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Q93T81

- URE11_BRUAB

UniProt

Q93T81 - URE11_BRUAB

Protein

Urease subunit alpha 1

Gene

ureC1

Organism
Brucella abortus biovar 1 (strain 9-941)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Urea + H2O = CO2 + 2 NH3.UniRule annotation

    Cofactori

    Binds 2 nickel ions per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi136 – 1361Nickel 1; via tele nitrogenUniRule annotation
    Metal bindingi138 – 1381Nickel 1; via tele nitrogenUniRule annotation
    Metal bindingi219 – 2191Nickel 1; via carbamate groupUniRule annotation
    Metal bindingi219 – 2191Nickel 2; via carbamate groupUniRule annotation
    Binding sitei221 – 2211SubstrateUniRule annotation
    Metal bindingi248 – 2481Nickel 2; via pros nitrogenUniRule annotation
    Metal bindingi274 – 2741Nickel 2; via tele nitrogenUniRule annotation
    Active sitei322 – 3221Proton donorUniRule annotation
    Metal bindingi362 – 3621Nickel 1UniRule annotation

    GO - Molecular functioni

    1. nickel cation binding Source: UniProtKB-HAMAP
    2. urease activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. urea catabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    Metal-binding, Nickel

    Enzyme and pathway databases

    BioCyciBABO262698:GJC2-301-MONOMER.
    UniPathwayiUPA00258; UER00370.

    Protein family/group databases

    MEROPSiM38.982.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Urease subunit alpha 1UniRule annotation (EC:3.5.1.5UniRule annotation)
    Alternative name(s):
    Urea amidohydrolase subunit alpha 1UniRule annotation
    Gene namesi
    Name:ureC1UniRule annotation
    Ordered Locus Names:BruAb1_0296
    OrganismiBrucella abortus biovar 1 (strain 9-941)
    Taxonomic identifieri262698 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000540: Chromosome I

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 570570Urease subunit alpha 1PRO_0000234139Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei219 – 2191N6-carboxylysineUniRule annotation

    Post-translational modificationi

    Carbamylation allows a single lysine to coordinate two nickel ions.UniRule annotation

    Interactioni

    Subunit structurei

    Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.UniRule annotation

    Protein-protein interaction databases

    STRINGi262698.BruAb1_0296.

    Structurei

    3D structure databases

    ProteinModelPortaliQ93T81.
    SMRiQ93T81. Positions 3-570.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini131 – 570440UreaseUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the urease family.UniRule annotation
    Contains 1 urease domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0804.
    HOGENOMiHOG000075064.
    KOiK01428.
    OMAiIRITEDW.
    OrthoDBiEOG6ND0GM.

    Family and domain databases

    Gene3Di2.30.40.10. 1 hit.
    HAMAPiMF_01953. Urease_alpha.
    InterProiIPR006680. Amidohydro_1.
    IPR011059. Metal-dep_hydrolase_composite.
    IPR011612. Urease_alpha_N_dom.
    IPR017950. Urease_AS.
    IPR005848. Urease_asu.
    IPR017951. Urease_asu_c.
    [Graphical view]
    PfamiPF01979. Amidohydro_1. 1 hit.
    PF00449. Urease_alpha. 1 hit.
    [Graphical view]
    PRINTSiPR01752. UREASE.
    SUPFAMiSSF51338. SSF51338. 2 hits.
    TIGRFAMsiTIGR01792. urease_alph. 1 hit.
    PROSITEiPS01120. UREASE_1. 1 hit.
    PS00145. UREASE_2. 1 hit.
    PS51368. UREASE_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q93T81-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPARISRATY AQMFGPTVGD KVRLADTDLI IEVERDLTTY GEEVKFGGGK    50
    VIRDGMGQSQ LSRAEGAMDT VITNALILDH SGIYKADIGL LDGRIALIGK 100
    AGNPDTQPGI SIIIGPGTEI IAGEGKIVTA GGIDTHVHFI SPQQVDEALN 150
    AGITCMVGGG TGPAHGTLAT TCTPGPWHIA RLIQSFDGLP MNIGVFGKGN 200
    ASLPGALEEM VRAGACGLKL HEDWGCTPAA IDNCLSVADH FDVQVAIHTD 250
    TLNEGGFVED TLNAFKGRTI HSFHTEGAGG GHAPDIIRVC QYPNVLPAST 300
    NPTRPYTVNT IAEHLDMLMV CHHLSPAIPE DIAFAESRIR KETIAAEDIL 350
    HDMGAFSIIS SDSQAMGRVG EMIIRCWQTA DKMKKQRGSL PDDRPGNDNY 400
    RARRYIAKYT INPAIAHGMA HEIGSVEVGK RADLVLWNPA FFGVKPDMVL 450
    LGGWIATAPM GDANGSIPTP QPMHTRPMFG SFGKALTNTS ITFVSQAAMD 500
    EGLREKIGVD KQLVAVVNTR GGIGKHSMIL NNAMPQMEVD PETYEVRADG 550
    ELLTCEPVDV VPMAQRYFLF 570
    Length:570
    Mass (Da):61,011
    Last modified:December 1, 2001 - v1
    Checksum:i648464AD7EDBB7EC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017223 Genomic DNA. Translation: AAX73699.1.
    RefSeqiYP_221060.1. NC_006932.1.

    Genome annotation databases

    EnsemblBacteriaiAAX73699; AAX73699; BruAb1_0296.
    GeneIDi3340771.
    KEGGibmb:BruAb1_0296.
    PATRICi17822172. VBIBruAbo15061_0324.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017223 Genomic DNA. Translation: AAX73699.1 .
    RefSeqi YP_221060.1. NC_006932.1.

    3D structure databases

    ProteinModelPortali Q93T81.
    SMRi Q93T81. Positions 3-570.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 262698.BruAb1_0296.

    Protein family/group databases

    MEROPSi M38.982.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAX73699 ; AAX73699 ; BruAb1_0296 .
    GeneIDi 3340771.
    KEGGi bmb:BruAb1_0296.
    PATRICi 17822172. VBIBruAbo15061_0324.

    Phylogenomic databases

    eggNOGi COG0804.
    HOGENOMi HOG000075064.
    KOi K01428.
    OMAi IRITEDW.
    OrthoDBi EOG6ND0GM.

    Enzyme and pathway databases

    UniPathwayi UPA00258 ; UER00370 .
    BioCyci BABO262698:GJC2-301-MONOMER.

    Family and domain databases

    Gene3Di 2.30.40.10. 1 hit.
    HAMAPi MF_01953. Urease_alpha.
    InterProi IPR006680. Amidohydro_1.
    IPR011059. Metal-dep_hydrolase_composite.
    IPR011612. Urease_alpha_N_dom.
    IPR017950. Urease_AS.
    IPR005848. Urease_asu.
    IPR017951. Urease_asu_c.
    [Graphical view ]
    Pfami PF01979. Amidohydro_1. 1 hit.
    PF00449. Urease_alpha. 1 hit.
    [Graphical view ]
    PRINTSi PR01752. UREASE.
    SUPFAMi SSF51338. SSF51338. 2 hits.
    TIGRFAMsi TIGR01792. urease_alph. 1 hit.
    PROSITEi PS01120. UREASE_1. 1 hit.
    PS00145. UREASE_2. 1 hit.
    PS51368. UREASE_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
      Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
      J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 9-941.

    Entry informationi

    Entry nameiURE11_BRUAB
    AccessioniPrimary (citable) accession number: Q93T81
    Secondary accession number(s): Q57F85
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 2, 2006
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Brucella abortus strain 9-941
      Brucella abortus (strain 9-941): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3