LVSVATAKQQ LSELQYRNAF TNWMIAHQRH YSSEEFNGRF
60 70 80 90 100
NIFKANMDYI NEWNTKGSET VLGLNVFADI TNEEYRATYL GTPFDASSLE
110 120 130 140 150
MTPSEKVFGG VQANSVDWRA KGAVTPIKNQ GECGGCWSFS ATGATEGAQY
160 170 180 190 200
IANGDSDLTS VSEQQLIDCS GSYGNNGCEG GLMTLAFEYI INNGGIDTES
210 220 230 240 250
SYPFTANTEK CKYNPSNIGA ELSSYVNVTS GSESDLAAKV TQGPTSVAID
260 270 280 290 300
ASQPSFQFYS SGIYNEPACS STQLDHGVLA VGFGSGSSGS QSQSAGSQSQ
310 320 330 340 350
SSNNNWSESS QSQDSNSWSQ SSQSQSSQDS NSWSQSSQSQ GSNSFTGAGT
360 370 380 390 400
GSGSGSVSGS GSASGSSSFS GSSNGGNSNS GDYPTDGNYW IVKNSWGLDW
410 420 430
GINGYILMSK DKDNQCGIAT MASIPQAIPK SKWN
Length:434
Mass (Da):45,765
Last modified:February 1, 1997 - v1
Checksum:i4F2297D8BDF7AFBD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U72745 mRNA. Translation: AAC47481.1.
AAFI02000030 Genomic DNA. Translation: EAL67741.1.
RefSeqiXP_641725.1. XM_636633.1.

Genome annotation databases

EnsemblProtistsiDDB0215002; DDB0215002; DDB_G0279185.
GeneIDi8621921.
KEGGiddi:DDB_G0279185.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U72745 mRNA. Translation: AAC47481.1.
AAFI02000030 Genomic DNA. Translation: EAL67741.1.
RefSeqiXP_641725.1. XM_636633.1.

3D structure databases

ProteinModelPortaliQ94503.
SMRiQ94503. Positions 389-426.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0215002.

Protein family/group databases

MEROPSiC01.081.

Proteomic databases

PaxDbiQ94503.
PRIDEiQ94503.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiDDB0215002; DDB0215002; DDB_G0279185.
GeneIDi8621921.
KEGGiddi:DDB_G0279185.

Organism-specific databases

dictyBaseiDDB_G0279185. cprF.

Phylogenomic databases

eggNOGiKOG1543. Eukaryota.
COG4870. LUCA.
InParanoidiQ94503.
OMAiNSWSQSS.
PhylomeDBiQ94503.

Enzyme and pathway databases

ReactomeiR-DDI-2132295. MHC class II antigen presentation.

Miscellaneous databases

PROiQ94503.

Family and domain databases

InterProiIPR025661. Pept_asp_AS.
IPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR013201. Prot_inhib_I29.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 2 hits.
PfamiPF08246. Inhibitor_I29. 1 hit.
PF00112. Peptidase_C1. 2 hits.
[Graphical view]
PRINTSiPR00705. PAPAIN.
SMARTiSM00848. Inhibitor_I29. 1 hit.
SM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCYSP6_DICDI
AccessioniPrimary (citable) accession number: Q94503
Secondary accession number(s): Q54X52
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: February 1, 1997
Last modified: September 7, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.