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Q93Z38

- TAR4_ARATH

UniProt

Q93Z38 - TAR4_ARATH

Protein

Tryptophan aminotransferase-related protein 4

Gene

TAR4

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Probable aminotransferase.By similarity

    Cofactori

    Pyridoxal phosphate.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei124 – 1241Pyridoxal phosphateBy similarity
    Binding sitei239 – 2391Pyridoxal phosphateBy similarity
    Binding sitei259 – 2591Pyridoxal phosphateBy similarity
    Binding sitei293 – 2931Pyridoxal phosphateBy similarity

    GO - Molecular functioni

    1. carbon-sulfur lyase activity Source: InterPro
    2. pyridoxal phosphate binding Source: InterPro
    3. transaminase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Aminotransferase, Transferase

    Keywords - Ligandi

    Pyridoxal phosphate

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tryptophan aminotransferase-related protein 4 (EC:2.6.1.-)
    Gene namesi
    Name:TAR4
    Ordered Locus Names:At1g34060
    ORF Names:F12G12.12, F12G12.150
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 1

    Organism-specific databases

    TAIRiAT1G34060.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 463463Tryptophan aminotransferase-related protein 4PRO_0000411677Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei285 – 2851N6-(pyridoxal phosphate)lysineSequence Analysis

    Proteomic databases

    PaxDbiQ93Z38.
    PRIDEiQ93Z38.

    Expressioni

    Gene expression databases

    GenevestigatoriQ93Z38.

    Structurei

    3D structure databases

    ProteinModelPortaliQ93Z38.
    SMRiQ93Z38. Positions 33-449.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei6 – 2621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni163 – 1642Pyridoxal phosphate bindingBy similarity
    Regioni259 – 2624Pyridoxal phosphate bindingBy similarity
    Regioni282 – 2854Pyridoxal phosphate bindingBy similarity

    Sequence similaritiesi

    Belongs to the alliinase family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG290378.
    HOGENOMiHOG000237549.
    InParanoidiQ9FX14.
    OMAiGRNDNIT.
    PhylomeDBiQ93Z38.

    Family and domain databases

    Gene3Di2.10.25.30. 1 hit.
    3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProiIPR006948. Alliinase_C.
    IPR006947. EGF_alliinase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PfamiPF04864. Alliinase_C. 1 hit.
    PF04863. EGF_alliinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q93Z38-1 [UniParc]FASTAAdd to Basket

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    MMQKKLLLIV SIILNLVFTI HILYYSSTTW NPTWTNRAAA EAETVASFSC    50
    SGHGRAFVDG LGVLDGQKPP CECNNCYIGK DCSVLLKDCP VDANSGDPLF 100
    LEPFWMRQAE RSAILVSGWH RMSYIYEDGT YVSRELEKVI RKLHSVVGNA 150
    VTDNRFVIFG SGTTQLLAAA VHALSLTNSS VSSPARLLTS IPYYAMYKDQ 200
    AEFFDSAHLK FEGNASAWKQ SGRNDNITQV IEVVTSPNNP DGKLKRAVLD 250
    GPNVKTLHDY AYYWPHFSPI THPVDEDLSL FSLSKTTGHA GSRFGWGLVK 300
    DKAIYEKMDR FIRLTSMGVS KETQLHVLQL LKVVVGDGGN EIFSFGYGTV 350
    KKRWETLNKI FSMSTRFSLQ TIKPEYCNYF KKVREFTPSY AWVKCERPED 400
    TNCYEIFRAA KITGRNGNVF GSEERFVRLS LIRSQDDFDQ LIAMLKKLVY 450
    HEEDVPSENF MYI 463
    Length:463
    Mass (Da):52,430
    Last modified:July 27, 2011 - v2
    Checksum:iAB0FD34E580AD0BA
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti100 – 1001F → S in AAL25576. (PubMed:14593172)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC015446 Genomic DNA. Translation: AAG12531.1.
    CP002684 Genomic DNA. Translation: AEE31667.1.
    AY058162 mRNA. Translation: AAL25576.1.
    PIRiE86464.
    RefSeqiNP_564435.1. NM_103128.3.
    UniGeneiAt.26614.

    Genome annotation databases

    EnsemblPlantsiAT1G34060.1; AT1G34060.1; AT1G34060.
    GeneIDi840303.
    KEGGiath:AT1G34060.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC015446 Genomic DNA. Translation: AAG12531.1 .
    CP002684 Genomic DNA. Translation: AEE31667.1 .
    AY058162 mRNA. Translation: AAL25576.1 .
    PIRi E86464.
    RefSeqi NP_564435.1. NM_103128.3.
    UniGenei At.26614.

    3D structure databases

    ProteinModelPortali Q93Z38.
    SMRi Q93Z38. Positions 33-449.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi Q93Z38.
    PRIDEi Q93Z38.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT1G34060.1 ; AT1G34060.1 ; AT1G34060 .
    GeneIDi 840303.
    KEGGi ath:AT1G34060.

    Organism-specific databases

    TAIRi AT1G34060.

    Phylogenomic databases

    eggNOGi NOG290378.
    HOGENOMi HOG000237549.
    InParanoidi Q9FX14.
    OMAi GRNDNIT.
    PhylomeDBi Q93Z38.

    Gene expression databases

    Genevestigatori Q93Z38.

    Family and domain databases

    Gene3Di 2.10.25.30. 1 hit.
    3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProi IPR006948. Alliinase_C.
    IPR006947. EGF_alliinase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    Pfami PF04864. Alliinase_C. 1 hit.
    PF04863. EGF_alliinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
      Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
      , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
      Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    4. "TAA1-mediated auxin biosynthesis is essential for hormone crosstalk and plant development."
      Stepanova A.N., Robertson-Hoyt J., Yun J., Benavente L.M., Xie D.Y., Dolezal K., Schlereth A., Juergens G., Alonso J.M.
      Cell 133:177-191(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY, NOMENCLATURE.
    5. "Rapid synthesis of auxin via a new tryptophan-dependent pathway is required for shade avoidance in plants."
      Tao Y., Ferrer J.L., Ljung K., Pojer F., Hong F., Long J.A., Li L., Moreno J.E., Bowman M.E., Ivans L.J., Cheng Y., Lim J., Zhao Y., Ballare C.L., Sandberg G., Noel J.P., Chory J.
      Cell 133:164-176(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY, NOMENCLATURE.

    Entry informationi

    Entry nameiTAR4_ARATH
    AccessioniPrimary (citable) accession number: Q93Z38
    Secondary accession number(s): Q9FX14
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 27, 2011
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 60 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3