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Q941B6

- UBC37_ARATH

UniProt

Q941B6 - UBC37_ARATH

Protein

Probable ubiquitin-conjugating enzyme E2 37

Gene

UBC37

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 2 (03 May 2011)
      Previous versions | rss
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    Functioni

    Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins.By similarity

    Catalytic activityi

    ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei99 – 991Glycyl thioester intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. acid-amino acid ligase activity Source: InterPro
    2. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. protein ubiquitination Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Ubl conjugation pathway

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciARA:AT3G24515-MONOMER.
    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable ubiquitin-conjugating enzyme E2 37 (EC:6.3.2.19)
    Alternative name(s):
    Ubiquitin carrier protein 37
    Gene namesi
    Name:UBC37
    Ordered Locus Names:At3g24515
    ORF Names:MOB24.7
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 3

    Organism-specific databases

    TAIRiAT3G24515.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 409409Probable ubiquitin-conjugating enzyme E2 37PRO_0000345202Add
    BLAST

    Proteomic databases

    PaxDbiQ941B6.
    PRIDEiQ941B6.

    Expressioni

    Gene expression databases

    GenevestigatoriQ941B6.

    Interactioni

    Protein-protein interaction databases

    STRINGi3702.AT3G24515.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliQ941B6.
    SMRiQ941B6. Positions 10-167.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi385 – 3884Poly-Glu

    Sequence similaritiesi

    Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5078.
    HOGENOMiHOG000185102.
    InParanoidiQ9LV54.
    KOiK13960.
    OMAiSAACKEN.

    Family and domain databases

    Gene3Di3.10.110.10. 1 hit.
    InterProiIPR000608. UBQ-conjugat_E2.
    IPR023313. UBQ-conjugating_AS.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view]
    PfamiPF00179. UQ_con. 1 hit.
    [Graphical view]
    SUPFAMiSSF54495. SSF54495. 1 hit.
    PROSITEiPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
    PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q941B6-1 [UniParc]FASTAAdd to Basket

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    MAQAARLSLR MQKELKLLLS DPPHGASFPH LSSAANGSGD FSTFSTIDAQ    50
    IEGPEDTVYA NGIFNLKIQI PERYPFQPPI VSFATPIYHP NIDNSGRICL 100
    DILNLPPKGA WQPSLNISTV LTSMRLLLSE PNPDDGLMCE VSREYKYNRQ 150
    TFDYKAREMT EKYAKVKADG CSTSLQIKNH GDEKSGESGN SVKLKLTVES 200
    SLSIAHTVKR ETAGRDEQED GNGKRKAVVG FGEGNSFGND GIKRSRKKLS 250
    LALPSQSQKK DLCGEEELTR GVSAACKENK KPNLNGKKLS LGLKQPCNDT 300
    LASFRTSAAK SDNNRLSRKL SLRSPLGELN EVSKPEVLAQ TDMKLEMNQN 350
    EDARSLRGEF ENSVLEETSM AESIVVLDSD DSGQEEEERV SSSRSRLSLA 400
    KRRVLKCRP 409
    Length:409
    Mass (Da):45,083
    Last modified:May 3, 2011 - v2
    Checksum:iD8E0591E25489ACE
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti398 – 3981S → L in AAY44876. (PubMed:16339806)Curated
    Sequence conflicti398 – 3981S → L in AAK96485. (PubMed:14593172)Curated
    Sequence conflicti398 – 3981S → L in AAL31249. (PubMed:14593172)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ027050 mRNA. Translation: AAY44876.1.
    AB020746 Genomic DNA. Translation: BAB02001.1.
    CP002686 Genomic DNA. Translation: AEE76912.1.
    AY052292 mRNA. Translation: AAK96485.1.
    AY061922 mRNA. Translation: AAL31249.1.
    RefSeqiNP_566751.1. NM_113362.1.
    UniGeneiAt.26504.

    Genome annotation databases

    EnsemblPlantsiAT3G24515.1; AT3G24515.1; AT3G24515.
    GeneIDi822045.
    KEGGiath:AT3G24515.

    Cross-referencesi

    Web resourcesi

    PlantsUBQ

    A functional genomics database for the ubiquitin/26S proteasome proteolytic pathway in plants

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ027050 mRNA. Translation: AAY44876.1 .
    AB020746 Genomic DNA. Translation: BAB02001.1 .
    CP002686 Genomic DNA. Translation: AEE76912.1 .
    AY052292 mRNA. Translation: AAK96485.1 .
    AY061922 mRNA. Translation: AAL31249.1 .
    RefSeqi NP_566751.1. NM_113362.1.
    UniGenei At.26504.

    3D structure databases

    ProteinModelPortali Q941B6.
    SMRi Q941B6. Positions 10-167.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 3702.AT3G24515.1-P.

    Proteomic databases

    PaxDbi Q941B6.
    PRIDEi Q941B6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT3G24515.1 ; AT3G24515.1 ; AT3G24515 .
    GeneIDi 822045.
    KEGGi ath:AT3G24515.

    Organism-specific databases

    TAIRi AT3G24515.

    Phylogenomic databases

    eggNOGi COG5078.
    HOGENOMi HOG000185102.
    InParanoidi Q9LV54.
    KOi K13960.
    OMAi SAACKEN.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .
    BioCyci ARA:AT3G24515-MONOMER.

    Miscellaneous databases

    PROi Q941B6.

    Gene expression databases

    Genevestigatori Q941B6.

    Family and domain databases

    Gene3Di 3.10.110.10. 1 hit.
    InterProi IPR000608. UBQ-conjugat_E2.
    IPR023313. UBQ-conjugating_AS.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view ]
    Pfami PF00179. UQ_con. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54495. SSF54495. 1 hit.
    PROSITEi PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
    PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome analysis and functional characterization of the E2 and RING-type E3 ligase ubiquitination enzymes of Arabidopsis."
      Kraft E., Stone S.L., Ma L., Su N., Gao Y., Lau O.-S., Deng X.-W., Callis J.
      Plant Physiol. 139:1597-1611(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, GENE FAMILY, NOMENCLATURE.
    2. "Structural analysis of Arabidopsis thaliana chromosome 3. II. Sequence features of the 4,251,695 bp regions covered by 90 P1, TAC and BAC clones."
      Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Tabata S.
      DNA Res. 7:217-221(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    3. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.

    Entry informationi

    Entry nameiUBC37_ARATH
    AccessioniPrimary (citable) accession number: Q941B6
    Secondary accession number(s): Q9LV54
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 22, 2008
    Last sequence update: May 3, 2011
    Last modified: October 1, 2014
    This is version 84 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3