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Q94125

- AGE1_CAEEL

UniProt

Q94125 - AGE1_CAEEL

Protein

Phosphatidylinositol 3-kinase age-1

Gene

age-1

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 6 (22 Sep 2009)
      Previous versions | rss
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    Functioni

    Phosphatidylinositol 3-kinase homolog that regulates longevity and diapause. Could function in the development or neuroendocrine signaling of the dauer pathway.1 Publication

    Catalytic activityi

    ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate.

    GO - Molecular functioni

    1. 1-phosphatidylinositol-3-kinase activity Source: UniProtKB
    2. 1-phosphatidylinositol-4-phosphate 3-kinase activity Source: RefGenome
    3. ATP binding Source: UniProtKB-KW
    4. phosphatidylinositol-4,5-bisphosphate 3-kinase activity Source: RefGenome

    GO - Biological processi

    1. aging Source: UniProtKB
    2. dauer entry Source: WormBase
    3. dauer larval development Source: UniProtKB
    4. determination of adult lifespan Source: WormBase
    5. embryo development ending in birth or egg hatching Source: WormBase
    6. learning or memory Source: WormBase
    7. phosphatidylinositol-3-phosphate biosynthetic process Source: GOC
    8. phosphatidylinositol-mediated signaling Source: InterPro
    9. regulation of chemotaxis Source: WormBase
    10. reproduction Source: WormBase
    11. response to cadmium ion Source: WormBase
    12. response to oxidative stress Source: WormBase

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.1.137. 1045.
    ReactomeiREACT_197684. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_197739. Synthesis of PIPs at the plasma membrane.
    REACT_197748. Signaling by FGFR1 fusion mutants.
    SignaLinkiQ94125.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphatidylinositol 3-kinase age-1 (EC:2.7.1.137)
    Short name:
    PI3-kinase age-1
    Short name:
    PI3K age-1
    Short name:
    PtdIns-3-kinase age-1
    Alternative name(s):
    Aging alteration protein 1
    Gene namesi
    Name:age-1
    ORF Names:B0334.8
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome II

    Organism-specific databases

    WormBaseiB0334.8; CE43431; WBGene00000090; age-1.

    Subcellular locationi

    GO - Cellular componenti

    1. phosphatidylinositol 3-kinase complex Source: UniProtKB
    2. plasma membrane Source: RefGenome

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi862 – 8621S → N in age1(MG109). 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11821182Phosphatidylinositol 3-kinase age-1PRO_0000088807Add
    BLAST

    Proteomic databases

    PaxDbiQ94125.
    PRIDEiQ94125.

    Expressioni

    Developmental stagei

    Expressed both maternally and zygotically.1 Publication

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini74 – 174101PI3K-ABDPROSITE-ProRule annotationAdd
    BLAST
    Domaini266 – 35893PI3K-RBDPROSITE-ProRule annotationAdd
    BLAST
    Domaini425 – 577153C2 PI3K-typePROSITE-ProRule annotationAdd
    BLAST
    Domaini601 – 788188PIK helicalPROSITE-ProRule annotationAdd
    BLAST
    Domaini885 – 1182298PI3K/PI4KPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the PI3/PI4-kinase family.PROSITE-ProRule annotation
    Contains 1 C2 PI3K-type domain.PROSITE-ProRule annotation
    Contains 1 PI3K-ABD domain.PROSITE-ProRule annotation
    Contains 1 PI3K-RBD domain.PROSITE-ProRule annotation
    Contains 1 PI3K/PI4K domain.PROSITE-ProRule annotation
    Contains 1 PIK helical domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5032.
    GeneTreeiENSGT00620000087742.
    HOGENOMiHOG000175698.
    OMAiCERAFLV.
    OrthoDBiEOG70CR65.
    PhylomeDBiQ94125.

