Reviewed, UniProtKB/Swiss-Prot Q93QD4 (FABD_STAAU)

Names and origin

Protein names

Recommended name:
    Malonyl-CoA-acyl carrier protein transacylase
      Short name=MCT
    EC=2.3.1.39

Gene names

Name:

fabD

Organism

Staphylococcus aureus

Taxonomic identifier

1280 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	308 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Malonyl-CoA + [acyl-carrier-protein] = CoA + malonyl-[acyl-carrier-protein].
Pathway	Lipid metabolism; fatty acid biosynthesis.
Sequence similarities	Belongs to the fabD family.

Ontologies

Keywords
Biological process	Fatty acid biosynthesis Lipid synthesis
Molecular function	Acyltransferase Transferase
Gene Ontology (GO)
Biological process	fatty acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	[acyl-carrier-protein] S-malonyltransferase activity Inferred from electronic annotation. Source: EC binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 308	308	Malonyl-CoA-acyl carrier protein transacylase		PRO_0000194220
Sites
	Active site	89	1	By similarity
	Active site	199	1	By similarity
Experimental info
	Sequence conflict	23	1	F → Y in BAD72836. Ref.2
	Sequence conflict	53	1	E → D in BAD72836. Ref.2
	Sequence conflict	220	1	R → H in BAD72836. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q93QD4-1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: C28AEC6CC50805C2	FASTA	308	33,635
	10 20 30 40 50 60 MSKTAIIFPG QGAQKVGMAQ DLFNNNDQAT EILTSAANTL DFDILETMFT DEEGKLGETE 70 80 90 100 110 120 NTQPALLTHS SALLAALKNL NPDFTMGHSL GEYSSLVAAD VLSFEDAVKI VRKRGQLMAQ 130 140 150 160 170 180 AFPTGVGSMA AVLGLDFDKV DEICKSLSSD DKIIEPANIN CPGQIVVSGH KALIDELVEK 190 200 210 220 230 240 GKSLGAKRVM PLAVSGPFHS SLMKVIEEDF SSYINQFEWR DAKFPVVQNV NAQGETDKEV 250 260 270 280 290 300 IKSNMVKQLY SPVQFINSTE WLIDQGVDHF IEIGPGKVLS GLIKKINRDV KLTSIQTLED VKGWNEND

References

[1]	"Cloning and characterization of S.aureus malonyl-CoA:ACP S-malonyl transferase." Lin A.H., Choi G.H., McCroskey M., Harris D.W., Murray R.W., Rockenbach S.K., Curry K.A., Marotti K.R. Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Cloning and expression of Staphylococcus aureus Smith fab genes." Morita Y., Ikeno S., Tsuchiya K.S. Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 6-303. Strain: Smith.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF275318 Genomic DNA. Translation: AAK69406.1. AB195288 Genomic DNA. Translation: BAD72836.1.
3D structure databases
HSSP	HSSP built from PDB template 1MLA based on UniProtKB P25715.
ModBase	Search...
Enzyme and pathway databases
BRENDA	2.3.1.39. 95.
Family and domain databases
InterPro	IPR001227. Ac_transferase_reg. IPR014043. Acyl_transferase. IPR004410. FabD. [Graphical view]
Gene3D	G3DSA:3.40.366.10. Ac_transferase_reg. 1 hit.
Pfam	PF00698. Acyl_transf_1. 1 hit. [Graphical view]
TIGRFAMs	TIGR00128. fabD. 1 hit.
ProtoNet	Search...

Entry information

Entry name

FABD_STAAU

Accession

Primary (citable) accession number: Q93QD4
Secondary accession number(s): Q5TKS3

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 24, 2006
Last sequence update:	December 1, 2001
Last modified:	June 16, 2009
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)