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Protein

Probable ubiquitin-conjugating enzyme E2 37

Gene

UBC37

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins.By similarity1 Publication

Catalytic activityi

S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.PROSITE-ProRule annotation

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.PROSITE-ProRule annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei99Glycyl thioester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ubiquitin-conjugating enzyme E2 37 (EC:2.3.2.23)
Alternative name(s):
E2 ubiquitin-conjugating enzyme 37
Ubiquitin carrier protein 37
Gene namesi
Name:UBC37
Ordered Locus Names:At3g24515
ORF Names:MOB24.7
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G24515.
TAIRilocus:505006371. AT3G24515.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003452021 – 409Probable ubiquitin-conjugating enzyme E2 37Add BLAST409

Proteomic databases

PaxDbiQ941B6.
PRIDEiQ941B6.

Expressioni

Gene expression databases

ExpressionAtlasiQ941B6. baseline and differential.
GenevisibleiQ941B6. AT.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi3702.AT3G24515.1.

Structurei

3D structure databases

ProteinModelPortaliQ941B6.
SMRiQ941B6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi385 – 388Poly-Glu4

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0417. Eukaryota.
COG5078. LUCA.
HOGENOMiHOG000185102.
InParanoidiQ941B6.
KOiK13960.
OMAiTDMKLEM.
OrthoDBiEOG093606OS.

Family and domain databases

CDDicd00195. UBCc. 1 hit.
Gene3Di3.10.110.10. 1 hit.
InterProiView protein in InterPro
IPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
PfamiView protein in Pfam
PF00179. UQ_con. 1 hit.
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiView protein in PROSITE
PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q941B6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQAARLSLR MQKELKLLLS DPPHGASFPH LSSAANGSGD FSTFSTIDAQ
60 70 80 90 100
IEGPEDTVYA NGIFNLKIQI PERYPFQPPI VSFATPIYHP NIDNSGRICL
110 120 130 140 150
DILNLPPKGA WQPSLNISTV LTSMRLLLSE PNPDDGLMCE VSREYKYNRQ
160 170 180 190 200
TFDYKAREMT EKYAKVKADG CSTSLQIKNH GDEKSGESGN SVKLKLTVES
210 220 230 240 250
SLSIAHTVKR ETAGRDEQED GNGKRKAVVG FGEGNSFGND GIKRSRKKLS
260 270 280 290 300
LALPSQSQKK DLCGEEELTR GVSAACKENK KPNLNGKKLS LGLKQPCNDT
310 320 330 340 350
LASFRTSAAK SDNNRLSRKL SLRSPLGELN EVSKPEVLAQ TDMKLEMNQN
360 370 380 390 400
EDARSLRGEF ENSVLEETSM AESIVVLDSD DSGQEEEERV SSSRSRLSLA

KRRVLKCRP
Length:409
Mass (Da):45,083
Last modified:May 3, 2011 - v2
Checksum:iD8E0591E25489ACE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti398S → L in AAY44876 (PubMed:16339806).Curated1
Sequence conflicti398S → L in AAK96485 (PubMed:14593172).Curated1
Sequence conflicti398S → L in AAL31249 (PubMed:14593172).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ027050 mRNA. Translation: AAY44876.1.
AB020746 Genomic DNA. Translation: BAB02001.1.
CP002686 Genomic DNA. Translation: AEE76912.1.
AY052292 mRNA. Translation: AAK96485.1.
AY061922 mRNA. Translation: AAL31249.1.
RefSeqiNP_566751.1. NM_113362.2.
UniGeneiAt.26504.

Genome annotation databases

EnsemblPlantsiAT3G24515.1; AT3G24515.1; AT3G24515.
GeneIDi822045.
GrameneiAT3G24515.1; AT3G24515.1; AT3G24515.
KEGGiath:AT3G24515.

Similar proteinsi

Entry informationi

Entry nameiUBC37_ARATH
AccessioniPrimary (citable) accession number: Q941B6
Secondary accession number(s): Q9LV54
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: May 3, 2011
Last modified: August 30, 2017
This is version 106 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families