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Protein

Stromal cell-derived factor 2-like protein

Gene

SDF2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the endoplasmic reticulum (ER) protein quality control and unfolded protein response. May be involved in the quality control of glycoproteins. Forms a complex in the ER with ERDJ3B and MED37A/BIP1 which is required for the proper accumulation and function of the surface-exposed leucine-rich repeat receptor kinases EFR involved in pathogen-associated molecular pattern (PAMP) triggered immunity.2 Publications

GO - Molecular functioni

GO - Biological processi

  • defense response to bacterium Source: TAIR
  • defense response to fungus Source: TAIR
  • pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response Source: TAIR
  • protein glycosylation Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Plant defense

Names & Taxonomyi

Protein namesi
Recommended name:
Stromal cell-derived factor 2-like protein
Short name:
AtSDF2
Short name:
SDF2-like protein
Gene namesi
Name:SDF2
Ordered Locus Names:At2g25110
ORF Names:F13D4.70
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

TAIRiAT2G25110.

Subcellular locationi

GO - Cellular componenti

  • endoplasmic reticulum Source: TAIR
  • membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

Pathology & Biotechi

Disruption phenotypei

No visible phenotype under normal growth conditions, but mutant plants are insensitive to seedling growth inhibition in response to the pathogen-associated molecular pattern (PAMP) elf18 and show increased susceptibility to phytopathogenic bacteria.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi64G → D in sdf2-3; decreased response to the PAMP elf18. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000003195922 – 218Stromal cell-derived factor 2-like proteinAdd BLAST197

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi214N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ93ZE8.

Expressioni

Inductioni

By tunicamycin.1 Publication

Gene expression databases

GenevisibleiQ93ZE8. AT.

Interactioni

Subunit structurei

Interacts with ERDJ3B.1 Publication

Protein-protein interaction databases

BioGridi2401. 1 interactor.
IntActiQ93ZE8. 1 interactor.
MINTiMINT-7950181.
STRINGi3702.AT2G25110.1.

Structurei

Secondary structure

1218
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi42 – 47Combined sources6
Turni48 – 50Combined sources3
Beta strandi53 – 60Combined sources8
Beta strandi68 – 73Combined sources6
Helixi79 – 81Combined sources3
Beta strandi83 – 86Combined sources4
Beta strandi104 – 109Combined sources6
Turni110 – 112Combined sources3
Beta strandi115 – 122Combined sources8
Turni124 – 126Combined sources3
Beta strandi128 – 134Combined sources7
Helixi142 – 144Combined sources3
Beta strandi146 – 153Combined sources8
Beta strandi162 – 167Combined sources6
Turni168 – 170Combined sources3
Beta strandi173 – 180Combined sources8
Beta strandi183 – 185Combined sources3
Beta strandi189 – 196Combined sources8
Helixi199 – 201Combined sources3
Beta strandi203 – 209Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3MALX-ray1.95A/B24-218[»]
ProteinModelPortaliQ93ZE8.
SMRiQ93ZE8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 88MIR 1PROSITE-ProRule annotationAdd BLAST55
Domaini96 – 151MIR 2PROSITE-ProRule annotationAdd BLAST56
Domaini154 – 208MIR 3PROSITE-ProRule annotationAdd BLAST55

Sequence similaritiesi

Contains 3 MIR domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG3358. Eukaryota.
ENOG410ZBU3. LUCA.
HOGENOMiHOG000236354.
InParanoidiQ93ZE8.
OMAiMAQPSQN.
OrthoDBiEOG09360MJO.
PhylomeDBiQ93ZE8.

Family and domain databases

InterProiIPR027005. GlyclTrfase_39-like.
IPR016093. MIR_motif.
[Graphical view]
PANTHERiPTHR10050. PTHR10050. 1 hit.
PfamiPF02815. MIR. 1 hit.
[Graphical view]
SMARTiSM00472. MIR. 3 hits.
[Graphical view]
SUPFAMiSSF82109. SSF82109. 1 hit.
PROSITEiPS50919. MIR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q93ZE8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALGFFCLAI FLYLSLDPDS GYTSASAAAS GKEGVEITYG SAIKLMHEKT
60 70 80 90 100
KFRLHSHDVP YGSGSGQQSV TGFPGVVDSN SYWIVKPVPG TTEKQGDAVK
110 120 130 140 150
SGATIRLQHM KTRKWLHSHL HASPISGNLE VSCFGDDTNS DTGDHWKLII
160 170 180 190 200
EGSGKTWKQD QRVRLQHIDT SGYLHSHDKK YQRIAGGQQE VCGIREKKAD
210
NIWLAAEGVY LPLNESSK
Length:218
Mass (Da):23,935
Last modified:December 1, 2001 - v1
Checksum:i575F683AC0C3BC87
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti203W → C in AAM65625 (Ref. 4) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002685 Genomic DNA. Translation: AEC07659.1.
AY057588 mRNA. Translation: AAL14383.1.
AY143822 mRNA. Translation: AAN28761.1.
AY088079 mRNA. Translation: AAM65625.1.
PIRiD84644.
RefSeqiNP_565585.1. NM_128068.3.
UniGeneiAt.14653.

Genome annotation databases

EnsemblPlantsiAT2G25110.1; AT2G25110.1; AT2G25110.
GeneIDi817049.
GrameneiAT2G25110.1; AT2G25110.1; AT2G25110.
KEGGiath:AT2G25110.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002685 Genomic DNA. Translation: AEC07659.1.
AY057588 mRNA. Translation: AAL14383.1.
AY143822 mRNA. Translation: AAN28761.1.
AY088079 mRNA. Translation: AAM65625.1.
PIRiD84644.
RefSeqiNP_565585.1. NM_128068.3.
UniGeneiAt.14653.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3MALX-ray1.95A/B24-218[»]
ProteinModelPortaliQ93ZE8.
SMRiQ93ZE8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi2401. 1 interactor.
IntActiQ93ZE8. 1 interactor.
MINTiMINT-7950181.
STRINGi3702.AT2G25110.1.

Proteomic databases

PaxDbiQ93ZE8.

Protocols and materials databases

DNASUi817049.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT2G25110.1; AT2G25110.1; AT2G25110.
GeneIDi817049.
GrameneiAT2G25110.1; AT2G25110.1; AT2G25110.
KEGGiath:AT2G25110.

Organism-specific databases

TAIRiAT2G25110.

Phylogenomic databases

eggNOGiKOG3358. Eukaryota.
ENOG410ZBU3. LUCA.
HOGENOMiHOG000236354.
InParanoidiQ93ZE8.
OMAiMAQPSQN.
OrthoDBiEOG09360MJO.
PhylomeDBiQ93ZE8.

Miscellaneous databases

PROiQ93ZE8.

Gene expression databases

GenevisibleiQ93ZE8. AT.

Family and domain databases

InterProiIPR027005. GlyclTrfase_39-like.
IPR016093. MIR_motif.
[Graphical view]
PANTHERiPTHR10050. PTHR10050. 1 hit.
PfamiPF02815. MIR. 1 hit.
[Graphical view]
SMARTiSM00472. MIR. 3 hits.
[Graphical view]
SUPFAMiSSF82109. SSF82109. 1 hit.
PROSITEiPS50919. MIR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSDF2_ARATH
AccessioniPrimary (citable) accession number: Q93ZE8
Secondary accession number(s): O81720, Q9SEZ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.