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Protein

Stromal cell-derived factor 2-like protein

Gene

SDF2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the endoplasmic reticulum (ER) protein quality control and unfolded protein response. May be involved in the quality control of glycoproteins. Forms a complex in the ER with ERDJ3B and MED37A/BIP1 which is required for the proper accumulation and function of the surface-exposed leucine-rich repeat receptor kinases EFR involved in pathogen-associated molecular pattern (PAMP) triggered immunity.2 Publications

GO - Molecular functioni

GO - Biological processi

  • defense response to bacterium Source: TAIR
  • defense response to fungus Source: TAIR
  • pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response Source: TAIR
  • protein glycosylation Source: GO_Central

Keywordsi

Biological processPlant defense

Names & Taxonomyi

Protein namesi
Recommended name:
Stromal cell-derived factor 2-like protein
Short name:
AtSDF2
Short name:
SDF2-like protein
Gene namesi
Name:SDF2
Ordered Locus Names:At2g25110
ORF Names:F13D4.70
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G25110
TAIRilocus:2040199 AT2G25110

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

Pathology & Biotechi

Disruption phenotypei

No visible phenotype under normal growth conditions, but mutant plants are insensitive to seedling growth inhibition in response to the pathogen-associated molecular pattern (PAMP) elf18 and show increased susceptibility to phytopathogenic bacteria.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi64G → D in sdf2-3; decreased response to the PAMP elf18. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000003195922 – 218Stromal cell-derived factor 2-like proteinAdd BLAST197

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi214N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ93ZE8
PRIDEiQ93ZE8

Expressioni

Inductioni

By tunicamycin.1 Publication

Gene expression databases

ExpressionAtlasiQ93ZE8 baseline and differential
GenevisibleiQ93ZE8 AT

Interactioni

Subunit structurei

Interacts with ERDJ3B.1 Publication

Protein-protein interaction databases

BioGridi2401, 1 interactor
IntActiQ93ZE8, 1 interactor
MINTiQ93ZE8
STRINGi3702.AT2G25110.1

Structurei

Secondary structure

1218
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi42 – 47Combined sources6
Turni48 – 50Combined sources3
Beta strandi53 – 60Combined sources8
Beta strandi68 – 73Combined sources6
Helixi79 – 81Combined sources3
Beta strandi83 – 86Combined sources4
Beta strandi104 – 109Combined sources6
Turni110 – 112Combined sources3
Beta strandi115 – 122Combined sources8
Turni124 – 126Combined sources3
Beta strandi128 – 134Combined sources7
Helixi142 – 144Combined sources3
Beta strandi146 – 153Combined sources8
Beta strandi162 – 167Combined sources6
Turni168 – 170Combined sources3
Beta strandi173 – 180Combined sources8
Beta strandi183 – 185Combined sources3
Beta strandi189 – 196Combined sources8
Helixi199 – 201Combined sources3
Beta strandi203 – 209Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3MALX-ray1.95A/B24-218[»]
ProteinModelPortaliQ93ZE8
SMRiQ93ZE8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 88MIR 1PROSITE-ProRule annotationAdd BLAST55
Domaini96 – 151MIR 2PROSITE-ProRule annotationAdd BLAST56
Domaini154 – 208MIR 3PROSITE-ProRule annotationAdd BLAST55

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG3358 Eukaryota
ENOG410ZBU3 LUCA
HOGENOMiHOG000236354
InParanoidiQ93ZE8
OMAiMAQPSQN
OrthoDBiEOG09360MJO
PhylomeDBiQ93ZE8

Family and domain databases

InterProiView protein in InterPro
IPR027005 GlyclTrfase_39-like
IPR036300 MIR_dom_sf
IPR016093 MIR_motif
PANTHERiPTHR10050 PTHR10050, 1 hit
PfamiView protein in Pfam
PF02815 MIR, 1 hit
SMARTiView protein in SMART
SM00472 MIR, 3 hits
SUPFAMiSSF82109 SSF82109, 1 hit
PROSITEiView protein in PROSITE
PS50919 MIR, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q93ZE8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALGFFCLAI FLYLSLDPDS GYTSASAAAS GKEGVEITYG SAIKLMHEKT
60 70 80 90 100
KFRLHSHDVP YGSGSGQQSV TGFPGVVDSN SYWIVKPVPG TTEKQGDAVK
110 120 130 140 150
SGATIRLQHM KTRKWLHSHL HASPISGNLE VSCFGDDTNS DTGDHWKLII
160 170 180 190 200
EGSGKTWKQD QRVRLQHIDT SGYLHSHDKK YQRIAGGQQE VCGIREKKAD
210
NIWLAAEGVY LPLNESSK
Length:218
Mass (Da):23,935
Last modified:December 1, 2001 - v1
Checksum:i575F683AC0C3BC87
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti203W → C in AAM65625 (Ref. 4) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002685 Genomic DNA Translation: AEC07659.1
AY057588 mRNA Translation: AAL14383.1
AY143822 mRNA Translation: AAN28761.1
AY088079 mRNA Translation: AAM65625.1
PIRiD84644
RefSeqiNP_565585.1, NM_128068.3
UniGeneiAt.14653

Genome annotation databases

EnsemblPlantsiAT2G25110.1; AT2G25110.1; AT2G25110
GeneIDi817049
GrameneiAT2G25110.1; AT2G25110.1; AT2G25110
KEGGiath:AT2G25110

Similar proteinsi

Entry informationi

Entry nameiSDF2_ARATH
AccessioniPrimary (citable) accession number: Q93ZE8
Secondary accession number(s): O81720, Q9SEZ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health