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Q940G6

- GID1C_ARATH

UniProt

Q940G6 - GID1C_ARATH

Protein

Gibberellin receptor GID1C

Gene

GID1C

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Functions as soluble gibberellin (GA) receptor. GA is an essential hormone that regulates growth and development in plants. Binds with high affinity the biologically active gibberellin GA4, but has no affinity for the biologically inactive GAs. In response to GA, interacts with specific DELLA proteins, known as repressors of GA-induced growth, and targets them for degradation via proteasome. Seems to be required for GA signaling that controls root growth, seed germination and stem elongation. Partially redundant with GID1A and GID1B.3 Publications

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei111 – 1111PROSITE-ProRule annotation
    Binding sitei125 – 1251GibberellinBy similarity
    Active sitei189 – 1891PROSITE-ProRule annotation
    Binding sitei189 – 1891GibberellinBy similarity
    Active sitei287 – 2871PROSITE-ProRule annotation
    Binding sitei318 – 3181Gibberellin; via amide nitrogenBy similarity

    GO - Molecular functioni

    1. hydrolase activity Source: UniProtKB-KW
    2. protein binding Source: IntAct

    GO - Biological processi

    1. floral organ morphogenesis Source: TAIR
    2. gibberellic acid mediated signaling pathway Source: UniProtKB-KW
    3. gibberellin mediated signaling pathway Source: TAIR
    4. positive regulation of gibberellic acid mediated signaling pathway Source: TAIR
    5. raffinose family oligosaccharide biosynthetic process Source: TAIR
    6. response to gibberellin Source: TAIR

    Keywords - Molecular functioni

    Hydrolase, Receptor

    Keywords - Biological processi

    Gibberellin signaling pathway

    Enzyme and pathway databases

    BioCyciARA:AT5G27320-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Gibberellin receptor GID1C (EC:3.-.-.-)
    Alternative name(s):
    AtCXE19
    Carboxylesterase 19
    GID1-like protein 3
    Protein GA INSENSITIVE DWARF 1C
    Short name:
    AtGID1C
    Gene namesi
    Name:GID1C
    Synonyms:CXE19, GID1L3
    Ordered Locus Names:At5g27320
    ORF Names:F21A20.30
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 5

    Organism-specific databases

    TAIRiAT5G27320.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Disruption phenotypei

    No visible phenotype under normal growth condition.2 Publications

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 344343Gibberellin receptor GID1CPRO_0000071560Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PRIDEiQ940G6.

    Expressioni

    Tissue specificityi

    Widely expressed.1 Publication

    Gene expression databases

    GenevestigatoriQ940G6.

    Interactioni

    Subunit structurei

    Interacts with the DELLA proteins GAI, RGA, RGL1, RGL2 and RGL3 in a GA-dependent manner.3 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    GAIQ9LQT84EBI-963794,EBI-963606
    RGAQ9SLH35EBI-963794,EBI-963624
    RGL2Q8GXW13EBI-963794,EBI-963665

    Protein-protein interaction databases

    BioGridi18064. 2 interactions.
    DIPiDIP-37663N.
    IntActiQ940G6. 5 interactions.
    STRINGi3702.AT5G27320.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliQ940G6.
    SMRiQ940G6. Positions 6-342.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni113 – 1142Gibberellin bindingBy similarity

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi111 – 1133Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion holeBy similarity

    Sequence similaritiesi

    Belongs to the 'GDXG' lipolytic enzyme family.Curated

    Phylogenomic databases

    eggNOGiCOG0657.
    HOGENOMiHOG000152323.
    InParanoidiQ940G6.
    KOiK14493.
    OMAiDLIQDWQ.
    PhylomeDBiQ940G6.

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR013094. AB_hydrolase_3.
    IPR002168. Lipase_GDXG_AS.
    [Graphical view]
    PfamiPF07859. Abhydrolase_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF53474. SSF53474. 1 hit.
    PROSITEiPS01173. LIPASE_GDXG_HIS. 1 hit.
    PS01174. LIPASE_GDXG_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q940G6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGSEEVNLI ESKTVVPLNT WVLISNFKLA YNLLRRPDGT FNRHLAEFLD    50
    RKVPANANPV NGVFSFDVII DRQTNLLSRV YRPADAGTSP SITDLQNPVD 100
    GEIVPVIVFF HGGSFAHSSA NSAIYDTLCR RLVGLCGAVV VSVNYRRAPE 150
    NRYPCAYDDG WAVLKWVNSS SWLRSKKDSK VRIFLAGDSS GGNIVHNVAV 200
    RAVESRIDVL GNILLNPMFG GTERTESEKR LDGKYFVTVR DRDWYWRAFL 250
    PEGEDREHPA CSPFGPRSKS LEGLSFPKSL VVVAGLDLIQ DWQLKYAEGL 300
    KKAGQEVKLL YLEQATIGFY LLPNNNHFHT VMDEIAAFVN AECQ 344
    Length:344
    Mass (Da):38,426
    Last modified:December 1, 2001 - v1
    Checksum:i40B4C048B1FB6C15
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC007123 Genomic DNA. No translation available.
    CP002688 Genomic DNA. Translation: AED93672.1.
    AY054653 mRNA. Translation: AAK96844.1.
    AY128729 mRNA. Translation: AAM91129.1.
    RefSeqiNP_198084.1. NM_122614.3.
    UniGeneiAt.22176.

