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Protein

Beta-galactosidase 17

Gene

BGAL17

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei218Proton donorSequence analysis1
Active sitei301NucleophileSequence analysis1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Enzyme and pathway databases

BioCyciARA:AT1G72990-MONOMER.
ReactomeiR-ATH-1660662. Glycosphingolipid metabolism.
R-ATH-2022857. Keratan sulfate degradation.
R-ATH-2024096. HS-GAG degradation.
R-ATH-6798695. Neutrophil degranulation.

Protein family/group databases

CAZyiGH35. Glycoside Hydrolase Family 35.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-galactosidase 17 (EC:3.2.1.23)
Short name:
Lactase 17
Gene namesi
Name:BGAL17
Ordered Locus Names:At1g72990
ORF Names:F3N23.19
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G72990.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Apoplast, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 35Sequence analysisAdd BLAST35
ChainiPRO_000029309636 – 697Beta-galactosidase 17Add BLAST662

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi333N-linked (GlcNAc...)Sequence analysis1
Glycosylationi519N-linked (GlcNAc...)Sequence analysis1
Glycosylationi573N-linked (GlcNAc...)Sequence analysis1
Glycosylationi583N-linked (GlcNAc...)Sequence analysis1
Glycosylationi690N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ93Z24.

Expressioni

Tissue specificityi

Ubiquitous, with higher expression levels in roots and siliques.2 Publications

Gene expression databases

GenevisibleiQ93Z24. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G72990.1.

Structurei

3D structure databases

ProteinModelPortaliQ93Z24.
SMRiQ93Z24.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 35 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0496. Eukaryota.
COG1874. LUCA.
HOGENOMiHOG000221607.
InParanoidiQ93Z24.
KOiK12309.
OMAiENMGRVS.
OrthoDBiEOG093603DJ.
PhylomeDBiQ93Z24.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR026283. B-gal_1-like.
IPR025300. BetaGal_jelly_roll_dom.
IPR008979. Galactose-bd-like.
IPR031330. Gly_Hdrlase_35_cat.
IPR019801. Glyco_hydro_35_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR23421. PTHR23421. 1 hit.
PfamiPF13364. BetaGal_dom4_5. 1 hit.
PF01301. Glyco_hydro_35. 1 hit.
[Graphical view]
PIRSFiPIRSF006336. B-gal. 1 hit.
PRINTSiPR00742. GLHYDRLASE35.
SUPFAMiSSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.
PROSITEiPS01182. GLYCOSYL_HYDROL_F35. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q93Z24-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAMTSWPSTG RQRRHQLASM LLLVLVVVGI YVPVFALLPS LSYTPQSLPS
60 70 80 90 100
AIPQDEKMIS RKFYIKDDNF WKDGNRFQII GGDLHYFRVL PEYWEDRLLR
110 120 130 140 150
ANALGLNTIQ VYVPWNLHEP KPGKMVFEGI GDLVSFLKLC EKLDFLVMLR
160 170 180 190 200
AGPYICGEWD LGGFPAWLLA VKPRLQLRTS DPVYLKLVER WWDVLLPKVF
210 220 230 240 250
PLLYSNGGPV IMVQIENEYG SYGNDKAYLR KLVSMARGHL GDDIIVYTTD
260 270 280 290 300
GGTKETLDKG TVPVADVYSA VDFSTGDDPW PIFKLQKKFN APGRSPPLSS
310 320 330 340 350
EFYTGWLTHW GEKITKTDAE FTAASLEKIL SRNGSAVLYM VHGGTNFGFY
360 370 380 390 400
NGANTGSEES DYKPDLTSYD YDAPIKESGD IDNPKFQALQ RVIKKYNASP
410 420 430 440 450
HPISPSNKQR KAYGSIKMQM TTSLFDLVRM TDPADVITSA NPISMESVGQ
460 470 480 490 500
MFGFLLYESS YIAKKSGNTL RIPKVHDRAQ VFVSCLSQDV DVGVLRYIGT
510 520 530 540 550
TERWNNQPIS LPTIECTTNT SLFILVENMG RVNYGPYIFD DKGILSSVYL
560 570 580 590 600
DGQILHGWKM IPIPFHNLNQ EPNLTFEMQH TKNRSKKFEL TNDVGRKEPA
610 620 630 640 650
LFAGEFSINS EEEIKDTYLS FNGWGKGVAF VNEFNIGRYW PSVGPQCNLY
660 670 680 690
VPAPLLKRGK NTLVVFELES PHLELSLEAV DHQDFTCGSN VSKVNQL
Length:697
Mass (Da):78,640
Last modified:December 1, 2001 - v1
Checksum:i7A13124157BCE54A
GO
Isoform 2 (identifier: Q93Z24-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-92: MAMTSWPSTG...DLHYFRVLPE → MTISGKMGIVFRSLVVICITFVFFQRLWMQ

