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Protein

Cytochrome P450 714A1

Gene

CYP714A1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the inactivation of early gibberellin (GA) intermediates.1 Publication

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi480 – 4801Iron (heme axial ligand)By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT5G24910-MONOMER.
ReactomeiR-ATH-193775. Synthesis of bile acids and bile salts via 24-hydroxycholesterol.
R-ATH-211976. Endogenous sterols.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 714A1 (EC:1.14.-.-)
Alternative name(s):
EUI-like P450 A1
Gene namesi
Name:CYP714A1
Synonyms:ELA1
Ordered Locus Names:At5g24910
ORF Names:F6A4.120
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

TAIRiAT5G24910.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 44LumenalSequence analysis
Transmembranei5 – 2521Helical; Signal-anchor for type III membrane proteinSequence analysisAdd
BLAST
Topological domaini26 – 532507CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Disruption phenotypei

No visible phenotype; due to the redundancy with CYP714A2. Cyp714a1 and cyp714a2 double mutants flower earlier and have an increased plant size and biomass.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 532532Cytochrome P450 714A1PRO_0000422410Add
BLAST

Proteomic databases

PaxDbiQ93Z79.
PRIDEiQ93Z79.

Expressioni

Tissue specificityi

Expressed in the shoot apical meristem (SAM), petioles of young leaves and emerging leaves, in sepals, stigma, anther and filaments of the developing flowers, and in the receptacle and stigma of the developing siliques.1 Publication

Gene expression databases

GenevisibleiQ93Z79. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT5G24910.1.

Structurei

3D structure databases

ProteinModelPortaliQ93Z79.
SMRiQ93Z79. Positions 46-529.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0157. Eukaryota.
COG2124. LUCA.
HOGENOMiHOG000039125.
InParanoidiQ93Z79.
OMAiWQTRIRD.
OrthoDBiEOG0936078A.
PhylomeDBiQ93Z79.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q93Z79-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENFMVEMAK TISWIVVIGV LGLGIRVYGK VMAEQWRMRR KLTMQGVKGP
60 70 80 90 100
PPSLFRGNVP EMQKIQSQIM SNSKHYSGDN IIAHDYTSSL FPYLDHWRKQ
110 120 130 140 150
YGRVYTYSTG VKQHLYMNHP ELVKELNQAN TLNLGKVSYV TKRLKSILGR
160 170 180 190 200
GVITSNGPHW AHQRRIIAPE FFLDKVKGMV GLVVESAMPM LSKWEEMMKR
210 220 230 240 250
EGEMVCDIIV DEDLRAASAD VISRACFGSS FSKGKEIFSK LRCLQKAITH
260 270 280 290 300
NNILFSLNGF TDVVFGTKKH GNGKIDELER HIESLIWETV KERERECVGD
310 320 330 340 350
HKKDLMQLIL EGARSSCDGN LEDKTQSYKS FVVDNCKSIY FAGHETSAVA
360 370 380 390 400
VSWCLMLLAL NPSWQTRIRD EVFLHCKNGI PDADSISNLK TVTMVIQETL
410 420 430 440 450
RLYPPAAFVS REALEDTKLG NLVVPKGVCI WTLIPTLHRD PEIWGADANE
460 470 480 490 500
FNPERFSEGV SKACKHPQSF VPFGLGTRLC LGKNFGMMEL KVLVSLIVSR
510 520 530
FSFTLSPTYQ HSPVFRMLVE PQHGVVIRVL RQ
Length:532
Mass (Da):60,335
Last modified:December 1, 2001 - v1
Checksum:i02CE05FFFE666041
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF069716 Genomic DNA. No translation available.
CP002688 Genomic DNA. Translation: AED93377.1.
AY058060 mRNA. Translation: AAL24168.1.
BT002687 mRNA. Translation: AAO11603.1.
RefSeqiNP_568463.1. NM_122400.2.
UniGeneiAt.26660.

Genome annotation databases

EnsemblPlantsiAT5G24910.1; AT5G24910.1; AT5G24910.
GeneIDi832560.
GrameneiAT5G24910.1; AT5G24910.1; AT5G24910.
KEGGiath:AT5G24910.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF069716 Genomic DNA. No translation available.
CP002688 Genomic DNA. Translation: AED93377.1.
AY058060 mRNA. Translation: AAL24168.1.
BT002687 mRNA. Translation: AAO11603.1.
RefSeqiNP_568463.1. NM_122400.2.
UniGeneiAt.26660.

3D structure databases

ProteinModelPortaliQ93Z79.
SMRiQ93Z79. Positions 46-529.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT5G24910.1.

Proteomic databases

PaxDbiQ93Z79.
PRIDEiQ93Z79.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G24910.1; AT5G24910.1; AT5G24910.
GeneIDi832560.
GrameneiAT5G24910.1; AT5G24910.1; AT5G24910.
KEGGiath:AT5G24910.

Organism-specific databases

TAIRiAT5G24910.

Phylogenomic databases

eggNOGiKOG0157. Eukaryota.
COG2124. LUCA.
HOGENOMiHOG000039125.
InParanoidiQ93Z79.
OMAiWQTRIRD.
OrthoDBiEOG0936078A.
PhylomeDBiQ93Z79.

Enzyme and pathway databases

BioCyciARA:AT5G24910-MONOMER.
ReactomeiR-ATH-193775. Synthesis of bile acids and bile salts via 24-hydroxycholesterol.
R-ATH-211976. Endogenous sterols.

Miscellaneous databases

PROiQ93Z79.

Gene expression databases

GenevisibleiQ93Z79. AT.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiC14A1_ARATH
AccessioniPrimary (citable) accession number: Q93Z79
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2013
Last sequence update: December 1, 2001
Last modified: September 7, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

Overexpression of CYP714A1 causes severe dwarfism with defective leaf development.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.