    Genome annotation databases

    EnsemblPlantsiAT5G27320.1; AT5G27320.1; AT5G27320.
    GeneIDi832790.
    KEGGiath:AT5G27320.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC007123 Genomic DNA. No translation available.
    CP002688 Genomic DNA. Translation: AED93672.1 .
    AY054653 mRNA. Translation: AAK96844.1 .
    AY128729 mRNA. Translation: AAM91129.1 .
    RefSeqi NP_198084.1. NM_122614.3.
    UniGenei At.22176.

    3D structure databases

    ProteinModelPortali Q940G6.
    SMRi Q940G6. Positions 6-342.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 18064. 2 interactions.
    DIPi DIP-37663N.
    IntActi Q940G6. 5 interactions.
    STRINGi 3702.AT5G27320.1-P.

    Proteomic databases

    PRIDEi Q940G6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT5G27320.1 ; AT5G27320.1 ; AT5G27320 .
    GeneIDi 832790.
    KEGGi ath:AT5G27320.

    Organism-specific databases

    TAIRi AT5G27320.

    Phylogenomic databases

    eggNOGi COG0657.
    HOGENOMi HOG000152323.
    InParanoidi Q940G6.
    KOi K14493.
    OMAi DLIQDWQ.
    PhylomeDBi Q940G6.

    Enzyme and pathway databases

    BioCyci ARA:AT5G27320-MONOMER.

    Gene expression databases

    Genevestigatori Q940G6.

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR013094. AB_hydrolase_3.
    IPR002168. Lipase_GDXG_AS.
    [Graphical view ]
    Pfami PF07859. Abhydrolase_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53474. SSF53474. 1 hit.
    PROSITEi PS01173. LIPASE_GDXG_HIS. 1 hit.
    PS01174. LIPASE_GDXG_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana."
      Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E., Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.
      , Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L., O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D., Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M., Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L., Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B., Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P., Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M., Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D., Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A., Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I., Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T., Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A., McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U., Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M., Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G., Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W., Bevan M., Fransz P.F.
      Nature 408:823-826(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    4. "The carboxylesterase gene family from Arabidopsis thaliana."
      Marshall S.D., Putterill J.J., Plummer K.M., Newcomb R.D.
      J. Mol. Evol. 57:487-500(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, GENE FAMILY.
    5. "Genetic characterization and functional analysis of the GID1 gibberellin receptors in Arabidopsis."
      Griffiths J., Murase K., Rieu I., Zentella R., Zhang Z.L., Powers S.J., Gong F., Phillips A.L., Hedden P., Sun T.P., Thomas S.G.
      Plant Cell 18:3399-3414(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH GAI AND RGA, DISRUPTION PHENOTYPE.
    6. Cited for: FUNCTION, INTERACTION WITH GAI; RGA; RGL1; RGL2 AND RGL3.
    7. "Multiple loss-of-function of Arabidopsis gibberellin receptor AtGID1s completely shuts down a gibberellin signal."
      Iuchi S., Suzuki H., Kim Y.C., Iuchi A., Kuromori T., Ueguchi-Tanaka M., Asami T., Yamaguchi I., Matsuoka M., Kobayashi M., Nakajima M.
      Plant J. 50:958-966(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE.
    8. "Differential expression and affinities of Arabidopsis gibberellin receptors can explain variation in phenotypes of multiple knock-out mutants."
      Suzuki H., Park S.-H., Okubo K., Kitamura J., Ueguchi-Tanaka M., Iuchi S., Katoh E., Kobayashi M., Yamaguchi I., Matsuoka M., Asami T., Nakajima M.
      Plant J. 60:48-55(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH RGL2.

    Entry informationi

    Entry nameiGID1C_ARATH
    AccessioniPrimary (citable) accession number: Q940G6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 22, 2005
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3