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Protein

Phosphoinositide phospholipase C 5

Gene

PLC5

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.1 Publication

Catalytic activityi

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei127PROSITE-ProRule annotation1
Active sitei173PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Transducer
Biological processLipid degradation, Lipid metabolism

Enzyme and pathway databases

BioCyciARA:AT5G58690-MONOMER
BRENDAi3.1.4.11 399
ReactomeiR-ATH-112043 PLC beta mediated events
R-ATH-114604 GPVI-mediated activation cascade
R-ATH-1855204 Synthesis of IP3 and IP4 in the cytosol
R-ATH-202433 Generation of second messenger molecules
R-ATH-399997 Acetylcholine regulates insulin secretion
R-ATH-416476 G alpha (q) signalling events
R-ATH-434316 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
R-ATH-5607764 CLEC7A (Dectin-1) signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoinositide phospholipase C 5 (EC:3.1.4.11)
Alternative name(s):
Phosphoinositide phospholipase PLC5
Short name:
AtPLC5
Short name:
AtPLCx
Short name:
PI-PLC5
Gene namesi
Name:PLC5
Synonyms:ATHATPLC6
Ordered Locus Names:At5g58690
ORF Names:MZN1.13, MZN1.15
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G58690
TAIRilocus:2178833 AT5G58690

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003241301 – 578Phosphoinositide phospholipase C 5Add BLAST578

Proteomic databases

PaxDbiQ944C2

Expressioni

Tissue specificityi

Expressed in leaves, roots, flowers and siliques. High levels of expression in the guard cells and vasculature of leaves and roots.1 Publication

Inductioni

By environmental stresses such as dehydration, salinity and low temperature.1 Publication

Gene expression databases

ExpressionAtlasiQ944C2 baseline and differential
GenevisibleiQ944C2 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT5G58690.1

Structurei

3D structure databases

ProteinModelPortaliQ944C2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 111EF-hand-likeAdd BLAST84
Domaini112 – 256PI-PLC X-boxPROSITE-ProRule annotationAdd BLAST145
Domaini314 – 430PI-PLC Y-boxPROSITE-ProRule annotationAdd BLAST117
Domaini436 – 543C2PROSITE-ProRule annotationAdd BLAST108

Phylogenomic databases

eggNOGiKOG0169 Eukaryota
ENOG410XPSW LUCA
HOGENOMiHOG000244119
InParanoidiQ944C2
KOiK05857
OMAiRITCERH
OrthoDBiEOG0936050V
PhylomeDBiQ944C2

Family and domain databases

Gene3Di2.60.40.150, 1 hit
3.20.20.190, 1 hit
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR011992 EF-hand-dom_pair
IPR001192 PI-PLC_fam
IPR017946 PLC-like_Pdiesterase_TIM-brl
IPR015359 PLC_EF-hand-like
IPR000909 PLipase_C_PInositol-sp_X_dom
IPR001711 PLipase_C_Pinositol-sp_Y
PANTHERiPTHR10336 PTHR10336, 1 hit
PfamiView protein in Pfam
PF00168 C2, 1 hit
PF09279 EF-hand_like, 1 hit
PF00388 PI-PLC-X, 1 hit
PF00387 PI-PLC-Y, 1 hit
PRINTSiPR00390 PHPHLIPASEC
SMARTiView protein in SMART
SM00239 C2, 1 hit
SM00148 PLCXc, 1 hit
SM00149 PLCYc, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
SSF51695 SSF51695, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 1 hit
PS50007 PIPLC_X_DOMAIN, 1 hit
PS50008 PIPLC_Y_DOMAIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q944C2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRDMGSYKM GLCCSDKLRM NRGAPPQDVV TAFVEYTEGR SHMTAEQLCR
60 70 80 90 100
FLVEVQDETE VLVSDAEKII ERITCERHHI TKFLRHTLNL DDFFSFLFSD
110 120 130 140 150
DLNHPIDSKV HQDMASPLSH YFIYTSHNSY LTGNQINSEC SDVPLIKALK
160 170 180 190 200
RGVRALELDM WPNSTKDDIL VLHGWAWTPP VELVKCLRSI KEHAFYASAY
210 220 230 240 250
PVILTLEDHL TPDLQAKAAE MMKEIFMDMV YFPEAGGLKE FPSPEDLKYK
260 270 280 290 300
IVISTKPPKG SLRKDKDSES DASGKASSDV SADDEKTEEE TSEAKNEEDG
310 320 330 340 350
FDQESSNLDF LTYSRLITIP SGNAKNGLKE ALTIDNGGVR RLSLREQKFK
360 370 380 390 400
KATEMYGTEV IKFTQKNLLR IYPKATRVNS SNYRPYNGWM YGAQMVAFNM
410 420 430 440 450
QGYGRALWMM HGMFRGNGGC GYVKKPDFMM NNNLSGEVFN PKAKLPIKKT
460 470 480 490 500
LKVKVYMGKG WDSGFQRTCF NTWSSPNFYT RVGITGVRGD KVMKKTKKEQ
510 520 530 540 550
KTWEPFWNEE FEFQLTVPEL ALLRIEVHDY NMPEKDDFSG QTCLPVSELR
560 570
QGIRSVPLYD RKGERLVSVT LLMRFHFL
Length:578
Mass (Da):66,253
Last modified:June 1, 2002 - v2
Checksum:iA744F73545FC7364
GO

Sequence cautioni

The sequence BAA97337 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF434167 mRNA Translation: AAL30748.2
AB020755 Genomic DNA Translation: BAA97337.1 Sequence problems.
CP002688 Genomic DNA Translation: AED97085.1
CP002688 Genomic DNA Translation: ANM70993.1
AY062681 mRNA Translation: AAL32759.1
BT010399 mRNA Translation: AAQ56842.1
RefSeqiNP_001332556.1, NM_001345318.1
NP_200677.2, NM_125256.3
UniGeneiAt.27264

Genome annotation databases

EnsemblPlantsiAT5G58690.1; AT5G58690.1; AT5G58690
AT5G58690.3; AT5G58690.3; AT5G58690
GeneIDi835983
GrameneiAT5G58690.1; AT5G58690.1; AT5G58690
AT5G58690.3; AT5G58690.3; AT5G58690
KEGGiath:AT5G58690

Similar proteinsi

Entry informationi

Entry nameiPLCD5_ARATH
AccessioniPrimary (citable) accession number: Q944C2
Secondary accession number(s): Q8W4B4, Q9LUZ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: June 1, 2002
Last modified: April 25, 2018
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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