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Q94360

- NDUS7_CAEEL

UniProt

Q94360 - NDUS7_CAEEL

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Protein

Probable NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

Gene

nduf-7

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).
NADH + acceptor = NAD+ + reduced acceptor.

Cofactori

[4Fe-4S] clusterCuratedNote: Binds 1 [4Fe-4S] cluster.Curated

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi74 – 741Iron-sulfur (4Fe-4S)Sequence Analysis
Metal bindingi75 – 751Iron-sulfur (4Fe-4S)Sequence Analysis
Metal bindingi139 – 1391Iron-sulfur (4Fe-4S)Sequence Analysis
Metal bindingi169 – 1691Iron-sulfur (4Fe-4S)Sequence Analysis

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC
  4. quinone binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

4Fe-4S, Iron, Iron-sulfur, Metal-binding, NAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
Probable NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (EC:1.6.5.3, EC:1.6.99.3)
Alternative name(s):
Complex I-20kD
Short name:
CI-20kD
NADH-ubiquinone oxidoreductase 20 kDa subunit
Gene namesi
Name:nduf-7
ORF Names:W10D5.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome I

Organism-specific databases

WormBaseiW10D5.2; CE14780; WBGene00012376; nduf-7.

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
  2. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 199Probable NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrialPRO_0000020030
Transit peptidei1 – ?MitochondrionSequence Analysis

Proteomic databases

PaxDbiQ94360.

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits This is a component of the iron-sulfur (IP) fragment of the enzyme.By similarity

Protein-protein interaction databases

BioGridi38165. 1 interaction.
STRINGi6239.W10D5.2.2.

Structurei

3D structure databases

ProteinModelPortaliQ94360.
SMRiQ94360. Positions 53-188.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I 20 kDa subunit family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0377.
GeneTreeiENSGT00390000006565.
HOGENOMiHOG000228249.
InParanoidiQ94360.
KOiK03940.
OMAiMIANWAR.
PhylomeDBiQ94360.

Family and domain databases

Gene3Di3.40.50.700. 1 hit.
HAMAPiMF_01356. NDH1_NuoB.
InterProiIPR006137. NADH_UbQ_OxRdtase-like_20kDa.
IPR006138. NADH_UQ_OxRdtase_20Kd_su.
[Graphical view]
PfamiPF01058. Oxidored_q6. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01957. nuoB_fam. 1 hit.
PROSITEiPS01150. COMPLEX1_20K. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q94360-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLSALRTAGA VGTRRLASTQ AIASNSEAPK GIATTGTPFL NPSSKAEYAL
60 70 80 90 100
ARLDDVLNLA QRGSIWPLTF GLACCAVEMM HFAAPRYDMD RYGVVFRASP
110 120 130 140 150
RQADLIFVAG TVTNKMAPAL RRIYDQMPEA KWVISMGSCA NGGGYYHYAY
160 170 180 190
SVLRGCDRVI PVDIYVPGCP PTAEALLYGV LQLQKKIKRK REAQLWYRR
Length:199
Mass (Da):21,912
Last modified:February 1, 1997 - v1
Checksum:iB40B33385A7DB667
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z79758 Genomic DNA. Translation: CAB02132.1.
PIRiT26329.
RefSeqiNP_492445.1. NM_060044.4.
UniGeneiCel.18304.

Genome annotation databases

EnsemblMetazoaiW10D5.2.1; W10D5.2.1; WBGene00012376.
W10D5.2.2; W10D5.2.2; WBGene00012376.
GeneIDi172734.
KEGGicel:CELE_W10D5.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z79758 Genomic DNA. Translation: CAB02132.1 .
PIRi T26329.
RefSeqi NP_492445.1. NM_060044.4.
UniGenei Cel.18304.

3D structure databases

ProteinModelPortali Q94360.
SMRi Q94360. Positions 53-188.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 38165. 1 interaction.
STRINGi 6239.W10D5.2.2.

Proteomic databases

PaxDbi Q94360.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai W10D5.2.1 ; W10D5.2.1 ; WBGene00012376 .
W10D5.2.2 ; W10D5.2.2 ; WBGene00012376 .
GeneIDi 172734.
KEGGi cel:CELE_W10D5.2.

Organism-specific databases

CTDi 172734.
WormBasei W10D5.2 ; CE14780 ; WBGene00012376 ; nduf-7.

Phylogenomic databases

eggNOGi COG0377.
GeneTreei ENSGT00390000006565.
HOGENOMi HOG000228249.
InParanoidi Q94360.
KOi K03940.
OMAi MIANWAR.
PhylomeDBi Q94360.

Miscellaneous databases

NextBioi 876791.
PROi Q94360.

Family and domain databases

Gene3Di 3.40.50.700. 1 hit.
HAMAPi MF_01356. NDH1_NuoB.
InterProi IPR006137. NADH_UbQ_OxRdtase-like_20kDa.
IPR006138. NADH_UQ_OxRdtase_20Kd_su.
[Graphical view ]
Pfami PF01058. Oxidored_q6. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01957. nuoB_fam. 1 hit.
PROSITEi PS01150. COMPLEX1_20K. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "The role of mitochondria in the life of the nematode, Caenorhabditis elegans."
    Tsang W.Y., Lemire B.D.
    Biochim. Biophys. Acta 1638:91-105(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiNDUS7_CAEEL
AccessioniPrimary (citable) accession number: Q94360
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: November 26, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3