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Protein

Histone deacetylase 2

Gene

HDA2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity).By similarity

Catalytic activityi

Hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei201By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator, Hydrolase, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylase 2 (EC:3.5.1.98)
Gene namesi
Name:HDA2
Ordered Locus Names:At5g26040
ORF Names:T1N24.9
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G26040
TAIRilocus:2180657 AT5G26040

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002800831 – 387Histone deacetylase 2Add BLAST387

Proteomic databases

PaxDbiQ944K3

Expressioni

Gene expression databases

ExpressionAtlasiQ944K3 baseline and differential
GenevisibleiQ944K3 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT5G26040.2

Structurei

3D structure databases

ProteinModelPortaliQ944K3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni73 – 382Histone deacetylaseAdd BLAST310

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1344 Eukaryota
COG0123 LUCA
HOGENOMiHOG000280018
InParanoidiQ944K3
KOiK11418
OMAiRVFTFSM
OrthoDBiEOG09360ETX
PhylomeDBiQ944K3

Family and domain databases

Gene3Di3.40.800.20, 1 hit
InterProiView protein in InterPro
IPR000286 His_deacetylse
IPR023801 His_deacetylse_dom
IPR037138 His_deacetylse_dom_sf
IPR023696 Ureohydrolase_dom_sf
PfamiView protein in Pfam
PF00850 Hist_deacetyl, 1 hit
PRINTSiPR01270 HDASUPER
SUPFAMiSSF52768 SSF52768, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q944K3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTHTRVISTW TELTRDLAIY LLFTFFAIKV FKFLFSCNRT SEISSFSMAT
60 70 80 90 100
HPEALRRERI LNSKLYFDVP LSKVSIIYSS SYDISFMGIE KLHPFDSSKW
110 120 130 140 150
GRVCKFLVSD GFLEEKAIVE PLEASKIDLL VVHSENYLNS LKSSATVARI
160 170 180 190 200
TEVAPVAFFP NFLVQQKVLY PFRKQVGGTI LAAKLATERG WAINIGGGFH
210 220 230 240 250
HCTAERGGGF CAFADISLCI HFAFLRLRIS RVMIIDLDAH QGNGHETDLG
260 270 280 290 300
DDNRVYILDM YNPEIYPFDY RARRFIDQKV EVMSGTTTDE YLRKLDEALE
310 320 330 340 350
VASRNFQPEL VIYNAGTDIL DGDPLGLLKI SPDGITSRDE KVFRFAREKN
360 370 380
IPLVMLTSGG YMKSSARVIA DSIENLSRQG LIQTRPE
Length:387
Mass (Da):43,804
Last modified:March 6, 2007 - v2
Checksum:i4BC4C14D6F0C4808
GO
Isoform 2 (identifier: Q944K3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     253-261: NRVYILDMY → SMIKTLYIS
     262-387: Missing.

Note: May be due to intron retention. No experimental confirmation available.
Show »
Length:261
Mass (Da):29,407
Checksum:i0452A8B9401EC669
GO
Isoform 3 (identifier: Q944K3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     208-235: Missing.

Note: Derived from EST data. May be due to a competing acceptor splice site. No experimental confirmation available.
Show »
Length:359
Mass (Da):40,651
Checksum:i24993D8597EDD144
GO

Sequence cautioni

The sequence AAD40129 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_023527208 – 235Missing in isoform 3. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_023528253 – 261NRVYILDMY → SMIKTLYIS in isoform 2. 1 Publication9
Alternative sequenceiVSP_023529262 – 387Missing in isoform 2. 1 PublicationAdd BLAST126

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF149413 Genomic DNA Translation: AAD40129.1 Sequence problems.
CP002688 Genomic DNA Translation: AED93516.1
CP002688 Genomic DNA Translation: AED93517.1
AF428336 mRNA Translation: AAL16266.1
BT002252 mRNA Translation: AAN72263.1
AF510671 mRNA Translation: AAM34784.1
AF510165 mRNA No translation available.
RefSeqiNP_568480.2, NM_122505.4 [Q944K3-1]
NP_851078.1, NM_180747.2 [Q944K3-3]
UniGeneiAt.58
At.70191

Genome annotation databases

EnsemblPlantsiAT5G26040.1; AT5G26040.1; AT5G26040 [Q944K3-3]
AT5G26040.2; AT5G26040.2; AT5G26040 [Q944K3-1]
GeneIDi832673
GrameneiAT5G26040.1; AT5G26040.1; AT5G26040 [Q944K3-3]
AT5G26040.2; AT5G26040.2; AT5G26040 [Q944K3-1]
KEGGiath:AT5G26040

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiHDA2_ARATH
AccessioniPrimary (citable) accession number: Q944K3
Secondary accession number(s): Q3E940, Q8LRK7, Q9XH00
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: March 6, 2007
Last modified: April 25, 2018
This is version 101 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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