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Protein
Submitted name:

Protease

Gene

PROF

Organism
Bacillus sp. KSM-KP43
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi392 – 3921Calcium 1Combined sources
Metal bindingi400 – 4001Calcium 1; via carbonyl oxygenCombined sources
Metal bindingi403 – 4031Calcium 1Combined sources
Metal bindingi407 – 4071Calcium 1; via pros nitrogenCombined sources
Metal bindingi573 – 5731Calcium 2Combined sources
Metal bindingi574 – 5741Calcium 2; via carbonyl oxygenCombined sources
Metal bindingi575 – 5751Calcium 2Combined sources
Metal bindingi590 – 5901Calcium 3Combined sources
Metal bindingi592 – 5921Calcium 3Combined sources
Metal bindingi594 – 5941Calcium 3; via carbonyl oxygenCombined sources
Metal bindingi597 – 5971Calcium 3Combined sources
Metal bindingi598 – 5981Calcium 3Combined sources
Metal bindingi600 – 6001Calcium 2; via carbonyl oxygenCombined sources
Metal bindingi606 – 6061Calcium 2Combined sources

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, ProteaseImported

Keywords - Ligandi

CalciumCombined sources, Metal-bindingCombined sources

Protein family/group databases

MEROPSiS08.123.

Names & Taxonomyi

Protein namesi
Submitted name:
ProteaseImported
Gene namesi
Name:PROFImported
OrganismiBacillus sp. KSM-KP43Imported
Taxonomic identifieri109322 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030Sequence analysisAdd
BLAST
Chaini31 – 640610Sequence analysisPRO_5004319800Add
BLAST

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WMDX-ray1.30A207-640[»]
1WMEX-ray1.50A207-640[»]
1WMFX-ray1.73A207-640[»]
ProteinModelPortaliQ93UV9.
SMRiQ93UV9. Positions 207-640.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ93UV9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini227 – 514288Peptidase S8InterPro annotationAdd
BLAST
Domaini540 – 62384PPCInterPro annotationAdd
BLAST

Keywords - Domaini

SignalSequence analysis

Family and domain databases

Gene3Di3.40.50.200. 1 hit.
InterProiIPR008979. Galactose-bd-like.
IPR007280. Peptidase_C_arc/bac.
IPR000209. Peptidase_S8/S53_dom.
IPR022398. Peptidase_S8_His-AS.
IPR023828. Peptidase_S8_Ser-AS.
IPR015500. Peptidase_S8_subtilisin-rel.
[Graphical view]
PANTHERiPTHR10795. PTHR10795. 1 hit.
PfamiPF00082. Peptidase_S8. 1 hit.
PF04151. PPC. 1 hit.
[Graphical view]
PRINTSiPR00723. SUBTILISIN.
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF52743. SSF52743. 1 hit.
PROSITEiPS00137. SUBTILASE_HIS. 1 hit.
PS00138. SUBTILASE_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q93UV9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKKKKVFLS VLSAAAILST VALSNPSAGG ARNFDLDFKG IQTTTDAKGF
60 70 80 90 100
SKQGQTGAAA FLVESENVKL PKGLQKKLET VPANNKLHII QFNGPILEET
110 120 130 140 150
KQQLEKTGAK ILDYIPDYAY IVEYEGDVKS ATSTIEHVES VEPYLPIYRI
160 170 180 190 200
DPQLFTKGAS ELVKAVALDT KQKNKEVQLR GIEQIAQFAI SNDVLYITAK
210 220 230 240 250
PEYKVMNDVA RGIVKADVAQ SSYGLYGQGQ IVAVADTGLD TGRNDSSMHE
260 270 280 290 300
AFRGKITALY ALGRTNNAND TNGHGTHVAG SVLGNGSTNK GMAPQANLVF
310 320 330 340 350
QSIMDSGGGL GGLPSNLQTL FSQAYSAGAR IHTNSWGAAV NGAYTTDSRN
360 370 380 390 400
VDDYVRKNDM TILFAAGNEG PNGGTISAPG TAKNAITVGA TENLRPSFGS
410 420 430 440 450
YADNINHVAQ FSSRGPTKDG RIKPDVMAPG TFILSARSSL APDSSFWANH
460 470 480 490 500
DSKYAYMGGT SMATPIVAGN VAQLREHFVK NRGITPKPSL LKAALIAGAA
510 520 530 540 550
DIGLGYPNGN QGWGRVTLDK SLNVAYVNES SSLSTSQKAT YSFTATAGKP
560 570 580 590 600
LKISLVWSDA PASTTASVTL VNDLDLVITA PNGTQYVGND FTSPYNDNWD
610 620 630 640
GRNNVENVFI NAPQSGTYTI EVQAYNVPVG PQTFSLAIVN
Length:640
Mass (Da):67,991
Last modified:October 1, 2002 - v2
Checksum:i4BBAF77E9D592C15
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051423 Genomic DNA. Translation: BAB55674.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051423 Genomic DNA. Translation: BAB55674.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WMDX-ray1.30A207-640[»]
1WMEX-ray1.50A207-640[»]
1WMFX-ray1.73A207-640[»]
ProteinModelPortaliQ93UV9.
SMRiQ93UV9. Positions 207-640.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiS08.123.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiQ93UV9.

Family and domain databases

Gene3Di3.40.50.200. 1 hit.
InterProiIPR008979. Galactose-bd-like.
IPR007280. Peptidase_C_arc/bac.
IPR000209. Peptidase_S8/S53_dom.
IPR022398. Peptidase_S8_His-AS.
IPR023828. Peptidase_S8_Ser-AS.
IPR015500. Peptidase_S8_subtilisin-rel.
[Graphical view]
PANTHERiPTHR10795. PTHR10795. 1 hit.
PfamiPF00082. Peptidase_S8. 1 hit.
PF04151. PPC. 1 hit.
[Graphical view]
PRINTSiPR00723. SUBTILISIN.
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF52743. SSF52743. 1 hit.
PROSITEiPS00137. SUBTILASE_HIS. 1 hit.
PS00138. SUBTILASE_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "new protease."
    Itoh S., Saeki K.
    Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: KP43Imported.
  2. "The crystal structure of an oxidatively stable subtilisin-like alkaline serine protease, KP-43, with a C-terminal beta-barrel domain."
    Nonaka T., Fujihashi M., Kita A., Saeki K., Ito S., Horikoshi K., Miki K.
    J. Biol. Chem. 279:47344-47351(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.30 ANGSTROMS) OF 207-640 IN COMPLEX WITH CALCIUM.

Entry informationi

Entry nameiQ93UV9_9BACI
AccessioniPrimary (citable) accession number: Q93UV9
Entry historyi
Integrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: October 1, 2002
Last modified: March 16, 2016
This is version 69 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.