Q941B6 (UBC37_ARATH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable ubiquitin-conjugating enzyme E2 37
EC=6.3.2.19

Alternative name(s):
Ubiquitin carrier protein 37

Gene names

Name:	UBC37
Ordered Locus Names:	At3g24515
ORF Names:	MOB24.7

Organism

Arabidopsis thaliana (Mouse-ear cress) [Reference proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length	409 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins By similarity. Ref.1
Catalytic activity	ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.
Pathway	Protein modification; protein ubiquitination.
Sequence similarities	Belongs to the ubiquitin-conjugating enzyme family.

Ontologies

Keywords
Biological process	Ubl conjugation pathway
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ubiquitin-protein ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 409	409	Probable ubiquitin-conjugating enzyme E2 37		PRO_0000345202
Regions
	Compositional bias	385 – 388	4	Poly-Glu
Sites
	Active site	99	1	Glycyl thioester intermediate By similarity
Experimental info
	Sequence conflict	398	1	S → L in AAY44876. Ref.1
	Sequence conflict	398	1	S → L in AAK96485. Ref.4
	Sequence conflict	398	1	S → L in AAL31249. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Q941B6 [UniParc]. Last modified May 3, 2011. Version 2. Checksum: D8E0591E25489ACE	FASTA	409	45,083
	10 20 30 40 50 60 MAQAARLSLR MQKELKLLLS DPPHGASFPH LSSAANGSGD FSTFSTIDAQ IEGPEDTVYA 70 80 90 100 110 120 NGIFNLKIQI PERYPFQPPI VSFATPIYHP NIDNSGRICL DILNLPPKGA WQPSLNISTV 130 140 150 160 170 180 LTSMRLLLSE PNPDDGLMCE VSREYKYNRQ TFDYKAREMT EKYAKVKADG CSTSLQIKNH 190 200 210 220 230 240 GDEKSGESGN SVKLKLTVES SLSIAHTVKR ETAGRDEQED GNGKRKAVVG FGEGNSFGND 250 260 270 280 290 300 GIKRSRKKLS LALPSQSQKK DLCGEEELTR GVSAACKENK KPNLNGKKLS LGLKQPCNDT 310 320 330 340 350 360 LASFRTSAAK SDNNRLSRKL SLRSPLGELN EVSKPEVLAQ TDMKLEMNQN EDARSLRGEF 370 380 390 400 ENSVLEETSM AESIVVLDSD DSGQEEEERV SSSRSRLSLA KRRVLKCRP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome analysis and functional characterization of the E2 and RING-type E3 ligase ubiquitination enzymes of Arabidopsis." Kraft E., Stone S.L., Ma L., Su N., Gao Y., Lau O.-S., Deng X.-W., Callis J. Plant Physiol. 139:1597-1611(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, GENE FAMILY, NOMENCLATURE.
[2]	"Structural analysis of Arabidopsis thaliana chromosome 3. II. Sequence features of the 4,251,695 bp regions covered by 90 P1, TAC and BAC clones." Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Tabata S. DNA Res. 7:217-221(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[3]	The Arabidopsis Information Resource (TAIR) Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: cv. Columbia.
[4]	"Empirical analysis of transcriptional activity in the Arabidopsis genome." Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R. Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia.

Web resources

PlantsUBQ

A functional genomics database for the ubiquitin/26S proteasome proteolytic pathway in plants

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ027050 mRNA. Translation: AAY44876.1. AB020746 Genomic DNA. Translation: BAB02001.1. CP002686 Genomic DNA. Translation: AEE76912.1. AY052292 mRNA. Translation: AAK96485.1. AY061922 mRNA. Translation: AAL31249.1.
IPI	IPI00525946.
RefSeq	NP_566751.1. NM_113362.1.
UniGene	At.26504.
3D structure databases
HSSP	HSSP built from PDB template 1YH2 based on UniProtKB Q9NPD8.
ProteinModelPortal	Q941B6.
SMR	Q941B6. Positions 10-167.
ModBase	Search...
Protein-protein interaction databases
STRING	3702.AT3G24515.1-P.
Proteomic databases
PaxDb	Q941B6.
PRIDE	Q941B6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblPlants	AT3G24515.1; AT3G24515.1; AT3G24515.
GeneID	822045.
KEGG	ath:AT3G24515.
Organism-specific databases
TAIR	At3g24515.
Phylogenomic databases
eggNOG	COG5078.
HOGENOM	HOG000185102.
InParanoid	Q9LV54.
KO	K13960.
OMA	SAACKEN.
ProtClustDB	CLSN2917253.
Enzyme and pathway databases
UniPathway	UPA00143.
Gene expression databases
Genevestigator	Q941B6.
Family and domain databases
Gene3D	3.10.110.10. 1 hit.
InterPro	IPR000608. UBQ-conjugat_E2. IPR023313. UBQ-conjugating_AS. IPR016135. UBQ-conjugating_enzyme/RWD. [Graphical view]
Pfam	PF00179. UQ_con. 1 hit. [Graphical view]
SUPFAM	SSF54495. UBQ-conjugat/RWD-like. 1 hit.
PROSITE	PS00183. UBIQUITIN_CONJUGAT_1. 1 hit. PS50127. UBIQUITIN_CONJUGAT_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UBC37_ARATH

Accession

Primary (citable) accession number: Q941B6
Secondary accession number(s): Q9LV54

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 22, 2008
Last sequence update:	May 3, 2011
Last modified:	May 1, 2013
This is version 75 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program