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Q93T81

- URE11_BRUAB

UniProt

Q93T81 - URE11_BRUAB

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Protein

Urease subunit alpha 1

Gene

ureC1

Organism
Brucella abortus biovar 1 (strain 9-941)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Urea + H2O = CO2 + 2 NH3.UniRule annotation

Cofactori

Binds 2 nickel ions per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi136 – 1361Nickel 1; via tele nitrogenUniRule annotation
Metal bindingi138 – 1381Nickel 1; via tele nitrogenUniRule annotation
Metal bindingi219 – 2191Nickel 1; via carbamate groupUniRule annotation
Metal bindingi219 – 2191Nickel 2; via carbamate groupUniRule annotation
Binding sitei221 – 2211SubstrateUniRule annotation
Metal bindingi248 – 2481Nickel 2; via pros nitrogenUniRule annotation
Metal bindingi274 – 2741Nickel 2; via tele nitrogenUniRule annotation
Active sitei322 – 3221Proton donorUniRule annotation
Metal bindingi362 – 3621Nickel 1UniRule annotation

GO - Molecular functioni

  1. nickel cation binding Source: UniProtKB-HAMAP
  2. urease activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. urea catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Metal-binding, Nickel

Enzyme and pathway databases

BioCyciBABO262698:GJC2-301-MONOMER.
UniPathwayiUPA00258; UER00370.

Names & Taxonomyi

Protein namesi
Recommended name:
Urease subunit alpha 1UniRule annotation (EC:3.5.1.5UniRule annotation)
Alternative name(s):
Urea amidohydrolase subunit alpha 1UniRule annotation
Gene namesi
Name:ureC1UniRule annotation
Ordered Locus Names:BruAb1_0296
OrganismiBrucella abortus biovar 1 (strain 9-941)
Taxonomic identifieri262698 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000540: Chromosome I

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 570570Urease subunit alpha 1PRO_0000234139Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei219 – 2191N6-carboxylysineUniRule annotation

Post-translational modificationi

Carbamylation allows a single lysine to coordinate two nickel ions.UniRule annotation

Interactioni

Subunit structurei

Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.UniRule annotation

Protein-protein interaction databases

STRINGi262698.BruAb1_0296.

Structurei

3D structure databases

ProteinModelPortaliQ93T81.
SMRiQ93T81. Positions 3-570.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini131 – 570440UreaseUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the urease family.UniRule annotation
Contains 1 urease domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG0804.
HOGENOMiHOG000075064.
KOiK01428.
OMAiIRITEDW.
OrthoDBiEOG6ND0GM.

Family and domain databases

Gene3Di2.30.40.10. 1 hit.
HAMAPiMF_01953. Urease_alpha.
InterProiIPR006680. Amidohydro_1.
IPR011059. Metal-dep_hydrolase_composite.
IPR011612. Urease_alpha_N_dom.
IPR017950. Urease_AS.
IPR005848. Urease_asu.
IPR017951. Urease_asu_c.
IPR029754. Urease_Ni-bd.
[Graphical view]
PfamiPF01979. Amidohydro_1. 1 hit.
PF00449. Urease_alpha. 1 hit.
[Graphical view]
PRINTSiPR01752. UREASE.
SUPFAMiSSF51338. SSF51338. 2 hits.
TIGRFAMsiTIGR01792. urease_alph. 1 hit.
PROSITEiPS01120. UREASE_1. 1 hit.
PS00145. UREASE_2. 1 hit.
PS51368. UREASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q93T81-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPARISRATY AQMFGPTVGD KVRLADTDLI IEVERDLTTY GEEVKFGGGK
60 70 80 90 100
VIRDGMGQSQ LSRAEGAMDT VITNALILDH SGIYKADIGL LDGRIALIGK
110 120 130 140 150
AGNPDTQPGI SIIIGPGTEI IAGEGKIVTA GGIDTHVHFI SPQQVDEALN
160 170 180 190 200
AGITCMVGGG TGPAHGTLAT TCTPGPWHIA RLIQSFDGLP MNIGVFGKGN
210 220 230 240 250
ASLPGALEEM VRAGACGLKL HEDWGCTPAA IDNCLSVADH FDVQVAIHTD
260 270 280 290 300
TLNEGGFVED TLNAFKGRTI HSFHTEGAGG GHAPDIIRVC QYPNVLPAST
310 320 330 340 350
NPTRPYTVNT IAEHLDMLMV CHHLSPAIPE DIAFAESRIR KETIAAEDIL
360 370 380 390 400
HDMGAFSIIS SDSQAMGRVG EMIIRCWQTA DKMKKQRGSL PDDRPGNDNY
410 420 430 440 450
RARRYIAKYT INPAIAHGMA HEIGSVEVGK RADLVLWNPA FFGVKPDMVL
460 470 480 490 500
LGGWIATAPM GDANGSIPTP QPMHTRPMFG SFGKALTNTS ITFVSQAAMD
510 520 530 540 550
EGLREKIGVD KQLVAVVNTR GGIGKHSMIL NNAMPQMEVD PETYEVRADG
560 570
ELLTCEPVDV VPMAQRYFLF
Length:570
Mass (Da):61,011
Last modified:December 1, 2001 - v1
Checksum:i648464AD7EDBB7EC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017223 Genomic DNA. Translation: AAX73699.1.
RefSeqiYP_221060.1. NC_006932.1.

Genome annotation databases

EnsemblBacteriaiAAX73699; AAX73699; BruAb1_0296.
GeneIDi3340771.
KEGGibmb:BruAb1_0296.
PATRICi17822172. VBIBruAbo15061_0324.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017223 Genomic DNA. Translation: AAX73699.1 .
RefSeqi YP_221060.1. NC_006932.1.

3D structure databases

ProteinModelPortali Q93T81.
SMRi Q93T81. Positions 3-570.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 262698.BruAb1_0296.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAX73699 ; AAX73699 ; BruAb1_0296 .
GeneIDi 3340771.
KEGGi bmb:BruAb1_0296.
PATRICi 17822172. VBIBruAbo15061_0324.

Phylogenomic databases

eggNOGi COG0804.
HOGENOMi HOG000075064.
KOi K01428.
OMAi IRITEDW.
OrthoDBi EOG6ND0GM.

Enzyme and pathway databases

UniPathwayi UPA00258 ; UER00370 .
BioCyci BABO262698:GJC2-301-MONOMER.

Family and domain databases

Gene3Di 2.30.40.10. 1 hit.
HAMAPi MF_01953. Urease_alpha.
InterProi IPR006680. Amidohydro_1.
IPR011059. Metal-dep_hydrolase_composite.
IPR011612. Urease_alpha_N_dom.
IPR017950. Urease_AS.
IPR005848. Urease_asu.
IPR017951. Urease_asu_c.
IPR029754. Urease_Ni-bd.
[Graphical view ]
Pfami PF01979. Amidohydro_1. 1 hit.
PF00449. Urease_alpha. 1 hit.
[Graphical view ]
PRINTSi PR01752. UREASE.
SUPFAMi SSF51338. SSF51338. 2 hits.
TIGRFAMsi TIGR01792. urease_alph. 1 hit.
PROSITEi PS01120. UREASE_1. 1 hit.
PS00145. UREASE_2. 1 hit.
PS51368. UREASE_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
    Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
    J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 9-941.

Entry informationi

Entry nameiURE11_BRUAB
AccessioniPrimary (citable) accession number: Q93T81
Secondary accession number(s): Q57F85
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella abortus strain 9-941
    Brucella abortus (strain 9-941): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3