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Protein

Probable isoleucine--tRNA ligase, mitochondrial

Gene
N/A
Organism
Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei301ATPBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable isoleucine--tRNA ligase, mitochondrial (EC:6.1.1.5)
Alternative name(s):
Isoleucyl-tRNA synthetase
Short name:
IleRS
OrganismiCiona intestinalis (Transparent sea squirt) (Ascidia intestinalis)
Taxonomic identifieri7719 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataTunicataAscidiaceaEnterogonaPhlebobranchiaCionidaeCiona
Proteomesi
  • UP000008144 Componenti: Unassembled WGS sequence
  • UP000192222 Componenti: Genome assembly

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000098600‹1 – 413Probable isoleucine--tRNA ligase, mitochondrialAdd BLAST›413

Structurei

3D structure databases

ProteinModelPortaliQ94425.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi298 – 302"KMSKS" region5

Sequence similaritiesi

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 1 hit.
InterProiView protein in InterPro
IPR002300. aa-tRNA-synth_Ia.
IPR002301. Ile-tRNA-ligase.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_Ia_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
PfamiView protein in Pfam
PF00133. tRNA-synt_1. 1 hit.
PRINTSiPR00984. TRNASYNTHILE.
SUPFAMiSSF50677. SSF50677. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q94425-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
GMICRHPIYL ERTVRMIGSD IANTSKGTGV VHIAPAHGMD DFGIGQKHNL
60 70 80 90 100
STESSVNSDG EFMANIAPNL EGKFIFTSGN EAVVEMLKEE MNLFHEHDYK
110 120 130 140 150
HSYPYDWRTK QPIFVHTSNQ WFVDTAMLAN KAEAAISGIT TYPDNGISSM
160 170 180 190 200
LNRLQLRSYW CISRQRAWGL PIPVFYHKES GELLLNESTI QHLVSLVLKH
210 220 230 240 250
GADIWWEGTE LLPTQYNADE YERGRDILDI WFDSGVSWDC VLRDSKNRTT
260 270 280 290 300
QADFYIEGKD QYGGWFQSSL LTSVGLQGVA PYKNLMVHGF VLDEKGQKMS
310 320 330 340 350
KSIGNVVDPM VLTNGGKNPQ RDPAYGADAL RWWVAESNVH QDVHISTTII
360 370 380 390 400
KSAAESVQKI RNSVRFMLGN LNEFDKMKIV PTPAMLILDL RYRFEDKKLW
410
YVTSMNYPLN LSV
Length:413
Mass (Da):46,895
Last modified:February 1, 1997 - v1
Checksum:i69B098FD71C100CE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z80904 Genomic DNA. Translation: CAB02584.1.
PIRiT31663.

Entry informationi

Entry nameiSYIM_CIOIN
AccessioniPrimary (citable) accession number: Q94425
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: August 30, 2017
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families