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Q940A2

- P2C31_ARATH

UniProt

Q940A2 - P2C31_ARATH

Protein

Protein kinase and PP2C-like domain-containing protein

Gene

At2g40860/At2g40870

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.
    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 magnesium or manganese ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei57 – 571ATPPROSITE-ProRule annotation
    Active sitei149 – 1491Proton acceptorPROSITE-ProRule annotation
    Metal bindingi428 – 4281Manganese 1By similarity
    Metal bindingi428 – 4281Manganese 2By similarity
    Metal bindingi429 – 4291Manganese 1; via carbonyl oxygenBy similarity
    Metal bindingi599 – 5991Manganese 2By similarity
    Metal bindingi639 – 6391Manganese 2By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi36 – 449ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. phosphoprotein phosphatase activity Source: UniProtKB-KW
    4. protein serine/threonine kinase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Kinase, Protein phosphatase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciARA:AT2G40860-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein kinase and PP2C-like domain-containing protein
    Including the following 2 domains:
    Probable serine/threonine protein kinase At2g40860 (EC:2.7.11.1)
    Probable protein phosphatase 2C 31 (EC:3.1.3.16)
    Short name:
    AtPP2C31
    Gene namesi
    Ordered Locus Names:At2g40860/At2g40870
    ORF Names:T20B5.6
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 2

    Organism-specific databases

    TAIRiAT2G40860.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 658658Protein kinase and PP2C-like domain-containing proteinPRO_0000367959Add
    BLAST

    Proteomic databases

    PaxDbiQ940A2.
    PRIDEiQ940A2.

    Expressioni

    Gene expression databases

    GenevestigatoriQ940A2.

    Structurei

    3D structure databases

    ProteinModelPortaliQ940A2.
    SMRiQ940A2. Positions 8-314, 388-650.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini30 – 314285Protein kinasePROSITE-ProRule annotationAdd
    BLAST
    Domaini391 – 641251PP2C-likeAdd
    BLAST

    Sequence similaritiesi

    In the N-terminal section; belongs to the protein kinase superfamily. Ser/Thr protein kinase family.Curated
    In the C-terminal section; belongs to the PP2C family.Curated
    Contains 1 PP2C-like domain.Curated
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000012809.
    InParanoidiQ940A2.
    OMAiVPYTDLR.
    PhylomeDBiQ940A2.

    Family and domain databases

    Gene3Di3.60.40.10. 1 hit.
    InterProiIPR011009. Kinase-like_dom.
    IPR001932. PP2C-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    PF00481. PP2C. 1 hit.
    [Graphical view]
    SMARTiSM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    SSF81606. SSF81606. 1 hit.
    PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q940A2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVMEIVKPNT CIRGCCTSES IPLHLPSSSF TLLSPIAKGS ESVVYEAILD    50
    GRRVAAKKPI LSTSDDLDKF HRNLQLSCNL NHPGVAKLLA AHAKPPNYMF 100
    FFDFYESGTL AEKLHVEEWS PSIDQVLLIT LHLAKALQYL HNNGIVHRDV 150
    KPANVLLDEK FFPYLADFGL AEYKKNLREV NLQNWRSSGK PTGGFHKKNM 200
    VGTLIYMAPE ILRKDMYTEK ADIYSFGILI NELLTGVVPY TDRRAEAQAH 250
    TVLEMNYTEQ QLTVAIVSSG LRPALAEIGL HLPKSLLSLI QNCWESDPSK 300
    RPSSDNVVLE LESIWEQVRG KQQGHLLEKT SNSQSDTDGA DIIKNSGDYR 350
    DTVNWFSQGE CLSKKSSVST VFDVKLWSSS TDEPSRYVPV ISCGSFATCG 400
    RRESMEDTHF IIPHMCNEES IHLFAIFDGH RGAAAAEFSA QVLPGLVQSL 450
    CSTSAGEALS QAFVRTDLAF RQELDSHRQS KRVSQKDWHP GCTAIASLLV 500
    ENKLFVANVG DSRAILCRAG HPFALSKAHL ATCIDERNRV IGEGGRIEWL 550
    VDTWRVAPAG LQVTRSIGDD DLKPAVTAEP EISETILSAD DEFLVMASDG 600
    LWDVMNDEEV IGIIRDTVKE PSMCSKRLAT EAAARGSGDN ITVIVVFLRP 650
    VSTAERIY 658
    Length:658
    Mass (Da):72,853
    Last modified:December 1, 2001 - v1
    Checksum:i66041EE6EAEFEE14
    GO

    Sequence cautioni

    The sequence AAB86446.1 differs from that shown. Reason: Erroneous gene model prediction. Was originally thought to correspond to two different genes At2g40860 and At2g40870.
    The sequence AAB86447.1 differs from that shown. Reason: Erroneous gene model prediction. Was originally thought to correspond to two different genes At2g40860 and At2g40870.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC002409 Genomic DNA. Translation: AAB86446.1. Sequence problems.
    AC002409 Genomic DNA. Translation: AAB86447.1. Sequence problems.
    CP002685 Genomic DNA. Translation: AEC09891.1.
    AY056151 mRNA. Translation: AAL07230.1.
    AY133729 mRNA. Translation: AAM91663.1.
    PIRiT00750.
    T00751.
    RefSeqiNP_850336.1. NM_180005.3.
    UniGeneiAt.42906.

    Genome annotation databases

    EnsemblPlantsiAT2G40860.1; AT2G40860.1; AT2G40860.
    GeneIDi818684.
    KEGGiath:AT2G40860.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC002409 Genomic DNA. Translation: AAB86446.1 . Sequence problems.
    AC002409 Genomic DNA. Translation: AAB86447.1 . Sequence problems.
    CP002685 Genomic DNA. Translation: AEC09891.1 .
    AY056151 mRNA. Translation: AAL07230.1 .
    AY133729 mRNA. Translation: AAM91663.1 .
    PIRi T00750.
    T00751.
    RefSeqi NP_850336.1. NM_180005.3.
    UniGenei At.42906.

    3D structure databases

    ProteinModelPortali Q940A2.
    SMRi Q940A2. Positions 8-314, 388-650.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi Q940A2.
    PRIDEi Q940A2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT2G40860.1 ; AT2G40860.1 ; AT2G40860 .
    GeneIDi 818684.
    KEGGi ath:AT2G40860.

    Organism-specific databases

    TAIRi AT2G40860.

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000012809.
    InParanoidi Q940A2.
    OMAi VPYTDLR.
    PhylomeDBi Q940A2.

    Enzyme and pathway databases

    BioCyci ARA:AT2G40860-MONOMER.

    Gene expression databases

    Genevestigatori Q940A2.

    Family and domain databases

    Gene3Di 3.60.40.10. 1 hit.
    InterProi IPR011009. Kinase-like_dom.
    IPR001932. PP2C-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    PF00481. PP2C. 1 hit.
    [Graphical view ]
    SMARTi SM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    SSF81606. SSF81606. 1 hit.
    PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    4. "Genome-wide and expression analysis of protein phosphatase 2C in rice and Arabidopsis."
      Xue T., Wang D., Zhang S., Ehlting J., Ni F., Jacab S., Zheng C., Zhong Y.
      BMC Genomics 9:550-550(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY, NOMENCLATURE.

    Entry informationi

    Entry nameiP2C31_ARATH
    AccessioniPrimary (citable) accession number: Q940A2
    Secondary accession number(s): O22200, O22201
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3