Note: Derived from EST data. No experimental confirmation available.
Show »
Length:635
Mass (Da):71,595
Checksum:iCC8D3A972BAF5982
GO

Sequence cautioni

The sequence AAD55646 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0264681 – 92MAMTS…RVLPE → MTISGKMGIVFRSLVVICIT FVFFQRLWMQ in isoform 2. CuratedAdd BLAST92

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008017 Genomic DNA. Translation: AAD55646.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE35400.1.
CP002684 Genomic DNA. Translation: AEE35401.1.
AY058198 mRNA. Translation: AAL25611.1.
AY142008 mRNA. Translation: AAM98272.1.
PIRiC96755.
RefSeqiNP_001031273.1. NM_001036196.2. [Q93Z24-2]
NP_565051.1. NM_105957.3. [Q93Z24-1]
UniGeneiAt.11678.

Genome annotation databases

EnsemblPlantsiAT1G72990.1; AT1G72990.1; AT1G72990. [Q93Z24-1]
GeneIDi843630.
GrameneiAT1G72990.1; AT1G72990.1; AT1G72990.
KEGGiath:AT1G72990.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008017 Genomic DNA. Translation: AAD55646.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE35400.1.
CP002684 Genomic DNA. Translation: AEE35401.1.
AY058198 mRNA. Translation: AAL25611.1.
AY142008 mRNA. Translation: AAM98272.1.
PIRiC96755.
RefSeqiNP_001031273.1. NM_001036196.2. [Q93Z24-2]
NP_565051.1. NM_105957.3. [Q93Z24-1]
UniGeneiAt.11678.

3D structure databases

ProteinModelPortaliQ93Z24.
SMRiQ93Z24.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT1G72990.1.

Protein family/group databases

CAZyiGH35. Glycoside Hydrolase Family 35.

Proteomic databases

PaxDbiQ93Z24.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G72990.1; AT1G72990.1; AT1G72990. [Q93Z24-1]
GeneIDi843630.
GrameneiAT1G72990.1; AT1G72990.1; AT1G72990.
KEGGiath:AT1G72990.

Organism-specific databases

TAIRiAT1G72990.

Phylogenomic databases

eggNOGiKOG0496. Eukaryota.
COG1874. LUCA.
HOGENOMiHOG000221607.
InParanoidiQ93Z24.
KOiK12309.
OMAiENMGRVS.
OrthoDBiEOG093603DJ.
PhylomeDBiQ93Z24.

Enzyme and pathway databases

BioCyciARA:AT1G72990-MONOMER.
ReactomeiR-ATH-1660662. Glycosphingolipid metabolism.
R-ATH-2022857. Keratan sulfate degradation.
R-ATH-2024096. HS-GAG degradation.
R-ATH-6798695. Neutrophil degranulation.

Miscellaneous databases

PROiQ93Z24.

Gene expression databases

GenevisibleiQ93Z24. AT.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR026283. B-gal_1-like.
IPR025300. BetaGal_jelly_roll_dom.
IPR008979. Galactose-bd-like.
IPR031330. Gly_Hdrlase_35_cat.
IPR019801. Glyco_hydro_35_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR23421. PTHR23421. 1 hit.
PfamiPF13364. BetaGal_dom4_5. 1 hit.
PF01301. Glyco_hydro_35. 1 hit.
[Graphical view]
PIRSFiPIRSF006336. B-gal. 1 hit.
PRINTSiPR00742. GLHYDRLASE35.
SUPFAMiSSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.
PROSITEiPS01182. GLYCOSYL_HYDROL_F35. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBGA17_ARATH
AccessioniPrimary (citable) accession number: Q93Z24
Secondary accession number(s): Q2V4C9, Q9SSM8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.