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Q93WK5

- APRR7_ARATH

UniProt

Q93WK5 - APRR7_ARATH

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Protein

Two-component response regulator-like APRR7

Gene

APRR7

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Transcriptional repressor of CCA1 and LHY, and positive regulator of LWD1 and LWD2 expression. Represses the expression of other clock proteins and master regulators of plant growth, development and response to abiotic stress. Involved in the positive and negative feedback loops of the circadian clock. Controls photoperiodic flowering response and temperature compensation. Expression of several members of the ARR-like family is controlled by circadian rhythm. APRR9, APRR7, and APRR5 coordinately act on the upstream region of the target genes to repress their expression from noon until midnight. The particular coordinated sequential expression of APRR9, APRR7, APRR5, APRR3 and APPR1 result to circadian waves that may be at the basis of the endogenous circadian clock.8 Publications

GO - Molecular functioni

  1. DNA binding Source: TAIR

GO - Biological processi

  1. circadian rhythm Source: TAIR
  2. negative regulation of transcription, DNA-templated Source: TAIR
  3. phosphorelay signal transduction system Source: UniProtKB-KW
  4. red or far-red light signaling pathway Source: TAIR
  5. regulation of transcription, DNA-templated Source: TAIR
  6. response to temperature stimulus Source: TAIR
  7. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Biological rhythms, Transcription, Transcription regulation, Two-component regulatory system

Names & Taxonomyi

Protein namesi
Recommended name:
Two-component response regulator-like APRR7
Alternative name(s):
Pseudo-response regulator 7
Gene namesi
Name:APRR7
Ordered Locus Names:At5g02810
ORF Names:F9G14_120
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 5

Organism-specific databases

TAIRiAT5G02810.

Subcellular locationi

Nucleus 1 PublicationPROSITE-ProRule annotation

GO - Cellular componenti

  1. mitochondrion Source: TAIR
  2. nucleus Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Insensitive to the effect of sucrose on the circadian period.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 727727Two-component response regulator-like APRR7PRO_0000081439Add
BLAST

Post-translational modificationi

Phosphorylated. Phosphorylation varies throughout the diurnal cycle.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ93WK5.
PRIDEiQ93WK5.

Expressioni

Inductioni

Up-regulated by heat-shock and light at dawn, and down-regulated by the sugars produced by photosynthesis.2 Publications

Gene expression databases

GenevestigatoriQ93WK5.

Interactioni

Protein-protein interaction databases

BioGridi17069. 9 interactions.
STRINGi3702.AT5G02810.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ93WK5.
SMRiQ93WK5. Positions 77-232.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini79 – 197119Response regulatoryPROSITE-ProRule annotationAdd
BLAST
Domaini669 – 71143CCTPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi202 – 25958Ser-richAdd
BLAST
Compositional biasi608 – 65851Gly-richAdd
BLAST

Sequence similaritiesi

Belongs to the ARR-like family.Curated
Contains 1 CCT domain.PROSITE-ProRule annotation
Contains 1 response regulatory domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG3437.
HOGENOMiHOG000034018.
InParanoidiQ93WK5.
KOiK12129.
OMAiIGAPRNS.
PhylomeDBiQ93WK5.

