Q93QD4 (FABD_STAAU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Malonyl CoA-acyl carrier protein transacylase
Short name=MCT
EC=2.3.1.39

Gene names

Name:

fabD

Organism

Staphylococcus aureus

Taxonomic identifier

1280 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Staphylococcaceae › Staphylococcus

Protein attributes

Sequence length	308 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Malonyl-CoA + [acyl-carrier-protein] = CoA + malonyl-[acyl-carrier-protein].
Pathway	Lipid metabolism; fatty acid biosynthesis.
Sequence similarities	Belongs to the FabD family.

Ontologies

Keywords
Biological process	Fatty acid biosynthesis Fatty acid metabolism Lipid biosynthesis Lipid metabolism
Molecular function	Acyltransferase Transferase
Gene Ontology (GO)
Biological_process	fatty acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	[acyl-carrier-protein] S-malonyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 308	308	Malonyl CoA-acyl carrier protein transacylase		PRO_0000194220
Sites
	Active site	89	1	By similarity
	Active site	199	1	By similarity
Experimental info
	Sequence conflict	23	1	F → Y in BAD72836. Ref.2
	Sequence conflict	53	1	E → D in BAD72836. Ref.2
	Sequence conflict	220	1	R → H in BAD72836. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q93QD4 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: C28AEC6CC50805C2	FASTA	308	33,635
	10 20 30 40 50 60 MSKTAIIFPG QGAQKVGMAQ DLFNNNDQAT EILTSAANTL DFDILETMFT DEEGKLGETE 70 80 90 100 110 120 NTQPALLTHS SALLAALKNL NPDFTMGHSL GEYSSLVAAD VLSFEDAVKI VRKRGQLMAQ 130 140 150 160 170 180 AFPTGVGSMA AVLGLDFDKV DEICKSLSSD DKIIEPANIN CPGQIVVSGH KALIDELVEK 190 200 210 220 230 240 GKSLGAKRVM PLAVSGPFHS SLMKVIEEDF SSYINQFEWR DAKFPVVQNV NAQGETDKEV 250 260 270 280 290 300 IKSNMVKQLY SPVQFINSTE WLIDQGVDHF IEIGPGKVLS GLIKKINRDV KLTSIQTLED VKGWNEND

References

[1]	"Cloning and characterization of S.aureus malonyl-CoA:ACP S-malonyl transferase." Lin A.H., Choi G.H., McCroskey M., Harris D.W., Murray R.W., Rockenbach S.K., Curry K.A., Marotti K.R. Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Cloning and expression of Staphylococcus aureus Smith fab genes." Morita Y., Ikeno S., Tsuchiya K.S. Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 6-303. Strain: Smith.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF275318 Genomic DNA. Translation: AAK69406.1. AB195288 Genomic DNA. Translation: BAD72836.1.
3D structure databases
ProteinModelPortal	Q93QD4.
SMR	Q93QD4. Positions 2-305.
ModBase	Search...
Proteomic databases
PRIDE	Q93QD4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
eggNOG	COG0331.
Enzyme and pathway databases
UniPathway	UPA00094.
Family and domain databases
Gene3D	3.40.366.10. 2 hits.
InterPro	IPR001227. Ac_transferase_dom. IPR014043. Acyl_transferase. IPR016035. Acyl_Trfase/lysoPLipase. IPR024925. Malonyl_CoA-ACP_transAc. IPR004410. Malonyl_CoA-ACP_transAc_FabD. IPR016036. Malonyl_transacylase_ACP-bd. [Graphical view]
Pfam	PF00698. Acyl_transf_1. 1 hit. [Graphical view]
PIRSF	PIRSF000446. Mct. 1 hit.
SUPFAM	SSF52151. Acyl_Trfase/lysoPlipase. 1 hit. SSF55048. Malonyl_transacylase_ACP-bd. 1 hit.
TIGRFAMs	TIGR00128. fabD. 1 hit.
ProtoNet	Search...
Other
ChEMBL	CHEMBL1075258.

Entry information

Entry name

FABD_STAAU

Accession

Primary (citable) accession number: Q93QD4
Secondary accession number(s): Q5TKS3

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 24, 2006
Last sequence update:	December 1, 2001
Last modified:	May 1, 2013
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program