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Q93ZB6 (DCUP1_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Uroporphyrinogen decarboxylase 1, chloroplastic
Short name=UPD1
Short name=URO-D1
EC=4.1.1.37
Gene names
Ordered Locus Names:At3g14930
ORF Names:K15M2.7
OrganismArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length418 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III By similarity.

Catalytic activity

Uroporphyrinogen III = coproporphyrinogen + 4 CO2.

Pathway

Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.

Subunit structure

Homodimer By similarity.

Subcellular location

Plastid › chloroplast Potential.

Sequence similarities

Belongs to the uroporphyrinogen decarboxylase family.

Sequence caution

The sequence BX824686 differs from that shown. Reason: Sequencing errors.

Ontologies

Keywords
   Biological processChlorophyll biosynthesis
Porphyrin biosynthesis
   Cellular componentChloroplast
Plastid
   Coding sequence diversityAlternative splicing
   DomainTransit peptide
   Molecular functionDecarboxylase
Lyase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processchlorophyll biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

response to cadmium ion

Inferred from expression pattern. Source: TAIR

   Cellular componentchloroplast stroma

Inferred from direct assay. Source: TAIR

   Molecular functionuroporphyrinogen decarboxylase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q93ZB6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q93ZB6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-77: Missing.
Note: May be due to a competing acceptor splice site. No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Chloroplast Potential
Chain? – 418Uroporphyrinogen decarboxylase 1, chloroplasticPRO_0000376071

Regions

Region80 – 845Substrate binding By similarity

Sites

Binding site991Substrate By similarity
Binding site1291Substrate By similarity
Binding site1301Substrate By similarity
Binding site2061Substrate By similarity
Binding site2611Substrate By similarity
Binding site3761Substrate By similarity
Site1301Transition state stabilizer By similarity

Natural variations

Alternative sequence1 – 7777Missing in isoform 2.
VSP_037402

Experimental info

Sequence conflict361V → G in AAL15294. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 26, 2009. Version 2.
Checksum: F8A78980A6B08CB2

FASTA41846,254
        10         20         30         40         50         60 
MSLSSPTSAC SSSRCYSSGL SFPIGFGSNP INVGLVCYPK RYSIAARKFV VACSSSSSDP 

        70         80         90        100        110        120 
LLVKAAKGQA ISRPPAWMMR QAGRYMAVYQ KLAKKHPSFR ERSENTDLIV EISLQPWQAF 

       130        140        150        160        170        180 
RPDGVIIFSD ILTPLPAFGV PFDIEEVKGP VIQSPIRTEE DMKRLHPIDF EKLQFVGDSL 

       190        200        210        220        230        240 
KILRREVGEH AAVLGFVGAP WTIATYIVEG GTTRTYTVIK NMCHTAPDVL RALLSHLTKA 

       250        260        270        280        290        300 
ITEYVVYQVE HGAHCIQIFD SWGGQLTPEM WERWSKPYIE EIIHAVKKRC PDTPIVFYIN 

       310        320        330        340        350        360 
GNGGLLERMK GTGADVIGLD WTVDMADGRR RLGSEVSVQG NVDPAYLFSP LPALTEEIER 

       370        380        390        400        410 
VVKCAGPKGH ILNLGHGVLV GTPEEAVAHF FETARNLDYQ TLFQNHVPAE KAEPELVV

« Hide

Isoform 2 [UniParc].

Checksum: 3554BCF60863A911
Show »

FASTA34138,268

References

« Hide 'large scale' references
[1]"Structural analysis of Arabidopsis thaliana chromosome 3. II. Sequence features of the 4,251,695 bp regions covered by 90 P1, TAC and BAC clones."
Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Tabata S.
DNA Res. 7:217-221(2000) [PubMed: 10907853] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[2]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[3]"Empirical analysis of transcriptional activity in the Arabidopsis genome."
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. expand/collapse author list , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
Science 302:842-846(2003) [PubMed: 14593172] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: cv. Columbia.
[4]"Whole genome sequence comparisons and 'full-length' cDNA sequences: a combined approach to evaluate and improve Arabidopsis genome annotation."
Castelli V., Aury J.-M., Jaillon O., Wincker P., Clepet C., Menard M., Cruaud C., Quetier F., Scarpelli C., Schaechter V., Temple G., Caboche M., Weissenbach J., Salanoubat M.
Genome Res. 14:406-413(2004) [PubMed: 14993207] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Strain: cv. Columbia.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP000370 Genomic DNA. Translation: BAA97056.1.
CP002686 Genomic DNA. Translation: AEE75589.1.
CP002686 Genomic DNA. Translation: AEE75590.1.
CP002686 Genomic DNA. Translation: AEE75591.1.
AY057663 mRNA. Translation: AAL15294.1.
AY136476 mRNA. Translation: AAM97141.1.
BT008826 mRNA. Translation: AAP68265.1.
BX824686 mRNA. No translation available.
IPIIPI00524385.
IPI00524782.
RefSeqNP_566495.1. NM_112355.2.
NP_850587.1. NM_180256.1.
NP_974316.1. NM_202587.1.
UniGeneAt.6655.

3D structure databases

HSSPHSSP built from PDB template 1J93 based on UniProtKB Q42967.
ProteinModelPortalQ93ZB6.
SMRQ93ZB6. Positions 58-399.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ93ZB6.

Proteomic databases

PRIDEQ93ZB6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT3G14930.1; AT3G14930.1; AT3G14930.
AT3G14930.2; AT3G14930.2; AT3G14930.
GeneID820722.
GenomeReviewsGene locus AT3G14930 in contig BA000014_GR.
KEGGath:AT3G14930.

Organism-specific databases

TAIRAt3g14930.

Phylogenomic databases

eggNOGKOG2872.
GeneTreeEPGT00070000030693.
HOGENOMHBG628392.
InParanoidQ93ZB6.
OMAENISIQL.
PhylomeDBQ93ZB6.
ProtClustDBPLN02433.

Gene expression databases

GenevestigatorQ93ZB6.

Family and domain databases

InterProIPR006361. Uroporphyrinogen_deCO2ase_HemE.
IPR000257. Uroporphyrinogen_deCOase.
[Graphical view]
KOK01599.
PANTHERPTHR21091:SF2. HemE. 1 hit.
PfamPF01208. URO-D. 1 hit.
[Graphical view]
TIGRFAMsTIGR01464. HemE. 1 hit.
PROSITEPS00906. UROD_1. 1 hit.
PS00907. UROD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDCUP1_ARATH
AccessionPrimary (citable) accession number: Q93ZB6
Secondary accession number(s): Q9LKB1
Entry history
Integrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: May 26, 2009
Last modified: December 14, 2011
This is version 68 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents