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Q94465

- GCH1_DICDI

UniProt

Q94465 - GCH1_DICDI

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Protein

GTP cyclohydrolase 1

Gene

gchA

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi121 – 1211ZincBy similarity
Metal bindingi124 – 1241ZincBy similarity
Metal bindingi192 – 1921ZincBy similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
  2. GTP cyclohydrolase I activity Source: dictyBase
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
  2. regulation of G-protein coupled receptor protein signaling pathway Source: dictyBase
  3. response to oxidative stress Source: dictyBase
  4. tetrahydrobiopterin biosynthetic process Source: dictyBase
  5. tetrahydrofolate biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Tetrahydrobiopterin biosynthesis

Keywords - Ligandi

GTP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase 1 (EC:3.5.4.16)
Alternative name(s):
GTP cyclohydrolase I
Short name:
GTP-CH-I
Gene namesi
Name:gchA
Synonyms:folE, gtoC
ORF Names:DDB_G0288481
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 5, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0288481. gchA.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: dictyBase
  2. membrane Source: dictyBase
  3. phagocytic vesicle Source: dictyBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 232232GTP cyclohydrolase 1PRO_0000119481Add
BLAST

Proteomic databases

PRIDEiQ94465.

Interactioni

Subunit structurei

Toroid-shaped homodecamer, composed of two pentamers of five dimers.By similarity

Protein-protein interaction databases

STRINGi44689.DDB_0191399.

Structurei

3D structure databases

ProteinModelPortaliQ94465.
SMRiQ94465. Positions 48-230.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase I family.Curated

Phylogenomic databases

eggNOGiCOG0302.
InParanoidiQ94465.
KOiK01495.
OMAiVYSHCEH.
PhylomeDBiQ94465.

Family and domain databases

HAMAPiMF_00223. FolE.
InterProiIPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
[Graphical view]
PANTHERiPTHR11109. PTHR11109. 1 hit.
PfamiPF01227. GTP_cyclohydroI. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00063. folE. 1 hit.
PROSITEiPS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q94465-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDNLKSYQD NHIENEDEEI YERSNGKGKE LVDFGKKREP LIHNHEVLNT
60 70 80 90 100
MQSSVKTLLS SLGEDPDREG LLKTPLRMSK ALLFFTQGYE QSVDEVIGEA
110 120 130 140 150
IFNENHHEMV VVRDIDIFSL CEHHMVPFHG KCHIGYIPDQ KVLGLSKLAR
160 170 180 190 200
VAEIFARRLQ VQERLTRQIA QAIQAHLNPM GVAVVIEASH MCMVMRGVQK
210 220 230
PGASTVTSSV CGIFEKDSRT RAEFFSLIKS NK
Length:232
Mass (Da):26,277
Last modified:December 4, 2007 - v2
Checksum:iD36603D793EE5EA2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti187 – 1871E → D in CAA89808. (PubMed:8870645)Curated
Sequence conflicti206 – 2061V → A in CAA89808. (PubMed:8870645)Curated
Sequence conflicti216 – 2161K → E in CAA89808. (PubMed:8870645)Curated
Sequence conflicti228 – 2325IKSNK → FNSTN in CAA89808. (PubMed:8870645)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49706 mRNA. Translation: CAA89808.1.
AAFI02000112 Genomic DNA. Translation: EAL63189.1.
PIRiS72439.
RefSeqiXP_636697.1. XM_631605.1.

Genome annotation databases

EnsemblProtistsiDDB0191399; DDB0191399; DDB_G0288481.
GeneIDi8626654.
KEGGiddi:DDB_G0288481.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49706 mRNA. Translation: CAA89808.1 .
AAFI02000112 Genomic DNA. Translation: EAL63189.1 .
PIRi S72439.
RefSeqi XP_636697.1. XM_631605.1.

3D structure databases

ProteinModelPortali Q94465.
SMRi Q94465. Positions 48-230.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDB_0191399.

Proteomic databases

PRIDEi Q94465.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0191399 ; DDB0191399 ; DDB_G0288481 .
GeneIDi 8626654.
KEGGi ddi:DDB_G0288481.

Organism-specific databases

dictyBasei DDB_G0288481. gchA.

Phylogenomic databases

eggNOGi COG0302.
InParanoidi Q94465.
KOi K01495.
OMAi VYSHCEH.
PhylomeDBi Q94465.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .

Miscellaneous databases

PROi Q94465.

Family and domain databases

HAMAPi MF_00223. FolE.
InterProi IPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
[Graphical view ]
PANTHERi PTHR11109. PTHR11109. 1 hit.
Pfami PF01227. GTP_cyclohydroI. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00063. folE. 1 hit.
PROSITEi PS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of a cDNA coding for GTP cyclohydrolase I from Dictyostelium discoideum."
    Witter K., Cahill D.J., Werner T., Ziegler I., Roedl W., Bacher A., Guetlich M.
    Biochem. J. 319:27-32(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: AX2.
  2. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  3. "Proteomics fingerprinting of phagosome maturation and evidence for the role of a Galpha during uptake."
    Gotthardt D., Blancheteau V., Bosserhoff A., Ruppert T., Delorenzi M., Soldati T.
    Mol. Cell. Proteomics 5:2228-2243(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: AX2.

Entry informationi

Entry nameiGCH1_DICDI
AccessioniPrimary (citable) accession number: Q94465
Secondary accession number(s): Q54IV6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: December 4, 2007
Last modified: November 26, 2014
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Allosteric enzyme, Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3