Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Warthog protein 4

Gene

wrt-4

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Intercellular signal essential for a variety of patterning events during development.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei415 – 4151Involved in auto-cleavageBy similarity
Sitei418 – 4181Essential for auto-cleavageBy similarity

GO - Molecular functioni

GO - Biological processi

  • cell-cell signaling Source: UniProtKB
  • intein-mediated protein splicing Source: InterPro
  • protein autoprocessing Source: UniProtKB
  • segment polarity determination Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Hydrolase, Protease

Protein family/group databases

MEROPSiC46.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Warthog protein 4
Alternative name(s):
Protein M75
Cleaved into the following 2 chains:
Gene namesi
Name:wrt-4
ORF Names:ZK678.5
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiZK678.5; CE24735; WBGene00006950; wrt-4.

Subcellular locationi

Warthog protein 4 :
  • Secreted By similarity
  • Cell surface By similarity

  • Note: Also secreted in either cleaved or uncleaved form to mediate signaling to other cells.By similarity
Warthog protein 4 C-product :
  • Secretedextracellular space By similarity

  • Note: Also secreted in either cleaved or uncleaved form to mediate signaling to other cells.By similarity

GO - Cellular componenti

  • cell surface Source: UniProtKB-SubCell
  • extracellular region Source: UniProtKB
  • extracellular space Source: UniProtKB-SubCell
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 557537Warthog protein 4PRO_0000013262Add
BLAST
Chaini21 – 346326Warthog protein 4 N-productBy similarityPRO_0000013263Add
BLAST
Chaini347 – 557211Warthog protein 4 C-productBy similarityPRO_0000013264Add
BLAST

Post-translational modificationi

The C-terminal domain displays an autoproteolysis activity.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei345 – 3462Cleavage; by autolysisBy similarity

Keywords - PTMi

Autocatalytic cleavage

Proteomic databases

EPDiQ94129.
PaxDbiQ94129.

Interactioni

Protein-protein interaction databases

BioGridi46556. 2 interactions.
IntActiQ94129. 1 interaction.
MINTiMINT-1113903.
STRINGi6239.ZK678.5.

Structurei

3D structure databases

ProteinModelPortaliQ94129.
SMRiQ94129. Positions 346-499.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi246 – 32176Gln-richAdd
BLAST

Sequence similaritiesi

Belongs to the hedgehog family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3638. Eukaryota.
ENOG410XQA3. LUCA.
GeneTreeiENSGT00530000065008.
HOGENOMiHOG000018248.
InParanoidiQ94129.
OMAiIPYSLEV.
OrthoDBiEOG779NZ5.
PhylomeDBiQ94129.

Family and domain databases

Gene3Di2.170.16.10. 1 hit.
InterProiIPR001657. Hedgehog.
IPR028992. Hedgehog/Intein_dom.
IPR001767. Hint_dom.
IPR003586. Hint_dom_C.
IPR003587. Hint_dom_N.
IPR006141. Intein_N.
IPR033386. Wrt-4.
[Graphical view]
PANTHERiPTHR11889:SF40. PTHR11889:SF40. 1 hit.
PfamiPF01079. Hint. 1 hit.
[Graphical view]
PRINTSiPR00632. SONICHHOG.
SMARTiSM00305. HintC. 1 hit.
SM00306. HintN. 1 hit.
[Graphical view]
SUPFAMiSSF51294. SSF51294. 1 hit.
PROSITEiPS50817. INTEIN_N_TER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q94129-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRFSLLALVL LSSSYKFTYG SECGDSTIPY SLEVLSSGQP ILGCARPTCF
60 70 80 90 100
GWHSNGHQLP TNAKFFRIDQ QSDGFLRDDP LAIHTFDAAD PRVYAQQQAS
110 120 130 140 150
CEQEFQSLSC NPEDQWVGGI APVMNASTTK IVAYKCCTYA PLRASIDRGV
160 170 180 190 200
ATVSGGQIVV GGEIFADNKP YAFDYISNVE KKIDSEGEIF YEVNIKRFSC
210 220 230 240 250
LDLQKVDRSV PEILNSENTI RHVNGHRFVV HQAPTVDVET PVETGQLVVP
260 270 280 290 300
QGVQNGQEVI IEEIVAQEGF VQETNPQPPP PPGQQGGFVQ PQGFQPQGGF
310 320 330 340 350
QPQGFQPQGF QPQAFQPQVV QNPVPAAPAG YAPMGFAPSG LQLYYCFPGD
360 370 380 390 400
AMVNVYNGGF KRMDELAVGD WVQALDKNGS QVTFIPVQYW LHRDPKQVAD
410 420 430 440 450
FVEFTLDNGE TFSLTEKHLV FVTQCSVPYS EDENINANPV PAERVNIGDC
460 470 480 490 500
FYIAHRKKSQ MYQRVKVLDI NIVQKTGIYS PMTSRGHLLV DRIHASCHSE
510 520 530 540 550
TDNYSLQNTF FTNVLRWKSQ IRNYFWTVED STNEDNIGYG LNGVMAVLDI

