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Protein

Probable ubiquitin-conjugating enzyme E2 37

Gene

UBC37

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins.By similarity

Catalytic activityi

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.PROSITE-ProRule annotation

Pathway: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.PROSITE-ProRule annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei99 – 991Glycyl thioester intermediatePROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT3G24515-MONOMER.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ubiquitin-conjugating enzyme E2 37 (EC:6.3.2.19)
Alternative name(s):
Ubiquitin carrier protein 37
Gene namesi
Name:UBC37
Ordered Locus Names:At3g24515
ORF Names:MOB24.7
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548 Componenti: Chromosome 3

Organism-specific databases

TAIRiAT3G24515.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 409409Probable ubiquitin-conjugating enzyme E2 37PRO_0000345202Add
BLAST

Proteomic databases

PaxDbiQ941B6.
PRIDEiQ941B6.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT3G24515.1.

Structurei

3D structure databases

ProteinModelPortaliQ941B6.
SMRiQ941B6. Positions 10-167.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi385 – 3884Poly-Glu

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5078.
HOGENOMiHOG000185102.
InParanoidiQ941B6.
KOiK13960.
OMAiSAACKEN.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q941B6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQAARLSLR MQKELKLLLS DPPHGASFPH LSSAANGSGD FSTFSTIDAQ
60 70 80 90 100
IEGPEDTVYA NGIFNLKIQI PERYPFQPPI VSFATPIYHP NIDNSGRICL
110 120 130 140 150
DILNLPPKGA WQPSLNISTV LTSMRLLLSE PNPDDGLMCE VSREYKYNRQ
160 170 180 190 200
TFDYKAREMT EKYAKVKADG CSTSLQIKNH GDEKSGESGN SVKLKLTVES
210 220 230 240 250
SLSIAHTVKR ETAGRDEQED GNGKRKAVVG FGEGNSFGND GIKRSRKKLS
260 270 280 290 300
LALPSQSQKK DLCGEEELTR GVSAACKENK KPNLNGKKLS LGLKQPCNDT
310 320 330 340 350
LASFRTSAAK SDNNRLSRKL SLRSPLGELN EVSKPEVLAQ TDMKLEMNQN
360 370 380 390 400
EDARSLRGEF ENSVLEETSM AESIVVLDSD DSGQEEEERV SSSRSRLSLA

KRRVLKCRP
Length:409
Mass (Da):45,083
Last modified:May 3, 2011 - v2
Checksum:iD8E0591E25489ACE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti398 – 3981S → L in AAY44876 (PubMed:16339806).Curated
Sequence conflicti398 – 3981S → L in AAK96485 (PubMed:14593172).Curated
Sequence conflicti398 – 3981S → L in AAL31249 (PubMed:14593172).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ027050 mRNA. Translation: AAY44876.1.
AB020746 Genomic DNA. Translation: BAB02001.1.
CP002686 Genomic DNA. Translation: AEE76912.1.
AY052292 mRNA. Translation: AAK96485.1.
AY061922 mRNA. Translation: AAL31249.1.
RefSeqiNP_566751.1. NM_113362.1.
UniGeneiAt.26504.

Genome annotation databases

EnsemblPlantsiAT3G24515.1; AT3G24515.1; AT3G24515.
GeneIDi822045.
KEGGiath:AT3G24515.

Cross-referencesi

Web resourcesi

PlantsUBQ

A functional genomics database for the ubiquitin/26S proteasome proteolytic pathway in plants

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ027050 mRNA. Translation: AAY44876.1.
AB020746 Genomic DNA. Translation: BAB02001.1.
CP002686 Genomic DNA. Translation: AEE76912.1.
AY052292 mRNA. Translation: AAK96485.1.
AY061922 mRNA. Translation: AAL31249.1.
RefSeqiNP_566751.1. NM_113362.1.
UniGeneiAt.26504.

3D structure databases

ProteinModelPortaliQ941B6.
SMRiQ941B6. Positions 10-167.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT3G24515.1.

Proteomic databases

PaxDbiQ941B6.
PRIDEiQ941B6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G24515.1; AT3G24515.1; AT3G24515.
GeneIDi822045.
KEGGiath:AT3G24515.

Organism-specific databases

TAIRiAT3G24515.

Phylogenomic databases

eggNOGiCOG5078.
HOGENOMiHOG000185102.
InParanoidiQ941B6.
KOiK13960.
OMAiSAACKEN.

Enzyme and pathway databases

UniPathwayiUPA00143.
BioCyciARA:AT3G24515-MONOMER.

Miscellaneous databases

PROiQ941B6.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome analysis and functional characterization of the E2 and RING-type E3 ligase ubiquitination enzymes of Arabidopsis."
    Kraft E., Stone S.L., Ma L., Su N., Gao Y., Lau O.-S., Deng X.-W., Callis J.
    Plant Physiol. 139:1597-1611(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, GENE FAMILY, NOMENCLATURE.
  2. "Structural analysis of Arabidopsis thaliana chromosome 3. II. Sequence features of the 4,251,695 bp regions covered by 90 P1, TAC and BAC clones."
    Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Tabata S.
    DNA Res. 7:217-221(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.

Entry informationi

Entry nameiUBC37_ARATH
AccessioniPrimary (citable) accession number: Q941B6
Secondary accession number(s): Q9LV54
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: May 3, 2011
Last modified: June 24, 2015
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.