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Q94464

- DYNA_DICDI

UniProt

Q94464 - DYNA_DICDI

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Protein

Dynamin-A

Gene

dymA

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Function in membrane trafficking processes along the endo-lysosomal pathway.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi32 – 398GTPBy similarity
Nucleotide bindingi138 – 1425GTPBy similarity
Nucleotide bindingi207 – 2104GTPBy similarity

GO - Molecular functioni

  1. GTPase activity Source: dictyBase
  2. GTP binding Source: dictyBase
  3. identical protein binding Source: dictyBase
  4. phospholipid binding Source: dictyBase
  5. profilin binding Source: dictyBase

GO - Biological processi

  1. actin filament organization Source: dictyBase
  2. cytokinetic cell separation Source: dictyBase
  3. endosome organization Source: dictyBase
  4. establishment or maintenance of cell polarity Source: dictyBase
  5. GTP catabolic process Source: GOC
  6. intracellular distribution of mitochondria Source: dictyBase
  7. mitochondrion organization Source: dictyBase
  8. nucleus organization Source: dictyBase
  9. phagocytosis Source: dictyBase
  10. phagosome acidification Source: dictyBase
  11. pinocytosis Source: dictyBase
  12. protein processing in phagocytic vesicle Source: dictyBase
  13. regulation of post-lysosomal vacuole size Source: dictyBase
  14. sorocarp morphogenesis Source: dictyBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Motor protein

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_204078. Apoptotic execution phase.

Names & Taxonomyi

Protein namesi
Recommended name:
Dynamin-A
Gene namesi
Name:dymA
ORF Names:DDB_G0277849
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 3, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0277849. dymA.

Subcellular locationi

Cytoplasm 1 Publication
Note: Found in association with endosomal and postlysosomal vacuoles.

GO - Cellular componenti

  1. cleavage furrow Source: dictyBase
  2. cytoplasm Source: dictyBase
  3. phagocytic cup base Source: dictyBase
  4. phagocytic vesicle Source: dictyBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 853853Dynamin-APRO_0000312856Add
BLAST

Proteomic databases

PRIDEiQ94464.

Expressioni

Developmental stagei

Present during all stages of development.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB_0216177.

Structurei

Secondary structure

1
853
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi4 – 1411
Turni15 – 173
Beta strandi18 – 203
Beta strandi27 – 326
Beta strandi34 – 374
Helixi38 – 469
Beta strandi63 – 697
Beta strandi82 – 887
Helixi97 – 10610
Beta strandi122 – 1287
Beta strandi133 – 1386
Helixi155 – 16713
Beta strandi171 – 18111
Helixi188 – 1958
Beta strandi200 – 2078
Helixi209 – 2113
Helixi219 – 2224
Beta strandi225 – 2273
Beta strandi233 – 2353
Helixi241 – 2444
Beta strandi245 – 2473
Helixi250 – 26213
Helixi267 – 2693
Helixi271 – 2733
Helixi276 – 30530

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1JWYX-ray2.30B2-316[»]
1JX2X-ray2.30B2-316[»]
ProteinModelPortaliQ94464.
SMRiQ94464. Positions 2-307.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ94464.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 296275Dynamin-type GAdd
BLAST
Domaini762 – 85392GEDPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi510 – 613104Gln-richAdd
BLAST
Compositional biasi539 – 728190Asn-richAdd
BLAST
Compositional biasi643 – 72684Ser-richAdd
BLAST

Sequence similaritiesi

Contains 1 GED domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0699.
InParanoidiQ94464.
KOiK17065.
OMAiCKAMIEI.
PhylomeDBiQ94464.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR000375. Dynamin_central.
IPR001401. Dynamin_GTPase.
IPR019762. Dynamin_GTPase_CS.
IPR022812. Dynamin_SF.
IPR003130. GED.
IPR020850. GTPase_effector_domain_GED.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11566. PTHR11566. 1 hit.
PfamiPF01031. Dynamin_M. 1 hit.
PF00350. Dynamin_N. 1 hit.
PF02212. GED. 1 hit.
[Graphical view]
PRINTSiPR00195. DYNAMIN.
SMARTiSM00053. DYNc. 1 hit.
SM00302. GED. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00410. G_DYNAMIN_1. 1 hit.
PS51718. G_DYNAMIN_2. 1 hit.
PS51388. GED. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q94464-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDQLIPVINK LQDVFNTLGS DPLDLPQIVV VGSQSSGKSS VLENIVGRDF
60 70 80 90 100
LPRGSGIVTR RPLILQLTHL PIADDGSQTQ EWGEFLHKPN DMFYDFSEIR
110 120 130 140 150
EEIIRDTDRM TGKNKGISAQ PINLKIYSPH VVNLTLVDLP GITKVPVGDQ
160 170 180 190 200
PTDIEQQIRR MVMAYIKKQN AIIVAVTPAN TDLANSDALQ LAKEVDPEGK
210 220 230 240 250
RTIGVITKLD LMDKGTDAME VLTGRVIPLT LGFIGVINRS QEDIIAKKSI
260 270 280 290 300
RESLKSEILY FKNHPIYKSI ANRSGTAYLS KTLNKLLMFH IRDTLPDLKV
310 320 330 340 350
KVSKMLSDVQ GELSTYGDPL YDTKNSQGAL LLQIITIFSS NFKDAIDGKL
360 370 380 390 400
TDLSNNELYG GARISYIFNE IYSHCVNNID PLEGISLNDI RTTMRNATGP
410 420 430 440 450
RAALFIPEIS FELLVKKQVV RLEEPSAQCV EYVYDELQRI VSQLEAKELS
460 470 480 490 500
RFINLKARVI EVVNNLLQKH KVPTKTMIEH LIKIETAFIN TSHPDFVGGE
510 520 530 540 550
GIFESLYKKQ QLQQQNHLQQ LQDQYQQQQQ QQQQQQQQNG INNNQKGDNG
560 570 580 590 600
NMNVNQQNMN QQNMNQQNQS TNPFLQQQQQ GQNKYPGGPP AQQQPNQQPN
610 620 630 640 650
QLNKGPQNMP PNQSKPSSIP QNGPNNNNNN NNNNNRQDHQ QGSFFSSFFR
660 670 680 690 700
ASPDPSLGQY GGANNSNNSN NPTSPINSSS NSGNNYNTFG GQQSSSSSSQ
710 720 730 740 750
QLQQSSQSQY KTSYNNNNNS SSNNSSYNRY QDDFYGRGDK LNQVPSIIKA
760 770 780 790 800
PDDLTSKEKF ETELIRELLI SYFNIVKKNV KDSVPKSIMH FLVNQSKEHI
810 820 830 840 850
QNELVAALYK EELFDELLEE SPQISSKRKS CKAMIEILRK ANEIINEIRD

