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Q93XI5

- HKT2_ORYSI

UniProt

Q93XI5 - HKT2_ORYSI

Protein

Cation transporter HKT2

Gene

HKT2

Organism
Oryza sativa subsp. indica (Rice)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Seems to be involved in regulation of K+/Na+ homeostasis. Seems to act as a potassium-sodium cotransporter, which mediates increased potassium uptake under external sodium accumulation and contributes to salt-tolerance in cultivar indica Pokkali.2 Publications

    GO - Molecular functioni

    1. cation transmembrane transporter activity Source: InterPro

    GO - Biological processi

    1. potassium ion transport Source: UniProtKB-KW
    2. sodium ion transport Source: UniProtKB-KW

    Keywords - Biological processi

    Ion transport, Potassium transport, Sodium transport, Transport

    Keywords - Ligandi

    Potassium, Sodium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cation transporter HKT2
    Short name:
    OsHKT2
    Alternative name(s):
    Po-OsHKT2
    Gene namesi
    Name:HKT2
    OrganismiOryza sativa subsp. indica (Rice)
    Taxonomic identifieri39946 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza

    Organism-specific databases

    GrameneiQ93XI5.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi88 – 881G → S: Loss of selectivity for potassium uptake. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 530530Cation transporter HKT2PRO_0000070467Add
    BLAST

    Expressioni

    Inductioni

    By potassium starvation in roots. Down-regulated by sodium.1 Publication

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4040CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini123 – 18664CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini281 – 31737CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini393 – 42028CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini515 – 53016CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei41 – 6121Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei102 – 12221Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei187 – 20721Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei260 – 28021Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei318 – 33821Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei372 – 39221Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei421 – 44121Helical; Name=7Sequence AnalysisAdd
    BLAST
    Transmembranei494 – 51421Helical; Name=8Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domaini

    HKT transporters are proposed to contain 4 pore-forming regions enclosed by transmembrane segments with each containing a potassium channel-like selectivity filter motif.1 Publication

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Family and domain databases

    InterProiIPR003445. Cat_transpt.
    [Graphical view]
    PfamiPF02386. TrkH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q93XI5-1 [UniParc]FASTAAdd to Basket

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    MTSIYQEFIH TKCQSFRSIG RYVLHSIVLI YRFVSLHVHP FWIQLSYFLL    50
    ISILGSVLLM FLKPSSPEFK PGYIDMLFLS TSAMTVSGLS TIEMEVLSSS 100
    QIVVLTLLML VGGEVFVSFL GLMLRLKHKH NPEFSGDRVS SVPIELDTIE 150
    PTRTVMSSEE LQIEAAAPDV PSSTIKDLKR SKRLRWFLGF VVFSYFVVIH 200
    VVGFLLVLWY ISRVSSAKAP LKKKGINIAL FSFSVTVSSF ANGGLVPTNE 250
    NMAIFSKNPG LLLLFIGQIL AGNTLYPLFL RILIWFLGKV TKLKDLKLMI 300
    KNSDELQYDY LLPKLPTAFL ASTVIGLMAS LVTLFGSVDW NSSVFDGLSS 350
    YQKIINALFM AVNARHSGEN SIDCSLIAPA VLVLFIILMY LPPSTTFALS 400
    NGDEKTANKK AKRKLGLVVR NLAFSQLACN AVFVIVALIT ERSRLRNDPL 450
    NFSALNMIFE VISAYGNVGL TTGYSCSRLQ KLHPGSICQD KPYSLSGWWS 500
    DEGKLLLVSV MLYGRLKAFT KGTGEYWRLW 530
    Length:530
    Mass (Da):59,152
    Last modified:December 1, 2001 - v1
    Checksum:i73087CF493AD3360
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB061313 mRNA. Translation: BAB61791.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB061313 mRNA. Translation: BAB61791.1 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    Gramenei Q93XI5.

    Family and domain databases

    InterProi IPR003445. Cat_transpt.
    [Graphical view ]
    Pfami PF02386. TrkH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Two types of HKT transporters with different properties of Na+ and K+ transport in Oryza sativa."
      Horie T., Yoshida K., Nakayama H., Yamada K., Oiki S., Shinmyo A.
      Plant J. 27:129-138(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INDUCTION.
      Strain: cv. Pokkali.
      Tissue: Seedling root.
    2. "Glycine residues in potassium channel-like selectivity filters determine potassium selectivity in four-loop-per-subunit HKT transporters from plants."
      Maeser P., Hosoo Y., Goshima S., Horie T., Eckelman B., Yamada K., Yoshida K., Bakker E.P., Shinmyo A., Oiki S., Schroeder J.I., Uozumi N.
      Proc. Natl. Acad. Sci. U.S.A. 99:6428-6433(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DOMAIN, MUTAGENESIS OF GLY-88.

    Entry informationi

    Entry nameiHKT2_ORYSI
    AccessioniPrimary (citable) accession number: Q93XI5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 20, 2005
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Caution

    HKT2 is found in salt-tolerant cultivar indica Pokkali. It does not exist in cultivar indica 93-11 or japonica Nipponbare.Curated

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3