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Protein

Sucrose nonfermenting 4-like protein

Gene

SNF4

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulatory subunit of the probable trimeric SNF1-related protein kinase (SnRK) complex, which may play a role in a signal transduction cascade regulating gene expression and carbohydrate metabolism in higher plants.

GO - Molecular functioni

  • protein kinase activator activity Source: TAIR
  • protein kinase regulator activity Source: TAIR
  • protein serine/threonine kinase activity Source: TAIR

GO - Biological processi

  • carbohydrate metabolic process Source: UniProtKB-KW
  • cellular response to glucose starvation Source: TAIR
  • mitochondrial fission Source: TAIR
  • peroxisome fission Source: TAIR
  • pollen hydration Source: TAIR
  • protein autophosphorylation Source: TAIR
  • regulation of protein kinase activity Source: TAIR
  • regulation of reactive oxygen species metabolic process Source: TAIR

Keywordsi

Biological processCarbohydrate metabolism

Enzyme and pathway databases

ReactomeiR-ATH-163680 AMPK inhibits chREBP transcriptional activation activity
R-ATH-200425 Import of palmitoyl-CoA into the mitochondrial matrix
R-ATH-380972 Energy dependent regulation of mTOR by LKB1-AMPK

Protein family/group databases

CAZyiCBM48 Carbohydrate-Binding Module Family 48

Names & Taxonomyi

Protein namesi
Recommended name:
Sucrose nonfermenting 4-like protein
Short name:
SNF4
Alternative name(s):
CBS domain-containing protein CBSCBS3
SNF1-related protein kinase regulatory subunit betagamma
Short name:
AKIN subunit betagamma
Short name:
AKINbetagamma
Gene namesi
Name:SNF4
Synonyms:CBSCBS3
Ordered Locus Names:At1g09020
ORF Names:F7G19.11
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G09020
TAIRilocus:2036079 AT1G09020

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004121951 – 487Sucrose nonfermenting 4-like proteinAdd BLAST487

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ944A6
PRIDEiQ944A6

PTM databases

iPTMnetiQ944A6

Expressioni

Tissue specificityi

Preferentially expressed in dividing cells, as well as in shoot apex and flower buds, but expressed at a lower level in differentiated tissues of roots, and leaves of rosette and inflorescence.2 Publications

Gene expression databases

ExpressionAtlasiQ944A6 baseline and differential
GenevisibleiQ944A6 AT

Interactioni

Subunit structurei

Subunit of a probable heterotrimeric complex consisting of an alpha catalytic (KIN10 or KIN11) subunit, and a beta (KINB) and a gamma (KING or SNF4) non-catalytic regulatory subunits. Interacts with KIN10, KIN11, KINB1, KINB2, KINB3, HSPRO1 AND HSPRO2.3 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi22664, 9 interactors
IntActiQ944A6, 8 interactors
STRINGi3702.AT1G09020.1

Structurei

3D structure databases

ProteinModelPortaliQ944A6
SMRiQ944A6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini165 – 227CBS 1PROSITE-ProRule annotationAdd BLAST63
Domaini260 – 324CBS 2PROSITE-ProRule annotationAdd BLAST65
Domaini350 – 408CBS 3PROSITE-ProRule annotationAdd BLAST59
Domaini432 – 487CBS 4PROSITE-ProRule annotationAdd BLAST56

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni22 – 101Kinase-interacting sequence (KIS)Add BLAST80

Domaini

Kinase-interacting sequence (KIS) is required for interaction with KIN10 or KIN11.1 Publication

Sequence similaritiesi

Keywords - Domaini

CBS domain, Repeat

Phylogenomic databases

eggNOGiKOG1616 Eukaryota
KOG1764 Eukaryota
COG0517 LUCA
HOGENOMiHOG000240774
InParanoidiQ944A6
OMAiEGVIKCY
OrthoDBiEOG093607GU
PhylomeDBiQ944A6

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR032640 AMPK1_CBM
IPR000644 CBS_dom
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
PfamiView protein in Pfam
PF16561 AMPK1_CBM, 1 hit
PF00571 CBS, 2 hits
SMARTiView protein in SMART
SM00116 CBS, 3 hits
SUPFAMiSSF81296 SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS51371 CBS, 4 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q944A6-1) [UniParc]FASTAAdd to basket
Also known as: AKINbetagamma

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFGSTLDSSR GNSAASGQLL TPTRFVWPYG GRRVFLSGSF TRWTEHVPMS
60 70 80 90 100
PLEGCPTVFQ VICNLTPGYH QYKFFVDGEW RHDEHQPFVS GNGGVVNTIF
110 120 130 140 150
ITGPDMVPAG FSPETLGRSN MDVDDVFLRT ADPSQEAVPR MSGVDLELSR
160 170 180 190 200
HRISVLLSTR TAYELLPESG KVIALDVNLP VKQAFHILYE QGIPLAPLWD
210 220 230 240 250
FGKGQFVGVL GPLDFILILR ELGTHGSNLT EEELETHTIA AWKEGKAHIS
260 270 280 290 300
RQYDGSGRPY PRPLVQVGPY DNLKDVALKI LQNKVAAVPV IYSSLQDGSY
310 320 330 340 350
PQLLHLASLS GILKCICRYF RHSSSSLPIL QQPICSIPLG TWVPRIGESS
360 370 380 390 400
SKPLATLRPH ASLGSALALL VQAEVSSIPV VDDNDSLIDI YSRSDITALA
410 420 430 440 450
KDKAYAQIHL DDMTVHQALQ LGQDASPPYG IFNGQRCHMC LRSDSLVKVM
460 470 480
ERLANPGVRR LVIVEAGSKR VEGIISLSDV FQFLLGL
Length:487
Mass (Da):53,466
Last modified:December 1, 2001 - v1
Checksum:i4545FE3BF2C4EBEC
GO
Isoform 2 (identifier: Q944A6-2) [UniParc]FASTAAdd to basket
Also known as: AKINbetagammaI

The sequence of this isoform differs from the canonical sequence as follows:
     394-394: S → R
     395-487: Missing.

Note: May be due to an intron retention. No experimental confirmation available.
Show »
Length:394
Mass (Da):43,302
Checksum:i4A16179AA13A1337
GO

Sequence cautioni

The sequence AAB70406 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAG10141 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_041656394S → R in isoform 2. 1 Publication1
Alternative sequenceiVSP_041657395 – 487Missing in isoform 2. 1 PublicationAdd BLAST93

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF250335 mRNA Translation: AAG10141.1 Different initiation.
DQ132632 mRNA Translation: ABA12450.1
DQ132633 mRNA Translation: ABA12451.1
AC000106 Genomic DNA Translation: AAB70406.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE28383.1
AF439826 mRNA Translation: AAL27498.1
BT000625 mRNA Translation: AAN18191.1
PIRiB86222
RefSeqiNP_563834.1, NM_100773.4 [Q944A6-1]
UniGeneiAt.10386

Genome annotation databases

EnsemblPlantsiAT1G09020.1; AT1G09020.1; AT1G09020 [Q944A6-1]
GeneIDi837423
GrameneiAT1G09020.1; AT1G09020.1; AT1G09020 [Q944A6-1]
KEGGiath:AT1G09020

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSNF4_ARATH
AccessioniPrimary (citable) accession number: Q944A6
Secondary accession number(s): O04028, Q2QCL5, Q9FV59
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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