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Protein

Histone deacetylase 14

Gene

HDA14

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity).By similarity1 Publication

Miscellaneous

HDA14 is not required for the cellular patterning in the root epidermis.

Catalytic activityi

Hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei202By similarity1

GO - Molecular functioni

  • alpha-tubulin binding Source: TAIR
  • beta-tubulin binding Source: TAIR
  • NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
  • protein phosphatase 2A binding Source: TAIR
  • protein self-association Source: TAIR
  • tubulin deacetylase activity Source: TAIR

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator, Hydrolase, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylase 14 (EC:3.5.1.98)
Gene namesi
Name:HDA14
Ordered Locus Names:At4g33470
ORF Names:F17M5.230
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G33470.
TAIRilocus:2119201. AT4G33470.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002800901 – 423Histone deacetylase 14Add BLAST423

Proteomic databases

PaxDbiQ941D6.

Expressioni

Gene expression databases

ExpressionAtlasiQ941D6. baseline and differential.
GenevisibleiQ941D6. AT.

Interactioni

Subunit structurei

Interacts with PP2A2.1 Publication

GO - Molecular functioni

  • alpha-tubulin binding Source: TAIR
  • beta-tubulin binding Source: TAIR
  • protein phosphatase 2A binding Source: TAIR
  • protein self-association Source: TAIR

Protein-protein interaction databases

BioGridi14768. 2 interactors.
STRINGi3702.AT4G33470.1.

Structurei

3D structure databases

ProteinModelPortaliQ941D6.
SMRiQ941D6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni62 – 392Histone deacetylaseAdd BLAST331

Sequence similaritiesi

Belongs to the histone deacetylase family.Curated

Phylogenomic databases

eggNOGiKOG1343. Eukaryota.
COG0123. LUCA.
HOGENOMiHOG000225183.
InParanoidiQ941D6.
OMAiFGSHHPL.
OrthoDBiEOG09360B29.
PhylomeDBiQ941D6.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiView protein in InterPro
IPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
IPR037138. His_deacetylse_dom_sf.
IPR023696. Ureohydrolase_dom_sf.
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiView protein in Pfam
PF00850. Hist_deacetyl. 1 hit.
PRINTSiPR01270. HDASUPER.
SUPFAMiSSF52768. SSF52768. 1 hit.

Sequencei

Sequence statusi: Complete.

Q941D6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSMALIVRPF FVPGSAGISG SRNICKKNQW RKYLLKPSGS SINCSFSTEK
60 70 80 90 100
NPLLPSIQQL ADARLIYSVS AALGHNKESH PECSARVPAI VNALEMNELT
110 120 130 140 150
PKFRGSQILE LANFKTATVE DIANVHDKAY VFGLEKAMDE ASDSGLIFIE
160 170 180 190 200
GSGPTYATST TFQDSLIAAG AGMALVDSVI AASRNSVDPP IGFALIRPPG
210 220 230 240 250
HHAVPKGPMG FCVFGNVAIA ARHAQRTHGL KRIFIIDFDV HHGNGTNDAF
260 270 280 290 300
TEDPDIFFLS THQDGSYPGT GKISDIGKGK GEGTTLNLPL PGGSGDIAMR
310 320 330 340 350
TVFEEIIVPC AQRFKPDIIL VSAGYDAHVL DPLANLQFTT ATYYSLAKDI
360 370 380 390 400
KRLAKEVCGG RCVFFLEGGY NLESLSSSVA DSFRALLGED SLASEFDNPA
410 420
YLYDEPMRKV RDAIQRAKSI HCL
Length:423
Mass (Da):45,577
Last modified:December 1, 2001 - v1
Checksum:iEA56909AFC9672E0
GO

Sequence cautioni

The sequence CAB38805 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAB80064 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL035678 Genomic DNA. Translation: CAB38805.1. Sequence problems.
AL161583 Genomic DNA. Translation: CAB80064.1. Sequence problems.
CP002687 Genomic DNA. Translation: AEE86231.1.
AY052234 mRNA. Translation: AAK97704.1.
AY113069 mRNA. Translation: AAM47377.1.
PIRiT05998.
RefSeqiNP_567921.1. NM_119501.4.
UniGeneiAt.26427.

Genome annotation databases

EnsemblPlantsiAT4G33470.1; AT4G33470.1; AT4G33470.
GeneIDi829484.
GrameneiAT4G33470.1; AT4G33470.1; AT4G33470.
KEGGiath:AT4G33470.

Similar proteinsi

Entry informationi

Entry nameiHDA14_ARATH
AccessioniPrimary (citable) accession number: Q941D6
Secondary accession number(s): Q9SZC4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: December 1, 2001
Last modified: November 22, 2017
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families