SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q94125

- AGE1_CAEEL

UniProt

Q94125 - AGE1_CAEEL

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Phosphatidylinositol 3-kinase age-1

Gene
age-1, B0334.8
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Phosphatidylinositol 3-kinase homolog that regulates longevity and diapause. Could function in the development or neuroendocrine signaling of the dauer pathway.1 Publication

Catalytic activityi

ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate.

GO - Molecular functioni

  1. 1-phosphatidylinositol-3-kinase activity Source: UniProtKB
  2. 1-phosphatidylinositol-4-phosphate 3-kinase activity Source: RefGenome
  3. ATP binding Source: UniProtKB-KW
  4. phosphatidylinositol-4,5-bisphosphate 3-kinase activity Source: RefGenome

GO - Biological processi

  1. aging Source: UniProtKB
  2. dauer entry Source: WormBase
  3. dauer larval development Source: UniProtKB
  4. determination of adult lifespan Source: WormBase
  5. embryo development ending in birth or egg hatching Source: WormBase
  6. learning or memory Source: WormBase
  7. phosphatidylinositol-3-phosphate biosynthetic process Source: GOC
  8. phosphatidylinositol-mediated signaling Source: InterPro
  9. regulation of chemotaxis Source: WormBase
  10. reproduction Source: WormBase
  11. response to cadmium ion Source: WormBase
  12. response to oxidative stress Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.1.137. 1045.
ReactomeiREACT_197684. Constitutive PI3K/AKT Signaling in Cancer.
REACT_197739. Synthesis of PIPs at the plasma membrane.
REACT_197748. Signaling by FGFR1 fusion mutants.
SignaLinkiQ94125.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol 3-kinase age-1 (EC:2.7.1.137)
Short name:
PI3-kinase age-1
Short name:
PI3K age-1
Short name:
PtdIns-3-kinase age-1
Alternative name(s):
Aging alteration protein 1
Gene namesi
Name:age-1
ORF Names:B0334.8
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome II

Organism-specific databases

WormBaseiB0334.8; CE43431; WBGene00000090; age-1.

Subcellular locationi

GO - Cellular componenti

  1. phosphatidylinositol 3-kinase complex Source: UniProtKB
  2. plasma membrane Source: RefGenome
Complete GO annotation...

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi862 – 8621S → N in age1(MG109). 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11821182Phosphatidylinositol 3-kinase age-1PRO_0000088807Add
BLAST

Proteomic databases

PaxDbiQ94125.
PRIDEiQ94125.

Expressioni

Developmental stagei

Expressed both maternally and zygotically.1 Publication

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini74 – 174101PI3K-ABDAdd
BLAST
Domaini266 – 35893PI3K-RBDAdd
BLAST
Domaini425 – 577153C2 PI3K-typeAdd
BLAST
Domaini601 – 788188PIK helicalAdd
BLAST
Domaini885 – 1182298PI3K/PI4KAdd
BLAST

Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.
Contains 1 PI3K-ABD domain.
Contains 1 PI3K-RBD domain.
Contains 1 PI3K/PI4K domain.
Contains 1 PIK helical domain.

Phylogenomic databases

eggNOGiCOG5032.
GeneTreeiENSGT00620000087742.
HOGENOMiHOG000175698.
OMAiCERAFLV.
OrthoDBiEOG70CR65.
PhylomeDBiQ94125.

