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Protein

Profilin-2

Gene
N/A
Organism
Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Profilin-2
Alternative name(s):
Minor food allergen Lyc e 1
Allergen: Lyc e 1
OrganismiSolanum lycopersicum (Tomato) (Lycopersicon esculentum)
Taxonomic identifieri4081 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanumLycopersicon
Proteomesi
  • UP000004994 Componenti: Chromosome 8

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Binds to IgE. This is a food allergen.1 Publication

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3358. Sola l 1.0101.
703. Sola l 1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001996452 – 131Profilin-2Add BLAST130

Proteomic databases

PaxDbiQ93YG7.

Interactioni

Subunit structurei

Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi4081.Solyc08g066110.2.1.

Structurei

3D structure databases

ProteinModelPortaliQ93YG7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the profilin family.Curated

Phylogenomic databases

eggNOGiKOG1755. Eukaryota.
ENOG41126PD. LUCA.
InParanoidiQ93YG7.
KOiK05759.
OMAiMVIQGEQ.
OrthoDBiEOG09360WEB.

Family and domain databases

CDDicd00148. PROF. 1 hit.
InterProiIPR005455. PFN.
IPR027310. Profilin_CS.
[Graphical view]
PANTHERiPTHR11604. PTHR11604. 1 hit.
PfamiPF00235. Profilin. 1 hit.
[Graphical view]
PRINTSiPR00392. PROFILIN.
PR01640. PROFILINPLNT.
SMARTiSM00392. PROF. 1 hit.
[Graphical view]
SUPFAMiSSF55770. SSF55770. 1 hit.
PROSITEiPS00414. PROFILIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q93YG7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWQTYVDEH LLCENEGNHL TSAAIIGQDG TVWAQSANFP QFKPEEITGI
60 70 80 90 100
MNDFAVPGTL APTGLYLGGT KYMVIQGEPE AVIRGKKGPG GITIKKTNQA
110 120 130
LIIGIYDEPM TPGQCNMIVE RLGDYLIEQS L
Length:131
Mass (Da):14,257
Last modified:December 1, 2001 - v1
Checksum:iE55E464A0E1168D2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ417553 mRNA. Translation: CAD10377.1.
RefSeqiNP_001233973.1. NM_001247044.3.
UniGeneiLes.3695.

Genome annotation databases

EnsemblPlantsiSolyc08g066110.2.1; Solyc08g066110.2.1; Solyc08g066110.2.
GeneIDi543782.
GrameneiSolyc08g066110.2.1; Solyc08g066110.2.1; Solyc08g066110.2.
KEGGisly:543782.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ417553 mRNA. Translation: CAD10377.1.
RefSeqiNP_001233973.1. NM_001247044.3.
UniGeneiLes.3695.

3D structure databases

ProteinModelPortaliQ93YG7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi4081.Solyc08g066110.2.1.

Protein family/group databases

Allergomei3358. Sola l 1.0101.
703. Sola l 1.

Proteomic databases

PaxDbiQ93YG7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiSolyc08g066110.2.1; Solyc08g066110.2.1; Solyc08g066110.2.
GeneIDi543782.
GrameneiSolyc08g066110.2.1; Solyc08g066110.2.1; Solyc08g066110.2.
KEGGisly:543782.

Phylogenomic databases

eggNOGiKOG1755. Eukaryota.
ENOG41126PD. LUCA.
InParanoidiQ93YG7.
KOiK05759.
OMAiMVIQGEQ.
OrthoDBiEOG09360WEB.

Family and domain databases

CDDicd00148. PROF. 1 hit.
InterProiIPR005455. PFN.
IPR027310. Profilin_CS.
[Graphical view]
PANTHERiPTHR11604. PTHR11604. 1 hit.
PfamiPF00235. Profilin. 1 hit.
[Graphical view]
PRINTSiPR00392. PROFILIN.
PR01640. PROFILINPLNT.
SMARTiSM00392. PROF. 1 hit.
[Graphical view]
SUPFAMiSSF55770. SSF55770. 1 hit.
PROSITEiPS00414. PROFILIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPROF2_SOLLC
AccessioniPrimary (citable) accession number: Q93YG7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.