Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

LysM domain-containing GPI-anchored protein 1

Gene

LYM1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required as a cell surface receptor for peptidoglycan (PGN) elicitor signaling leading to innate immunity. Plays an essential role in detecting PGNs and restricting bacterial growth (of Pseudomonas syringae pv. tomato DC3000 for example).1 Publication

GO - Molecular functioni

  • peptidoglycan binding Source: TAIR

GO - Biological processi

  • defense response Source: UniProtKB-KW
  • immune response Source: TAIR

Keywordsi

Biological processPlant defense

Names & Taxonomyi

Protein namesi
Recommended name:
LysM domain-containing GPI-anchored protein 1
Gene namesi
Name:LYM1
Ordered Locus Names:At1g21880
ORF Names:T26F17.10, T26F17_5
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G21880
TAIRilocus:2201143 AT1G21880

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Disruption phenotypei

Impaired sensitivity to peptidoglycans (PGNs) leading to higher susceptibility to infection with virulent Pseudomonas syringae pv. tomato DC3000.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000002162728 – 391LysM domain-containing GPI-anchored protein 1Add BLAST364
PropeptideiPRO_0000021628392 – 416Removed in mature formSequence analysisAdd BLAST25

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi34 ↔ 100By similarity
Glycosylationi37N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi40 ↔ 163By similarity
Disulfide bondi98 ↔ 161By similarity
Disulfide bondi100 ↔ 163By similarity
Glycosylationi165N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi224 ↔ 256By similarity
Glycosylationi241N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi251 ↔ 279By similarity
Glycosylationi288N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi299N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi310N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi391GPI-anchor amidated alanineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ93ZH0
PRIDEiQ93ZH0

PTM databases

iPTMnetiQ93ZH0

Expressioni

Gene expression databases

ExpressionAtlasiQ93ZH0 baseline and differential
GenevisibleiQ93ZH0 AT

Interactioni

Subunit structurei

Interacts with peptidoglycans.1 Publication

Protein-protein interaction databases

STRINGi3702.AT1G21880.2

Structurei

3D structure databases

ProteinModelPortaliQ93ZH0
SMRiQ93ZH0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini110 – 157LysM 1PROSITE-ProRule annotationAdd BLAST48
Domaini176 – 219LysM 2PROSITE-ProRule annotationAdd BLAST44

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410II8Y Eukaryota
ENOG410YAMN LUCA
HOGENOMiHOG000083326
InParanoidiQ93ZH0
OMAiCDYNGIA
OrthoDBiEOG09360D4P
PhylomeDBiQ93ZH0

Family and domain databases

CDDicd00118 LysM, 2 hits
Gene3Di3.10.350.10, 2 hits
InterProiView protein in InterPro
IPR018392 LysM_dom
IPR036779 LysM_dom_sf
PfamiView protein in Pfam
PF01476 LysM, 2 hits
SMARTiView protein in SMART
SM00257 LysM, 2 hits
PROSITEiView protein in PROSITE
PS51782 LYSM, 2 hits

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q93ZH0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKIPEKPIFL IFVSLILASS LTFTATAKST IEPCSSNDTC NALLGYTLYT
60 70 80 90 100
DLKVSEVASL FQVDPISILL ANAIDISYPD VENHILPSKL FLKIPITCSC
110 120 130 140 150
VDGIRKSVST HYKTRPSDNL GSIADSVYGG LVSAEQIQEA NSVNDPSLLD
160 170 180 190 200
VGTSLVIPLP CACFNGTDNS LPAVYLSYVV KEIDTLVGIA RRYSTTITDL
210 220 230 240 250
MNVNAMGAPD VSSGDILAVP LSACASKFPR YASDFGLIVP NGSYALAAGH
260 270 280 290 300
CVQCSCALGS RNLYCEPASL AVSCSSMQCR NSNLMLGNIT VQQTSAGCNV
310 320 330 340 350
TTCDYNGIAN GTILTMLTRS LQPRCPGPQQ FAPLLAPPDT VPRDVMYAPA
360 370 380 390 400
PSPDFDGPGS IASSPRSSML PGGGILPGNP ANGPAGSIST ASASSVSYFF
410
ITFLISIASF SLALSS
Note: GPI-anchored form.
Length:416
Mass (Da):43,490
Last modified:December 1, 2001 - v1
Checksum:i2655D586032D019E
GO
Isoform 2 (identifier: Q93ZH0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     317-416: Missing.

Note: Gene prediction confirmed by EST data. May be due to a competing donor splice site. Has no GPI-anchor.
Show »
Length:316
Mass (Da):33,401
Checksum:iF1ACE8D265470F31
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_008744317 – 416Missing in isoform 2. CuratedAdd BLAST100

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC013482 Genomic DNA Translation: AAF16531.1
CP002684 Genomic DNA Translation: AEE30167.1
CP002684 Genomic DNA Translation: AEE30168.1
AY057542 mRNA Translation: AAL09782.1
BT015782 mRNA Translation: AAU90072.1
PIRiB86352
RefSeqiNP_564153.1, NM_102036.4 [Q93ZH0-1]
NP_849697.1, NM_179366.1 [Q93ZH0-2]
UniGeneiAt.25611
At.48217

Genome annotation databases

EnsemblPlantsiAT1G21880.1; AT1G21880.1; AT1G21880 [Q93ZH0-2]
AT1G21880.2; AT1G21880.2; AT1G21880 [Q93ZH0-1]
GeneIDi838790
GrameneiAT1G21880.1; AT1G21880.1; AT1G21880 [Q93ZH0-2]
AT1G21880.2; AT1G21880.2; AT1G21880 [Q93ZH0-1]
KEGGiath:AT1G21880

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiLYM1_ARATH
AccessioniPrimary (citable) accession number: Q93ZH0
Secondary accession number(s): Q5XF34, Q9SFE8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health