Q93TG4 (TOLB_BRUME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein TolB

Gene names

Name:	tolB
Ordered Locus Names:	BMEI0339

Organism

Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094) [Complete proteome] [HAMAP]

Taxonomic identifier

224914 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella › Brucella melitensis › Brucella melitensis bv. 1

Protein attributes

Sequence length	443 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the TonB-independent uptake of proteins By similarity. HAMAP-Rule MF_00671
Subcellular location	Periplasm Potential HAMAP-Rule MF_00671.
Sequence similarities	Belongs to the TolB family.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Periplasm
Domain	Signal
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	protein import Inferred from electronic annotation. Source: HAMAP
Cellular_component	periplasmic space Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 33	33	Potential
	Chain	34 – 443	410	Protein TolB HAMAP-Rule MF_00671		PRO_0000034630

Sequences

	Sequence		Length	Mass (Da)
	Q93TG4 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 327A09043D974762	FASTA	443	48,501
	10 20 30 40 50 60 MKIGIINTKI RTVFSAFACM IAASLVCTMP ARAVVEININ KGVIEPLPIA ITDFLSADQL 70 80 90 100 110 120 GSNITSVIAA DLERSGLFAP IDTGAFIEKI SNPDAAPRFE DWKVINAQAL VTGRITKQPD 130 140 150 160 170 180 GRLKAEFRLW DTFGGQQMIG QQFFTTPDNW RRVAHIIADA IYERLTGDKG YFDTRVVFVD 190 200 210 220 230 240 ESGPAQKRVK RLAIMDQDGA NVRFISDGRA LSLTPRFSPN RQEVTYMSFE GGSPKVYLLQ 250 260 270 280 290 300 LETGQRELVG NFPGMTIAPR FSPDGQKVVM SLLQDDGSAN IYTMDLRNRT TTRLTSSQAI 310 320 330 340 350 360 DTGASYSPDG SQIVFTSDRG GRPQLYVMGA DGSNPRRISM GDGSYSTPVW SPRGDLIAFT 370 380 390 400 410 420 KQSQGQFSIG VMKTDGSGER LLTSGFHNEG PTWAPNGRVL MFFRKAAGAG GPKLFTIDLT 430 440 GRNERQIQTP NFASDPAWSP LLE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The tol-pal region in Brucella encodes homologs of the Tol-Pal system of E. coli." Tibor A., Aidant N., Letesson J.-J. Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 16M / ATCC 23456 / NCTC 10094.
[2]	"The genome sequence of the facultative intracellular pathogen Brucella melitensis." DelVecchio V.G., Kapatral V., Redkar R.J., Patra G., Mujer C., Los T., Ivanova N., Anderson I., Bhattacharyya A., Lykidis A., Reznik G., Jablonski L., Larsen N., D'Souza M., Bernal A., Mazur M., Goltsman E., Selkov E. , Elzer P.H., Hagius S., O'Callaghan D., Letesson J.-J., Haselkorn R., Kyrpides N.C., Overbeek R. Proc. Natl. Acad. Sci. U.S.A. 99:443-448(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 16M / ATCC 23456 / NCTC 10094.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF358662 Genomic DNA. Translation: AAK48918.1. AE008917 Genomic DNA. Translation: AAL51520.1.
PIR	AE3294.
RefSeq	NP_539256.1. NC_003317.1.
3D structure databases
ProteinModelPortal	Q93TG4.
ModBase	Search...
Protein-protein interaction databases
STRING	224914.BMEI0339.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAL51520; AAL51520; BMEI0339.
GeneID	1196050.
KEGG	bme:BMEI0339.
PATRIC	17802329. VBIBruMel146950_3481.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HOG000004097.
KO	K03641.
OMA	VREPSWG.
ProtClustDB	PRK05137.
Family and domain databases
Gene3D	2.130.10.10. 1 hit. 3.40.50.10070. 1 hit.
HAMAP	MF_00671. TolB.
InterPro	IPR011659. PD40. IPR014167. Tol-Pal_propeller_TolB. IPR007195. TolB_N. IPR015943. WD40/YVTN_repeat-like_dom. [Graphical view]
Pfam	PF07676. PD40. 4 hits. PF04052. TolB_N. 1 hit. [Graphical view]
SUPFAM	SSF52964. TolB_N. 1 hit.
TIGRFAMs	TIGR02800. propeller_TolB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TOLB_BRUME

Accession

Primary (citable) accession number: Q93TG4

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2003
Last sequence update:	December 1, 2001
Last modified:	May 1, 2013
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program