Q93T42 (Q93T42_BACAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Beta-lactamase EMBL AAT31618.2
EC=3.5.2.6 EMBL AAT31618.2

Submitted name:
Beta-lactamase Bla1 EMBL AAP26365.1
Submitted name:
Beta-lactamase I EMBL AAK53749.2

Gene names

Name:	bla1 EMBL AAK53749.2
Ordered Locus Names:	BA_2507 EMBL AAP26365.1, GBAA_2507 EMBL AAT31618.2

Organism

Bacillus anthracis [Reference proteome] [HAMAP] EMBL AAK53749.2

Taxonomic identifier

1392 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	309 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity

A beta-lactam + H2O = a substituted beta-amino acid. SAAS SAAS000871

Ontologies

Keywords
Biological process	Antibiotic resistance SAAS SAAS000871
Molecular function	Hydrolase SAAS SAAS000871 EMBL AAT31618.2
Technical term	3D-structure PDB 3QHY Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	beta-lactam antibiotic catabolic process Inferred from electronic annotation. Source: InterPro response to antibiotic Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	beta-lactamase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q93T42 [UniParc]. Last modified October 1, 2002. Version 2. Checksum: C5EF493FE49100F8	FASTA	309	33,679
	10 20 30 40 50 60 MIVLKNKKML KIGMCVGILG LSITSLVTFT GGALQVEAKE KTGQVKHKNQ ATHKEFSQLE 70 80 90 100 110 120 KKFDARLGVY AIDTGTNQTI AYRPNERFAF ASTYKALAAG VLLQQNSTKK LDEVITYTKE 130 140 150 160 170 180 DLVDYSPVTE KHVDTGMTLG EIAEAAVRYS DNTAGNILFH KIGGPKGYEK ALRQMGDRVT 190 200 210 220 230 240 MSDRFETELN EAIPGDIRDT STAKAIATNL KAFTAGNALP NHKRNILTKW MKGNATGDKL 250 260 270 280 290 300 IRAGVPTNWV VADKSGAGSY GTRNDIAIVW PPNRAPIIIA ILSSKDEKGA TYDNQLIAEA AEVIVNAFR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Beta-lactamase genes of the penicillin-susceptible Bacillus anthracis Sterne strain." Chen Y., Succi J., Tenover F.C., Koehler T.M. J. Bacteriol. 185:823-830(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	"The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria." Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J. , Brinkac L.M., Gwinn M.L., DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C., Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y., Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M., Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E., White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M., Hanna P.C., Kolstoe A.-B., Fraser C.M. Nature 423:81-86(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Ames EMBL AAP26365.1 and Ames / isolate Porton.
[3]	"Beta-lactamase gene expression in a penicillin-resistant Bacillus anthracis strain." Chen Y., Tenover F.C., Koehler T.M. Antimicrob. Agents Chemother. 48:4873-4877(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: UT223 EMBL AAR20595.1.
[4]	"The complete genome sequence of Bacillus anthracis Ames "Ancestor"." Ravel J., Jiang L., Stanley S.T., Wilson M.R., Decker R.S., Read T.D., Worsham P., Keim P.S., Salzberg S.L., Fraser-Liggett C.M., Rasko D.A. J. Bacteriol. 191:445-446(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Ames ancestor and Ames Ancestor EMBL AAT31618.2.
[5]	Joardar V., Shrivastava S., Brinkac L.M., Harkins D.M., Durkin A.S., Sutton G. Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Ames EMBL AAP26365.1.
[6]	"Analysis of the binding forces driving the tight interactions between beta-lactamase inhibitory protein-II (BLIP-II) and class A beta-lactamases." Brown N.G., Chow D.C., Sankaran B., Zwart P., Prasad B.V., Palzkill T. J. Biol. Chem. 286:32723-32735(2011) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.06 ANGSTROMS) OF 39-309.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF367983 Genomic DNA. Translation: AAK53749.2.
AE016879 Genomic DNA. Translation: AAP26365.1.
AY453161 Genomic DNA. Translation: AAR20595.1.
AE017334 Genomic DNA. Translation: AAT31618.2.

RefSeq

NP_844879.1. NC_003997.3.
YP_019143.2. NC_007530.2.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3QHY	X-ray	2.06	A	39-309	[»]

SMR

Q93T42. Positions 55-308.

ModBase

Search...

Protein-protein interaction databases

STRING

198094.BA_2507.

Protocols and materials databases

DNASU

1084799.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblBacteria

AAP26365; AAP26365; BA_2507.
AAT31618; AAT31618; GBAA_2507.

GeneID

1084799.
2816644.

KEGG

ban:BA_2507.
bar:GBAA_2507.

PATRIC

18782608. VBIBacAnt69550_2479.

Phylogenomic databases

HOGENOM

HOG000201073.

KO

K01467.

OMA

DLVNYSP.

ProtClustDB

CLSK887392.

Enzyme and pathway databases

BioCyc

BANT261594:GJ7F-2484-MONOMER.

Family and domain databases

Gene3D

3.40.710.10. 1 hit.

InterPro

IPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view]

PRINTS

PR00118. BLACTAMASEA.

SUPFAM

SSF56601. PBP_transp_fold. 1 hit.

PROSITE

PS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChEMBL

CHEMBL5751.

EvolutionaryTrace

Q93T42.

Entry information

Entry name

Q93T42_BACAN

Accession

Primary (citable) accession number: Q93T42
Secondary accession number(s): E9QWB8 , E9QWB9, Q6KSK0, Q81QC2

Entry history

Integrated into UniProtKB/TrEMBL:	December 1, 2001
Last sequence update:	October 1, 2002
Last modified:	May 1, 2013
This is version 88 of the entry and version 2 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)