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Protein

Ubiquitin carboxyl-terminal hydrolase 9

Gene

UBP9

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei312NucleophilePROSITE-ProRule annotation1
Active sitei852Proton acceptorPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-ATH-5689880 Ub-specific processing proteases

Protein family/group databases

MEROPSiC19.A03

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 9 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 9
Short name:
AtUBP9
Ubiquitin thioesterase 9
Ubiquitin-specific-processing protease 9
Gene namesi
Name:UBP9
Ordered Locus Names:At4g10590
ORF Names:F3H7.7, T4F9.50
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G10590
TAIRilocus:2139222 AT4G10590

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003130361 – 910Ubiquitin carboxyl-terminal hydrolase 9Add BLAST910

Proteomic databases

PaxDbiQ93Y01

Expressioni

Gene expression databases

ExpressionAtlasiQ93Y01 baseline and differential
GenevisibleiQ93Y01 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT4G10590.1

Structurei

3D structure databases

ProteinModelPortaliQ93Y01
SMRiQ93Y01
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 134DUSPPROSITE-ProRule annotationAdd BLAST116
Domaini303 – 894USPAdd BLAST592

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi231 – 236Poly-Ser6

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated

Phylogenomic databases

eggNOGiKOG1870 Eukaryota
COG5560 LUCA
HOGENOMiHOG000264375
InParanoidiQ93Y01
OMAiCTEETCK
OrthoDBiEOG09360187
PhylomeDBiQ93Y01

Family and domain databases

InterProiView protein in InterPro
IPR035927 DUSP-like_sf
IPR006615 Pept_C19_DUSP
IPR001394 Peptidase_C19_UCH
IPR028134 USP4
IPR018200 USP_CS
IPR028889 USP_dom
PANTHERiPTHR43913 PTHR43913, 1 hit
PfamiView protein in Pfam
PF06337 DUSP, 1 hit
PF00443 UCH, 1 hit
SMARTiView protein in SMART
SM00695 DUSP, 1 hit
SUPFAMiSSF143791 SSF143791, 1 hit
PROSITEiView protein in PROSITE
PS51283 DUSP, 1 hit
PS00972 USP_1, 1 hit
PS00973 USP_2, 1 hit
PS50235 USP_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q93Y01-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIPNSDFMI ENGVCDFPTT PEEEKRIVSE LITESEDNLK EGNLYFVISK
60 70 80 90 100
RWYTSWEKYV EQSTKEYISG ESSEASRPGP IDNHDIIESE SDVNDPQLRR
110 120 130 140 150
LLMERVDYVL VPQEVWKRLV EWYSGGPPIE RKLICQGFYT RSYSVEVYPL
160 170 180 190 200
CLMLTDGRDE SRTVIRLGKQ ASIRELYEKV CALTGVPQEK AHIWDYFDKR
210 220 230 240 250
KNGLLDSLSY KSLEESSLHM DQDILLEVDG SSSSQSAMSS TGNELALVPL
260 270 280 290 300
EPSRSSVTIA GGPTLSNGHS TTSNFSLFPR ITSEDDGSNS LSILGKGEKG
310 320 330 340 350
GLAGLSNLGN TCFMNSALQC LAHTPPIVEY FLQDYSDDIN RDNPLGMCGE
360 370 380 390 400
LAIAFGDLLK KLWSSGRNSV APRAFKTKLA RFAPQFSGYN QHDSQELLAF
410 420 430 440 450
LLDGLHEDLN KVKRKPYIEL KDSDSRPDDE VAEELWNYHK ARNDSVIVDV
460 470 480 490 500
CQGQYKSTLV CPACGKISIT FDPFMYLSVP LPSTLTRSMT VTVFYCDGSH
510 520 530 540 550
LPMPYTVIVP KNGSIRDLIT ALGTACLLAE DESLLLAEVY DHKIFKYFEN
560 570 580 590 600
PLDSLSSIKD DEHIVAYRLN QMPKGSGKAK LEILHGGQKR PILESVRGRD
610 620 630 640 650
VKLFGTPFVT YVNTEPLSGA DIDAVLSRFL SPLHKVHAPS KIHNGSENGH
660 670 680 690 700
LPDATVDEAS EILSSPDTEI DDASDRELSF RIFLTDERGL NFKPLQSESS
710 720 730 740 750
ISLGIATRVL VEWNEGEHER YDSSYLSDLP EVHKTSFSAK KTRQESISLF
760 770 780 790 800
SCLEAFLAEE PLGPDDMWFC PSCKEHRQAN KKLDLWKLPD ILVFHLKRFT
810 820 830 840 850
YSRYLKNKID TFVNFPVHDL DLSKYVKNKN DQSYLYELYA VSNHYGGLGG
860 870 880 890 900
GHYTAYAKLI DDNEWYHFDD SHVSSVNESE IKNSAAYVLF YRRVRSETET
910
QTVEMSTDMD
Length:910
Mass (Da):102,649
Last modified:December 1, 2001 - v1
Checksum:iE01B0AD928A8EE71
GO

Sequence cautioni

The sequence AAD03434 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAB40025 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAB78182 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF118222 Genomic DNA Translation: AAD03434.1 Sequence problems.
AL049523 Genomic DNA Translation: CAB40025.1 Sequence problems.
AL161517 Genomic DNA Translation: CAB78182.1 Sequence problems.
CP002687 Genomic DNA Translation: AEE82901.1
CP002687 Genomic DNA Translation: AEE82902.1
CP002687 Genomic DNA Translation: ANM66517.1
CP002687 Genomic DNA Translation: ANM66518.1
AY054463 mRNA Translation: AAK96655.1
BT010363 mRNA Translation: AAQ56806.1
PIRiT04194
RefSeqiNP_001328408.1, NM_001340677.1
NP_001328409.1, NM_001340676.1
NP_567363.1, NM_117127.2
NP_849356.1, NM_179025.2
UniGeneiAt.10964
At.67146

Genome annotation databases

EnsemblPlantsiAT4G10590.1; AT4G10590.1; AT4G10590
AT4G10590.2; AT4G10590.2; AT4G10590
AT4G10590.3; AT4G10590.3; AT4G10590
AT4G10590.4; AT4G10590.4; AT4G10590
GeneIDi826651
GrameneiAT4G10590.1; AT4G10590.1; AT4G10590
AT4G10590.2; AT4G10590.2; AT4G10590
AT4G10590.3; AT4G10590.3; AT4G10590
AT4G10590.4; AT4G10590.4; AT4G10590
KEGGiath:AT4G10590

Similar proteinsi

Entry informationi

Entry nameiUBP9_ARATH
AccessioniPrimary (citable) accession number: Q93Y01
Secondary accession number(s): Q9T0B8, Q9ZSB6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 1, 2001
Last modified: April 25, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health