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Q93WK5

- APRR7_ARATH

UniProt

Q93WK5 - APRR7_ARATH

Protein

Two-component response regulator-like APRR7

Gene

APRR7

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Transcriptional repressor of CCA1 and LHY, and positive regulator of LWD1 and LWD2 expression. Represses the expression of other clock proteins and master regulators of plant growth, development and response to abiotic stress. Involved in the positive and negative feedback loops of the circadian clock. Controls photoperiodic flowering response and temperature compensation. Expression of several members of the ARR-like family is controlled by circadian rhythm. APRR9, APRR7, and APRR5 coordinately act on the upstream region of the target genes to repress their expression from noon until midnight. The particular coordinated sequential expression of APRR9, APRR7, APRR5, APRR3 and APPR1 result to circadian waves that may be at the basis of the endogenous circadian clock.8 Publications

    GO - Molecular functioni

    1. DNA binding Source: TAIR
    2. phosphorelay response regulator activity Source: InterPro

    GO - Biological processi

    1. circadian rhythm Source: TAIR
    2. negative regulation of transcription, DNA-templated Source: TAIR
    3. red or far-red light signaling pathway Source: TAIR
    4. regulation of transcription, DNA-templated Source: TAIR
    5. response to temperature stimulus Source: TAIR
    6. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Biological rhythms, Transcription, Transcription regulation, Two-component regulatory system

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Two-component response regulator-like APRR7
    Alternative name(s):
    Pseudo-response regulator 7
    Gene namesi
    Name:APRR7
    Ordered Locus Names:At5g02810
    ORF Names:F9G14_120
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 5

    Organism-specific databases

    TAIRiAT5G02810.

    Subcellular locationi

    Nucleus 1 PublicationPROSITE-ProRule annotation

    GO - Cellular componenti

    1. mitochondrion Source: TAIR
    2. nucleus Source: TAIR

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Disruption phenotypei

    Insensitive to the effect of sucrose on the circadian period.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 727727Two-component response regulator-like APRR7PRO_0000081439Add
    BLAST

    Post-translational modificationi

    Phosphorylated. Phosphorylation varies throughout the diurnal cycle.1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ93WK5.
    PRIDEiQ93WK5.

    Expressioni

    Inductioni

    Up-regulated by heat-shock and light at dawn, and down-regulated by the sugars produced by photosynthesis.2 Publications

    Gene expression databases

    GenevestigatoriQ93WK5.

    Interactioni

    Protein-protein interaction databases

    BioGridi17069. 9 interactions.
    STRINGi3702.AT5G02810.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliQ93WK5.
    SMRiQ93WK5. Positions 77-232.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini79 – 197119Response regulatoryPROSITE-ProRule annotationAdd
    BLAST
    Domaini669 – 71143CCTPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi202 – 25958Ser-richAdd
    BLAST
    Compositional biasi608 – 65851Gly-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ARR-like family.Curated
    Contains 1 CCT domain.PROSITE-ProRule annotation
    Contains 1 response regulatory domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG3437.
    HOGENOMiHOG000034018.
    InParanoidiQ93WK5.
    KOiK12129.
    OMAiIGAPRNS.
    PhylomeDBiQ93WK5.