    Family and domain databases

    Gene3Di1.10.1070.11. 2 hits.
    1.25.40.70. 1 hit.
    2.60.40.150. 1 hit.
    InterProiIPR016024. ARM-type_fold.
    IPR000008. C2_dom.
    IPR011009. Kinase-like_dom.
    IPR000403. PI3/4_kinase_cat_dom.
    IPR018936. PI3/4_kinase_CS.
    IPR003113. PI3K_adapt-bd_dom.
    IPR002420. PI3K_C2_dom.
    IPR000341. PI3K_Ras-bd_dom.
    IPR015433. PI_Kinase.
    IPR001263. PInositide-3_kin_accessory_dom.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view]
    PANTHERiPTHR10048. PTHR10048. 1 hit.
    PfamiPF00454. PI3_PI4_kinase. 1 hit.
    PF00792. PI3K_C2. 1 hit.
    PF02192. PI3K_p85B. 1 hit.
    PF00794. PI3K_rbd. 1 hit.
    PF00613. PI3Ka. 1 hit.
    [Graphical view]
    SMARTiSM00239. C2. 1 hit.
    SM00142. PI3K_C2. 1 hit.
    SM00143. PI3K_p85B. 1 hit.
    SM00144. PI3K_rbd. 1 hit.
    SM00145. PI3Ka. 1 hit.
    SM00146. PI3Kc. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 1 hit.
    SSF49562. SSF49562. 1 hit.
    SSF54236. SSF54236. 1 hit.
    SSF56112. SSF56112. 2 hits.
    PROSITEiPS00915. PI3_4_KINASE_1. 1 hit.
    PS00916. PI3_4_KINASE_2. 1 hit.
    PS50290. PI3_4_KINASE_3. 1 hit.
    PS51544. PI3K_ABD. 1 hit.
    PS51547. PI3K_C2. 1 hit.
    PS51546. PI3K_RBD. 1 hit.
    PS51545. PIK_HELICAL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q94125-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSMGRSPSTT FRSRTGSHGA RDLIAGHGRN SRRISQMHVN ILHPQLQTMV     50
    EQWQMRERPS LETENGKGSL LLENEGVADI ITMCPFGEVI SVVFPWFLAN 100
    VRTSLEIKLS DFKHQLFELI APMKWGTYSV KPQDYVFRQL NNFGEIEVIF 150
    NDDQPLSKLE LHGTFPMLFL YQPDGINRDK ELMSDISHCL GYSLDKLEES 200
    LDEELRQFRA SLWARTKKTC LTRGLEGTSH YAFPEEQYLC VGESCPKDLE 250
    SKVKAAKLSY QMFWRKRKAE INGVCEKMMK IQIEFNPNET PKSLLHTFLY 300
    EMRKLDVYDT DDPADEGWFL QLAGRTTFVT NPDVKLTSYD GVRSELESYR 350
    CPGFVVRRQS LVLKDYCRPK PLYEPHYVRA HERKLALDVL SVSIDSTPKQ 400
    SKNSDMVMTD FRPTASLKQV SLWDLDANLM IRPVNISGFD FPADVDMYVR 450
    IEFSVYVGTL TLASKSTTKV NAQFAKWNKE MYTFDLYMKD MPPSAVLSIR 500
    VLYGKVKLKS EEFEVGWVNM SLTDWRDELR QGQFLFHLWA PEPTANRSRI 550
    GENGARIGTN AAVTIEISSY GGRVRMPSQG QYTYLVKHRS TWTETLNIMG 600
    DDYESCIRDP GYKKLQMLVK KHESGIVLEE DEQRHVWMWR RYIQKQEPDL 650
    LIVLSELAFV WTDRENFSEL YVMLEKWKPP SVAAALTLLG KRCTDRVIRK 700
    FAVEKLNEQL SPVTFHLFIL PLIQALKYEP RAQSEVGMML LTRALCDYRI 750
    GHRLFWLLRA EIARLRDCDL KSEEYRRISL LMEAYLRGNE EHIKIITRQV 800
    DMVDELTRIS TLVKGMPKDV ATMKLRDELR SISHKMENMD SPLDPVYKLG 850
    EMIIDKAIVL GSAKRPLMLH WKNKNPKSDL HLPFCAMIFK NGDDLRQDML 900
    VLQVLEVMDN IWKAANIDCC LNPYAVLPMG EMIGIIEVVP NCKTIFEIQV 950
    GTGFMNTAVR SIDPSFMNKW IRKQCGIEDE KKKSKKDSTK NPIEKKIDNT 1000
    QAMKKYFESV DRFLYSCVGY SVATYIMGIK DRHSDNLMLT EDGKYFHIDF 1050
    GHILGHGKTK LGIQRDRQPF ILTEHFMTVI RSGKSVDGNS HELQKFKTLC 1100
    VEAYEVMWNN RDLFVSLFTL MLGMELPELS TKADLDHLKK TLFCNGESKE 1150
    EARKFFAGIY EEAFNGSWST KTNWLFHAVK HY 1182
    Length:1,182
    Mass (Da):136,873
    Last modified:September 22, 2009 - v6
    Checksum:iC82DA6F98A383EAC
    GO

    Sequence cautioni

    The sequence AAC47459.1 differs from that shown. Reason: Frameshift at position 32.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1046 – 10461F → V in AAC47459. (PubMed:8700226)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z66519, AL110499 Genomic DNA. Translation: CAA91377.3.
    U56101 mRNA. Translation: AAC47459.1. Frameshift.
    PIRiB88318.
    S71792.
    RefSeqiNP_496462.2. NM_064061.4.
    UniGeneiCel.18292.

    Genome annotation databases

    EnsemblMetazoaiB0334.8; B0334.8; WBGene00000090.
    GeneIDi174762.
    KEGGicel:CELE_B0334.8.
    UCSCiB0334.8. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z66519 , AL110499 Genomic DNA. Translation: CAA91377.3 .
    U56101 mRNA. Translation: AAC47459.1 . Frameshift.
    PIRi B88318.
    S71792.
    RefSeqi NP_496462.2. NM_064061.4.
    UniGenei Cel.18292.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi Q94125.
    PRIDEi Q94125.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai B0334.8 ; B0334.8 ; WBGene00000090 .
    GeneIDi 174762.
    KEGGi cel:CELE_B0334.8.
    UCSCi B0334.8. c. elegans.

    Organism-specific databases

    CTDi 174762.
    WormBasei B0334.8 ; CE43431 ; WBGene00000090 ; age-1.

    Phylogenomic databases

    eggNOGi COG5032.
    GeneTreei ENSGT00620000087742.
    HOGENOMi HOG000175698.
    OMAi CERAFLV.
    OrthoDBi EOG70CR65.
    PhylomeDBi Q94125.

    Enzyme and pathway databases

    BRENDAi 2.7.1.137. 1045.
    Reactomei REACT_197684. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_197739. Synthesis of PIPs at the plasma membrane.
    REACT_197748. Signaling by FGFR1 fusion mutants.
    SignaLinki Q94125.

    Family and domain databases

    Gene3Di 1.10.1070.11. 2 hits.
    1.25.40.70. 1 hit.
    2.60.40.150. 1 hit.
    InterProi IPR016024. ARM-type_fold.
    IPR000008. C2_dom.
    IPR011009. Kinase-like_dom.
    IPR000403. PI3/4_kinase_cat_dom.
    IPR018936. PI3/4_kinase_CS.
    IPR003113. PI3K_adapt-bd_dom.
    IPR002420. PI3K_C2_dom.
    IPR000341. PI3K_Ras-bd_dom.
    IPR015433. PI_Kinase.
    IPR001263. PInositide-3_kin_accessory_dom.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view ]
    PANTHERi PTHR10048. PTHR10048. 1 hit.
    Pfami PF00454. PI3_PI4_kinase. 1 hit.
    PF00792. PI3K_C2. 1 hit.
    PF02192. PI3K_p85B. 1 hit.
    PF00794. PI3K_rbd. 1 hit.
    PF00613. PI3Ka. 1 hit.
    [Graphical view ]
    SMARTi SM00239. C2. 1 hit.
    SM00142. PI3K_C2. 1 hit.
    SM00143. PI3K_p85B. 1 hit.
    SM00144. PI3K_rbd. 1 hit.
    SM00145. PI3Ka. 1 hit.
    SM00146. PI3Kc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 1 hit.
    SSF49562. SSF49562. 1 hit.
    SSF54236. SSF54236. 1 hit.
    SSF56112. SSF56112. 2 hits.
    PROSITEi PS00915. PI3_4_KINASE_1. 1 hit.
    PS00916. PI3_4_KINASE_2. 1 hit.
    PS50290. PI3_4_KINASE_3. 1 hit.
    PS51544. PI3K_ABD. 1 hit.
    PS51547. PI3K_C2. 1 hit.
    PS51546. PI3K_RBD. 1 hit.
    PS51545. PIK_HELICAL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.
    2. "A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans."
      Morris J.Z., Tissenbaum H.A., Ruvkun G.
      Nature 382:536-539(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 16-1182, FUNCTION, DEVELOPMENTAL STAGE, MUTAGENESIS OF SER-862.
      Strain: Bristol N2.
    3. Morris J.Z., Tissenbaum H.A., Ruvkun G.
      Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.

    Entry informationi

    Entry nameiAGE1_CAEEL
    AccessioniPrimary (citable) accession number: Q94125
    Secondary accession number(s): Q17482
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: September 22, 2009
    Last modified: October 1, 2014
    This is version 121 of the entry and version 6 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3