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Protein

Two-component response regulator-like APRR7

Gene

APRR7

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional repressor of CCA1 and LHY, and positive regulator of LWD1 and LWD2 expression. Represses the expression of other clock proteins and master regulators of plant growth, development and response to abiotic stress. Involved in the positive and negative feedback loops of the circadian clock. Controls photoperiodic flowering response and temperature compensation. Expression of several members of the ARR-like family is controlled by circadian rhythm. APRR9, APRR7, and APRR5 coordinately act on the upstream region of the target genes to repress their expression from noon until midnight. The particular coordinated sequential expression of APRR9, APRR7, APRR5, APRR3 and APPR1 result to circadian waves that may be at the basis of the endogenous circadian clock.8 Publications

GO - Molecular functioni

  • DNA binding Source: TAIR

GO - Biological processi

  • circadian rhythm Source: TAIR
  • negative regulation of transcription, DNA-templated Source: TAIR
  • phosphorelay signal transduction system Source: UniProtKB-KW
  • red or far-red light signaling pathway Source: TAIR
  • regulation of transcription, DNA-templated Source: TAIR
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Biological rhythms, Transcription, Transcription regulation, Two-component regulatory system

Names & Taxonomyi

Protein namesi
Recommended name:
Two-component response regulator-like APRR7
Alternative name(s):
Pseudo-response regulator 7
Gene namesi
Name:APRR7
Ordered Locus Names:At5g02810
ORF Names:F9G14_120
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

TAIRiAT5G02810.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation1 Publication

GO - Cellular componenti

  • mitochondrion Source: TAIR
  • nucleus Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Insensitive to the effect of sucrose on the circadian period.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000814391 – 727Two-component response regulator-like APRR7Add BLAST727

Post-translational modificationi

Phosphorylated. Phosphorylation varies throughout the diurnal cycle.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ93WK5.

PTM databases

iPTMnetiQ93WK5.

Expressioni

Inductioni

Up-regulated by heat-shock and light at dawn, and down-regulated by the sugars produced by photosynthesis.2 Publications

Gene expression databases

GenevisibleiQ93WK5. AT.

Interactioni

Protein-protein interaction databases

BioGridi17069. 9 interactors.
STRINGi3702.AT5G02810.1.

Structurei

3D structure databases

ProteinModelPortaliQ93WK5.
SMRiQ93WK5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini79 – 197Response regulatoryPROSITE-ProRule annotationAdd BLAST119
Domaini669 – 711CCTPROSITE-ProRule annotationAdd BLAST43

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi202 – 259Ser-richAdd BLAST58
Compositional biasi608 – 658Gly-richAdd BLAST51

Sequence similaritiesi

Belongs to the ARR-like family.Curated
Contains 1 CCT domain.PROSITE-ProRule annotation
Contains 1 response regulatory domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1601. Eukaryota.
COG5641. LUCA.
HOGENOMiHOG000034018.
InParanoidiQ93WK5.
KOiK12129.
OMAiHSNMNES.
OrthoDBiEOG093604MA.
PhylomeDBiQ93WK5.

Family and domain databases

InterProiIPR010402. CCT_domain.
IPR011006. CheY-like_superfamily.
IPR001789. Sig_transdc_resp-reg_receiver.
[Graphical view]
PfamiPF06203. CCT. 1 hit.
PF00072. Response_reg. 1 hit.
[Graphical view]
SMARTiSM00448. REC. 1 hit.
[Graphical view]
SUPFAMiSSF52172. SSF52172. 1 hit.
PROSITEiPS51017. CCT. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q93WK5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNANEEGEGS RYPITDRKTG ETKFDRVESR TEKHSEEEKT NGITMDVRNG
60 70 80 90 100
SSGGLQIPLS QQTAATVCWE RFLHVRTIRV LLVENDDCTR YIVTALLRNC
110 120 130 140 150
SYEVVEASNG IQAWKVLEDL NNHIDIVLTE VIMPYLSGIG LLCKILNHKS
160 170 180 190 200
RRNIPVIMMS SHDSMGLVFK CLSKGAVDFL VKPIRKNELK ILWQHVWRRC
210 220 230 240 250
QSSSGSGSES GTHQTQKSVK SKSIKKSDQD SGSSDENENG SIGLNASDGS
260 270 280 290 300
SDGSGAQSSW TKKAVDVDDS PRAVSLWDRV DSTCAQVVHS NPEFPSNQLV
310 320 330 340 350
APPAEKETQE HDDKFEDVTM GRDLEISIRR NCDLALEPKD EPLSKTTGIM
360 370 380 390 400
RQDNSFEKSS SKWKMKVGKG PLDLSSESPS SKQMHEDGGS SFKAMSSHLQ
410 420 430 440 450
DNREPEAPNT HLKTLDTNEA SVKISEELMH VEHSSKRHRG TKDDGTLVRD
460 470 480 490 500
DRNVLRRSEG SAFSRYNPAS NANKISGGNL GSTSLQDNNS QDLIKKTEAA
510 520 530 540 550
YDCHSNMNES LPHNHRSHVG SNNFDMSSTT ENNAFTKPGA PKVSSAGSSS
560 570 580 590 600
VKHSSFQPLP CDHHNNHASY NLVHVAERKK LPPQCGSSNV YNETIEGNNN
610 620 630 640 650
TVNYSVNGSV SGSGHGSNGP YGSSNGMNAG GMNMGSDNGA GKNGNGDGSG
660 670 680 690 700
SGSGSGSGNL ADENKISQRE AALTKFRQKR KERCFRKKVR YQSRKKLAEQ
710 720
RPRVRGQFVR KTAAATDDND IKNIEDS
Length:727
Mass (Da):79,663
Last modified:December 1, 2001 - v1
Checksum:i13057E6AE6E50C00
GO

Sequence cautioni

The sequence CAB86035 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046954 mRNA. Translation: BAB13742.1.
AL162973 Genomic DNA. Translation: CAB86035.1. Sequence problems.
CP002688 Genomic DNA. Translation: AED90520.1.
AY039943 mRNA. Translation: AAK64047.1.
AY142560 mRNA. Translation: AAN13129.1.
PIRiT48302.
RefSeqiNP_568107.1. NM_120359.3.
UniGeneiAt.20552.

Genome annotation databases

EnsemblPlantsiAT5G02810.1; AT5G02810.1; AT5G02810.
GeneIDi831793.
GrameneiAT5G02810.1; AT5G02810.1; AT5G02810.
KEGGiath:AT5G02810.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046954 mRNA. Translation: BAB13742.1.
AL162973 Genomic DNA. Translation: CAB86035.1. Sequence problems.
CP002688 Genomic DNA. Translation: AED90520.1.
AY039943 mRNA. Translation: AAK64047.1.
AY142560 mRNA. Translation: AAN13129.1.
PIRiT48302.
RefSeqiNP_568107.1. NM_120359.3.
UniGeneiAt.20552.

3D structure databases

ProteinModelPortaliQ93WK5.
SMRiQ93WK5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi17069. 9 interactors.
STRINGi3702.AT5G02810.1.

PTM databases

iPTMnetiQ93WK5.

Proteomic databases

PaxDbiQ93WK5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G02810.1; AT5G02810.1; AT5G02810.
GeneIDi831793.
GrameneiAT5G02810.1; AT5G02810.1; AT5G02810.
KEGGiath:AT5G02810.

Organism-specific databases

TAIRiAT5G02810.

Phylogenomic databases

eggNOGiKOG1601. Eukaryota.
COG5641. LUCA.
HOGENOMiHOG000034018.
InParanoidiQ93WK5.
KOiK12129.
OMAiHSNMNES.
OrthoDBiEOG093604MA.
PhylomeDBiQ93WK5.

Miscellaneous databases

PROiQ93WK5.

Gene expression databases

GenevisibleiQ93WK5. AT.

Family and domain databases

InterProiIPR010402. CCT_domain.
IPR011006. CheY-like_superfamily.
IPR001789. Sig_transdc_resp-reg_receiver.
[Graphical view]
PfamiPF06203. CCT. 1 hit.
PF00072. Response_reg. 1 hit.
[Graphical view]
SMARTiSM00448. REC. 1 hit.
[Graphical view]
SUPFAMiSSF52172. SSF52172. 1 hit.
PROSITEiPS51017. CCT. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAPRR7_ARATH
AccessioniPrimary (citable) accession number: Q93WK5
Secondary accession number(s): Q9LZ04
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

Regulated at the level of mRNA maturation and alternative splicing by SKIP (PubMed:22942380). The expression of APRR9, APRR7, and APRR5 requires the presence of LWD1 and/or LWD2, indicating the existence of a positive feedback loop within the circadian clock (PubMed:21357491).2 Publications

Caution

Lacks the phospho-accepting Asp (here Glu-130), present in the receiver domain, which is one of the conserved features of two-component response regulators (ARRs) family.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.