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Q93Q56

- PROB_LISMO

UniProt

Q93Q56 - PROB_LISMO

Protein

Glutamate 5-kinase

Gene

proB

Organism
Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.UniRule annotation

    Catalytic activityi

    ATP + L-glutamate = ADP + L-glutamate 5-phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei14 – 141ATPUniRule annotation
    Binding sitei54 – 541SubstrateUniRule annotation
    Binding sitei141 – 1411SubstrateUniRule annotation
    Binding sitei157 – 1571Substrate; via amide nitrogenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi177 – 1782ATPUniRule annotation
    Nucleotide bindingi219 – 2257ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. glutamate 5-kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. L-proline biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Proline biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciLMON169963:LMO1260-MONOMER.
    UniPathwayiUPA00098; UER00359.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate 5-kinaseUniRule annotation (EC:2.7.2.11UniRule annotation)
    Alternative name(s):
    Gamma-glutamyl kinaseUniRule annotation
    Short name:
    GKUniRule annotation
    Gene namesi
    Name:proBUniRule annotation
    Ordered Locus Names:lmo1260
    OrganismiListeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
    Taxonomic identifieri169963 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
    ProteomesiUP000000817: Chromosome

    Organism-specific databases

    GenoListiLMO1260.

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 276276Glutamate 5-kinasePRO_0000109689Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi169963.lmo1260.

    Structurei

    3D structure databases

    ProteinModelPortaliQ93Q56.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glutamate 5-kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0263.
    HOGENOMiHOG000246368.
    KOiK00931.
    OMAiDIHYRQA.
    OrthoDBiEOG6PGK7G.
    PhylomeDBiQ93Q56.

    Family and domain databases

    Gene3Di3.40.1160.10. 1 hit.
    HAMAPiMF_00456. ProB.
    InterProiIPR001048. Asp/Glu/Uridylate_kinase.
    IPR001057. Glu/AcGlu_kinase.
    IPR011529. Glu_5kinase.
    IPR005715. Glu_5kinase/COase_Synthase.
    IPR019797. Glutamate_5-kinase_CS.
    [Graphical view]
    PfamiPF00696. AA_kinase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000729. GK. 1 hit.
    PRINTSiPR00474. GLU5KINASE.
    SUPFAMiSSF53633. SSF53633. 1 hit.
    TIGRFAMsiTIGR01027. proB. 1 hit.
    PROSITEiPS00902. GLUTAMATE_5_KINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q93Q56-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRESLKNSKR LVIKVGTSTL MYGNGHINLR TIEKLAMVLS DLRNEGKEVI    50
    LVSSGAIGVG CHKLQLPVRP TSIPEQQAVA SVGQSELMHI YSKFFGEYGQ 100
    VVGQVLLTRD VTDFPISREN VMNTLESLLE RGIIPIVNEN DTVAVEELEH 150
    VTKYGDNDLL SAIVAKLVQA DLLIMLSDID GFYGSNPSTD PDAVMFSEIN 200
    QITPEIEALA GGKGSKFGTG GMLTKLSAAS YCMNANQKMI LTNGKNPTII 250
    FDIMQGEQIG TLFASKKEEF SHDGTH 276
    Length:276
    Mass (Da):30,034
    Last modified:December 1, 2001 - v1
    Checksum:iF9A94811AFC5AD06
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF282880 Genomic DNA. Translation: AAK62254.1.
    AL591978 Genomic DNA. Translation: CAC99338.1.
    PIRiAD1232.
    RefSeqiNP_464785.1. NC_003210.1.
    WP_003723561.1. NC_003210.1.
    YP_007603599.1. NC_020557.1.
    YP_008296767.1. NC_021837.1.

    Genome annotation databases

    EnsemblBacteriaiCAC99338; CAC99338; CAC99338.
    GeneIDi14825808.
    16333908.
    985996.
    KEGGilmo:lmo1260.
    lmoe:BN418_1494.
    PATRICi20311637. VBILisMon69206_1295.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF282880 Genomic DNA. Translation: AAK62254.1 .
    AL591978 Genomic DNA. Translation: CAC99338.1 .
    PIRi AD1232.
    RefSeqi NP_464785.1. NC_003210.1.
    WP_003723561.1. NC_003210.1.
    YP_007603599.1. NC_020557.1.
    YP_008296767.1. NC_021837.1.

    3D structure databases

    ProteinModelPortali Q93Q56.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 169963.lmo1260.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAC99338 ; CAC99338 ; CAC99338 .
    GeneIDi 14825808.
    16333908.
    985996.
    KEGGi lmo:lmo1260.
    lmoe:BN418_1494.
    PATRICi 20311637. VBILisMon69206_1295.

    Organism-specific databases

    GenoListi LMO1260.

    Phylogenomic databases

    eggNOGi COG0263.
    HOGENOMi HOG000246368.
    KOi K00931.
    OMAi DIHYRQA.
    OrthoDBi EOG6PGK7G.
    PhylomeDBi Q93Q56.

    Enzyme and pathway databases

    UniPathwayi UPA00098 ; UER00359 .
    BioCyci LMON169963:LMO1260-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1160.10. 1 hit.
    HAMAPi MF_00456. ProB.
    InterProi IPR001048. Asp/Glu/Uridylate_kinase.
    IPR001057. Glu/AcGlu_kinase.
    IPR011529. Glu_5kinase.
    IPR005715. Glu_5kinase/COase_Synthase.
    IPR019797. Glutamate_5-kinase_CS.
    [Graphical view ]
    Pfami PF00696. AA_kinase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000729. GK. 1 hit.
    PRINTSi PR00474. GLU5KINASE.
    SUPFAMi SSF53633. SSF53633. 1 hit.
    TIGRFAMsi TIGR01027. proB. 1 hit.
    PROSITEi PS00902. GLUTAMATE_5_KINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and disruption of the proBA Locus in Listeria monocytogenes: role of proline biosynthesis in salt tolerance and murine infection."
      Sleator R.D., Gahan C.G.M., Hill C.
      Appl. Environ. Microbiol. 67:2571-2577(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-679 / EGD-e.

    Entry informationi

    Entry nameiPROB_LISMO
    AccessioniPrimary (citable) accession number: Q93Q56
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 6, 2002
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3