Family and domain databases

InterProiIPR010402. CCT_domain.
IPR011006. CheY-like_superfamily.
IPR001789. Sig_transdc_resp-reg_receiver.
[Graphical view]
PfamiPF06203. CCT. 1 hit.
PF00072. Response_reg. 1 hit.
[Graphical view]
SMARTiSM00448. REC. 1 hit.
[Graphical view]
SUPFAMiSSF52172. SSF52172. 1 hit.
PROSITEiPS51017. CCT. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q93WK5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNANEEGEGS RYPITDRKTG ETKFDRVESR TEKHSEEEKT NGITMDVRNG
60 70 80 90 100
SSGGLQIPLS QQTAATVCWE RFLHVRTIRV LLVENDDCTR YIVTALLRNC
110 120 130 140 150
SYEVVEASNG IQAWKVLEDL NNHIDIVLTE VIMPYLSGIG LLCKILNHKS
160 170 180 190 200
RRNIPVIMMS SHDSMGLVFK CLSKGAVDFL VKPIRKNELK ILWQHVWRRC
210 220 230 240 250
QSSSGSGSES GTHQTQKSVK SKSIKKSDQD SGSSDENENG SIGLNASDGS
260 270 280 290 300
SDGSGAQSSW TKKAVDVDDS PRAVSLWDRV DSTCAQVVHS NPEFPSNQLV
310 320 330 340 350
APPAEKETQE HDDKFEDVTM GRDLEISIRR NCDLALEPKD EPLSKTTGIM
360 370 380 390 400
RQDNSFEKSS SKWKMKVGKG PLDLSSESPS SKQMHEDGGS SFKAMSSHLQ
410 420 430 440 450
DNREPEAPNT HLKTLDTNEA SVKISEELMH VEHSSKRHRG TKDDGTLVRD
460 470 480 490 500
DRNVLRRSEG SAFSRYNPAS NANKISGGNL GSTSLQDNNS QDLIKKTEAA
510 520 530 540 550
YDCHSNMNES LPHNHRSHVG SNNFDMSSTT ENNAFTKPGA PKVSSAGSSS
560 570 580 590 600
VKHSSFQPLP CDHHNNHASY NLVHVAERKK LPPQCGSSNV YNETIEGNNN
610 620 630 640 650
TVNYSVNGSV SGSGHGSNGP YGSSNGMNAG GMNMGSDNGA GKNGNGDGSG
660 670 680 690 700
SGSGSGSGNL ADENKISQRE AALTKFRQKR KERCFRKKVR YQSRKKLAEQ
710 720
RPRVRGQFVR KTAAATDDND IKNIEDS
Length:727
Mass (Da):79,663
Last modified:December 1, 2001 - v1
Checksum:i13057E6AE6E50C00
GO

Sequence cautioni

The sequence CAB86035.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046954 mRNA. Translation: BAB13742.1.
AL162973 Genomic DNA. Translation: CAB86035.1. Sequence problems.
CP002688 Genomic DNA. Translation: AED90520.1.
AY039943 mRNA. Translation: AAK64047.1.
AY142560 mRNA. Translation: AAN13129.1.
PIRiT48302.
RefSeqiNP_568107.1. NM_120359.2.
UniGeneiAt.20552.

Genome annotation databases

EnsemblPlantsiAT5G02810.1; AT5G02810.1; AT5G02810.
GeneIDi831793.
KEGGiath:AT5G02810.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046954 mRNA. Translation: BAB13742.1 .
AL162973 Genomic DNA. Translation: CAB86035.1 . Sequence problems.
CP002688 Genomic DNA. Translation: AED90520.1 .
AY039943 mRNA. Translation: AAK64047.1 .
AY142560 mRNA. Translation: AAN13129.1 .
PIRi T48302.
RefSeqi NP_568107.1. NM_120359.2.
UniGenei At.20552.

3D structure databases

ProteinModelPortali Q93WK5.
SMRi Q93WK5. Positions 77-232.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 17069. 9 interactions.
STRINGi 3702.AT5G02810.1-P.

Proteomic databases

PaxDbi Q93WK5.
PRIDEi Q93WK5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT5G02810.1 ; AT5G02810.1 ; AT5G02810 .
GeneIDi 831793.
KEGGi ath:AT5G02810.

Organism-specific databases

GeneFarmi 4348. 437.
TAIRi AT5G02810.

Phylogenomic databases

eggNOGi COG3437.
HOGENOMi HOG000034018.
InParanoidi Q93WK5.
KOi K12129.
OMAi IGAPRNS.
PhylomeDBi Q93WK5.

Gene expression databases

Genevestigatori Q93WK5.

Family and domain databases

InterProi IPR010402. CCT_domain.
IPR011006. CheY-like_superfamily.
IPR001789. Sig_transdc_resp-reg_receiver.
[Graphical view ]
Pfami PF06203. CCT. 1 hit.
PF00072. Response_reg. 1 hit.
[Graphical view ]
SMARTi SM00448. REC. 1 hit.
[Graphical view ]
SUPFAMi SSF52172. SSF52172. 1 hit.
PROSITEi PS51017. CCT. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Circadian waves of expression of the APRR1/TOC1 family of pseudo-response regulators in Arabidopsis thaliana: insight into the plant circadian clock."
    Matsushika A., Makino S., Kojima M., Mizuno T.
    Plant Cell Physiol. 41:1002-1012(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
  2. "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana."
    Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E., Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.
    , Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L., O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D., Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M., Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L., Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B., Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P., Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M., Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D., Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A., Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I., Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T., Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A., McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U., Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M., Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G., Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W., Bevan M., Fransz P.F.
    Nature 408:823-826(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "Genes encoding pseudo-response regulators: insight into His-to-Asp phosphorelay and circadian rhythm in Arabidopsis thaliana."
    Makino S., Kiba T., Imamura A., Hanaki N., Nakamura A., Suzuki T., Taniguchi M., Ueguchi C., Sugiyama T., Mizuno T.
    Plant Cell Physiol. 41:791-803(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY.
  6. "Arabidopsis PSEUDO-RESPONSE REGULATOR 7 is a signaling intermediate in phytochrome-regulated seedling deetiolation and phasing of the circadian clock."
    Kaczorowski K.A., Quail P.H.
    Plant Cell 15:2654-2665(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  7. "Post-translational regulation of the Arabidopsis circadian clock through selective proteolysis and phosphorylation of pseudo-response regulator proteins."
    Fujiwara S., Wang L., Han L., Suh S.-S., Salome P.A., McClung C.R., Somers D.E.
    J. Biol. Chem. 283:23073-23083(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION.
  8. "PSEUDO-RESPONSE REGULATORS 9, 7, and 5 are transcriptional repressors in the Arabidopsis circadian clock."
    Nakamichi N., Kiba T., Henriques R., Mizuno T., Chua N.H., Sakakibara H.
    Plant Cell 22:594-605(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  9. "The role of the Arabidopsis morning loop components CCA1, LHY, PRR7, and PRR9 in temperature compensation."
    Salome P.A., Weigel D., McClung C.R.
    Plant Cell 22:3650-3661(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  10. "LIGHT-REGULATED WD1 and PSEUDO-RESPONSE REGULATOR9 form a positive feedback regulatory loop in the Arabidopsis circadian clock."
    Wang Y., Wu J.F., Nakamichi N., Sakakibara H., Nam H.G., Wu S.H.
    Plant Cell 23:486-498(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  11. "SKIP is a component of the spliceosome linking alternative splicing and the circadian clock in Arabidopsis."
    Wang X., Wu F., Xie Q., Wang H., Wang Y., Yue Y., Gahura O., Ma S., Liu L., Cao Y., Jiao Y., Puta F., McClung C.R., Xu X., Ma L.
    Plant Cell 24:3278-3295(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: REGULATION.
  12. Cited for: FUNCTION.
  13. "Heat shock-induced fluctuations in clock and light signaling enhance phytochrome B-mediated Arabidopsis deetiolation."
    Karayekov E., Sellaro R., Legris M., Yanovsky M.J., Casal J.J.
    Plant Cell 25:2892-2906(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION BY HEAT-SHOCK.
  14. "Direct regulation of abiotic responses by the Arabidopsis circadian clock component PRR7."
    Liu T., Carlsson J., Takeuchi T., Newton L., Farre E.M.
    Plant J. 76:101-114(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  15. "Photosynthetic entrainment of the Arabidopsis thaliana circadian clock."
    Haydon M.J., Mielczarek O., Robertson F.C., Hubbard K.E., Webb A.A.
    Nature 502:689-692(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE, INDUCTION BY LIGHT AND SUCROSE.

Entry informationi

Entry nameiAPRR7_ARATH
AccessioniPrimary (citable) accession number: Q93WK5
Secondary accession number(s): Q9LZ04
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

Regulated at the level of mRNA maturation and alternative splicing by SKIP (PubMed:22942380). The expression of APRR9, APRR7, and APRR5 requires the presence of LWD1 and/or LWD2, indicating the existence of a positive feedback loop within the circadian clock (PubMed:21357491).2 Publications

Caution

Lacks the phospho-accepting Asp (here Glu-130), present in the receiver domain, which is one of the conserved features of two-component response regulators (ARRs) family.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3