Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q94465 (GCH1_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP cyclohydrolase 1

EC=3.5.4.16
Alternative name(s):
GTP cyclohydrolase I
Short name=GTP-CH-I
Gene names
Name:gchA
Synonyms:folE, gtoC
ORF Names:DDB_G0288481
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length232 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_00223

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_00223

Subunit structure

Toroid-shaped homodecamer, composed of two pentamers of five dimers By similarity.

Sequence similarities

Belongs to the GTP cyclohydrolase I family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 232232GTP cyclohydrolase 1 HAMAP-Rule MF_00223
PRO_0000119481

Sites

Metal binding1211Zinc By similarity
Metal binding1241Zinc By similarity
Metal binding1921Zinc By similarity

Experimental info

Sequence conflict1871E → D in CAA89808. Ref.1
Sequence conflict2061V → A in CAA89808. Ref.1
Sequence conflict2161K → E in CAA89808. Ref.1
Sequence conflict228 – 2325IKSNK → FNSTN in CAA89808. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q94465 [UniParc].

Last modified December 4, 2007. Version 2.
Checksum: D36603D793EE5EA2

FASTA23226,277
        10         20         30         40         50         60 
MSDNLKSYQD NHIENEDEEI YERSNGKGKE LVDFGKKREP LIHNHEVLNT MQSSVKTLLS 

        70         80         90        100        110        120 
SLGEDPDREG LLKTPLRMSK ALLFFTQGYE QSVDEVIGEA IFNENHHEMV VVRDIDIFSL 

       130        140        150        160        170        180 
CEHHMVPFHG KCHIGYIPDQ KVLGLSKLAR VAEIFARRLQ VQERLTRQIA QAIQAHLNPM 

       190        200        210        220        230 
GVAVVIEASH MCMVMRGVQK PGASTVTSSV CGIFEKDSRT RAEFFSLIKS NK 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning of a cDNA coding for GTP cyclohydrolase I from Dictyostelium discoideum."
Witter K., Cahill D.J., Werner T., Ziegler I., Roedl W., Bacher A., Guetlich M.
Biochem. J. 319:27-32(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: AX2.
[2]"The genome of the social amoeba Dictyostelium discoideum."
Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. expand/collapse author list , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AX4.
[3]"Proteomics fingerprinting of phagosome maturation and evidence for the role of a Galpha during uptake."
Gotthardt D., Blancheteau V., Bosserhoff A., Ruppert T., Delorenzi M., Soldati T.
Mol. Cell. Proteomics 5:2228-2243(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Strain: AX2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z49706 mRNA. Translation: CAA89808.1.
AAFI02000112 Genomic DNA. Translation: EAL63189.1.
PIRS72439.
RefSeqXP_636697.1. XM_631605.1.

3D structure databases

ProteinModelPortalQ94465.
SMRQ94465. Positions 48-230.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING44689.DDB_0191399.

Proteomic databases

PRIDEQ94465.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0191399; DDB0191399; DDB_G0288481.
GeneID8626654.
KEGGddi:DDB_G0288481.

Organism-specific databases

dictyBaseDDB_G0288481. gchA.

Phylogenomic databases

eggNOGCOG0302.
OMAVYSHCEH.
PhylomeDBQ94465.

Enzyme and pathway databases

UniPathwayUPA00848; UER00151.

Family and domain databases

HAMAPMF_00223. FolE.
InterProIPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
[Graphical view]
PANTHERPTHR11109. PTHR11109. 1 hit.
PfamPF01227. GTP_cyclohydroI. 1 hit.
[Graphical view]
TIGRFAMsTIGR00063. folE. 1 hit.
PROSITEPS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ94465.

Entry information

Entry nameGCH1_DICDI
AccessionPrimary (citable) accession number: Q94465
Secondary accession number(s): Q54IV6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: December 4, 2007
Last modified: July 9, 2014
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase