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Reviewed, UniProtKB/Swiss-Prot Q94420 (MEL26_CAEEL)

Last modified June 16, 2009. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Protein maternal effect lethal 26
Gene names
Name: mel-26
ORF Names: ZK858.4
OrganismCaenorhabditis elegans [Complete proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

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Protein attributes

Sequence length395 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Controls degradation of mei-1. Ref.3 Ref.4

Pathway

Protein modification; protein ubiquitination.

Subunit structure

Interacts with cul-3. Seems to be a component of a E3 ubiquitin-protein ligase complex containing cul-3. Ref.3 Ref.4

Sequence similarities

Contains 1 BTB (POZ) domain.

Contains 1 MATH domain.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 395395Protein maternal effect lethal 26
PRO_0000312628

Regions

Domain41 – 162122MATH
Domain201 – 26969BTB

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Sequences

Sequence LengthMass (Da)Tools
Q94420-1 [UniParc].

Last modified June 1, 2002. Version 2.
Checksum: 3AED944583A155AC

FASTA39544,492
        10         20         30         40         50         60 
MEPRIDGGVF IGGIGNSGNE MCSNGVPALG VSSQTEIKVE KVQHTWTVKN FSHCYQEYLE 

        70         80         90        100        110        120 
NFVYLQRGDE QLTWSIKIYP KGNGENNKDF VFLCLNRVIN NNVKAGKIGF KSQFKLRTAE 

       130        140        150        160        170        180 
NKDIEMRIHP NPSHSDYVSY IKRDVLFPQI MPRDMIIVNV EIDVAVETIT TTNEPIQFEP 

       190        200        210        220        230        240 
TNSEQQLIED YQRLFSQELL CDFAINVNGK IIRAHKAVLA ARSPVFNAML THQDTDEAKS 

       250        260        270        280        290        300 
SMMYINDMDY DVIYEMVYYI YCGRCNKDIT DMATALLIAA DKYRLEELKS HCEKYLVENI 

       310        320        330        340        350        360 
NIENACSLLI IGDLYSAPKL RKRAVTYILA RPKNVTGTPG WEDILKGHPN LITDIFSQID 

       370        380        390 
RQSSTGATSS VSNLPGVPMD IPGITGNIVP PPSGL

« Hide

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References

« Hide 'large scale' references
[1]"Genetic and molecular characterization of the Caenorhabditis elegans gene, mel-26, a postmeiotic negative regulator of mei-1, a meiotic-specific spindle component."
Dow M.R., Mains P.E.
Genetics 150:119-128(1998) [PubMed: 9725834] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Bristol N2.
[2]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
[3]"Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases."
Furukawa M., He Y.J., Borchers C., Xiong Y.
Nat. Cell Biol. 5:1001-1007(2003) [PubMed: 14528312] [Abstract]
Cited for: FUNCTION AS A E3 UBIQUITIN-PROTEIN LIGASE, INTERACTION WITH CUL3.
[4]"BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3."
Xu L., Wei Y., Reboul J., Vaglio P., Shin T.H., Vidal M., Elledge S.J., Harper J.W.
Nature 425:316-321(2003) [PubMed: 13679922] [Abstract]
Cited for: FUNCTION AS A E3 UBIQUITIN-PROTEIN LIGASE, INTERACTION WITH CUL3.
+Additional computationally mapped references.

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Cross-references

Sequence databases

U67737 Genomic DNA. Translation: AAC63596.1.
Z79759 Genomic DNA. Translation: CAB02139.2.
PIRT28056.
RefSeqNP_492449.2.
UniGeneCel.5086

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

DIPDIP:27179N.
IntActQ94420. 20 interactions.

Genome annotation databases

EnsemblZK858.4. Caenorhabditis elegans. [Contig view]
GeneID172737.
KEGGcel:ZK858.4.
NMPDRfig|6239.3.peg.2418.

Organism-specific databases

WormBaseWBGene00003209. ZK858.4.
WormPepZK858.4. CE30580. [WorfDB]

Phylogenomic databases

OMAQ94420. EYLENFV.

Gene expression databases

ArrayExpressQ94420.

Family and domain databases

InterProIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR013089. Kelch_related.
IPR002083. MATH.
[Graphical view]
Gene3DG3DSA:3.30.710.10. BTB/POZ_fold. 1 hit.
PANTHERPTHR23230. Kelch_related. 1 hit.
PfamPF00651. BTB. 1 hit.
PF00917. MATH. 1 hit.
[Graphical view]
SMARTSM00225. BTB. 1 hit.
SM00061. MATH. 1 hit.
[Graphical view]
PROSITEPS50097. BTB. 1 hit.
PS50144. MATH. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio876803.

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Entry information

Entry nameMEL26_CAEEL
AccessionPrimary (citable) accession number: Q94420
Secondary accession number(s): Q94139
Entry history
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: June 1, 2002
Last modified: June 16, 2009
This is version 71 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectCaenorhabditis annotation project

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Relevant documents

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormPep

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents