Gibberellin receptor GID1C - Arabidopsis thaliana (Mouse-ear cress)

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Q940G6 (GID1C_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 73. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Gibberellin receptor GID1C
EC=3.-.-.-

Alternative name(s):
AtCXE19
Carboxylesterase 19
GID1-like protein 3
Protein GA INSENSITIVE DWARF 1C
Short name=AtGID1C

Gene names

Name:	GID1C
Synonyms:	CXE19, GID1L3
Ordered Locus Names:	At5g27320
ORF Names:	F21A20.30

Organism

Arabidopsis thaliana (Mouse-ear cress) [Reference proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length	344 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Functions as soluble gibberellin (GA) receptor. GA is an essential hormone that regulates growth and development in plants. Binds with high affinity the biologically active gibberellin GA4, but has no affinity for the biologically inactive GAs. In response to GA, interacts with specific DELLA proteins, known as repressors of GA-induced growth, and targets them for degradation via proteasome. Seems to be required for GA signaling that controls root growth, seed germination and stem elongation. Partially redundant with GID1A and GID1B. Ref.5 Ref.6 Ref.7
Subunit structure	Interacts with the DELLA proteins GAI, RGA, RGL1, RGL2 and RGL3 in a GA-dependent manner. Ref.5 Ref.6 Ref.8
Subcellular location	Nucleus By similarity.
Tissue specificity	Widely expressed. Ref.4
Disruption phenotype	No visible phenotype under normal growth condition. Ref.5 Ref.7
Sequence similarities	Belongs to the 'GDXG' lipolytic enzyme family.

Ontologies

Keywords
Biological process	Gibberellin signaling pathway
Cellular component	Nucleus
Molecular function	Hydrolase Receptor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	floral organ morphogenesis Inferred from genetic interaction Ref.5. Source: TAIR gibberellic acid mediated signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW gibberellin mediated signaling pathway Inferred from genetic interaction Ref.7. Source: TAIR positive regulation of gibberellic acid mediated signaling pathway Inferred from genetic interaction Ref.5. Source: TAIR raffinose family oligosaccharide biosynthetic process Inferred from genetic interaction Ref.6. Source: TAIR
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	hydrolase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct
GAI	Q9LQT8	4	EBI-963794,EBI-963606
RGA	Q9SLH3	5	EBI-963794,EBI-963624
RGL2	Q8GXW1	3	EBI-963794,EBI-963665

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 344

344

Gibberellin receptor GID1C

PRO_0000071560

Regions

Region

113 – 114

Gibberellin binding By similarity

Sites

Active site

111

By similarity

Active site

189

By similarity

Active site

287

By similarity

Binding site

125

Gibberellin By similarity

Binding site

189

Gibberellin By similarity

Binding site

318

Gibberellin; via amide nitrogen By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

Q940G6 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 40B4C048B1FB6C15
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FASTA

344

38,426

        10         20         30         40         50         60 
MAGSEEVNLI ESKTVVPLNT WVLISNFKLA YNLLRRPDGT FNRHLAEFLD RKVPANANPV 

        70         80         90        100        110        120 
NGVFSFDVII DRQTNLLSRV YRPADAGTSP SITDLQNPVD GEIVPVIVFF HGGSFAHSSA 

       130        140        150        160        170        180 
NSAIYDTLCR RLVGLCGAVV VSVNYRRAPE NRYPCAYDDG WAVLKWVNSS SWLRSKKDSK 

       190        200        210        220        230        240 
VRIFLAGDSS GGNIVHNVAV RAVESRIDVL GNILLNPMFG GTERTESEKR LDGKYFVTVR 

       250        260        270        280        290        300 
DRDWYWRAFL PEGEDREHPA CSPFGPRSKS LEGLSFPKSL VVVAGLDLIQ DWQLKYAEGL 

