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Q94425

- SYIM_CIOIN

UniProt

Q94425 - SYIM_CIOIN

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Protein

Probable isoleucine--tRNA ligase, mitochondrial

Gene
N/A
Organism
Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei301 – 3011ATPBy similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-KW
  3. isoleucine-tRNA ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. isoleucyl-tRNA aminoacylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable isoleucine--tRNA ligase, mitochondrial (EC:6.1.1.5)
Alternative name(s):
Isoleucyl-tRNA synthetase
Short name:
IleRS
OrganismiCiona intestinalis (Transparent sea squirt) (Ascidia intestinalis)
Taxonomic identifieri7719 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataTunicataAscidiaceaEnterogonaPhlebobranchiaCionidaeCiona
ProteomesiUP000008144: Unplaced

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 413›413Probable isoleucine--tRNA ligase, mitochondrialPRO_0000098600Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi7719.ENSCINP00000017328.

Structurei

3D structure databases

ProteinModelPortaliQ94425.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi298 – 3025"KMSKS" region

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0060.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 1 hit.
3.90.740.10. 1 hit.
InterProiIPR002300. aa-tRNA-synth_Ia.
IPR002301. Ile-tRNA-ligase.
IPR023585. Ile-tRNA-ligase_type1.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF9. PTHR11946:SF9. 1 hit.
PfamiPF00133. tRNA-synt_1. 1 hit.
[Graphical view]
PRINTSiPR00984. TRNASYNTHILE.
SUPFAMiSSF50677. SSF50677. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q94425-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
GMICRHPIYL ERTVRMIGSD IANTSKGTGV VHIAPAHGMD DFGIGQKHNL
60 70 80 90 100
STESSVNSDG EFMANIAPNL EGKFIFTSGN EAVVEMLKEE MNLFHEHDYK
110 120 130 140 150
HSYPYDWRTK QPIFVHTSNQ WFVDTAMLAN KAEAAISGIT TYPDNGISSM
160 170 180 190 200
LNRLQLRSYW CISRQRAWGL PIPVFYHKES GELLLNESTI QHLVSLVLKH
210 220 230 240 250
GADIWWEGTE LLPTQYNADE YERGRDILDI WFDSGVSWDC VLRDSKNRTT
260 270 280 290 300
QADFYIEGKD QYGGWFQSSL LTSVGLQGVA PYKNLMVHGF VLDEKGQKMS
310 320 330 340 350
KSIGNVVDPM VLTNGGKNPQ RDPAYGADAL RWWVAESNVH QDVHISTTII
360 370 380 390 400
KSAAESVQKI RNSVRFMLGN LNEFDKMKIV PTPAMLILDL RYRFEDKKLW
410
YVTSMNYPLN LSV
Length:413
Mass (Da):46,895
Last modified:February 1, 1997 - v1
Checksum:i69B098FD71C100CE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z80904 Genomic DNA. Translation: CAB02584.1.
PIRiT31663.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z80904 Genomic DNA. Translation: CAB02584.1 .
PIRi T31663.

3D structure databases

ProteinModelPortali Q94425.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7719.ENSCINP00000017328.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi COG0060.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 1 hit.
3.90.740.10. 1 hit.
InterProi IPR002300. aa-tRNA-synth_Ia.
IPR002301. Ile-tRNA-ligase.
IPR023585. Ile-tRNA-ligase_type1.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF9. PTHR11946:SF9. 1 hit.
Pfami PF00133. tRNA-synt_1. 1 hit.
[Graphical view ]
PRINTSi PR00984. TRNASYNTHILE.
SUPFAMi SSF50677. SSF50677. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Bird A.P., Clark V., Jones S.J.M., Leitgeb S., Lennard N., Tweedie S.
    Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiSYIM_CIOIN
AccessioniPrimary (citable) accession number: Q94425
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: October 29, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3