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Protein

Mitochondrial Rho GTPase 1

Gene

miro-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi16 – 23GTP 1Sequence analysis8
Nucleotide bindingi62 – 66GTP 1Sequence analysis5
Nucleotide bindingi123 – 126GTP 1Sequence analysis4
Calcium bindingi201 – 2121PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi321 – 3322PROSITE-ProRule annotationAdd BLAST12
Nucleotide bindingi433 – 440GTP 2Sequence analysis8
Nucleotide bindingi470 – 474GTP 2Sequence analysis5
Nucleotide bindingi537 – 540GTP 2Sequence analysis4

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Calcium, GTP-binding, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-194840. Rho GTPase cycle.
R-CEL-5689880. Ub-specific processing proteases.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial Rho GTPase 1 (EC:3.6.5.-)
Short name:
Miro
Gene namesi
Name:miro-1Imported
ORF Names:K08F11.5Imported
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiK08F11.5; CE11958; WBGene00019544; miro-1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 601Mitochondrial intermembraneSequence analysisAdd BLAST601
Transmembranei602 – 622Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini623 – 625CytoplasmicSequence analysis3

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002393261 – 625Mitochondrial Rho GTPase 1CuratedAdd BLAST625

Proteomic databases

EPDiQ94263.
PaxDbiQ94263.
PeptideAtlasiQ94263.
PRIDEiQ94263.

Expressioni

Gene expression databases

BgeeiWBGene00019544.

Interactioni

Protein-protein interaction databases

STRINGi6239.K08F11.5.2.

Structurei

3D structure databases

ProteinModelPortaliQ94263.
SMRiQ94263.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 170Miro 1Add BLAST168
Domaini188 – 223EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini308 – 343EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini420 – 625Miro 2Add BLAST206

Sequence similaritiesi

Belongs to the mitochondrial Rho GTPase family.Curated
Contains 2 EF-hand domains.PROSITE-ProRule annotation
Contains 2 Miro domains.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1707. Eukaryota.
ENOG410XRHW. LUCA.
GeneTreeiENSGT00390000014374.
HOGENOMiHOG000215553.
InParanoidiQ94263.
KOiK07870.
OMAiKEEHRSY.
OrthoDBiEOG091G04UF.
PhylomeDBiQ94263.

Family and domain databases

Gene3Di1.10.238.10. 3 hits.
3.40.50.300. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR013566. EF_hand_assoc_1.
IPR013567. EF_hand_assoc_2.
IPR002048. EF_hand_dom.
IPR020860. MIRO_dom.
IPR021181. Mt_Rho_GTPase.
IPR027417. P-loop_NTPase.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF13202. EF-hand_5. 1 hit.
PF08355. EF_assoc_1. 1 hit.
PF08356. EF_assoc_2. 1 hit.
PF00071. Ras. 1 hit.
[Graphical view]
PIRSFiPIRSF037488. Mt_Rho_GTPase. 1 hit.
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 2 hits.
SSF52540. SSF52540. 2 hits.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
PS51423. MIRO. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q94263-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDDETLADV RIVLIGDEGC GKTSLVMSLL EDEWVDAVPR RLDRVLIPAD
60 70 80 90 100
VTPENVTTSI VDLSIKEEDE NWIVSEIRQA NVICVVYSVT DESTVDGIQT
110 120 130 140 150
KWLPLIRQSF GEYHETPVIL VGNKSDGTAN NTDKILPIME ANTEVETCVE
160 170 180 190 200
CSARTMKNVS EIFYYAQKAV IYPTRPLYDA DTKQLTDRAR KALIRVFKIC
210 220 230 240 250
DRDNDGYLSD TELNDFQKLC FGIPLTSTAL EDVKRAVSDG CPDGVANDSL
260 270 280 290 300
MLAGFLYLHL LFIERGRHET TWAVLRKFGY ETSLKLSEDY LYPRITIPVG
310 320 330 340 350
CSTELSPEGV QFVSALFEKY DEDKDGCLSP SELQNLFSVC PVPVITKDNI
360 370 380 390 400
LALETNQRGW LTYNGYMAYW NMTTLINLTQ TFEQLAYLGF PVGRSGPGRA
410 420 430 440 450
GNTLDSIRVT RERKKDLENH GTDRKVFQCL VVGAKDAGKT VFMQSLAGRG
460 470 480 490 500
MADVAQIGRR HSPFVINRVR VKEESKYLLL REVDVLSPQD ALGSGETSAD
510 520 530 540 550
VVAFLYDISN PDSFAFCATV YQKYFYRTKT PCVMIATKVE REEVDQRWEV
560 570 580 590 600
PPEEFCRQFE LPKPIKFSTG NIGQSSSPIF EQLAMMAVYP HLRRVFYLND
610 620
SNLLSKITFG AAIVALAGFL VLKNL
Length:625
Mass (Da):70,222
Last modified:February 1, 1997 - v1
Checksum:i1568FBA1315806C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081041 Genomic DNA. Translation: CCD68726.1.
PIRiT30022.
RefSeqiNP_500620.1. NM_068219.3.
UniGeneiCel.6465.

Genome annotation databases

EnsemblMetazoaiK08F11.5; K08F11.5; WBGene00019544.
GeneIDi177238.
KEGGicel:CELE_K08F11.5.
UCSCiK08F11.5.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081041 Genomic DNA. Translation: CCD68726.1.
PIRiT30022.
RefSeqiNP_500620.1. NM_068219.3.
UniGeneiCel.6465.

3D structure databases

ProteinModelPortaliQ94263.
SMRiQ94263.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.K08F11.5.2.

Proteomic databases

EPDiQ94263.
PaxDbiQ94263.
PeptideAtlasiQ94263.
PRIDEiQ94263.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiK08F11.5; K08F11.5; WBGene00019544.
GeneIDi177238.
KEGGicel:CELE_K08F11.5.
UCSCiK08F11.5.1. c. elegans.

Organism-specific databases

CTDi177238.
WormBaseiK08F11.5; CE11958; WBGene00019544; miro-1.

Phylogenomic databases

eggNOGiKOG1707. Eukaryota.
ENOG410XRHW. LUCA.
GeneTreeiENSGT00390000014374.
HOGENOMiHOG000215553.
InParanoidiQ94263.
KOiK07870.
OMAiKEEHRSY.
OrthoDBiEOG091G04UF.
PhylomeDBiQ94263.

Enzyme and pathway databases

ReactomeiR-CEL-194840. Rho GTPase cycle.
R-CEL-5689880. Ub-specific processing proteases.

Miscellaneous databases

PROiQ94263.

Gene expression databases

BgeeiWBGene00019544.

Family and domain databases

Gene3Di1.10.238.10. 3 hits.
3.40.50.300. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR013566. EF_hand_assoc_1.
IPR013567. EF_hand_assoc_2.
IPR002048. EF_hand_dom.
IPR020860. MIRO_dom.
IPR021181. Mt_Rho_GTPase.
IPR027417. P-loop_NTPase.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF13202. EF-hand_5. 1 hit.
PF08355. EF_assoc_1. 1 hit.
PF08356. EF_assoc_2. 1 hit.
PF00071. Ras. 1 hit.
[Graphical view]
PIRSFiPIRSF037488. Mt_Rho_GTPase. 1 hit.
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 2 hits.
SSF52540. SSF52540. 2 hits.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
PS51423. MIRO. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMIRO1_CAEEL
AccessioniPrimary (citable) accession number: Q94263
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: February 1, 1997
Last modified: November 2, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.