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Q93Y01

- UBP9_ARATH

UniProt

Q93Y01 - UBP9_ARATH

Protein

Ubiquitin carboxyl-terminal hydrolase 9

Gene

UBP9

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins By similarity.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei312 – 3121NucleophilePROSITE-ProRule annotation
    Active sitei852 – 8521Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ubiquitin-specific protease activity Source: InterPro

    GO - Biological processi

    1. protein deubiquitination Source: InterPro
    2. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Enzyme and pathway databases

    BioCyciARA:AT4G10590-MONOMER.
    ARA:GQT-1184-MONOMER.

    Protein family/group databases

    MEROPSiC19.A03.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 9 (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme 9
    Short name:
    AtUBP9
    Ubiquitin thioesterase 9
    Ubiquitin-specific-processing protease 9
    Gene namesi
    Name:UBP9
    Ordered Locus Names:At4g10590
    ORF Names:F3H7.7, T4F9.50
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 4

    Organism-specific databases

    TAIRiAT4G10590.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 910910Ubiquitin carboxyl-terminal hydrolase 9PRO_0000313036Add
    BLAST

    Proteomic databases

    PaxDbiQ93Y01.
    PRIDEiQ93Y01.

    Expressioni

    Gene expression databases

    GenevestigatoriQ93Y01.

    Structurei

    3D structure databases

    ProteinModelPortaliQ93Y01.
    SMRiQ93Y01. Positions 29-227, 301-482, 746-893.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini19 – 134116DUSPPROSITE-ProRule annotationAdd
    BLAST
    Domaini303 – 894592USPAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi231 – 2366Poly-Ser

    Sequence similaritiesi

    Belongs to the peptidase C19 family.Curated
    Contains 1 DUSP domain.PROSITE-ProRule annotation
    Contains 1 USP domain.Curated

    Phylogenomic databases

    eggNOGiCOG5560.
    HOGENOMiHOG000264375.
    InParanoidiQ93Y01.
    KOiK11835.
    OMAiDKEHELY.
    PhylomeDBiQ93Y01.

    Family and domain databases

    Gene3Di3.30.2230.10. 1 hit.
    InterProiIPR006615. Pept_C19_DUSP.
    IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    IPR028134. USP.
    [Graphical view]
    PANTHERiPTHR24006:SF360. PTHR24006:SF360. 1 hit.
    PfamiPF06337. DUSP. 1 hit.
    PF00443. UCH. 1 hit.
    [Graphical view]
    SMARTiSM00695. DUSP. 1 hit.
    [Graphical view]
    SUPFAMiSSF143791. SSF143791. 1 hit.
    PROSITEiPS51283. DUSP. 1 hit.
    PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q93Y01-1 [UniParc]FASTAAdd to Basket

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    MTIPNSDFMI ENGVCDFPTT PEEEKRIVSE LITESEDNLK EGNLYFVISK    50
    RWYTSWEKYV EQSTKEYISG ESSEASRPGP IDNHDIIESE SDVNDPQLRR 100
    LLMERVDYVL VPQEVWKRLV EWYSGGPPIE RKLICQGFYT RSYSVEVYPL 150
    CLMLTDGRDE SRTVIRLGKQ ASIRELYEKV CALTGVPQEK AHIWDYFDKR 200
    KNGLLDSLSY KSLEESSLHM DQDILLEVDG SSSSQSAMSS TGNELALVPL 250
    EPSRSSVTIA GGPTLSNGHS TTSNFSLFPR ITSEDDGSNS LSILGKGEKG 300
    GLAGLSNLGN TCFMNSALQC LAHTPPIVEY FLQDYSDDIN RDNPLGMCGE 350
    LAIAFGDLLK KLWSSGRNSV APRAFKTKLA RFAPQFSGYN QHDSQELLAF 400
    LLDGLHEDLN KVKRKPYIEL KDSDSRPDDE VAEELWNYHK ARNDSVIVDV 450
    CQGQYKSTLV CPACGKISIT FDPFMYLSVP LPSTLTRSMT VTVFYCDGSH 500
    LPMPYTVIVP KNGSIRDLIT ALGTACLLAE DESLLLAEVY DHKIFKYFEN 550
    PLDSLSSIKD DEHIVAYRLN QMPKGSGKAK LEILHGGQKR PILESVRGRD 600
    VKLFGTPFVT YVNTEPLSGA DIDAVLSRFL SPLHKVHAPS KIHNGSENGH 650
    LPDATVDEAS EILSSPDTEI DDASDRELSF RIFLTDERGL NFKPLQSESS 700
    ISLGIATRVL VEWNEGEHER YDSSYLSDLP EVHKTSFSAK KTRQESISLF 750
    SCLEAFLAEE PLGPDDMWFC PSCKEHRQAN KKLDLWKLPD ILVFHLKRFT 800
    YSRYLKNKID TFVNFPVHDL DLSKYVKNKN DQSYLYELYA VSNHYGGLGG 850
    GHYTAYAKLI DDNEWYHFDD SHVSSVNESE IKNSAAYVLF YRRVRSETET 900
    QTVEMSTDMD 910
    Length:910
    Mass (Da):102,649
    Last modified:December 1, 2001 - v1
    Checksum:iE01B0AD928A8EE71
    GO

