Reviewed, UniProtKB/Swiss-Prot Q94126 (CES2_CAEEL)

Names and origin

Protein names

Recommended name:
    Cell death specification protein 2

Gene names

Name:	ces-2
ORF Names:	ZK909.4

Organism

Caenorhabditis elegans [Complete proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	211 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Required to activate programmed cell death in the sister cells of the serotoninergic neurosecretory motor (NSM) neurons. Negatively regulates the activity of ces-1 which in turn negatively regulates the activities of cell-killing genes. Binds to the DNA sequence 5'-RTTACGTAAY-3'.
Subcellular location	Nucleus.
Sequence similarities	Belongs to the bZIP family. Contains 1 bZIP domain.

Ontologies

Keywords
Biological process	Apoptosis Transcription Transcription regulation
Cellular component	Nucleus
Ligand	DNA-binding
Molecular function	Repressor
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	apoptosis Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein dimerization activity Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
	Q22676	1	EBI-328155,EBI-328141
	Q9NAE4	1	EBI-328155,EBI-332523
atf-2	Q21361	1	EBI-328155,EBI-317743

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 211	211	Cell death specification protein 2		PRO_0000076638
Regions
	Domain	144 – 172	29	Leucine-zipper
	DNA binding	114 – 140	27	Basic motif
Experimental info
	Mutagenesis	129	1	A → T in ces2(N732). Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q94126-1 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: A791D04893FC67A0	FASTA	211	23,133
	10 20 30 40 50 60 MDFHRALSAL FTNQAAVQPL LGSLGFPFND GTSILTTALA AQSGGKKLDT PLGILPFDSL 70 80 90 100 110 120 PTTNLLTPTK KIKLEDELCA SPVSSRSSTV SSSHFSSPQR SPSRKMSVPI PEEKKDSAYF 130 140 150 160 170 180 ERRRKNNDAA KRSRDARRQK EEQIASKAHA LERENMQLRG KVSSLEQEAA QLRFLLFSKI 190 200 210 SPANSEVSCE SNDSTETNDS NDSKSDSTIE V

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Transcriptional regulator of programmed cell death encoded by Caenorhabditis elegans gene ces-2." Metzstein M.M., Hengartner M.O., Tsung N., Ellis R., Horvitz H.R. Nature 382:545-547(1996) [PubMed: 8700229] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], MUTAGENESIS OF ALA-129. Strain: Bristol N2.
[2]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U60979 Genomic DNA. Translation: AAC47277.1. Z82096 Genomic DNA. Translation: CAB05032.1.
PIR	T28098.
RefSeq	NP_493610.1.
UniGene	Cel.22746
3D structure databases
HSSP	HSSP built from PDB template 1H89 based on UniProtKB P17676.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:27195N.
IntAct	Q94126. 4 interactions.
Genome annotation databases
Ensembl	ZK909.4. Caenorhabditis elegans. [Contig view]
GeneID	173365.
KEGG	cel:ZK909.4.
NMPDR	fig|6239.3.peg.3871.
Organism-specific databases
WormBase	WBGene00000469. ces-2.
WormPep	ZK909.4. CE15479. [WorfDB]
Phylogenomic databases
OMA	Q94126. KDSAYFE.
Gene expression databases
ArrayExpress	Q94126.
Family and domain databases
InterPro	IPR011700. bZIP_2. IPR004827. TF_bZIP. [Graphical view]
Pfam	PF07716. bZIP_2. 1 hit. [Graphical view]
SMART	SM00338. BRLZ. 1 hit. [Graphical view]
PROSITE	PS50217. BZIP. 1 hit. PS00036. BZIP_BASIC. False negative. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	879343.

Entry information

Entry name

CES2_CAEEL

Accession

Primary (citable) accession number: Q94126

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	February 1, 1997
Last modified:	June 16, 2009
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Caenorhabditis annotation project