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Q93XI5

- HKT2_ORYSI

UniProt

Q93XI5 - HKT2_ORYSI

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Protein

Cation transporter HKT2

Gene
HKT2
Organism
Oryza sativa subsp. indica (Rice)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Seems to be involved in regulation of K+/Na+ homeostasis. Seems to act as a potassium-sodium cotransporter, which mediates increased potassium uptake under external sodium accumulation and contributes to salt-tolerance in cultivar indica Pokkali.2 Publications

GO - Molecular functioni

  1. cation transmembrane transporter activity Source: InterPro

GO - Biological processi

  1. potassium ion transport Source: UniProtKB-KW
  2. sodium ion transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Ion transport, Potassium transport, Sodium transport, Transport

Keywords - Ligandi

Potassium, Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Cation transporter HKT2
Short name:
OsHKT2
Alternative name(s):
Po-OsHKT2
Gene namesi
Name:HKT2
OrganismiOryza sativa subsp. indica (Rice)
Taxonomic identifieri39946 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza

Organism-specific databases

GrameneiQ93XI5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4040Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei41 – 6121Helical; Name=1; Reviewed predictionAdd
BLAST
Transmembranei102 – 12221Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini123 – 18664Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei187 – 20721Helical; Name=3; Reviewed predictionAdd
BLAST
Transmembranei260 – 28021Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini281 – 31737Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei318 – 33821Helical; Name=5; Reviewed predictionAdd
BLAST
Transmembranei372 – 39221Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini393 – 42028Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei421 – 44121Helical; Name=7; Reviewed predictionAdd
BLAST
Transmembranei494 – 51421Helical; Name=8; Reviewed predictionAdd
BLAST
Topological domaini515 – 53016Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi88 – 881G → S: Loss of selectivity for potassium uptake. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 530530Cation transporter HKT2PRO_0000070467Add
BLAST

Expressioni

Inductioni

By potassium starvation in roots. Down-regulated by sodium.1 Publication

Family & Domainsi

Domaini

HKT transporters are proposed to contain 4 pore-forming regions enclosed by transmembrane segments with each containing a potassium channel-like selectivity filter motif.1 Publication

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR003445. Cat_transpt.
[Graphical view]
PfamiPF02386. TrkH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q93XI5-1 [UniParc]FASTAAdd to Basket

« Hide

MTSIYQEFIH TKCQSFRSIG RYVLHSIVLI YRFVSLHVHP FWIQLSYFLL    50
ISILGSVLLM FLKPSSPEFK PGYIDMLFLS TSAMTVSGLS TIEMEVLSSS 100
QIVVLTLLML VGGEVFVSFL GLMLRLKHKH NPEFSGDRVS SVPIELDTIE 150
PTRTVMSSEE LQIEAAAPDV PSSTIKDLKR SKRLRWFLGF VVFSYFVVIH 200
VVGFLLVLWY ISRVSSAKAP LKKKGINIAL FSFSVTVSSF ANGGLVPTNE 250
NMAIFSKNPG LLLLFIGQIL AGNTLYPLFL RILIWFLGKV TKLKDLKLMI 300
KNSDELQYDY LLPKLPTAFL ASTVIGLMAS LVTLFGSVDW NSSVFDGLSS 350
YQKIINALFM AVNARHSGEN SIDCSLIAPA VLVLFIILMY LPPSTTFALS 400
NGDEKTANKK AKRKLGLVVR NLAFSQLACN AVFVIVALIT ERSRLRNDPL 450
NFSALNMIFE VISAYGNVGL TTGYSCSRLQ KLHPGSICQD KPYSLSGWWS 500
DEGKLLLVSV MLYGRLKAFT KGTGEYWRLW 530
Length:530
Mass (Da):59,152
Last modified:December 1, 2001 - v1
Checksum:i73087CF493AD3360
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB061313 mRNA. Translation: BAB61791.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB061313 mRNA. Translation: BAB61791.1 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

Gramenei Q93XI5.

Family and domain databases

InterProi IPR003445. Cat_transpt.
[Graphical view ]
Pfami PF02386. TrkH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Two types of HKT transporters with different properties of Na+ and K+ transport in Oryza sativa."
    Horie T., Yoshida K., Nakayama H., Yamada K., Oiki S., Shinmyo A.
    Plant J. 27:129-138(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INDUCTION.
    Strain: cv. Pokkali.
    Tissue: Seedling root.
  2. "Glycine residues in potassium channel-like selectivity filters determine potassium selectivity in four-loop-per-subunit HKT transporters from plants."
    Maeser P., Hosoo Y., Goshima S., Horie T., Eckelman B., Yamada K., Yoshida K., Bakker E.P., Shinmyo A., Oiki S., Schroeder J.I., Uozumi N.
    Proc. Natl. Acad. Sci. U.S.A. 99:6428-6433(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DOMAIN, MUTAGENESIS OF GLY-88.

Entry informationi

Entry nameiHKT2_ORYSI
AccessioniPrimary (citable) accession number: Q93XI5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Caution

HKT2 is found in salt-tolerant cultivar indica Pokkali. It does not exist in cultivar indica 93-11 or japonica Nipponbare.

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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