    Sequence cautioni

    The sequence AAD03434.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAB40025.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAB78182.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF118222 Genomic DNA. Translation: AAD03434.1. Sequence problems.
    AL049523 Genomic DNA. Translation: CAB40025.1. Sequence problems.
    AL161517 Genomic DNA. Translation: CAB78182.1. Sequence problems.
    CP002687 Genomic DNA. Translation: AEE82901.1.
    CP002687 Genomic DNA. Translation: AEE82902.1.
    AY054463 mRNA. Translation: AAK96655.1.
    BT010363 mRNA. Translation: AAQ56806.1.
    PIRiT04194.
    RefSeqiNP_567363.1. NM_117127.2.
    NP_849356.1. NM_179025.1.
    UniGeneiAt.10964.
    At.67146.

    Genome annotation databases

    EnsemblPlantsiAT4G10590.1; AT4G10590.1; AT4G10590.
    AT4G10590.2; AT4G10590.2; AT4G10590.
    GeneIDi826651.
    KEGGiath:AT4G10590.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF118222 Genomic DNA. Translation: AAD03434.1 . Sequence problems.
    AL049523 Genomic DNA. Translation: CAB40025.1 . Sequence problems.
    AL161517 Genomic DNA. Translation: CAB78182.1 . Sequence problems.
    CP002687 Genomic DNA. Translation: AEE82901.1 .
    CP002687 Genomic DNA. Translation: AEE82902.1 .
    AY054463 mRNA. Translation: AAK96655.1 .
    BT010363 mRNA. Translation: AAQ56806.1 .
    PIRi T04194.
    RefSeqi NP_567363.1. NM_117127.2.
    NP_849356.1. NM_179025.1.
    UniGenei At.10964.
    At.67146.

    3D structure databases

    ProteinModelPortali Q93Y01.
    SMRi Q93Y01. Positions 29-227, 301-482, 746-893.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi C19.A03.

    Proteomic databases

    PaxDbi Q93Y01.
    PRIDEi Q93Y01.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT4G10590.1 ; AT4G10590.1 ; AT4G10590 .
    AT4G10590.2 ; AT4G10590.2 ; AT4G10590 .
    GeneIDi 826651.
    KEGGi ath:AT4G10590.

    Organism-specific databases

    TAIRi AT4G10590.

    Phylogenomic databases

    eggNOGi COG5560.
    HOGENOMi HOG000264375.
    InParanoidi Q93Y01.
    KOi K11835.
    OMAi DKEHELY.
    PhylomeDBi Q93Y01.

    Enzyme and pathway databases

    BioCyci ARA:AT4G10590-MONOMER.
    ARA:GQT-1184-MONOMER.

    Gene expression databases

    Genevestigatori Q93Y01.

    Family and domain databases

    Gene3Di 3.30.2230.10. 1 hit.
    InterProi IPR006615. Pept_C19_DUSP.
    IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    IPR028134. USP.
    [Graphical view ]
    PANTHERi PTHR24006:SF360. PTHR24006:SF360. 1 hit.
    Pfami PF06337. DUSP. 1 hit.
    PF00443. UCH. 1 hit.
    [Graphical view ]
    SMARTi SM00695. DUSP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF143791. SSF143791. 1 hit.
    PROSITEi PS51283. DUSP. 1 hit.
    PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana."
      Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T., Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B., Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M., de Simone V., Obermaier B.
      , Mache R., Mueller M., Kreis M., Delseny M., Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D., Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J., Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B., Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J., Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R., Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M., Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C., Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J., Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S., Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A., Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M., Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D., Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E., Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S., Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R., Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M., Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E., Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P., Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K., Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K., de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K., Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M., Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G., Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K., Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K., Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W., Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H., Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B., Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J., Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K., O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N., Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A., Martienssen R., McCombie W.R.
      Nature 402:769-777(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    4. "The ubiquitin-specific protease family from Arabidopsis. AtUBP1 and 2 are required for the resistance to the amino acid analog canavanine."
      Yan N., Doelling J.H., Falbel T.G., Durski A.M., Vierstra R.D.
      Plant Physiol. 124:1828-1843(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY ORGANIZATION, NOMENCLATURE.

    Entry informationi

    Entry nameiUBP9_ARATH
    AccessioniPrimary (citable) accession number: Q93Y01
    Secondary accession number(s): Q9T0B8, Q9ZSB6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3