    Family and domain databases

    InterProiIPR010402. CCT_domain.
    IPR011006. CheY-like_superfamily.
    IPR001789. Sig_transdc_resp-reg_receiver.
    [Graphical view]
    PfamiPF06203. CCT. 1 hit.
    PF00072. Response_reg. 1 hit.
    [Graphical view]
    SMARTiSM00448. REC. 1 hit.
    [Graphical view]
    SUPFAMiSSF52172. SSF52172. 1 hit.
    PROSITEiPS51017. CCT. 1 hit.
    PS50110. RESPONSE_REGULATORY. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q93WK5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNANEEGEGS RYPITDRKTG ETKFDRVESR TEKHSEEEKT NGITMDVRNG    50
    SSGGLQIPLS QQTAATVCWE RFLHVRTIRV LLVENDDCTR YIVTALLRNC 100
    SYEVVEASNG IQAWKVLEDL NNHIDIVLTE VIMPYLSGIG LLCKILNHKS 150
    RRNIPVIMMS SHDSMGLVFK CLSKGAVDFL VKPIRKNELK ILWQHVWRRC 200
    QSSSGSGSES GTHQTQKSVK SKSIKKSDQD SGSSDENENG SIGLNASDGS 250
    SDGSGAQSSW TKKAVDVDDS PRAVSLWDRV DSTCAQVVHS NPEFPSNQLV 300
    APPAEKETQE HDDKFEDVTM GRDLEISIRR NCDLALEPKD EPLSKTTGIM 350
    RQDNSFEKSS SKWKMKVGKG PLDLSSESPS SKQMHEDGGS SFKAMSSHLQ 400
    DNREPEAPNT HLKTLDTNEA SVKISEELMH VEHSSKRHRG TKDDGTLVRD 450
    DRNVLRRSEG SAFSRYNPAS NANKISGGNL GSTSLQDNNS QDLIKKTEAA 500
    YDCHSNMNES LPHNHRSHVG SNNFDMSSTT ENNAFTKPGA PKVSSAGSSS 550
    VKHSSFQPLP CDHHNNHASY NLVHVAERKK LPPQCGSSNV YNETIEGNNN 600
    TVNYSVNGSV SGSGHGSNGP YGSSNGMNAG GMNMGSDNGA GKNGNGDGSG 650
    SGSGSGSGNL ADENKISQRE AALTKFRQKR KERCFRKKVR YQSRKKLAEQ 700
    RPRVRGQFVR KTAAATDDND IKNIEDS 727
    Length:727
    Mass (Da):79,663
    Last modified:December 1, 2001 - v1
    Checksum:i13057E6AE6E50C00
    GO

    Sequence cautioni

    The sequence CAB86035.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB046954 mRNA. Translation: BAB13742.1.
    AL162973 Genomic DNA. Translation: CAB86035.1. Sequence problems.
    CP002688 Genomic DNA. Translation: AED90520.1.
    AY039943 mRNA. Translation: AAK64047.1.
    AY142560 mRNA. Translation: AAN13129.1.
    PIRiT48302.
    RefSeqiNP_568107.1. NM_120359.2.
    UniGeneiAt.20552.

    Genome annotation databases

    EnsemblPlantsiAT5G02810.1; AT5G02810.1; AT5G02810.
    GeneIDi831793.
    KEGGiath:AT5G02810.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB046954 mRNA. Translation: BAB13742.1 .
    AL162973 Genomic DNA. Translation: CAB86035.1 . Sequence problems.
    CP002688 Genomic DNA. Translation: AED90520.1 .
    AY039943 mRNA. Translation: AAK64047.1 .
    AY142560 mRNA. Translation: AAN13129.1 .
    PIRi T48302.
    RefSeqi NP_568107.1. NM_120359.2.
    UniGenei At.20552.

    3D structure databases

    ProteinModelPortali Q93WK5.
    SMRi Q93WK5. Positions 77-232.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 17069. 9 interactions.
    STRINGi 3702.AT5G02810.1-P.

    Proteomic databases

    PaxDbi Q93WK5.
    PRIDEi Q93WK5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT5G02810.1 ; AT5G02810.1 ; AT5G02810 .
    GeneIDi 831793.
    KEGGi ath:AT5G02810.

    Organism-specific databases

    GeneFarmi 4348. 437.
    TAIRi AT5G02810.

    Phylogenomic databases

    eggNOGi COG3437.
    HOGENOMi HOG000034018.
    InParanoidi Q93WK5.
    KOi K12129.
    OMAi IGAPRNS.
    PhylomeDBi Q93WK5.

    Gene expression databases

    Genevestigatori Q93WK5.

