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Protein

Gibberellin receptor GID1C

Gene

GID1C

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions as soluble gibberellin (GA) receptor. GA is an essential hormone that regulates growth and development in plants. Binds with high affinity the biologically active gibberellin GA4, but has no affinity for the biologically inactive GAs. In response to GA, interacts with specific DELLA proteins, known as repressors of GA-induced growth, and targets them for degradation via proteasome. Seems to be required for GA signaling that controls root growth, seed germination and stem elongation. Partially redundant with GID1A and GID1B.3 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei111 – 1111PROSITE-ProRule annotation
Binding sitei125 – 1251GibberellinBy similarity
Active sitei189 – 1891PROSITE-ProRule annotation
Binding sitei189 – 1891GibberellinBy similarity
Active sitei287 – 2871PROSITE-ProRule annotation
Binding sitei318 – 3181Gibberellin; via amide nitrogenBy similarity

GO - Molecular functioni

  1. hydrolase activity Source: UniProtKB-KW

GO - Biological processi

  1. floral organ morphogenesis Source: TAIR
  2. gibberellic acid mediated signaling pathway Source: UniProtKB-KW
  3. gibberellin mediated signaling pathway Source: TAIR
  4. positive regulation of gibberellic acid mediated signaling pathway Source: TAIR
  5. raffinose family oligosaccharide biosynthetic process Source: TAIR
  6. response to gibberellin Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Receptor

Keywords - Biological processi

Gibberellin signaling pathway

Enzyme and pathway databases

BioCyciARA:AT5G27320-MONOMER.

Protein family/group databases

MEROPSiS09.A10.

Names & Taxonomyi

Protein namesi
Recommended name:
Gibberellin receptor GID1C (EC:3.-.-.-)
Alternative name(s):
AtCXE19
Carboxylesterase 19
GID1-like protein 3
Protein GA INSENSITIVE DWARF 1C
Short name:
AtGID1C
Gene namesi
Name:GID1C
Synonyms:CXE19, GID1L3
Ordered Locus Names:At5g27320
ORF Names:F21A20.30
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 5

Organism-specific databases

TAIRiAT5G27320.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

No visible phenotype under normal growth condition.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 344343Gibberellin receptor GID1CPRO_0000071560Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiQ940G6.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

GenevestigatoriQ940G6.

Interactioni

Subunit structurei

Interacts with the DELLA proteins GAI, RGA, RGL1, RGL2 and RGL3 in a GA-dependent manner.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
GAIQ9LQT84EBI-963794,EBI-963606
RGAQ9SLH35EBI-963794,EBI-963624
RGL2Q8GXW13EBI-963794,EBI-963665

Protein-protein interaction databases

BioGridi18064. 2 interactions.
DIPiDIP-37663N.
IntActiQ940G6. 5 interactions.
STRINGi3702.AT5G27320.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ940G6.
SMRiQ940G6. Positions 6-342.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni113 – 1142Gibberellin bindingBy similarity

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi111 – 1133Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion holeBy similarity

Sequence similaritiesi

Belongs to the 'GDXG' lipolytic enzyme family.Curated

Phylogenomic databases

eggNOGiCOG0657.
HOGENOMiHOG000152323.
InParanoidiQ940G6.
KOiK14493.
OMAiAVPIHTW.
PhylomeDBiQ940G6.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR013094. AB_hydrolase_3.
IPR002168. Lipase_GDXG_AS.
[Graphical view]
PfamiPF07859. Abhydrolase_3. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS01173. LIPASE_GDXG_HIS. 1 hit.
PS01174. LIPASE_GDXG_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q940G6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGSEEVNLI ESKTVVPLNT WVLISNFKLA YNLLRRPDGT FNRHLAEFLD
60 70 80 90 100
RKVPANANPV NGVFSFDVII DRQTNLLSRV YRPADAGTSP SITDLQNPVD
110 120 130 140 150
GEIVPVIVFF HGGSFAHSSA NSAIYDTLCR RLVGLCGAVV VSVNYRRAPE
160 170 180 190 200
NRYPCAYDDG WAVLKWVNSS SWLRSKKDSK VRIFLAGDSS GGNIVHNVAV
210 220 230 240 250
RAVESRIDVL GNILLNPMFG GTERTESEKR LDGKYFVTVR DRDWYWRAFL
260 270 280 290 300
PEGEDREHPA CSPFGPRSKS LEGLSFPKSL VVVAGLDLIQ DWQLKYAEGL
310 320 330 340
KKAGQEVKLL YLEQATIGFY LLPNNNHFHT VMDEIAAFVN AECQ
Length:344
Mass (Da):38,426
Last modified:December 1, 2001 - v1
Checksum:i40B4C048B1FB6C15
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007123 Genomic DNA. No translation available.
CP002688 Genomic DNA. Translation: AED93672.1.
AY054653 mRNA. Translation: AAK96844.1.
AY128729 mRNA. Translation: AAM91129.1.
RefSeqiNP_198084.1. NM_122614.3.
UniGeneiAt.22176.

