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Q93RP5 (Q93RP5_THETH) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Arginine--tRNA ligase HAMAP MF_00123

EC=6.1.1.19 HAMAP MF_00123
Alternative name(s):
Arginyl-tRNA synthetase HAMAP MF_00123
Gene names
Name:argS HAMAP MF_00123 EMBL CAC39622.1
OrganismThermus thermophilus EMBL CAC39622.1
Taxonomic identifier274 [NCBI]
Taxonomic lineageBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus

Protein attributes

Sequence length592 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP MF_00123

Subunit structure

Monomer By similarity. HAMAP MF_00123

Subcellular location

Cytoplasm By similarity HAMAP MF_00123.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family. RuleBase RU003489 HAMAP MF_00123

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Motif112 – 12211"HIGH" region By similarity HAMAP MF_00123

Sequences

Sequence LengthMass (Da)Tools
Q93RP5 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: BA300E5F28F672E6

FASTA59266,227
        10         20         30         40         50         60 
MLRRALEEAI AQALKEMGVP VRLKVARAPK DKPGDYGVPL FALAKELRKP PQAIAQELKD 

        70         80         90        100        110        120 
RLPLPEFVEE AVPVGGYLNF RLRTEALLRE ALRPKAPFPR RPGVVLVEHT SVNPNKELHV 

       130        140        150        160        170        180 
GHLRNIALGD AIARILAYAG REVLVLNYID DTGRQAAETL FALRHYGLTW DGKEKYDHFA 

       190        200        210        220        230        240 
GRAYVRLHQD PEYERLQPAI EEVLHALERG ELREEVNRIL LAQMATMHAL NARYDLLVWE 

       250        260        270        280        290        300 
SDIVRAGLLQ KALALLEQSP HVFRPREGKY AGALVMDASP VIPGLEDPFF VLLRSNGTAT 

       310        320        330        340        350        360 
YYAKDIAFQF WKMGILEGLR FRPYENPYYP GLRTSAPEGE AYTPKAEETI NVVDVRQSHP 

       370        380        390        400        410        420 
QALVRAALAL AGYPALAEKA HHLAYETVLL EGRQMSGRKG LAVSVDEVLE EATRRARAIV 

       430        440        450        460        470        480 
EEKNPDHPDK EEAARMVALG AIRFSMVKTE PKKQIDFRYQ EALSFEGDTG PYVQYAHARA 

       490        500        510        520        530        540 
HSILRKAGEW GAPDLSQATP YERALALDLL DFEEAVLEAA EERTPHVLAQ YLLDLAASWN 

       550        560        570        580        590 
AYYNARENGQ PATPVLTAPE GLRELRLSLV QSLQRTLATG LDLLGIPAPE VM 

« Hide

References

[1]"Gene cloning, expression, crystallization and preliminary X-ray analysis of Thermus thermophilus arginyl-tRNA synthetase."
Shimada A., Nureki O., Dohmae N., Takio K., Yokoyama S.
Acta Crystallogr. 50:760-763(2001)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: HB8 EMBL CAC39622.1.
[2]"Structural and mutational studies of the recognition of the arginine tRNA-specific major identity element, A20, by arginyl-tRNA synthetase."
Shimada A., Nureki O., Goto M., Takahashi S., Yokoyama S.
Proc. Natl. Acad. Sci. U.S.A. 98:13537-13542(2001) [PubMed: 11698642] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ278815 Genomic DNA. Translation: CAC39622.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1IQ0X-ray2.30A1-592[»]
ProteinModelPortalQ93RP5.
SMRQ93RP5. Positions 1-592.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

BRENDA6.1.1.19. 245.

Family and domain databases

HAMAPMF_00123. Arg_tRNA_synth.
[Tree]
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-synth_Ia.
IPR015945. Arg-tRNA-synth_Ia_core.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
Gene3DG3DSA:3.30.1360.70. Arg-tRNA-synth_Ic_N. 1 hit.
G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
PANTHERPTHR11956. Arg_tRNA-synt_1c. 1 hit.
PfamPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 2 hits.
[Graphical view]
PRINTSPR01038. TRNASYNTHARG.
SMARTSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMSSF55190. Arg-tRNA-synth_Ic_N. 1 hit.
SSF47323. tRNAsyn_1a_bind. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ93RP5_THETH
AccessionPrimary (citable) accession number: Q93RP5
Entry history
Integrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: January 25, 2012
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)