       310        320        330        340 
KKAGQEVKLL YLEQATIGFY LLPNNNHFHT VMDEIAAFVN AECQ

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana." Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E., Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K. Fransz P.F. Nature 408:823-826(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[2]	The Arabidopsis Information Resource (TAIR) Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: cv. Columbia.
[3]	"Empirical analysis of transcriptional activity in the Arabidopsis genome." Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. Ecker J.R. Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia.
[4]	"The carboxylesterase gene family from Arabidopsis thaliana." Marshall S.D., Putterill J.J., Plummer K.M., Newcomb R.D. J. Mol. Evol. 57:487-500(2003) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY, GENE FAMILY.
[5]	"Genetic characterization and functional analysis of the GID1 gibberellin receptors in Arabidopsis." Griffiths J., Murase K., Rieu I., Zentella R., Zhang Z.L., Powers S.J., Gong F., Phillips A.L., Hedden P., Sun T.P., Thomas S.G. Plant Cell 18:3399-3414(2006) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH GAI AND RGA, DISRUPTION PHENOTYPE.
[6]	"Identification and characterization of Arabidopsis gibberellin receptors." Nakajima M., Shimada A., Takashi Y., Kim Y.C., Park S.H., Ueguchi-Tanaka M., Suzuki H., Katoh E., Iuchi S., Kobayashi M., Maeda T., Matsuoka M., Yamaguchi I. Plant J. 46:880-889(2006) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH GAI; RGA; RGL1; RGL2 AND RGL3.
[7]	"Multiple loss-of-function of Arabidopsis gibberellin receptor AtGID1s completely shuts down a gibberellin signal." Iuchi S., Suzuki H., Kim Y.C., Iuchi A., Kuromori T., Ueguchi-Tanaka M., Asami T., Yamaguchi I., Matsuoka M., Kobayashi M., Nakajima M. Plant J. 50:958-966(2007) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, DISRUPTION PHENOTYPE.
[8]	"Differential expression and affinities of Arabidopsis gibberellin receptors can explain variation in phenotypes of multiple knock-out mutants." Suzuki H., Park S.-H., Okubo K., Kitamura J., Ueguchi-Tanaka M., Iuchi S., Katoh E., Kobayashi M., Yamaguchi I., Matsuoka M., Asami T., Nakajima M. Plant J. 60:48-55(2009) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH RGL2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC007123 Genomic DNA. No translation available. CP002688 Genomic DNA. Translation: AED93672.1. AY054653 mRNA. Translation: AAK96844.1. AY128729 mRNA. Translation: AAM91129.1.
IPI	IPI00546420.
RefSeq	NP_198084.1. NM_122614.3.
UniGene	At.22176.
3D structure databases
ProteinModelPortal	Q940G6.
SMR	Q940G6. Positions 6-342.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q940G6. 5 interactions.
STRING	3702.AT5G27320.1-P.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblPlants	AT5G27320.1; AT5G27320.1; AT5G27320.
GeneID	832790.
KEGG	ath:AT5G27320.
Organism-specific databases
TAIR	At5g27320.
Phylogenomic databases
eggNOG	COG0657.
HOGENOM	HOG000152323.
InParanoid	Q940G6.
KO	K14493.
OMA	WIADNAK.
PhylomeDB	Q940G6.
ProtClustDB	CLSN2684300.
Gene expression databases
Genevestigator	Q940G6.
GermOnline	AT5G27320. Arabidopsis thaliana.
Family and domain databases
InterPro	IPR013094. AB_hydrolase_3. IPR002168. Lipase_GDXG_AS. [Graphical view]
Pfam	PF07859. Abhydrolase_3. 1 hit. [Graphical view]
PROSITE	PS01173. LIPASE_GDXG_HIS. 1 hit. PS01174. LIPASE_GDXG_SER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GID1C_ARATH

Accession

Primary (citable) accession number: Q940G6

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 22, 2005
Last sequence update:	December 1, 2001
Last modified:	May 1, 2013
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program

Relevant documents

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Sites

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Entry information

Relevant documents