Family and domain databases

Gene3Di1.10.1070.11. 2 hits.
1.25.40.70. 1 hit.
2.60.40.150. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR000008. C2_dom.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR003113. PI3K_adapt-bd_dom.
IPR002420. PI3K_C2_dom.
IPR000341. PI3K_Ras-bd_dom.
IPR015433. PI_Kinase.
IPR001263. PInositide-3_kin_accessory_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PANTHERiPTHR10048. PTHR10048. 1 hit.
PfamiPF00454. PI3_PI4_kinase. 1 hit.
PF00792. PI3K_C2. 1 hit.
PF02192. PI3K_p85B. 1 hit.
PF00794. PI3K_rbd. 1 hit.
PF00613. PI3Ka. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 1 hit.
SM00142. PI3K_C2. 1 hit.
SM00143. PI3K_p85B. 1 hit.
SM00144. PI3K_rbd. 1 hit.
SM00145. PI3Ka. 1 hit.
SM00146. PI3Kc. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF54236. SSF54236. 1 hit.
SSF56112. SSF56112. 2 hits.
PROSITEiPS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
PS51544. PI3K_ABD. 1 hit.
PS51547. PI3K_C2. 1 hit.
PS51546. PI3K_RBD. 1 hit.
PS51545. PIK_HELICAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q94125-1 [UniParc]FASTAAdd to Basket

« Hide

MSMGRSPSTT FRSRTGSHGA RDLIAGHGRN SRRISQMHVN ILHPQLQTMV     50
EQWQMRERPS LETENGKGSL LLENEGVADI ITMCPFGEVI SVVFPWFLAN 100
VRTSLEIKLS DFKHQLFELI APMKWGTYSV KPQDYVFRQL NNFGEIEVIF 150
NDDQPLSKLE LHGTFPMLFL YQPDGINRDK ELMSDISHCL GYSLDKLEES 200
LDEELRQFRA SLWARTKKTC LTRGLEGTSH YAFPEEQYLC VGESCPKDLE 250
SKVKAAKLSY QMFWRKRKAE INGVCEKMMK IQIEFNPNET PKSLLHTFLY 300
EMRKLDVYDT DDPADEGWFL QLAGRTTFVT NPDVKLTSYD GVRSELESYR 350
CPGFVVRRQS LVLKDYCRPK PLYEPHYVRA HERKLALDVL SVSIDSTPKQ 400
SKNSDMVMTD FRPTASLKQV SLWDLDANLM IRPVNISGFD FPADVDMYVR 450
IEFSVYVGTL TLASKSTTKV NAQFAKWNKE MYTFDLYMKD MPPSAVLSIR 500
VLYGKVKLKS EEFEVGWVNM SLTDWRDELR QGQFLFHLWA PEPTANRSRI 550
GENGARIGTN AAVTIEISSY GGRVRMPSQG QYTYLVKHRS TWTETLNIMG 600
DDYESCIRDP GYKKLQMLVK KHESGIVLEE DEQRHVWMWR RYIQKQEPDL 650
LIVLSELAFV WTDRENFSEL YVMLEKWKPP SVAAALTLLG KRCTDRVIRK 700
FAVEKLNEQL SPVTFHLFIL PLIQALKYEP RAQSEVGMML LTRALCDYRI 750
GHRLFWLLRA EIARLRDCDL KSEEYRRISL LMEAYLRGNE EHIKIITRQV 800
DMVDELTRIS TLVKGMPKDV ATMKLRDELR SISHKMENMD SPLDPVYKLG 850
EMIIDKAIVL GSAKRPLMLH WKNKNPKSDL HLPFCAMIFK NGDDLRQDML 900
VLQVLEVMDN IWKAANIDCC LNPYAVLPMG EMIGIIEVVP NCKTIFEIQV 950
GTGFMNTAVR SIDPSFMNKW IRKQCGIEDE KKKSKKDSTK NPIEKKIDNT 1000
QAMKKYFESV DRFLYSCVGY SVATYIMGIK DRHSDNLMLT EDGKYFHIDF 1050
GHILGHGKTK LGIQRDRQPF ILTEHFMTVI RSGKSVDGNS HELQKFKTLC 1100
VEAYEVMWNN RDLFVSLFTL MLGMELPELS TKADLDHLKK TLFCNGESKE 1150
EARKFFAGIY EEAFNGSWST KTNWLFHAVK HY 1182
Length:1,182
Mass (Da):136,873
Last modified:September 22, 2009 - v6
Checksum:iC82DA6F98A383EAC
GO

Sequence cautioni

The sequence AAC47459.1 differs from that shown. Reason: Frameshift at position 32.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1046 – 10461F → V in AAC47459. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z66519, AL110499 Genomic DNA. Translation: CAA91377.3.
U56101 mRNA. Translation: AAC47459.1. Frameshift.
PIRiB88318.
S71792.
RefSeqiNP_496462.2. NM_064061.4.
UniGeneiCel.18292.

