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Q94425

- SYIM_CIOIN

UniProt

Q94425 - SYIM_CIOIN

Protein

Probable isoleucine--tRNA ligase, mitochondrial

Gene
N/A
Organism
Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei301 – 3011ATPBy similarity

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-KW
    3. isoleucine-tRNA ligase activity Source: UniProtKB-EC

    GO - Biological processi

    1. isoleucyl-tRNA aminoacylation Source: InterPro

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable isoleucine--tRNA ligase, mitochondrial (EC:6.1.1.5)
    Alternative name(s):
    Isoleucyl-tRNA synthetase
    Short name:
    IleRS
    OrganismiCiona intestinalis (Transparent sea squirt) (Ascidia intestinalis)
    Taxonomic identifieri7719 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataTunicataAscidiaceaEnterogonaPhlebobranchiaCionidaeCiona
    ProteomesiUP000008144: Unplaced

    Subcellular locationi

    Mitochondrion matrix By similarity

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – 413›413Probable isoleucine--tRNA ligase, mitochondrialPRO_0000098600Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi7719.ENSCINP00000017328.

    Structurei

    3D structure databases

    ProteinModelPortaliQ94425.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi298 – 3025"KMSKS" region

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0060.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 1 hit.
    3.90.740.10. 1 hit.
    InterProiIPR002300. aa-tRNA-synth_Ia.
    IPR002301. Ile-tRNA-ligase.
    IPR023585. Ile-tRNA-ligase_type1.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF9. PTHR11946:SF9. 1 hit.
    PfamiPF00133. tRNA-synt_1. 1 hit.
    [Graphical view]
    PRINTSiPR00984. TRNASYNTHILE.
    SUPFAMiSSF50677. SSF50677. 1 hit.

    Sequencei

    Sequence statusi: Fragment.

    Q94425-1 [UniParc]FASTAAdd to Basket

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    GMICRHPIYL ERTVRMIGSD IANTSKGTGV VHIAPAHGMD DFGIGQKHNL    50
    STESSVNSDG EFMANIAPNL EGKFIFTSGN EAVVEMLKEE MNLFHEHDYK 100
    HSYPYDWRTK QPIFVHTSNQ WFVDTAMLAN KAEAAISGIT TYPDNGISSM 150
    LNRLQLRSYW CISRQRAWGL PIPVFYHKES GELLLNESTI QHLVSLVLKH 200
    GADIWWEGTE LLPTQYNADE YERGRDILDI WFDSGVSWDC VLRDSKNRTT 250
    QADFYIEGKD QYGGWFQSSL LTSVGLQGVA PYKNLMVHGF VLDEKGQKMS 300
    KSIGNVVDPM VLTNGGKNPQ RDPAYGADAL RWWVAESNVH QDVHISTTII 350
    KSAAESVQKI RNSVRFMLGN LNEFDKMKIV PTPAMLILDL RYRFEDKKLW 400
    YVTSMNYPLN LSV 413
    Length:413
    Mass (Da):46,895
    Last modified:February 1, 1997 - v1
    Checksum:i69B098FD71C100CE
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z80904 Genomic DNA. Translation: CAB02584.1.
    PIRiT31663.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z80904 Genomic DNA. Translation: CAB02584.1 .
    PIRi T31663.

    3D structure databases

    ProteinModelPortali Q94425.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7719.ENSCINP00000017328.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi COG0060.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 1 hit.
    3.90.740.10. 1 hit.
    InterProi IPR002300. aa-tRNA-synth_Ia.
    IPR002301. Ile-tRNA-ligase.
    IPR023585. Ile-tRNA-ligase_type1.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF9. PTHR11946:SF9. 1 hit.
    Pfami PF00133. tRNA-synt_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00984. TRNASYNTHILE.
    SUPFAMi SSF50677. SSF50677. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Bird A.P., Clark V., Jones S.J.M., Leitgeb S., Lennard N., Tweedie S.
      Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiSYIM_CIOIN
    AccessioniPrimary (citable) accession number: Q94425
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3