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Protein

Alanine--glyoxylate aminotransferase 2 homolog 1, mitochondrial

Gene

AGT2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

L-alanine + glyoxylate = pyruvate + glycine.

Cofactori

GO - Molecular functioni

  • alanine-glyoxylate transaminase activity Source: UniProtKB
  • identical protein binding Source: GO_Central
  • pyridoxal phosphate binding Source: GO_Central
  • zinc ion binding Source: TAIR

GO - Biological processi

  • arginine catabolic process to glutamate Source: UniProtKB
  • photorespiration Source: UniProtKB-KW
  • response to cadmium ion Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Keywords - Biological processi

Photorespiration

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciARA:AT4G39660-MONOMER.
ReactomeiR-ATH-389661. Glyoxylate metabolism and glycine degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine--glyoxylate aminotransferase 2 homolog 1, mitochondrial (EC:2.6.1.44)
Alternative name(s):
Beta-alanine-pyruvate aminotransferase 1
Gene namesi
Name:AGT2
Ordered Locus Names:At4g39660
ORF Names:T19P19.50
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

TAIRiAT4G39660.

Subcellular locationi

GO - Cellular componenti

  • membrane Source: TAIR
  • mitochondrion Source: UniProtKB
  • vacuolar membrane Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 1212MitochondrionSequence analysisAdd
BLAST
Chaini13 – 476464Alanine--glyoxylate aminotransferase 2 homolog 1, mitochondrialPRO_0000041945Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei320 – 3201N6-(pyridoxal phosphate)lysineBy similarity

Proteomic databases

PaxDbiQ940M2.
PRIDEiQ940M2.

Expressioni

Gene expression databases

ExpressionAtlasiQ940M2. baseline and differential.
GenevisibleiQ940M2. AT.

Interactioni

Subunit structurei

Homotetramer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi15400. 1 interaction.
STRINGi3702.AT4G39660.1.

Structurei

3D structure databases

ProteinModelPortaliQ940M2.
SMRiQ940M2. Positions 77-475.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1404. Eukaryota.
COG0160. LUCA.
HOGENOMiHOG000020206.
InParanoidiQ940M2.
KOiK00827.
OMAiLTSKMPG.
PhylomeDBiQ940M2.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
InterProiIPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q940M2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALQRQLLKR ATSDIYHRRA ISLLRTDFST SPSIADAPPH IPPFVHQPRP
60 70 80 90 100
YKGPSADEVL QKRKKFLGPS LFHYYQKPLN IVEGKMQYLY DESGRRYLDA
110 120 130 140 150
FAGIVTVSCG HCHPDILNAI TEQSKLLQHA TTIYLHHAIG DFAEALAAKM
160 170 180 190 200
PGNLKVVYFV NSGSEANELA MMMARLYTGS LEMISLRNAY HGGSSNTIGL
210 220 230 240 250
TALNTWKYPL PQGEIHHVVN PDPYRGVFGS DGSLYAKDVH DHIEYGTSGK
260 270 280 290 300
VAGFIAETIQ GVGGAVELAP GYLKSVYEIV RNAGGVCIAD EVQTGFGRTG
310 320 330 340 350
SHYWGFQTQD VVPDIVTMAK GIGNGLPLGA VVTTPEIASV LASKILFNTF
360 370 380 390 400
GGNPVCSAGG LAVLNVIDKE KRQEHCAEVG SHLIQRLKDV QKRHDIIGDV
410 420 430 440 450
RGRGLMVGIE LVSDRKDKTP AKAETSVLFE QLRELGILVG KGGLHGNVFR
460 470
IKPPMCFTKD DADFLVDALD YSISRL
Length:476
Mass (Da):51,953
Last modified:December 1, 2001 - v1
Checksum:i9E5ABC10C3C2EC83
GO

Sequence cautioni

The sequence CAA18752.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAB80629.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti240 – 2401H → Q in AAD48837 (PubMed:12529529).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF166351 mRNA. Translation: AAD48837.1.
AL022605 Genomic DNA. Translation: CAA18752.1. Sequence problems.
AL161595 Genomic DNA. Translation: CAB80629.1. Sequence problems.
CP002687 Genomic DNA. Translation: AEE87100.1.
AY054264 mRNA. Translation: AAL06923.1.
BT002306 mRNA. Translation: AAN73303.1.
PIRiT05003.
RefSeqiNP_568064.1. NM_120126.4.
UniGeneiAt.22488.