Genome annotation databases

EnsemblMetazoaiB0334.8; B0334.8; WBGene00000090.
GeneIDi174762.
KEGGicel:CELE_B0334.8.
UCSCiB0334.8. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z66519 , AL110499 Genomic DNA. Translation: CAA91377.3 .
U56101 mRNA. Translation: AAC47459.1 . Frameshift.
PIRi B88318.
S71792.
RefSeqi NP_496462.2. NM_064061.4.
UniGenei Cel.18292.

3D structure databases

ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi Q94125.
PRIDEi Q94125.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai B0334.8 ; B0334.8 ; WBGene00000090 .
GeneIDi 174762.
KEGGi cel:CELE_B0334.8.
UCSCi B0334.8. c. elegans.

Organism-specific databases

CTDi 174762.
WormBasei B0334.8 ; CE43431 ; WBGene00000090 ; age-1.

Phylogenomic databases

eggNOGi COG5032.
GeneTreei ENSGT00620000087742.
HOGENOMi HOG000175698.
OMAi CERAFLV.
OrthoDBi EOG70CR65.
PhylomeDBi Q94125.

Enzyme and pathway databases

BRENDAi 2.7.1.137. 1045.
Reactomei REACT_197684. Constitutive PI3K/AKT Signaling in Cancer.
REACT_197739. Synthesis of PIPs at the plasma membrane.
REACT_197748. Signaling by FGFR1 fusion mutants.
SignaLinki Q94125.

Family and domain databases

Gene3Di 1.10.1070.11. 2 hits.
1.25.40.70. 1 hit.
2.60.40.150. 1 hit.
InterProi IPR016024. ARM-type_fold.
IPR000008. C2_dom.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR003113. PI3K_adapt-bd_dom.
IPR002420. PI3K_C2_dom.
IPR000341. PI3K_Ras-bd_dom.
IPR015433. PI_Kinase.
IPR001263. PInositide-3_kin_accessory_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view ]
PANTHERi PTHR10048. PTHR10048. 1 hit.
Pfami PF00454. PI3_PI4_kinase. 1 hit.
PF00792. PI3K_C2. 1 hit.
PF02192. PI3K_p85B. 1 hit.
PF00794. PI3K_rbd. 1 hit.
PF00613. PI3Ka. 1 hit.
[Graphical view ]
SMARTi SM00239. C2. 1 hit.
SM00142. PI3K_C2. 1 hit.
SM00143. PI3K_p85B. 1 hit.
SM00144. PI3K_rbd. 1 hit.
SM00145. PI3Ka. 1 hit.
SM00146. PI3Kc. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF54236. SSF54236. 1 hit.
SSF56112. SSF56112. 2 hits.
PROSITEi PS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
PS51544. PI3K_ABD. 1 hit.
PS51547. PI3K_C2. 1 hit.
PS51546. PI3K_RBD. 1 hit.
PS51545. PIK_HELICAL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans."
    Morris J.Z., Tissenbaum H.A., Ruvkun G.
    Nature 382:536-539(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 16-1182, FUNCTION, DEVELOPMENTAL STAGE, MUTAGENESIS OF SER-862.
    Strain: Bristol N2.
  3. Morris J.Z., Tissenbaum H.A., Ruvkun G.
    Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.

Entry informationi

Entry nameiAGE1_CAEEL
AccessioniPrimary (citable) accession number: Q94125
Secondary accession number(s): Q17482
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 22, 2009
Last modified: September 3, 2014
This is version 120 of the entry and version 6 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi