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Protein

Protein kinase and PP2C-like domain-containing protein

Gene

At2g40860/At2g40870

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei57ATPPROSITE-ProRule annotation1
Active sitei149Proton acceptorPROSITE-ProRule annotation1
Metal bindingi428Manganese 1By similarity1
Metal bindingi428Manganese 2By similarity1
Metal bindingi429Manganese 1; via carbonyl oxygenBy similarity1
Metal bindingi599Manganese 2By similarity1
Metal bindingi639Manganese 2By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi36 – 44ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Kinase, Multifunctional enzyme, Protein phosphatase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein kinase and PP2C-like domain-containing protein
Including the following 2 domains:
Probable serine/threonine protein kinase At2g40860 (EC:2.7.11.1)
Probable protein phosphatase 2C 31 (EC:3.1.3.16)
Short name:
AtPP2C31
Gene namesi
Ordered Locus Names:At2g40860/At2g40870
ORF Names:T20B5.6
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G40860
TAIRilocus:2058495 AT2G40860

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003679591 – 658Protein kinase and PP2C-like domain-containing proteinAdd BLAST658

Proteomic databases

PaxDbiQ940A2

PTM databases

iPTMnetiQ940A2

Expressioni

Gene expression databases

ExpressionAtlasiQ940A2 baseline and differential
GenevisibleiQ940A2 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT2G40860.1

Structurei

3D structure databases

ProteinModelPortaliQ940A2
SMRiQ940A2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 314Protein kinasePROSITE-ProRule annotationAdd BLAST285
Domaini392 – 648PPM-type phosphatasePROSITE-ProRule annotationAdd BLAST257

Sequence similaritiesi

In the N-terminal section; belongs to the protein kinase superfamily. Ser/Thr protein kinase family.Curated
In the C-terminal section; belongs to the PP2C family.Curated

Phylogenomic databases

eggNOGiKOG0192 Eukaryota
KOG0698 Eukaryota
COG0515 LUCA
COG0631 LUCA
HOGENOMiHOG000012809
InParanoidiQ940A2
OMAiPEESNRC
OrthoDBiEOG09360FJK
PhylomeDBiQ940A2

Family and domain databases

CDDicd00143 PP2Cc, 1 hit
Gene3Di3.60.40.10, 1 hit
InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR036457 PPM-type_dom_sf
IPR001932 PPM-type_phosphatase_dom
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
PF00481 PP2C, 1 hit
SMARTiView protein in SMART
SM00331 PP2C_SIG, 1 hit
SM00332 PP2Cc, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
SSF81606 SSF81606, 1 hit
PROSITEiView protein in PROSITE
PS51746 PPM_2, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q940A2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVMEIVKPNT CIRGCCTSES IPLHLPSSSF TLLSPIAKGS ESVVYEAILD
60 70 80 90 100
GRRVAAKKPI LSTSDDLDKF HRNLQLSCNL NHPGVAKLLA AHAKPPNYMF
110 120 130 140 150
FFDFYESGTL AEKLHVEEWS PSIDQVLLIT LHLAKALQYL HNNGIVHRDV
160 170 180 190 200
KPANVLLDEK FFPYLADFGL AEYKKNLREV NLQNWRSSGK PTGGFHKKNM
210 220 230 240 250
VGTLIYMAPE ILRKDMYTEK ADIYSFGILI NELLTGVVPY TDRRAEAQAH
260 270 280 290 300
TVLEMNYTEQ QLTVAIVSSG LRPALAEIGL HLPKSLLSLI QNCWESDPSK
310 320 330 340 350
RPSSDNVVLE LESIWEQVRG KQQGHLLEKT SNSQSDTDGA DIIKNSGDYR
360 370 380 390 400
DTVNWFSQGE CLSKKSSVST VFDVKLWSSS TDEPSRYVPV ISCGSFATCG
410 420 430 440 450
RRESMEDTHF IIPHMCNEES IHLFAIFDGH RGAAAAEFSA QVLPGLVQSL
460 470 480 490 500
CSTSAGEALS QAFVRTDLAF RQELDSHRQS KRVSQKDWHP GCTAIASLLV
510 520 530 540 550
ENKLFVANVG DSRAILCRAG HPFALSKAHL ATCIDERNRV IGEGGRIEWL
560 570 580 590 600
VDTWRVAPAG LQVTRSIGDD DLKPAVTAEP EISETILSAD DEFLVMASDG
610 620 630 640 650
LWDVMNDEEV IGIIRDTVKE PSMCSKRLAT EAAARGSGDN ITVIVVFLRP

VSTAERIY
Length:658
Mass (Da):72,853
Last modified:December 1, 2001 - v1
Checksum:i66041EE6EAEFEE14
GO

Sequence cautioni

The sequence AAB86446 differs from that shown. Reason: Erroneous gene model prediction. Was originally thought to correspond to two different genes At2g40860 and At2g40870.Curated
The sequence AAB86447 differs from that shown. Reason: Erroneous gene model prediction. Was originally thought to correspond to two different genes At2g40860 and At2g40870.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC002409 Genomic DNA Translation: AAB86446.1 Sequence problems.
AC002409 Genomic DNA Translation: AAB86447.1 Sequence problems.
CP002685 Genomic DNA Translation: AEC09891.1
AY056151 mRNA Translation: AAL07230.1
AY133729 mRNA Translation: AAM91663.1
PIRiT00750
T00751
RefSeqiNP_850336.1, NM_180005.4
UniGeneiAt.42906

Genome annotation databases

EnsemblPlantsiAT2G40860.1; AT2G40860.1; AT2G40860
GeneIDi818684
GrameneiAT2G40860.1; AT2G40860.1; AT2G40860
KEGGiath:AT2G40860

Similar proteinsi

Entry informationi

Entry nameiP2C31_ARATH
AccessioniPrimary (citable) accession number: Q940A2
Secondary accession number(s): O22200, O22201
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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