Genome annotation databases

EnsemblPlantsiAT4G39660.1; AT4G39660.1; AT4G39660.
GeneIDi830120.
GrameneiAT4G39660.1; AT4G39660.1; AT4G39660.
KEGGiath:AT4G39660.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF166351 mRNA. Translation: AAD48837.1.
AL022605 Genomic DNA. Translation: CAA18752.1. Sequence problems.
AL161595 Genomic DNA. Translation: CAB80629.1. Sequence problems.
CP002687 Genomic DNA. Translation: AEE87100.1.
AY054264 mRNA. Translation: AAL06923.1.
BT002306 mRNA. Translation: AAN73303.1.
PIRiT05003.
RefSeqiNP_568064.1. NM_120126.4.
UniGeneiAt.22488.

3D structure databases

ProteinModelPortaliQ940M2.
SMRiQ940M2. Positions 77-475.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi15400. 1 interaction.
STRINGi3702.AT4G39660.1.

Proteomic databases

PaxDbiQ940M2.
PRIDEiQ940M2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT4G39660.1; AT4G39660.1; AT4G39660.
GeneIDi830120.
GrameneiAT4G39660.1; AT4G39660.1; AT4G39660.
KEGGiath:AT4G39660.

Organism-specific databases

TAIRiAT4G39660.

Phylogenomic databases

eggNOGiKOG1404. Eukaryota.
COG0160. LUCA.
HOGENOMiHOG000020206.
InParanoidiQ940M2.
KOiK00827.
OMAiLTSKMPG.
PhylomeDBiQ940M2.

Enzyme and pathway databases

BioCyciARA:AT4G39660-MONOMER.
ReactomeiR-ATH-389661. Glyoxylate metabolism and glycine degradation.

Miscellaneous databases

PROiQ940M2.

Gene expression databases

ExpressionAtlasiQ940M2. baseline and differential.
GenevisibleiQ940M2. AT.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
InterProiIPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Alanine aminotransferase homologs catalyze the glutamate:glyoxylate aminotransferase reaction in peroxisomes of Arabidopsis."
    Liepman A.H., Olsen L.J.
    Plant Physiol. 131:215-227(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Columbia.
  2. "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana."
    Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T., Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B., Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M., de Simone V., Obermaier B.
    , Mache R., Mueller M., Kreis M., Delseny M., Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D., Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J., Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B., Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J., Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R., Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M., Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C., Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J., Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S., Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A., Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M., Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D., Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E., Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S., Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R., Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M., Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E., Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P., Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K., Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K., de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K., Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M., Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G., Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K., Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K., Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W., Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H., Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B., Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J., Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K., O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N., Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A., Martienssen R., McCombie W.R.
    Nature 402:769-777(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "Experimental analysis of the Arabidopsis mitochondrial proteome highlights signaling and regulatory components, provides assessment of targeting prediction programs, and indicates plant-specific mitochondrial proteins."
    Heazlewood J.L., Tonti-Filippini J.S., Gout A.M., Day D.A., Whelan J., Millar A.H.
    Plant Cell 16:241-256(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Strain: cv. Landsberg erecta.

Entry informationi

Entry nameiAGT21_ARATH
AccessioniPrimary (citable) accession number: Q940M2
Secondary accession number(s): Q9SU41, Q9SWE2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: December 1, 2001
Last modified: February 17, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.