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Protein

Cation transporter HKT2

Gene

HKT2

Organism
Oryza sativa subsp. indica (Rice)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Seems to be involved in regulation of K+/Na+ homeostasis. Seems to act as a potassium-sodium cotransporter, which mediates increased potassium uptake under external sodium accumulation and contributes to salt-tolerance in cultivar indica Pokkali.2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processIon transport, Potassium transport, Sodium transport, Transport
LigandPotassium, Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Cation transporter HKT2
Short name:
OsHKT2
Alternative name(s):
Po-OsHKT2
Gene namesi
Name:HKT2
OrganismiOryza sativa subsp. indica (Rice)
Taxonomic identifieri39946 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 40CytoplasmicSequence analysisAdd BLAST40
Transmembranei41 – 61Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei102 – 122Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini123 – 186CytoplasmicSequence analysisAdd BLAST64
Transmembranei187 – 207Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei260 – 280Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini281 – 317CytoplasmicSequence analysisAdd BLAST37
Transmembranei318 – 338Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei372 – 392Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini393 – 420CytoplasmicSequence analysisAdd BLAST28
Transmembranei421 – 441Helical; Name=7Sequence analysisAdd BLAST21
Transmembranei494 – 514Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini515 – 530CytoplasmicSequence analysisAdd BLAST16

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi88G → S: Loss of selectivity for potassium uptake. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000704671 – 530Cation transporter HKT2Add BLAST530

Expressioni

Inductioni

By potassium starvation in roots. Down-regulated by sodium.1 Publication

Family & Domainsi

Domaini

HKT transporters are proposed to contain 4 pore-forming regions enclosed by transmembrane segments with each containing a potassium channel-like selectivity filter motif.1 Publication

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

InterProiView protein in InterPro
IPR003445. Cat_transpt.
PfamiView protein in Pfam
PF02386. TrkH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q93XI5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSIYQEFIH TKCQSFRSIG RYVLHSIVLI YRFVSLHVHP FWIQLSYFLL
60 70 80 90 100
ISILGSVLLM FLKPSSPEFK PGYIDMLFLS TSAMTVSGLS TIEMEVLSSS
110 120 130 140 150
QIVVLTLLML VGGEVFVSFL GLMLRLKHKH NPEFSGDRVS SVPIELDTIE
160 170 180 190 200
PTRTVMSSEE LQIEAAAPDV PSSTIKDLKR SKRLRWFLGF VVFSYFVVIH
210 220 230 240 250
VVGFLLVLWY ISRVSSAKAP LKKKGINIAL FSFSVTVSSF ANGGLVPTNE
260 270 280 290 300
NMAIFSKNPG LLLLFIGQIL AGNTLYPLFL RILIWFLGKV TKLKDLKLMI
310 320 330 340 350
KNSDELQYDY LLPKLPTAFL ASTVIGLMAS LVTLFGSVDW NSSVFDGLSS
360 370 380 390 400
YQKIINALFM AVNARHSGEN SIDCSLIAPA VLVLFIILMY LPPSTTFALS
410 420 430 440 450
NGDEKTANKK AKRKLGLVVR NLAFSQLACN AVFVIVALIT ERSRLRNDPL
460 470 480 490 500
NFSALNMIFE VISAYGNVGL TTGYSCSRLQ KLHPGSICQD KPYSLSGWWS
510 520 530
DEGKLLLVSV MLYGRLKAFT KGTGEYWRLW
Length:530
Mass (Da):59,152
Last modified:December 1, 2001 - v1
Checksum:i73087CF493AD3360
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB061313 mRNA. Translation: BAB61791.1.

Similar proteinsi

Entry informationi

Entry nameiHKT2_ORYSI
AccessioniPrimary (citable) accession number: Q93XI5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 1, 2001
Last modified: August 30, 2017
This is version 45 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Caution

HKT2 is found in salt-tolerant cultivar indica Pokkali. It does not exist in cultivar indica 93-11 or japonica Nipponbare.Curated

Documents

  1. SIMILARITY comments
    Index of protein domains and families