    Family and domain databases

    InterProi IPR010402. CCT_domain.
    IPR011006. CheY-like_superfamily.
    IPR001789. Sig_transdc_resp-reg_receiver.
    [Graphical view ]
    Pfami PF06203. CCT. 1 hit.
    PF00072. Response_reg. 1 hit.
    [Graphical view ]
    SMARTi SM00448. REC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52172. SSF52172. 1 hit.
    PROSITEi PS51017. CCT. 1 hit.
    PS50110. RESPONSE_REGULATORY. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Circadian waves of expression of the APRR1/TOC1 family of pseudo-response regulators in Arabidopsis thaliana: insight into the plant circadian clock."
      Matsushika A., Makino S., Kojima M., Mizuno T.
      Plant Cell Physiol. 41:1002-1012(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    2. "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana."
      Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E., Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.
      , Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L., O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D., Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M., Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L., Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B., Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P., Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M., Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D., Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A., Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I., Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T., Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A., McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U., Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M., Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G., Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W., Bevan M., Fransz P.F.
      Nature 408:823-826(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    3. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    5. "Genes encoding pseudo-response regulators: insight into His-to-Asp phosphorelay and circadian rhythm in Arabidopsis thaliana."
      Makino S., Kiba T., Imamura A., Hanaki N., Nakamura A., Suzuki T., Taniguchi M., Ueguchi C., Sugiyama T., Mizuno T.
      Plant Cell Physiol. 41:791-803(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY.
    6. "Arabidopsis PSEUDO-RESPONSE REGULATOR 7 is a signaling intermediate in phytochrome-regulated seedling deetiolation and phasing of the circadian clock."
      Kaczorowski K.A., Quail P.H.
      Plant Cell 15:2654-2665(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    7. "Post-translational regulation of the Arabidopsis circadian clock through selective proteolysis and phosphorylation of pseudo-response regulator proteins."
      Fujiwara S., Wang L., Han L., Suh S.-S., Salome P.A., McClung C.R., Somers D.E.
      J. Biol. Chem. 283:23073-23083(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION.
    8. "PSEUDO-RESPONSE REGULATORS 9, 7, and 5 are transcriptional repressors in the Arabidopsis circadian clock."
      Nakamichi N., Kiba T., Henriques R., Mizuno T., Chua N.H., Sakakibara H.
      Plant Cell 22:594-605(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    9. "The role of the Arabidopsis morning loop components CCA1, LHY, PRR7, and PRR9 in temperature compensation."
      Salome P.A., Weigel D., McClung C.R.
      Plant Cell 22:3650-3661(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    10. "LIGHT-REGULATED WD1 and PSEUDO-RESPONSE REGULATOR9 form a positive feedback regulatory loop in the Arabidopsis circadian clock."
      Wang Y., Wu J.F., Nakamichi N., Sakakibara H., Nam H.G., Wu S.H.
      Plant Cell 23:486-498(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    11. "SKIP is a component of the spliceosome linking alternative splicing and the circadian clock in Arabidopsis."
      Wang X., Wu F., Xie Q., Wang H., Wang Y., Yue Y., Gahura O., Ma S., Liu L., Cao Y., Jiao Y., Puta F., McClung C.R., Xu X., Ma L.
      Plant Cell 24:3278-3295(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: REGULATION.
    12. Cited for: FUNCTION.
    13. "Heat shock-induced fluctuations in clock and light signaling enhance phytochrome B-mediated Arabidopsis deetiolation."
      Karayekov E., Sellaro R., Legris M., Yanovsky M.J., Casal J.J.
      Plant Cell 25:2892-2906(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION BY HEAT-SHOCK.
    14. "Direct regulation of abiotic responses by the Arabidopsis circadian clock component PRR7."
      Liu T., Carlsson J., Takeuchi T., Newton L., Farre E.M.
      Plant J. 76:101-114(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    15. "Photosynthetic entrainment of the Arabidopsis thaliana circadian clock."
      Haydon M.J., Mielczarek O., Robertson F.C., Hubbard K.E., Webb A.A.
      Nature 502:689-692(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE, INDUCTION BY LIGHT AND SUCROSE.

    Entry informationi

    Entry nameiAPRR7_ARATH
    AccessioniPrimary (citable) accession number: Q93WK5
    Secondary accession number(s): Q9LZ04
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2004
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Regulated at the level of mRNA maturation and alternative splicing by SKIP (PubMed:22942380). The expression of APRR9, APRR7, and APRR5 requires the presence of LWD1 and/or LWD2, indicating the existence of a positive feedback loop within the circadian clock (PubMed:21357491).2 Publications

    Caution

    Lacks the phospho-accepting Asp (here Glu-130), present in the receiver domain, which is one of the conserved features of two-component response regulators (ARRs) family.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3