Genome annotation databases

EnsemblPlantsiAT5G27320.1; AT5G27320.1; AT5G27320.
GeneIDi832790.
KEGGiath:AT5G27320.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007123 Genomic DNA. No translation available.
CP002688 Genomic DNA. Translation: AED93672.1.
AY054653 mRNA. Translation: AAK96844.1.
AY128729 mRNA. Translation: AAM91129.1.
RefSeqiNP_198084.1. NM_122614.3.
UniGeneiAt.22176.

3D structure databases

ProteinModelPortaliQ940G6.
SMRiQ940G6. Positions 6-342.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi18064. 2 interactions.
DIPiDIP-37663N.
IntActiQ940G6. 5 interactions.
STRINGi3702.AT5G27320.1-P.

Protein family/group databases

MEROPSiS09.A10.

Proteomic databases

PRIDEiQ940G6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G27320.1; AT5G27320.1; AT5G27320.
GeneIDi832790.
KEGGiath:AT5G27320.

Organism-specific databases

TAIRiAT5G27320.

Phylogenomic databases

eggNOGiCOG0657.
HOGENOMiHOG000152323.
InParanoidiQ940G6.
KOiK14493.
OMAiAVPIHTW.
PhylomeDBiQ940G6.

Enzyme and pathway databases

BioCyciARA:AT5G27320-MONOMER.

Gene expression databases

GenevestigatoriQ940G6.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR013094. AB_hydrolase_3.
IPR002168. Lipase_GDXG_AS.
[Graphical view]
PfamiPF07859. Abhydrolase_3. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS01173. LIPASE_GDXG_HIS. 1 hit.
PS01174. LIPASE_GDXG_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana."
    Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E., Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.
    , Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L., O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D., Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M., Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L., Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B., Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P., Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M., Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D., Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A., Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I., Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T., Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A., McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U., Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M., Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G., Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W., Bevan M., Fransz P.F.
    Nature 408:823-826(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "The carboxylesterase gene family from Arabidopsis thaliana."
    Marshall S.D., Putterill J.J., Plummer K.M., Newcomb R.D.
    J. Mol. Evol. 57:487-500(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, GENE FAMILY.
  5. "Genetic characterization and functional analysis of the GID1 gibberellin receptors in Arabidopsis."
    Griffiths J., Murase K., Rieu I., Zentella R., Zhang Z.L., Powers S.J., Gong F., Phillips A.L., Hedden P., Sun T.P., Thomas S.G.
    Plant Cell 18:3399-3414(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH GAI AND RGA, DISRUPTION PHENOTYPE.
  6. Cited for: FUNCTION, INTERACTION WITH GAI; RGA; RGL1; RGL2 AND RGL3.
  7. "Multiple loss-of-function of Arabidopsis gibberellin receptor AtGID1s completely shuts down a gibberellin signal."
    Iuchi S., Suzuki H., Kim Y.C., Iuchi A., Kuromori T., Ueguchi-Tanaka M., Asami T., Yamaguchi I., Matsuoka M., Kobayashi M., Nakajima M.
    Plant J. 50:958-966(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  8. "Differential expression and affinities of Arabidopsis gibberellin receptors can explain variation in phenotypes of multiple knock-out mutants."
    Suzuki H., Park S.-H., Okubo K., Kitamura J., Ueguchi-Tanaka M., Iuchi S., Katoh E., Kobayashi M., Yamaguchi I., Matsuoka M., Asami T., Nakajima M.
    Plant J. 60:48-55(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RGL2.

Entry informationi

Entry nameiGID1C_ARATH
AccessioniPrimary (citable) accession number: Q940G6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: December 1, 2001
Last modified: January 7, 2015
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.