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Q94360

- NDUS7_CAEEL

UniProt

Q94360 - NDUS7_CAEEL

Protein

Probable NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

Gene

nduf-7

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.By similarity

    Catalytic activityi

    NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).
    NADH + acceptor = NAD+ + reduced acceptor.

    Cofactori

    Binds 1 4Fe-4S cluster.Curated

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi74 – 741Iron-sulfur (4Fe-4S)Sequence Analysis
    Metal bindingi75 – 751Iron-sulfur (4Fe-4S)Sequence Analysis
    Metal bindingi139 – 1391Iron-sulfur (4Fe-4S)Sequence Analysis
    Metal bindingi169 – 1691Iron-sulfur (4Fe-4S)Sequence Analysis

    GO - Molecular functioni

    1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC
    4. quinone binding Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    4Fe-4S, Iron, Iron-sulfur, Metal-binding, NAD, Ubiquinone

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (EC:1.6.5.3, EC:1.6.99.3)
    Alternative name(s):
    Complex I-20kD
    Short name:
    CI-20kD
    NADH-ubiquinone oxidoreductase 20 kDa subunit
    Gene namesi
    Name:nduf-7
    ORF Names:W10D5.2
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome I

    Organism-specific databases

    WormBaseiW10D5.2; CE14780; WBGene00012376; nduf-7.

    Subcellular locationi

    Mitochondrion By similarity

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB-SubCell
    2. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 199Probable NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrialPRO_0000020030
    Transit peptidei1 – ?MitochondrionSequence Analysis

    Proteomic databases

    PaxDbiQ94360.

    Interactioni

    Subunit structurei

    Complex I is composed of 45 different subunits This is a component of the iron-sulfur (IP) fragment of the enzyme.By similarity

    Protein-protein interaction databases

    BioGridi38165. 1 interaction.
    STRINGi6239.W10D5.2.2.

    Structurei

    3D structure databases

    ProteinModelPortaliQ94360.
    SMRiQ94360. Positions 53-188.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the complex I 20 kDa subunit family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0377.
    GeneTreeiENSGT00390000006565.
    HOGENOMiHOG000228249.
    InParanoidiQ94360.
    KOiK03940.
    OMAiMIANWAR.
    PhylomeDBiQ94360.

    Family and domain databases

    Gene3Di3.40.50.700. 1 hit.
    HAMAPiMF_01356. NDH1_NuoB.
    InterProiIPR006137. NADH_UbQ_OxRdtase-like_20kDa.
    IPR006138. NADH_UQ_OxRdtase_20Kd_su.
    [Graphical view]
    PfamiPF01058. Oxidored_q6. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01957. nuoB_fam. 1 hit.
    PROSITEiPS01150. COMPLEX1_20K. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q94360-1 [UniParc]FASTAAdd to Basket

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    MLSALRTAGA VGTRRLASTQ AIASNSEAPK GIATTGTPFL NPSSKAEYAL    50
    ARLDDVLNLA QRGSIWPLTF GLACCAVEMM HFAAPRYDMD RYGVVFRASP 100
    RQADLIFVAG TVTNKMAPAL RRIYDQMPEA KWVISMGSCA NGGGYYHYAY 150
    SVLRGCDRVI PVDIYVPGCP PTAEALLYGV LQLQKKIKRK REAQLWYRR 199
    Length:199
    Mass (Da):21,912
    Last modified:February 1, 1997 - v1
    Checksum:iB40B33385A7DB667
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z79758 Genomic DNA. Translation: CAB02132.1.
    PIRiT26329.
    RefSeqiNP_492445.1. NM_060044.4.
    UniGeneiCel.18304.

    Genome annotation databases

    EnsemblMetazoaiW10D5.2.1; W10D5.2.1; WBGene00012376.
    W10D5.2.2; W10D5.2.2; WBGene00012376.
    GeneIDi172734.
    KEGGicel:CELE_W10D5.2.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z79758 Genomic DNA. Translation: CAB02132.1 .
    PIRi T26329.
    RefSeqi NP_492445.1. NM_060044.4.
    UniGenei Cel.18304.

    3D structure databases

    ProteinModelPortali Q94360.
    SMRi Q94360. Positions 53-188.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 38165. 1 interaction.
    STRINGi 6239.W10D5.2.2.

    Proteomic databases

    PaxDbi Q94360.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai W10D5.2.1 ; W10D5.2.1 ; WBGene00012376 .
    W10D5.2.2 ; W10D5.2.2 ; WBGene00012376 .
    GeneIDi 172734.
    KEGGi cel:CELE_W10D5.2.

    Organism-specific databases

    CTDi 172734.
    WormBasei W10D5.2 ; CE14780 ; WBGene00012376 ; nduf-7.

    Phylogenomic databases

    eggNOGi COG0377.
    GeneTreei ENSGT00390000006565.
    HOGENOMi HOG000228249.
    InParanoidi Q94360.
    KOi K03940.
    OMAi MIANWAR.
    PhylomeDBi Q94360.

    Miscellaneous databases

    NextBioi 876791.
    PROi Q94360.

    Family and domain databases

    Gene3Di 3.40.50.700. 1 hit.
    HAMAPi MF_01356. NDH1_NuoB.
    InterProi IPR006137. NADH_UbQ_OxRdtase-like_20kDa.
    IPR006138. NADH_UQ_OxRdtase_20Kd_su.
    [Graphical view ]
    Pfami PF01058. Oxidored_q6. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01957. nuoB_fam. 1 hit.
    PROSITEi PS01150. COMPLEX1_20K. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.
    2. "The role of mitochondria in the life of the nematode, Caenorhabditis elegans."
      Tsang W.Y., Lemire B.D.
      Biochim. Biophys. Acta 1638:91-105(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiNDUS7_CAEEL
    AccessioniPrimary (citable) accession number: Q94360
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3