Reviewed,
UniProtKB/Swiss-Prot Q94425 (SYIM_CIOIN)
Last modified
January 19, 2010.
Version 57.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Probable isoleucyl-tRNA synthetase, mitochondrial EC=6.1.1.5 Alternative name(s): Isoleucine--tRNA ligase Short name=IleRS |
| Organism | Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis) |
| Taxonomic identifier | 7719 [NCBI] |
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Urochordata › Ascidiacea › Enterogona › Phlebobranchia › Cionidae › Ciona |
Protein attributes
| Sequence length | 413 AA. |
| Sequence status | Fragment. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile). |
| Subcellular location | Mitochondrion matrix By similarity. |
| Sequence similarities | Belongs to the class-I aminoacyl-tRNA synthetase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Protein biosynthesis |
| Cellular component | Mitochondrion |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Aminoacyl-tRNA synthetase Ligase |
| Gene Ontology (GO) | |
| Biological process | tRNA aminoacylation for protein translation Inferred from electronic annotation. Source: InterPro |
| Cellular component | mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW isoleucine-tRNA ligase activityInferred from electronic annotation. Source: EC zinc ion bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| [1] | Bird A.P., Clark V., Jones S.J.M., Leitgeb S., Lennard N., Tweedie S. Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | Z80904 Genomic DNA. Translation: CAB02584.1. |
| PIR | T31663. |
3D structure databases | |
| SMR | Q94425. Positions 1-383. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q94425. |
Phylogenomic databases | |
| eggNOG | meNOG04200. |
| HOVERGEN | Q94425. |
Enzyme and pathway databases | |
| BRENDA | 6.1.1.5. 39480. |
Family and domain databases | |
| InterPro | IPR002300. aa-tRNA-synth_Ia. IPR015905. Ile-tRNA-synt_Ia_N. IPR018353. Isoleucyl-tRNA_synthetase. IPR014729. Rossmann-like_a/b/a_fold. IPR009008. Val/Leu/Ile-tRNA-synth_Ia_edit. [Graphical view] |
| Gene3D | G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit. |
| PANTHER | PTHR11946:SF9. Ile-tRNA-synt_Ia. 1 hit. |
| Pfam | PF00133. tRNA-synt_1. 1 hit. [Graphical view] |
| PRINTS | PR00984. TRNASYNTHILE. |
| PROSITE | PS00178. AA_TRNA_LIGASE_I. Partial match. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | SYIM_CIOIN | ||||||||
| Accession | Primary (citable) accession number: Q94425 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
Relevant documents
| Aminoacyl-tRNA synthetases List of aminoacyl-tRNA synthetase entries |
| SIMILARITY comments Index of protein domains and families |

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