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Q94126 (CES2_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Cell death specification protein 2
Gene names
Name:ces-2
ORF Names:ZK909.4
OrganismCaenorhabditis elegans
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length211 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required to activate programmed cell death in the sister cells of the serotoninergic neurosecretory motor (NSM) neurons. Negatively regulates the activity of ces-1 which in turn negatively regulates the activities of cell-killing genes. Binds to the DNA sequence 5'-RTTACGTAAY-3'.

Subcellular location

Nucleus.

Sequence similarities

Belongs to the bZIP family.

Contains 1 bZIP domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 211211Cell death specification protein 2
PRO_0000076638

Regions

Domain144 – 17229Leucine-zipper
DNA binding114 – 14027Basic motif

Experimental info

Mutagenesis1291A → T in ces2(N732). Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q94126 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: A791D04893FC67A0

FASTA21123,133
        10         20         30         40         50         60 
MDFHRALSAL FTNQAAVQPL LGSLGFPFND GTSILTTALA AQSGGKKLDT PLGILPFDSL 

        70         80         90        100        110        120 
PTTNLLTPTK KIKLEDELCA SPVSSRSSTV SSSHFSSPQR SPSRKMSVPI PEEKKDSAYF 

       130        140        150        160        170        180 
ERRRKNNDAA KRSRDARRQK EEQIASKAHA LERENMQLRG KVSSLEQEAA QLRFLLFSKI 

       190        200        210 
SPANSEVSCE SNDSTETNDS NDSKSDSTIE V 

« Hide

References

« Hide 'large scale' references
[1]"Transcriptional regulator of programmed cell death encoded by Caenorhabditis elegans gene ces-2."
Metzstein M.M., Hengartner M.O., Tsung N., Ellis R., Horvitz H.R.
Nature 382:545-547(1996) [PubMed: 8700229] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], MUTAGENESIS OF ALA-129.
Strain: Bristol N2.
[2]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U60979 Genomic DNA. Translation: AAC47277.1.
Z82096 Genomic DNA. Translation: CAB05032.1.
PIRT28098.
RefSeqNP_493610.1. NM_061209.4.
UniGeneCel.22746.

3D structure databases

ProteinModelPortalQ94126.
SMRQ94126. Positions 119-178.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-27195N.
IntActQ94126. 5 interactions.
MINTMINT-1061292.
STRINGQ94126.

Proteomic databases

PRIDEQ94126.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaZK909.4; ZK909.4; ZK909.4.
GeneID173365.
KEGGcel:ZK909.4.
NMPDRfig|6239.3.peg.3871.
UCSCZK909.4. c. elegans.

Organism-specific databases

CTD173365.
WormBaseZK909.4; CE15479; WBGene00000469; ces-2.

Phylogenomic databases

eggNOGmeNOG09509.
GeneTreeEMGT00050000005179.
HOGENOMHBG378650.
InParanoidQ94126.
OMASHFSSPQ.
PhylomeDBQ94126.

Gene expression databases

ArrayExpressQ94126.

Family and domain databases

InterProIPR004827. bZIP.
IPR011700. bZIP_2.
[Graphical view]
PfamPF07716. bZIP_2. 1 hit.
[Graphical view]
SMARTSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. False negative.
[Graphical view]
ProtoNetSearch...

Other

NextBio879343.

Entry information

Entry nameCES2_CAEEL
AccessionPrimary (citable) accession number: Q94126
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: December 14, 2011
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormPep

SIMILARITY comments

Index of protein domains and families