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Q93Q56 (PROB_LISMO) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutamate 5-kinase

EC=2.7.2.11
Alternative name(s):
Gamma-glutamyl kinase
Short name=GK
Gene names
Name:proB
Ordered Locus Names:lmo1260
OrganismListeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e) [Reference proteome] [HAMAP]
Taxonomic identifier169963 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria

Protein attributes

Sequence length276 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5-oxoproline By similarity. HAMAP-Rule MF_00456

Catalytic activity

ATP + L-glutamate = ADP + L-glutamate 5-phosphate. HAMAP-Rule MF_00456

Pathway

Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 1/2. HAMAP-Rule MF_00456

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00456.

Sequence similarities

Belongs to the glutamate 5-kinase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Proline biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processL-proline biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

glutamate 5-kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 276276Glutamate 5-kinase HAMAP-Rule MF_00456
PRO_0000109689

Regions

Nucleotide binding177 – 1782ATP By similarity
Nucleotide binding219 – 2257ATP By similarity

Sites

Binding site141ATP By similarity
Binding site541Substrate By similarity
Binding site1411Substrate By similarity
Binding site1571Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q93Q56 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: F9A94811AFC5AD06

FASTA27630,034
        10         20         30         40         50         60 
MRESLKNSKR LVIKVGTSTL MYGNGHINLR TIEKLAMVLS DLRNEGKEVI LVSSGAIGVG 

        70         80         90        100        110        120 
CHKLQLPVRP TSIPEQQAVA SVGQSELMHI YSKFFGEYGQ VVGQVLLTRD VTDFPISREN 

       130        140        150        160        170        180 
VMNTLESLLE RGIIPIVNEN DTVAVEELEH VTKYGDNDLL SAIVAKLVQA DLLIMLSDID 

       190        200        210        220        230        240 
GFYGSNPSTD PDAVMFSEIN QITPEIEALA GGKGSKFGTG GMLTKLSAAS YCMNANQKMI 

       250        260        270 
LTNGKNPTII FDIMQGEQIG TLFASKKEEF SHDGTH 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF282880 Genomic DNA. Translation: AAK62254.1.
AL591978 Genomic DNA. Translation: CAC99338.1.
PIRAD1232.
RefSeqNP_464785.1. NC_003210.1.
YP_007603599.1. NC_020557.1.
YP_008296767.1. NC_021837.1.

3D structure databases

ProteinModelPortalQ93Q56.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING169963.lmo1260.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAC99338; CAC99338; CAC99338.
GeneID14825808.
16333908.
985996.
KEGGlmo:lmo1260.
lmoe:BN418_1494.
PATRIC20311637. VBILisMon69206_1295.

Organism-specific databases

GenoListLMO1260.

Phylogenomic databases

eggNOGCOG0263.
HOGENOMHOG000246368.
KOK00931.
OMADIHYRQA.
OrthoDBEOG6PGK7G.
PhylomeDBQ93Q56.

Enzyme and pathway databases

BioCycLMON169963:LMO1260-MONOMER.
UniPathwayUPA00098; UER00359.

Family and domain databases

Gene3D3.40.1160.10. 1 hit.
HAMAPMF_00456. ProB.
InterProIPR001048. Asp/Glu/Uridylate_kinase.
IPR001057. Glu/AcGlu_kinase.
IPR011529. Glu_5kinase.
IPR005715. Glu_5kinase/COase_Synthase.
IPR019797. Glutamate_5-kinase_CS.
[Graphical view]
PfamPF00696. AA_kinase. 1 hit.
[Graphical view]
PIRSFPIRSF000729. GK. 1 hit.
PRINTSPR00474. GLU5KINASE.
SUPFAMSSF53633. SSF53633. 1 hit.
TIGRFAMsTIGR01027. proB. 1 hit.
PROSITEPS00902. GLUTAMATE_5_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePROB_LISMO
AccessionPrimary (citable) accession number: Q93Q56
Entry history
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways