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Protein

Dynamin-A

Gene

dymA

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Function in membrane trafficking processes along the endo-lysosomal pathway.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi32 – 40GTPBy similarity9
Nucleotide bindingi207 – 213GTPBy similarity7
Nucleotide bindingi238 – 241GTPBy similarity4

GO - Molecular functioni

  • GTPase activity Source: dictyBase
  • GTP binding Source: dictyBase
  • identical protein binding Source: dictyBase
  • microtubule binding Source: GO_Central
  • phospholipid binding Source: dictyBase
  • profilin binding Source: dictyBase

GO - Biological processi

  • actin filament organization Source: dictyBase
  • cell separation after cytokinesis Source: dictyBase
  • dynamin family protein polymerization involved in mitochondrial fission Source: GO_Central
  • endosome organization Source: dictyBase
  • establishment or maintenance of cell polarity Source: dictyBase
  • intracellular distribution of mitochondria Source: dictyBase
  • membrane fusion Source: GO_Central
  • mitochondrial fission Source: GO_Central
  • mitochondrion organization Source: dictyBase
  • nucleus organization Source: dictyBase
  • phagocytosis Source: dictyBase
  • phagosome acidification Source: dictyBase
  • pinocytosis Source: dictyBase
  • protein processing in phagocytic vesicle Source: dictyBase
  • regulation of post-lysosomal vacuole size Source: dictyBase
  • sorocarp morphogenesis Source: dictyBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Motor protein

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Dynamin-A
Gene namesi
Name:dymA
ORF Names:DDB_G0277849
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 3, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0277849. dymA.

Subcellular locationi

  • Cytoplasm 1 Publication

  • Note: Found in association with endosomal and postlysosomal vacuoles.

GO - Cellular componenti

  • cleavage furrow Source: dictyBase
  • cytoplasm Source: dictyBase
  • mitochondrial membrane Source: GO_Central
  • phagocytic cup base Source: dictyBase
  • phagocytic vesicle Source: dictyBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003128561 – 853Dynamin-AAdd BLAST853

Proteomic databases

PaxDbiQ94464.
PRIDEiQ94464.

Expressioni

Developmental stagei

Present during all stages of development.1 Publication

Interactioni

GO - Molecular functioni

  • identical protein binding Source: dictyBase
  • microtubule binding Source: GO_Central
  • profilin binding Source: dictyBase

Protein-protein interaction databases

STRINGi44689.DDB0216177.

Structurei

Secondary structure

1853
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 14Combined sources11
Turni15 – 17Combined sources3
Beta strandi18 – 20Combined sources3
Beta strandi27 – 32Combined sources6
Beta strandi34 – 37Combined sources4
Helixi38 – 46Combined sources9
Beta strandi63 – 69Combined sources7
Beta strandi82 – 88Combined sources7
Helixi97 – 106Combined sources10
Beta strandi122 – 128Combined sources7
Beta strandi133 – 138Combined sources6
Helixi155 – 167Combined sources13
Beta strandi171 – 181Combined sources11
Helixi188 – 195Combined sources8
Beta strandi200 – 207Combined sources8
Helixi209 – 211Combined sources3
Helixi219 – 222Combined sources4
Beta strandi225 – 227Combined sources3
Beta strandi233 – 235Combined sources3
Helixi241 – 244Combined sources4
Beta strandi245 – 247Combined sources3
Helixi250 – 262Combined sources13
Helixi267 – 269Combined sources3
Helixi271 – 273Combined sources3
Helixi276 – 305Combined sources30

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JWYX-ray2.30B2-316[»]
1JX2X-ray2.30B2-316[»]
ProteinModelPortaliQ94464.
SMRiQ94464.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ94464.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 296Dynamin-type GAdd BLAST275
Domaini762 – 853GEDPROSITE-ProRule annotationAdd BLAST92

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi510 – 613Gln-richAdd BLAST104
Compositional biasi539 – 728Asn-richAdd BLAST190
Compositional biasi643 – 726Ser-richAdd BLAST84

Sequence similaritiesi

Contains 1 GED domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0446. Eukaryota.
COG0699. LUCA.
InParanoidiQ94464.
KOiK17065.
OMAiCKAMIEI.
PhylomeDBiQ94464.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR000375. Dynamin_central.
IPR001401. Dynamin_GTPase.
IPR019762. Dynamin_GTPase_CS.
IPR022812. Dynamin_SF.
IPR030381. G_DYNAMIN_dom.
IPR003130. GED.
IPR020850. GED_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11566. PTHR11566. 3 hits.
PfamiPF01031. Dynamin_M. 1 hit.
PF00350. Dynamin_N. 1 hit.
PF02212. GED. 1 hit.
[Graphical view]
PRINTSiPR00195. DYNAMIN.
SMARTiSM00053. DYNc. 1 hit.
SM00302. GED. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00410. G_DYNAMIN_1. 1 hit.
PS51718. G_DYNAMIN_2. 1 hit.
PS51388. GED. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q94464-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDQLIPVINK LQDVFNTLGS DPLDLPQIVV VGSQSSGKSS VLENIVGRDF
60 70 80 90 100
LPRGSGIVTR RPLILQLTHL PIADDGSQTQ EWGEFLHKPN DMFYDFSEIR
110 120 130 140 150
EEIIRDTDRM TGKNKGISAQ PINLKIYSPH VVNLTLVDLP GITKVPVGDQ
160 170 180 190 200
PTDIEQQIRR MVMAYIKKQN AIIVAVTPAN TDLANSDALQ LAKEVDPEGK
210 220 230 240 250
RTIGVITKLD LMDKGTDAME VLTGRVIPLT LGFIGVINRS QEDIIAKKSI
260 270 280 290 300
RESLKSEILY FKNHPIYKSI ANRSGTAYLS KTLNKLLMFH IRDTLPDLKV
310 320 330 340 350
KVSKMLSDVQ GELSTYGDPL YDTKNSQGAL LLQIITIFSS NFKDAIDGKL
360 370 380 390 400
TDLSNNELYG GARISYIFNE IYSHCVNNID PLEGISLNDI RTTMRNATGP
410 420 430 440 450
RAALFIPEIS FELLVKKQVV RLEEPSAQCV EYVYDELQRI VSQLEAKELS
460 470 480 490 500
RFINLKARVI EVVNNLLQKH KVPTKTMIEH LIKIETAFIN TSHPDFVGGE
510 520 530 540 550
GIFESLYKKQ QLQQQNHLQQ LQDQYQQQQQ QQQQQQQQNG INNNQKGDNG
560 570 580 590 600
NMNVNQQNMN QQNMNQQNQS TNPFLQQQQQ GQNKYPGGPP AQQQPNQQPN
610 620 630 640 650
QLNKGPQNMP PNQSKPSSIP QNGPNNNNNN NNNNNRQDHQ QGSFFSSFFR
660 670 680 690 700
ASPDPSLGQY GGANNSNNSN NPTSPINSSS NSGNNYNTFG GQQSSSSSSQ
710 720 730 740 750
QLQQSSQSQY KTSYNNNNNS SSNNSSYNRY QDDFYGRGDK LNQVPSIIKA
760 770 780 790 800
PDDLTSKEKF ETELIRELLI SYFNIVKKNV KDSVPKSIMH FLVNQSKEHI
810 820 830 840 850
QNELVAALYK EELFDELLEE SPQISSKRKS CKAMIEILRK ANEIINEIRD

FRN
Length:853
Mass (Da):96,106
Last modified:June 1, 1998 - v2
Checksum:i5812FF0B90CB97BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99669 mRNA. Translation: CAA67983.1.
AAFI02000023 Genomic DNA. Translation: EAL68097.1.
RefSeqiXP_642112.1. XM_637020.1.

Genome annotation databases

EnsemblProtistsiEAL68097; EAL68097; DDB_G0277849.
GeneIDi8621323.
KEGGiddi:DDB_G0277849.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99669 mRNA. Translation: CAA67983.1.
AAFI02000023 Genomic DNA. Translation: EAL68097.1.
RefSeqiXP_642112.1. XM_637020.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JWYX-ray2.30B2-316[»]
1JX2X-ray2.30B2-316[»]
ProteinModelPortaliQ94464.
SMRiQ94464.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0216177.

Proteomic databases

PaxDbiQ94464.
PRIDEiQ94464.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAL68097; EAL68097; DDB_G0277849.
GeneIDi8621323.
KEGGiddi:DDB_G0277849.

Organism-specific databases

dictyBaseiDDB_G0277849. dymA.

Phylogenomic databases

eggNOGiKOG0446. Eukaryota.
COG0699. LUCA.
InParanoidiQ94464.
KOiK17065.
OMAiCKAMIEI.
PhylomeDBiQ94464.

Miscellaneous databases

EvolutionaryTraceiQ94464.
PROiQ94464.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR000375. Dynamin_central.
IPR001401. Dynamin_GTPase.
IPR019762. Dynamin_GTPase_CS.
IPR022812. Dynamin_SF.
IPR030381. G_DYNAMIN_dom.
IPR003130. GED.
IPR020850. GED_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11566. PTHR11566. 3 hits.
PfamiPF01031. Dynamin_M. 1 hit.
PF00350. Dynamin_N. 1 hit.
PF02212. GED. 1 hit.
[Graphical view]
PRINTSiPR00195. DYNAMIN.
SMARTiSM00053. DYNc. 1 hit.
SM00302. GED. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00410. G_DYNAMIN_1. 1 hit.
PS51718. G_DYNAMIN_2. 1 hit.
PS51388. GED. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDYNA_DICDI
AccessioniPrimary (citable) accession number: Q94464
Secondary accession number(s): Q54YU0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: June 1, 1998
Last modified: November 2, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.