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Protein

Gibberellin receptor GID1C

Gene

GID1C

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions as soluble gibberellin (GA) receptor. GA is an essential hormone that regulates growth and development in plants. Binds with high affinity the biologically active gibberellin GA4, but has no affinity for the biologically inactive GAs. In response to GA, interacts with specific DELLA proteins, known as repressors of GA-induced growth, and targets them for degradation via proteasome. Seems to be required for GA signaling that controls root growth, seed germination and stem elongation. Partially redundant with GID1A and GID1B.3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei125GibberellinBy similarity1
Active sitei189PROSITE-ProRule annotationBy similarity1
Binding sitei189GibberellinBy similarity1
Active sitei287PROSITE-ProRule annotationBy similarity1
Binding sitei318Gibberellin; via amide nitrogenBy similarity1

GO - Molecular functioni

GO - Biological processi

  • floral organ morphogenesis Source: TAIR
  • gibberellic acid mediated signaling pathway Source: UniProtKB-KW
  • gibberellin mediated signaling pathway Source: TAIR
  • metabolic process Source: InterPro
  • positive regulation of gibberellic acid mediated signaling pathway Source: TAIR
  • response to gibberellin Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Receptor

Keywords - Biological processi

Gibberellin signaling pathway

Enzyme and pathway databases

BioCyciARA:AT5G27320-MONOMER.

Protein family/group databases

ESTHERiarath-AT5G27320. Plant_carboxylesterase.
MEROPSiS09.A10.

Names & Taxonomyi

Protein namesi
Recommended name:
Gibberellin receptor GID1C (EC:3.-.-.-)
Alternative name(s):
AtCXE19
Carboxylesterase 19
GID1-like protein 3
Protein GA INSENSITIVE DWARF 1C
Short name:
AtGID1C
Gene namesi
Name:GID1C
Synonyms:CXE19, GID1L3
Ordered Locus Names:At5g27320
ORF Names:F21A20.30
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

TAIRiAT5G27320.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

No visible phenotype under normal growth condition.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000715602 – 344Gibberellin receptor GID1CAdd BLAST343

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ940G6.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

GenevisibleiQ940G6. AT.

Interactioni

Subunit structurei

Interacts with the DELLA proteins GAI, RGA, RGL1, RGL2 and RGL3 in a GA-dependent manner.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
GAIQ9LQT84EBI-963794,EBI-963606
RGAQ9SLH35EBI-963794,EBI-963624
RGL2Q8GXW13EBI-963794,EBI-963665

Protein-protein interaction databases

BioGridi18064. 3 interactors.
DIPiDIP-37663N.
IntActiQ940G6. 5 interactors.
STRINGi3702.AT5G27320.1.

Structurei

3D structure databases

ProteinModelPortaliQ940G6.
SMRiQ940G6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni113 – 114Gibberellin bindingBy similarity2

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi111 – 113Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion holeBy similarity3

Sequence similaritiesi

Belongs to the 'GDXG' lipolytic enzyme family.Curated

Phylogenomic databases

eggNOGiKOG1515. Eukaryota.
COG0657. LUCA.
HOGENOMiHOG000152323.
InParanoidiQ940G6.
KOiK14493.
OMAiAVPIHTW.
OrthoDBiEOG09360EOQ.
PhylomeDBiQ940G6.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR013094. AB_hydrolase_3.
IPR002168. Lipase_GDXG_HIS_AS.
IPR033140. Lipase_GDXG_put_SER_AS.
[Graphical view]
PfamiPF07859. Abhydrolase_3. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS01173. LIPASE_GDXG_HIS. 1 hit.
PS01174. LIPASE_GDXG_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q940G6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGSEEVNLI ESKTVVPLNT WVLISNFKLA YNLLRRPDGT FNRHLAEFLD
60 70 80 90 100
RKVPANANPV NGVFSFDVII DRQTNLLSRV YRPADAGTSP SITDLQNPVD
110 120 130 140 150
GEIVPVIVFF HGGSFAHSSA NSAIYDTLCR RLVGLCGAVV VSVNYRRAPE
160 170 180 190 200
NRYPCAYDDG WAVLKWVNSS SWLRSKKDSK VRIFLAGDSS GGNIVHNVAV
210 220 230 240 250
RAVESRIDVL GNILLNPMFG GTERTESEKR LDGKYFVTVR DRDWYWRAFL
260 270 280 290 300
PEGEDREHPA CSPFGPRSKS LEGLSFPKSL VVVAGLDLIQ DWQLKYAEGL
310 320 330 340
KKAGQEVKLL YLEQATIGFY LLPNNNHFHT VMDEIAAFVN AECQ
Length:344
Mass (Da):38,426
Last modified:December 1, 2001 - v1
Checksum:i40B4C048B1FB6C15
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007123 Genomic DNA. No translation available.
CP002688 Genomic DNA. Translation: AED93672.1.
AY054653 mRNA. Translation: AAK96844.1.
AY128729 mRNA. Translation: AAM91129.1.
RefSeqiNP_198084.1. NM_122614.4.
UniGeneiAt.22176.

Genome annotation databases

EnsemblPlantsiAT5G27320.1; AT5G27320.1; AT5G27320.
GeneIDi832790.
GrameneiAT5G27320.1; AT5G27320.1; AT5G27320.
KEGGiath:AT5G27320.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007123 Genomic DNA. No translation available.
CP002688 Genomic DNA. Translation: AED93672.1.
AY054653 mRNA. Translation: AAK96844.1.
AY128729 mRNA. Translation: AAM91129.1.
RefSeqiNP_198084.1. NM_122614.4.
UniGeneiAt.22176.

3D structure databases

ProteinModelPortaliQ940G6.
SMRiQ940G6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi18064. 3 interactors.
DIPiDIP-37663N.
IntActiQ940G6. 5 interactors.
STRINGi3702.AT5G27320.1.

Protein family/group databases

ESTHERiarath-AT5G27320. Plant_carboxylesterase.
MEROPSiS09.A10.

Proteomic databases

PaxDbiQ940G6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G27320.1; AT5G27320.1; AT5G27320.
GeneIDi832790.
GrameneiAT5G27320.1; AT5G27320.1; AT5G27320.
KEGGiath:AT5G27320.

Organism-specific databases

TAIRiAT5G27320.

Phylogenomic databases

eggNOGiKOG1515. Eukaryota.
COG0657. LUCA.
HOGENOMiHOG000152323.
InParanoidiQ940G6.
KOiK14493.
OMAiAVPIHTW.
OrthoDBiEOG09360EOQ.
PhylomeDBiQ940G6.

Enzyme and pathway databases

BioCyciARA:AT5G27320-MONOMER.

Miscellaneous databases

PROiQ940G6.

Gene expression databases

GenevisibleiQ940G6. AT.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR013094. AB_hydrolase_3.
IPR002168. Lipase_GDXG_HIS_AS.
IPR033140. Lipase_GDXG_put_SER_AS.
[Graphical view]
PfamiPF07859. Abhydrolase_3. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS01173. LIPASE_GDXG_HIS. 1 hit.
PS01174. LIPASE_GDXG_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGID1C_ARATH
AccessioniPrimary (citable) accession number: Q940G6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.