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Q93Z70 (ARGC_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable N-acetyl-gamma-glutamyl-phosphate reductase, chloroplastic
Short name=AGPR
EC=1.2.1.38
Alternative name(s):
N-acetyl-glutamate semialdehyde dehydrogenase
Short name=NAGSA dehydrogenase
Gene names
Ordered Locus Names:At2g19940
ORF Names:F6F22.3
OrganismArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length401 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH.

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4.

Subunit structure

Homotetramer. Ref.4

Subcellular location

Plastid › chloroplast Potential.

Sequence similarities

Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.

Sequence caution

The sequence AAC62122.2 differs from that shown. Reason: Erroneous gene model prediction.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

BRL1Q9ZPS91EBI-2293228,EBI-2292728

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 4848Chloroplast Potential
Chain49 – 401353Probable N-acetyl-gamma-glutamyl-phosphate reductase, chloroplastic
PRO_0000002066

Sites

Active site2051 By similarity

Secondary structure

1 ..................................................................... 401
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q93Z70 [UniParc].

Last modified August 30, 2005. Version 2.
Checksum: 70A1CFECD1EAD162

FASTA40144,136
        10         20         30         40         50         60 
MSTASAFSSI QGCWFKGERK IRVADKRAKR LTLGSHVASP SSMSFRVSAS SSVKPEKDIR 

        70         80         90        100        110        120 
IGLLGASGYT GAEIVRLLAN HPHFQVTLMT ADRKAGQSME SVFPHLRAQK LPTLVSVKDA 

       130        140        150        160        170        180 
DFSTVDAVFC CLPHGTTQEI IKELPTALKI VDLSADFRLR NIAEYEEWYG QPHKAVELQK 

       190        200        210        220        230        240 
EVVYGLTEIL REDIKKARLV ANPGCYPTTI QLPLVPLLKA NLIKHENIII DAKSGVSGAG 

       250        260        270        280        290        300 
RGAKEANLYS EIAEGISSYG VTRHRHVPEI EQGLSDVAQS KVTVSFTPHL MPMIRGMQST 

       310        320        330        340        350        360 
IYVEMAPGVR TEDLHQQLKT SYEDEEFVKV LDEGVVPRTH NVRGSNYCHM SVFPDRIPGR 

       370        380        390        400 
AIIISVIDNL VKGASGQALQ NLNIMLGYPE TTGLLHQPLF P

« Hide

References

« Hide 'large scale' references
[1]"Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana."
Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D., Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V., Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S., Cronin L.A. expand/collapse author list , Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J., Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M., Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O., Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.
Nature 402:761-768(1999) [PubMed: 10617197] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[2]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[3]"Empirical analysis of transcriptional activity in the Arabidopsis genome."
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. expand/collapse author list , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
Science 302:842-846(2003) [PubMed: 14593172] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: cv. Columbia.
[4]"X-ray structure of gene product from Arabidopsis thaliana At2g19940."
Center for eukaryotic structural genomics (CESG)
Submitted (FEB-2005) to the PDB data bank
Cited for: X-RAY CRYSTALLOGRAPHY (2.19 ANGSTROMS) OF 43-401, SUBUNIT.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AC005169 Genomic DNA. Translation: AAC62122.2. Sequence problems.
CP002685 Genomic DNA. Translation: AEC06945.1.
CP002685 Genomic DNA. Translation: AEC06946.1.
AY058082 mRNA. Translation: AAL24190.1.
AY090309 mRNA. Translation: AAL90970.1.
IPIIPI00530622.
PIRA84583.
RefSeqNP_180668.5. NM_128666.5.
NP_565461.4. NM_127552.7.
NP_849993.4. NM_179662.6.
UniGeneAt.21379.
At.38263.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1XYGX-ray2.19A/B/C/D43-401[»]
2Q49X-ray2.19A/B/C/D43-401[»]
ProteinModelPortalQ93Z70.
SMRQ93Z70. Positions 57-401.
ModBaseSearch...

Protein-protein interaction databases

IntActQ93Z70. 1 interaction.
STRINGQ93Z70.

Proteomic databases

PRIDEQ93Z70.
ProMEXQ93Z70.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT2G19940.1; AT2G19940.1; AT2G19940.
AT2G19940.2; AT2G19940.2; AT2G19940.
GeneID816513.
817666.
GenomeReviewsGene locus AT2G19940 in contig CT485783_GR.
KEGGath:AT2G19940.
ath:AT2G31100.
NMPDRfig|3702.1.peg.8987.

Organism-specific databases

TAIRAt2g19940.

Phylogenomic databases

eggNOGKOG4354.
GeneTreeEPGT00050000010868.
HOGENOMHBG294213.
InParanoidQ93Z70.
PhylomeDBQ93Z70.
ProtClustDBPLN02968.

Gene expression databases

GenevestigatorQ93Z70.
GermOnlineAT2G19940. Arabidopsis thaliana.

Family and domain databases

InterProIPR023013. AGPR_AS.
IPR000706. AGPR_type-1.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
IPR012280. Semialdhyde_DH_dimer_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK00145.
PfamPF01118. Semialdhyde_dh. 1 hit.
PF02774. Semialdhyde_dhC. 1 hit.
[Graphical view]
SMARTSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR01850. ArgC. 1 hit.
PROSITEPS01224. ARGC. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameARGC_ARATH
AccessionPrimary (citable) accession number: Q93Z70
Secondary accession number(s): O82187
Entry history
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: August 30, 2005
Last modified: November 16, 2011
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents