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Protein

Tryptophan aminotransferase-related protein 4

Gene

TAR4

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probable aminotransferase.By similarity

Cofactori

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei124 – 1241Pyridoxal phosphateBy similarity
Binding sitei239 – 2391Pyridoxal phosphateBy similarity
Binding sitei259 – 2591Pyridoxal phosphateBy similarity
Binding sitei293 – 2931Pyridoxal phosphateBy similarity

GO - Molecular functioni

  1. carbon-sulfur lyase activity Source: InterPro
  2. pyridoxal phosphate binding Source: InterPro
  3. transaminase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan aminotransferase-related protein 4 (EC:2.6.1.-)
Gene namesi
Name:TAR4
Ordered Locus Names:At1g34060
ORF Names:F12G12.12, F12G12.150
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 1

Organism-specific databases

TAIRiAT1G34060.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei6 – 2621HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 463463Tryptophan aminotransferase-related protein 4PRO_0000411677Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei285 – 2851N6-(pyridoxal phosphate)lysineSequence Analysis

Proteomic databases

PaxDbiQ93Z38.
PRIDEiQ93Z38.

Expressioni

Gene expression databases

GenevestigatoriQ93Z38.

Structurei

3D structure databases

ProteinModelPortaliQ93Z38.
SMRiQ93Z38. Positions 33-449.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni163 – 1642Pyridoxal phosphate bindingBy similarity
Regioni259 – 2624Pyridoxal phosphate bindingBy similarity
Regioni282 – 2854Pyridoxal phosphate bindingBy similarity

Sequence similaritiesi

Belongs to the alliinase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG290378.
HOGENOMiHOG000237549.
InParanoidiQ93Z38.
OMAiICECNAC.
PhylomeDBiQ93Z38.

Family and domain databases

Gene3Di2.10.25.30. 1 hit.
3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR006948. Alliinase_C.
IPR006947. EGF_alliinase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF04864. Alliinase_C. 1 hit.
PF04863. EGF_alliinase. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q93Z38-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMQKKLLLIV SIILNLVFTI HILYYSSTTW NPTWTNRAAA EAETVASFSC
60 70 80 90 100
SGHGRAFVDG LGVLDGQKPP CECNNCYIGK DCSVLLKDCP VDANSGDPLF
110 120 130 140 150
LEPFWMRQAE RSAILVSGWH RMSYIYEDGT YVSRELEKVI RKLHSVVGNA
160 170 180 190 200
VTDNRFVIFG SGTTQLLAAA VHALSLTNSS VSSPARLLTS IPYYAMYKDQ
210 220 230 240 250
AEFFDSAHLK FEGNASAWKQ SGRNDNITQV IEVVTSPNNP DGKLKRAVLD
260 270 280 290 300
GPNVKTLHDY AYYWPHFSPI THPVDEDLSL FSLSKTTGHA GSRFGWGLVK
310 320 330 340 350
DKAIYEKMDR FIRLTSMGVS KETQLHVLQL LKVVVGDGGN EIFSFGYGTV
360 370 380 390 400
KKRWETLNKI FSMSTRFSLQ TIKPEYCNYF KKVREFTPSY AWVKCERPED
410 420 430 440 450
TNCYEIFRAA KITGRNGNVF GSEERFVRLS LIRSQDDFDQ LIAMLKKLVY
460
HEEDVPSENF MYI
Length:463
Mass (Da):52,430
Last modified:July 27, 2011 - v2
Checksum:iAB0FD34E580AD0BA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti100 – 1001F → S in AAL25576. (PubMed:14593172)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC015446 Genomic DNA. Translation: AAG12531.1.
CP002684 Genomic DNA. Translation: AEE31667.1.
AY058162 mRNA. Translation: AAL25576.1.
PIRiE86464.
RefSeqiNP_564435.1. NM_103128.3.
UniGeneiAt.26614.

Genome annotation databases

EnsemblPlantsiAT1G34060.1; AT1G34060.1; AT1G34060.
GeneIDi840303.
KEGGiath:AT1G34060.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC015446 Genomic DNA. Translation: AAG12531.1.
CP002684 Genomic DNA. Translation: AEE31667.1.
AY058162 mRNA. Translation: AAL25576.1.
PIRiE86464.
RefSeqiNP_564435.1. NM_103128.3.
UniGeneiAt.26614.

3D structure databases

ProteinModelPortaliQ93Z38.
SMRiQ93Z38. Positions 33-449.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiQ93Z38.
PRIDEiQ93Z38.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G34060.1; AT1G34060.1; AT1G34060.
GeneIDi840303.
KEGGiath:AT1G34060.

Organism-specific databases

TAIRiAT1G34060.

Phylogenomic databases

eggNOGiNOG290378.
HOGENOMiHOG000237549.
InParanoidiQ93Z38.
OMAiICECNAC.
PhylomeDBiQ93Z38.

Gene expression databases

GenevestigatoriQ93Z38.

Family and domain databases

Gene3Di2.10.25.30. 1 hit.
3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR006948. Alliinase_C.
IPR006947. EGF_alliinase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF04864. Alliinase_C. 1 hit.
PF04863. EGF_alliinase. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "TAA1-mediated auxin biosynthesis is essential for hormone crosstalk and plant development."
    Stepanova A.N., Robertson-Hoyt J., Yun J., Benavente L.M., Xie D.Y., Dolezal K., Schlereth A., Juergens G., Alonso J.M.
    Cell 133:177-191(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.
  5. "Rapid synthesis of auxin via a new tryptophan-dependent pathway is required for shade avoidance in plants."
    Tao Y., Ferrer J.L., Ljung K., Pojer F., Hong F., Long J.A., Li L., Moreno J.E., Bowman M.E., Ivans L.J., Cheng Y., Lim J., Zhao Y., Ballare C.L., Sandberg G., Noel J.P., Chory J.
    Cell 133:164-176(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiTAR4_ARATH
AccessioniPrimary (citable) accession number: Q93Z38
Secondary accession number(s): Q9FX14
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: July 27, 2011
Last modified: January 7, 2015
This is version 63 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.