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Protein
Submitted name:

TBC (Tre-2/Bub2/Cdc16) domain family

Gene

tbc-18

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
TBC (Tre-2/Bub2/Cdc16) domain familyImported
Gene namesi
Name:tbc-18Imported
ORF Names:CELE_F41D9.1Imported, F41D9.1Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiF41D9.1; CE30984; WBGene00018281; tbc-18.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiQ94222.
PeptideAtlasiQ94222.

Expressioni

Gene expression databases

BgeeiWBGene00018281.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ94222. 3 interactors.
STRINGi6239.F41D9.1.

Structurei

3D structure databases

ProteinModelPortaliQ94222.
SMRiQ94222.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini150 – 341Rab-GAP TBCInterPro annotationAdd BLAST192
Domaini524 – 583SH3InterPro annotationAdd BLAST60
Domaini599 – 766RUNInterPro annotationAdd BLAST168

Sequence similaritiesi

Contains 1 SH3 domain.UniRule annotation

Keywords - Domaini

SH3 domainUniRule annotation

Phylogenomic databases

eggNOGiKOG2222. Eukaryota.
COG5210. LUCA.
GeneTreeiENSGT00760000119137.
HOGENOMiHOG000007875.
InParanoidiQ94222.
KOiK20176.
OMAiFQVTLGM.
OrthoDBiEOG091G02H8.
PhylomeDBiQ94222.

Family and domain databases

InterProiIPR000195. Rab-GTPase-TBC_dom.
IPR004012. Run_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00566. RabGAP-TBC. 1 hit.
PF02759. RUN. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
SMARTiSM00593. RUN. 1 hit.
SM00326. SH3. 1 hit.
SM00164. TBC. 1 hit.
[Graphical view]
SUPFAMiSSF47923. SSF47923. 2 hits.
SSF50044. SSF50044. 1 hit.
PROSITEiPS50826. RUN. 1 hit.
PS50002. SH3. 1 hit.
PS50086. TBC_RABGAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q94222-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKYKKGKDA KYADAVADDD DVFPVARKIA EHTKEKDQEI HSSYFELDGK
60 70 80 90 100
PFSAINKAML PIYIEDPLEF FDEFGFRKQD DDHDPNLGDE EETSSAKHLS
110 120 130 140 150
EPLENSTHKL KLISYLQDVH KEVKDDVLWS HILGPELKTD RFEELLKEGG
160 170 180 190 200
IPHSMRPFLW PRLSGATKKQ KDAKYTYESV LQQCAQDKPS IGVQIERDLL
210 220 230 240 250
RTLPNNICFW KKNSEGIEAL RRILKCVAFI YPDLGYCQGM GVIVATLLLY
260 270 280 290 300
CSEETTFWMM TALIEDILPP NFYTQTLLGL QADERVSRHL MKCHVPDLNK
310 320 330 340 350
ALEDYEVEVS LLTVSWLLTL FGSVFRTRVM LRVWDFIFYS GGVNIFRVII
360 370 380 390 400
SILKMKEQEI VEIAETTQSS ADIFTALSQL PASVTEVEKV IEYMGSFEFT
410 420 430 440 450
ITDHLIAELR KKHQAVLMAD QGMIVNTATD TNLPKQTTQR RKLTRSKSII
460 470 480 490 500
KQIFSSKDET ANDPKSKNIR QTEILVDLKE SVLQICRYFI SCDEKMELNV
510 520 530 540 550
CTQADYSPES HNKDIANYLK GRRVGAKRAR ALLDFAREEE NELGFRKNDI
560 570 580 590 600
VTIISEKDEH CWVGEVNGLR GWFPAKFVEV VDERGKSYTI YGDEAVSPEI
610 620 630 640 650
TEYIRGRLAN SFRQIMDHGI RENALYTSMA YHPWSFIEDI AYYSVEKNFN
660 670 680 690 700
SVYSRLTLCN TFNLDEDGKI LTPEELLFRS VQLINDSHNA VSAHSDVKLR
710 720 730 740 750
SLLVVGVNEQ CIHLWFDLLC SATQHEHIRN KYYHSWAFIR SPAWRQIKCD
760 770 780 790 800
LRLLSQFSFN LSMSFEIEGI DKKKRKFVNG LLTSQKKKIL STVVSSSQDN
810 820
KQNGEEPLKQ GVTDMLIKHH LFSWDL
Length:826
Mass (Da):95,168
Last modified:October 1, 2002 - v2
Checksum:iFAD2D88B6A9F3804
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284606 Genomic DNA. Translation: CCD69040.1.
PIRiT25748.
RefSeqiNP_509421.2. NM_077020.4.
UniGeneiCel.17080.

Genome annotation databases

EnsemblMetazoaiF41D9.1; F41D9.1; WBGene00018281.
GeneIDi181091.
KEGGicel:CELE_F41D9.1.
UCSCiF41D9.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284606 Genomic DNA. Translation: CCD69040.1.
PIRiT25748.
RefSeqiNP_509421.2. NM_077020.4.
UniGeneiCel.17080.

3D structure databases

ProteinModelPortaliQ94222.
SMRiQ94222.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ94222. 3 interactors.
STRINGi6239.F41D9.1.

Proteomic databases

PaxDbiQ94222.
PeptideAtlasiQ94222.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF41D9.1; F41D9.1; WBGene00018281.
GeneIDi181091.
KEGGicel:CELE_F41D9.1.
UCSCiF41D9.1. c. elegans.

Organism-specific databases

CTDi181091.
WormBaseiF41D9.1; CE30984; WBGene00018281; tbc-18.

Phylogenomic databases

eggNOGiKOG2222. Eukaryota.
COG5210. LUCA.
GeneTreeiENSGT00760000119137.
HOGENOMiHOG000007875.
InParanoidiQ94222.
KOiK20176.
OMAiFQVTLGM.
OrthoDBiEOG091G02H8.
PhylomeDBiQ94222.

Gene expression databases

BgeeiWBGene00018281.

Family and domain databases

InterProiIPR000195. Rab-GTPase-TBC_dom.
IPR004012. Run_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00566. RabGAP-TBC. 1 hit.
PF02759. RUN. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
SMARTiSM00593. RUN. 1 hit.
SM00326. SH3. 1 hit.
SM00164. TBC. 1 hit.
[Graphical view]
SUPFAMiSSF47923. SSF47923. 2 hits.
SSF50044. SSF50044. 1 hit.
PROSITEiPS50826. RUN. 1 hit.
PS50002. SH3. 1 hit.
PS50086. TBC_RABGAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ94222_CAEEL
AccessioniPrimary (citable) accession number: Q94222
Entry historyi
Integrated into UniProtKB/TrEMBL: February 1, 1997
Last sequence update: October 1, 2002
Last modified: November 30, 2016
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.