Reviewed,
UniProtKB/Swiss-Prot Q94126 (CES2_CAEEL)
Last modified
June 16, 2009.
Version 62.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Cell death specification protein 2 | ||||
| Gene names |
| ||||
| Organism | Caenorhabditis elegans [Complete proteome] | ||||
| Taxonomic identifier | 6239 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Protein attributes
| Sequence length | 211 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Required to activate programmed cell death in the sister cells of the serotoninergic neurosecretory motor (NSM) neurons. Negatively regulates the activity of ces-1 which in turn negatively regulates the activities of cell-killing genes. Binds to the DNA sequence 5'-RTTACGTAAY-3'. |
| Subcellular location | |
| Sequence similarities | Belongs to the bZIP family. Contains 1 bZIP domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Apoptosis Transcription Transcription regulation |
| Cellular component | Nucleus |
| Ligand | DNA-binding |
| Molecular function | Repressor |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | apoptosis Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription, DNA-dependentInferred from electronic annotation. Source: UniProtKB-KW transcriptionInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | protein dimerization activity Inferred from electronic annotation. Source: InterPro sequence-specific DNA bindingInferred from electronic annotation. Source: InterPro transcription factor activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| Q22676 | 1 | EBI-328155,EBI-328141 | ||
| Q9NAE4 | 1 | EBI-328155,EBI-332523 | ||
| atf-2 | Q21361 | 1 | EBI-328155,EBI-317743 |
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Transcriptional regulator of programmed cell death encoded by Caenorhabditis elegans gene ces-2." Metzstein M.M., Hengartner M.O., Tsung N., Ellis R., Horvitz H.R. Nature 382:545-547(1996) [PubMed: 8700229] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], MUTAGENESIS OF ALA-129. Strain: Bristol N2. |
| [2] | "Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| U60979 Genomic DNA. Translation: AAC47277.1. Z82096 Genomic DNA. Translation: CAB05032.1. | |
| PIR | T28098. |
| RefSeq | NP_493610.1. |
| UniGene | Cel.22746 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1H89 based on UniProtKB P17676. |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP:27195N. |
| IntAct | Q94126. 4 interactions. |
Genome annotation databases | |
| Ensembl | ZK909.4. Caenorhabditis elegans. [Contig view] |
| GeneID | 173365. |
| KEGG | cel:ZK909.4. |
| NMPDR | fig|6239.3.peg.3871. |
Organism-specific databases | |
| WormBase | WBGene00000469. ces-2. |
| WormPep | ZK909.4. CE15479. [WorfDB] |
Phylogenomic databases | |
| OMA | Q94126. KDSAYFE. |
Gene expression databases | |
| ArrayExpress | Q94126. |
Family and domain databases | |
| InterPro | IPR011700. bZIP_2. IPR004827. TF_bZIP. [Graphical view] |
| Pfam | PF07716. bZIP_2. 1 hit. [Graphical view] |
| SMART | SM00338. BRLZ. 1 hit. [Graphical view] |
| PROSITE | PS50217. BZIP. 1 hit. PS00036. BZIP_BASIC. False negative. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 879343. |
Entry information
| Entry name | CES2_CAEEL | ||||||||
| Accession | Primary (citable) accession number: Q94126 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Caenorhabditis annotation project | ||||||||
Relevant documents
| Caenorhabditis elegans Caenorhabditis elegans: entries, gene names and cross-references to WormPep |
| SIMILARITY comments Index of protein domains and families |

Clusters with


