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Protein

Warthog protein 4

Gene

wrt-4

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Intercellular signal essential for a variety of patterning events during development.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei415Involved in auto-cleavageBy similarity1
Sitei418Essential for auto-cleavageBy similarity1

GO - Molecular functioni

GO - Biological processi

  • cell-cell signaling Source: UniProtKB
  • intein-mediated protein splicing Source: InterPro
  • protein autoprocessing Source: UniProtKB
  • segment polarity determination Source: UniProtKB

Keywordsi

Molecular functionDevelopmental protein, Hydrolase, Protease

Protein family/group databases

MEROPSiC46.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Warthog protein 4
Alternative name(s):
Protein M75
Cleaved into the following 2 chains:
Gene namesi
Name:wrt-4
ORF Names:ZK678.5
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiZK678.5; CE24735; WBGene00006950; wrt-4.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000001326221 – 557Warthog protein 4Add BLAST537
ChainiPRO_000001326321 – 346Warthog protein 4 N-productBy similarityAdd BLAST326
ChainiPRO_0000013264347 – 557Warthog protein 4 C-productBy similarityAdd BLAST211

Post-translational modificationi

The C-terminal domain displays an autoproteolysis activity.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei345 – 346Cleavage; by autolysisBy similarity2

Keywords - PTMi

Autocatalytic cleavage

Proteomic databases

EPDiQ94129.
PaxDbiQ94129.
PeptideAtlasiQ94129.

Expressioni

Gene expression databases

BgeeiWBGene00006950.

Interactioni

Protein-protein interaction databases

BioGridi46556. 2 interactors.
IntActiQ94129. 3 interactors.
MINTiMINT-1113903.
STRINGi6239.ZK678.5.

Structurei

3D structure databases

ProteinModelPortaliQ94129.
SMRiQ94129.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi246 – 321Gln-richAdd BLAST76

Sequence similaritiesi

Belongs to the hedgehog family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3638. Eukaryota.
ENOG410XQA3. LUCA.
GeneTreeiENSGT00530000065008.
HOGENOMiHOG000018248.
InParanoidiQ94129.
OMAiIPYSLEV.
OrthoDBiEOG091G0N90.
PhylomeDBiQ94129.

Family and domain databases

InterProiView protein in InterPro
IPR001657. Hedgehog.
IPR028992. Hedgehog/Intein_dom.
IPR001767. Hint_dom.
IPR003586. Hint_dom_C.
IPR003587. Hint_dom_N.
IPR006141. Intein_N.
PfamiView protein in Pfam
PF01079. Hint. 1 hit.
PRINTSiPR00632. SONICHHOG.
SMARTiView protein in SMART
SM00305. HintC. 1 hit.
SM00306. HintN. 1 hit.
SUPFAMiSSF51294. SSF51294. 1 hit.
PROSITEiView protein in PROSITE
PS50817. INTEIN_N_TER. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q94129-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRFSLLALVL LSSSYKFTYG SECGDSTIPY SLEVLSSGQP ILGCARPTCF
60 70 80 90 100
GWHSNGHQLP TNAKFFRIDQ QSDGFLRDDP LAIHTFDAAD PRVYAQQQAS
110 120 130 140 150
CEQEFQSLSC NPEDQWVGGI APVMNASTTK IVAYKCCTYA PLRASIDRGV
160 170 180 190 200
ATVSGGQIVV GGEIFADNKP YAFDYISNVE KKIDSEGEIF YEVNIKRFSC
210 220 230 240 250
LDLQKVDRSV PEILNSENTI RHVNGHRFVV HQAPTVDVET PVETGQLVVP
260 270 280 290 300
QGVQNGQEVI IEEIVAQEGF VQETNPQPPP PPGQQGGFVQ PQGFQPQGGF
310 320 330 340 350
QPQGFQPQGF QPQAFQPQVV QNPVPAAPAG YAPMGFAPSG LQLYYCFPGD
360 370 380 390 400
AMVNVYNGGF KRMDELAVGD WVQALDKNGS QVTFIPVQYW LHRDPKQVAD
410 420 430 440 450
FVEFTLDNGE TFSLTEKHLV FVTQCSVPYS EDENINANPV PAERVNIGDC
460 470 480 490 500
FYIAHRKKSQ MYQRVKVLDI NIVQKTGIYS PMTSRGHLLV DRIHASCHSE
510 520 530 540 550
TDNYSLQNTF FTNVLRWKSQ IRNYFWTVED STNEDNIGYG LNGVMAVLDI

VIPSKLM
Length:557
Mass (Da):61,929
Last modified:March 1, 2003 - v2
Checksum:iF9B785A3E3AD73A2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti53H → N in AAB17541 (PubMed:8689684).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U61236 mRNA. Translation: AAB17541.1.
Z79605 Genomic DNA. Translation: CAB01902.2.
PIRiT27975.
RefSeqiNP_510593.1. NM_078192.5.
UniGeneiCel.19706.

Genome annotation databases

EnsemblMetazoaiZK678.5; ZK678.5; WBGene00006950.
GeneIDi181664.
KEGGicel:CELE_ZK678.5.
UCSCiZK678.5.1. c. elegans.

Similar proteinsi

Entry informationi

Entry nameiWRT4_CAEEL
AccessioniPrimary (citable) accession number: Q94129
Secondary accession number(s): Q94410
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: March 1, 2003
Last modified: September 27, 2017
This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families