FRN
Length:853
Mass (Da):96,106
Last modified:June 1, 1998 - v2
Checksum:i5812FF0B90CB97BC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X99669 mRNA. Translation: CAA67983.1.
AAFI02000023 Genomic DNA. Translation: EAL68097.1.
RefSeqiXP_642112.1. XM_637020.1.

Genome annotation databases

EnsemblProtistsiDDB0216177; DDB0216177; DDB_G0277849.
GeneIDi8621323.
KEGGiddi:DDB_G0277849.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X99669 mRNA. Translation: CAA67983.1 .
AAFI02000023 Genomic DNA. Translation: EAL68097.1 .
RefSeqi XP_642112.1. XM_637020.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1JWY X-ray 2.30 B 2-316 [» ]
1JX2 X-ray 2.30 B 2-316 [» ]
ProteinModelPortali Q94464.
SMRi Q94464. Positions 2-307.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDB_0216177.

Proteomic databases

PRIDEi Q94464.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0216177 ; DDB0216177 ; DDB_G0277849 .
GeneIDi 8621323.
KEGGi ddi:DDB_G0277849.

Organism-specific databases

dictyBasei DDB_G0277849. dymA.

Phylogenomic databases

eggNOGi COG0699.
InParanoidi Q94464.
KOi K17065.
OMAi CKAMIEI.
PhylomeDBi Q94464.

Enzyme and pathway databases

Reactomei REACT_204078. Apoptotic execution phase.

Miscellaneous databases

EvolutionaryTracei Q94464.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR000375. Dynamin_central.
IPR001401. Dynamin_GTPase.
IPR019762. Dynamin_GTPase_CS.
IPR022812. Dynamin_SF.
IPR003130. GED.
IPR020850. GTPase_effector_domain_GED.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR11566. PTHR11566. 1 hit.
Pfami PF01031. Dynamin_M. 1 hit.
PF00350. Dynamin_N. 1 hit.
PF02212. GED. 1 hit.
[Graphical view ]
PRINTSi PR00195. DYNAMIN.
SMARTi SM00053. DYNc. 1 hit.
SM00302. GED. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00410. G_DYNAMIN_1. 1 hit.
PS51718. G_DYNAMIN_2. 1 hit.
PS51388. GED. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Disruption of a dynamin homologue affects endocytosis, organelle morphology, and cytokinesis in Dictyostelium discoideum."
    Wienke D.C., Knetsch M.L., Neuhaus E.M., Reedy M.C., Manstein D.J.
    Mol. Biol. Cell 10:225-243(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.
    Strain: AX2.
  2. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  3. "Identification and isolation of Dictyostelium microtubule-associated protein interactors by tandem affinity purification."
    Koch K.V., Reinders Y., Ho T.-H., Sickmann A., Graef R.
    Eur. J. Cell Biol. 85:1079-1090(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: AX2.
  4. "Proteomics fingerprinting of phagosome maturation and evidence for the role of a Galpha during uptake."
    Gotthardt D., Blancheteau V., Bosserhoff A., Ruppert T., Delorenzi M., Soldati T.
    Mol. Cell. Proteomics 5:2228-2243(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: AX2.
  5. "Crystal structure of a dynamin GTPase domain in both nucleotide-free and GDP-bound forms."
    Niemann H.H., Knetsch M.L., Scherer A., Manstein D.J., Kull F.J.
    EMBO J. 20:5813-5821(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 2-316.

Entry informationi

Entry nameiDYNA_DICDI
AccessioniPrimary (citable) accession number: Q94464
Secondary accession number(s): Q54YU0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: June 1, 1998
Last modified: October 29, 2014
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3