VIPSKLM
Length:557
Mass (Da):61,929
Last modified:March 1, 2003 - v2
Checksum:iF9B785A3E3AD73A2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti53 – 531H → N in AAB17541 (PubMed:8689684).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U61236 mRNA. Translation: AAB17541.1.
Z79605 Genomic DNA. Translation: CAB01902.2.
PIRiT27975.
RefSeqiNP_510593.1. NM_078192.5.
UniGeneiCel.19706.

Genome annotation databases

EnsemblMetazoaiZK678.5; ZK678.5; WBGene00006950.
GeneIDi181664.
KEGGicel:CELE_ZK678.5.
UCSCiZK678.5.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U61236 mRNA. Translation: AAB17541.1.
Z79605 Genomic DNA. Translation: CAB01902.2.
PIRiT27975.
RefSeqiNP_510593.1. NM_078192.5.
UniGeneiCel.19706.

3D structure databases

ProteinModelPortaliQ94129.
SMRiQ94129. Positions 346-499.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi46556. 2 interactions.
IntActiQ94129. 1 interaction.
MINTiMINT-1113903.
STRINGi6239.ZK678.5.

Protein family/group databases

MEROPSiC46.007.

Proteomic databases

EPDiQ94129.
PaxDbiQ94129.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiZK678.5; ZK678.5; WBGene00006950.
GeneIDi181664.
KEGGicel:CELE_ZK678.5.
UCSCiZK678.5.1. c. elegans.

Organism-specific databases

CTDi181664.
WormBaseiZK678.5; CE24735; WBGene00006950; wrt-4.

Phylogenomic databases

eggNOGiKOG3638. Eukaryota.
ENOG410XQA3. LUCA.
GeneTreeiENSGT00530000065008.
HOGENOMiHOG000018248.
InParanoidiQ94129.
OMAiIPYSLEV.
OrthoDBiEOG779NZ5.
PhylomeDBiQ94129.

Miscellaneous databases

NextBioi914874.
PROiQ94129.

Family and domain databases

Gene3Di2.170.16.10. 1 hit.
InterProiIPR001657. Hedgehog.
IPR028992. Hedgehog/Intein_dom.
IPR001767. Hint_dom.
IPR003586. Hint_dom_C.
IPR003587. Hint_dom_N.
IPR006141. Intein_N.
IPR033386. Wrt-4.
[Graphical view]
PANTHERiPTHR11889:SF40. PTHR11889:SF40. 1 hit.
PfamiPF01079. Hint. 1 hit.
[Graphical view]
PRINTSiPR00632. SONICHHOG.
SMARTiSM00305. HintC. 1 hit.
SM00306. HintN. 1 hit.
[Graphical view]
SUPFAMiSSF51294. SSF51294. 1 hit.
PROSITEiPS50817. INTEIN_N_TER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Hedgehog patterning activity: role of a lipophilic modification mediated by the carboxy-terminal autoprocessing domain."
    Porter J.A., Ekker S.C., Park W.-J., von Kessler D.P., Young K.E., Chen C.-H., Ma Y., Woods A.S., Cotter R.J., Koonin E.V., Beachy P.A.
    Cell 86:21-34(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Bristol N2.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiWRT4_CAEEL
AccessioniPrimary (citable) accession number: Q94129
Secondary accession number(s): Q94410
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: March 1, 2003
Last modified: May 11, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.