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Protein

Probable NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

Gene

nduf-7

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).
NADH + acceptor = NAD+ + reduced acceptor.

Cofactori

[4Fe-4S] clusterCuratedNote: Binds 1 [4Fe-4S] cluster.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi74Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi75Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi139Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi169Iron-sulfur (4Fe-4S)Sequence analysis1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
Ligand4Fe-4S, Iron, Iron-sulfur, Metal-binding, NAD, Ubiquinone

Enzyme and pathway databases

ReactomeiR-CEL-6799198 Complex I biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Probable NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (EC:1.6.5.3, EC:1.6.99.3)
Alternative name(s):
Complex I-20kD
Short name:
CI-20kD
NADH-ubiquinone oxidoreductase 20 kDa subunit
Gene namesi
Name:nduf-7
ORF Names:W10D5.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiW10D5.2 ; CE14780 ; WBGene00012376 ; nduf-7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000020030? – 199Probable NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

EPDiQ94360
PaxDbiQ94360
PeptideAtlasiQ94360
PRIDEiQ94360

Expressioni

Gene expression databases

BgeeiWBGene00012376

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits This is a component of the iron-sulfur (IP) fragment of the enzyme.By similarity

Protein-protein interaction databases

BioGridi381651 interactor.
STRINGi6239.W10D5.2.1

Structurei

3D structure databases

ProteinModelPortaliQ94360
SMRiQ94360
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I 20 kDa subunit family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1687 Eukaryota
COG0377 LUCA
GeneTreeiENSGT00390000006565
HOGENOMiHOG000228249
InParanoidiQ94360
KOiK03940
OMAiGPYWEHG
OrthoDBiEOG091G0ST7
PhylomeDBiQ94360

Family and domain databases

HAMAPiMF_01356 NDH1_NuoB, 1 hit
InterProiView protein in InterPro
IPR006137 NADH_UbQ_OxRdtase-like_20kDa
IPR006138 NADH_UQ_OxRdtase_20Kd_su
PfamiView protein in Pfam
PF01058 Oxidored_q6, 1 hit
TIGRFAMsiTIGR01957 nuoB_fam, 1 hit
PROSITEiView protein in PROSITE
PS01150 COMPLEX1_20K, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q94360-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSALRTAGA VGTRRLASTQ AIASNSEAPK GIATTGTPFL NPSSKAEYAL
60 70 80 90 100
ARLDDVLNLA QRGSIWPLTF GLACCAVEMM HFAAPRYDMD RYGVVFRASP
110 120 130 140 150
RQADLIFVAG TVTNKMAPAL RRIYDQMPEA KWVISMGSCA NGGGYYHYAY
160 170 180 190
SVLRGCDRVI PVDIYVPGCP PTAEALLYGV LQLQKKIKRK REAQLWYRR
Length:199
Mass (Da):21,912
Last modified:February 1, 1997 - v1
Checksum:iB40B33385A7DB667
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z79758 Genomic DNA Translation: CAB02132.1
PIRiT26329
RefSeqiNP_492445.1, NM_060044.4
UniGeneiCel.18304

Genome annotation databases

EnsemblMetazoaiW10D5.2.1; W10D5.2.1; WBGene00012376
W10D5.2.2; W10D5.2.2; WBGene00012376
GeneIDi172734
KEGGicel:CELE_W10D5.2

Similar proteinsi

Entry informationi

Entry nameiNDUS7_CAEEL
AccessioniPrimary (citable) accession number: Q94360
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: February 28, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome