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Protein

Arginine--tRNA ligase

Gene

argS

Organism
Thermus thermophilus
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetaseUniRule annotationImported, Ligase
Biological processProtein biosynthesisUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BRENDAi6.1.1.19 2305

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine--tRNA ligaseUniRule annotation (EC:6.1.1.19UniRule annotation)
Alternative name(s):
Arginyl-tRNA synthetaseUniRule annotation
Short name:
ArgRSUniRule annotation
Gene namesi
Name:argSUniRule annotationImported
OrganismiThermus thermophilusImported
Taxonomic identifieri274 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Monomer.UniRule annotation

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1IQ0X-ray2.30A1-592[»]
ProteinModelPortaliQ93RP5
SMRiQ93RP5
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ93RP5

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 82Arg_tRNA_synt_NInterPro annotationAdd BLAST81
Domaini473 – 592DALR_1InterPro annotationAdd BLAST120

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi112 – 122"HIGH" regionUniRule annotationAdd BLAST11

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C75 Bacteria
COG0018 LUCA
KOiK01887

Family and domain databases

CDDicd00671 ArgRS_core, 1 hit
Gene3Di3.30.1360.70, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_00123 Arg_tRNA_synth, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR001278 Arg-tRNA-ligase
IPR005148 Arg-tRNA-synth_N
IPR036695 Arg-tRNA-synth_N_sf
IPR035684 ArgRS_core
IPR008909 DALR_anticod-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
PANTHERiPTHR11956 PTHR11956, 1 hit
PfamiView protein in Pfam
PF03485 Arg_tRNA_synt_N, 1 hit
PF05746 DALR_1, 1 hit
PF00750 tRNA-synt_1d, 2 hits
PRINTSiPR01038 TRNASYNTHARG
SMARTiView protein in SMART
SM01016 Arg_tRNA_synt_N, 1 hit
SM00836 DALR_1, 1 hit
SUPFAMiSSF47323 SSF47323, 1 hit
SSF55190 SSF55190, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q93RP5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRRALEEAI AQALKEMGVP VRLKVARAPK DKPGDYGVPL FALAKELRKP
60 70 80 90 100
PQAIAQELKD RLPLPEFVEE AVPVGGYLNF RLRTEALLRE ALRPKAPFPR
110 120 130 140 150
RPGVVLVEHT SVNPNKELHV GHLRNIALGD AIARILAYAG REVLVLNYID
160 170 180 190 200
DTGRQAAETL FALRHYGLTW DGKEKYDHFA GRAYVRLHQD PEYERLQPAI
210 220 230 240 250
EEVLHALERG ELREEVNRIL LAQMATMHAL NARYDLLVWE SDIVRAGLLQ
260 270 280 290 300
KALALLEQSP HVFRPREGKY AGALVMDASP VIPGLEDPFF VLLRSNGTAT
310 320 330 340 350
YYAKDIAFQF WKMGILEGLR FRPYENPYYP GLRTSAPEGE AYTPKAEETI
360 370 380 390 400
NVVDVRQSHP QALVRAALAL AGYPALAEKA HHLAYETVLL EGRQMSGRKG
410 420 430 440 450
LAVSVDEVLE EATRRARAIV EEKNPDHPDK EEAARMVALG AIRFSMVKTE
460 470 480 490 500
PKKQIDFRYQ EALSFEGDTG PYVQYAHARA HSILRKAGEW GAPDLSQATP
510 520 530 540 550
YERALALDLL DFEEAVLEAA EERTPHVLAQ YLLDLAASWN AYYNARENGQ
560 570 580 590
PATPVLTAPE GLRELRLSLV QSLQRTLATG LDLLGIPAPE VM
Length:592
Mass (Da):66,227
Last modified:December 1, 2001 - v1
Checksum:iBA300E5F28F672E6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ278815 Genomic DNA Translation: CAC39622.1
RefSeqiYP_143364.1, NC_006461.1

Genome annotation databases

GeneIDi3169614
KEGGittj:TTHA0098
PATRICifig|300852.9.peg.96

Similar proteinsi

Entry informationi

Entry nameiQ93RP5_THETH
AccessioniPrimary (citable) accession number: Q93RP5
Entry historyiIntegrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: March 28, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

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