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Q93Q56

- PROB_LISMO

UniProt

Q93Q56 - PROB_LISMO

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Protein

Glutamate 5-kinase

Gene

proB

Organism
Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.UniRule annotation

Catalytic activityi

ATP + L-glutamate = ADP + L-glutamate 5-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei14 – 141ATPUniRule annotation
Binding sitei54 – 541SubstrateUniRule annotation
Binding sitei141 – 1411SubstrateUniRule annotation
Binding sitei157 – 1571Substrate; via amide nitrogenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi177 – 1782ATPUniRule annotation
Nucleotide bindingi219 – 2257ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. glutamate 5-kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. L-proline biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Proline biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLMON169963:LMO1260-MONOMER.
UniPathwayiUPA00098; UER00359.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate 5-kinaseUniRule annotation (EC:2.7.2.11UniRule annotation)
Alternative name(s):
Gamma-glutamyl kinaseUniRule annotation
Short name:
GKUniRule annotation
Gene namesi
Name:proBUniRule annotation
Ordered Locus Names:lmo1260
OrganismiListeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Taxonomic identifieri169963 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
ProteomesiUP000000817: Chromosome

Organism-specific databases

GenoListiLMO1260.

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 276276Glutamate 5-kinasePRO_0000109689Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi169963.lmo1260.

Structurei

3D structure databases

ProteinModelPortaliQ93Q56.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutamate 5-kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0263.
HOGENOMiHOG000246368.
KOiK00931.
OMAiDIHYRQA.
OrthoDBiEOG6PGK7G.
PhylomeDBiQ93Q56.

Family and domain databases

Gene3Di3.40.1160.10. 1 hit.
HAMAPiMF_00456. ProB.
InterProiIPR001048. Asp/Glu/Uridylate_kinase.
IPR001057. Glu/AcGlu_kinase.
IPR011529. Glu_5kinase.
IPR005715. Glu_5kinase/COase_Synthase.
IPR019797. Glutamate_5-kinase_CS.
[Graphical view]
PfamiPF00696. AA_kinase. 1 hit.
[Graphical view]
PIRSFiPIRSF000729. GK. 1 hit.
PRINTSiPR00474. GLU5KINASE.
SUPFAMiSSF53633. SSF53633. 1 hit.
TIGRFAMsiTIGR01027. proB. 1 hit.
PROSITEiPS00902. GLUTAMATE_5_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q93Q56-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRESLKNSKR LVIKVGTSTL MYGNGHINLR TIEKLAMVLS DLRNEGKEVI
60 70 80 90 100
LVSSGAIGVG CHKLQLPVRP TSIPEQQAVA SVGQSELMHI YSKFFGEYGQ
110 120 130 140 150
VVGQVLLTRD VTDFPISREN VMNTLESLLE RGIIPIVNEN DTVAVEELEH
160 170 180 190 200
VTKYGDNDLL SAIVAKLVQA DLLIMLSDID GFYGSNPSTD PDAVMFSEIN
210 220 230 240 250
QITPEIEALA GGKGSKFGTG GMLTKLSAAS YCMNANQKMI LTNGKNPTII
260 270
FDIMQGEQIG TLFASKKEEF SHDGTH
Length:276
Mass (Da):30,034
Last modified:December 1, 2001 - v1
Checksum:iF9A94811AFC5AD06
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF282880 Genomic DNA. Translation: AAK62254.1.
AL591978 Genomic DNA. Translation: CAC99338.1.
PIRiAD1232.
RefSeqiNP_464785.1. NC_003210.1.
WP_003723561.1. NC_003210.1.
YP_007603599.1. NC_020557.1.
YP_008296767.1. NC_021837.1.

Genome annotation databases

EnsemblBacteriaiCAC99338; CAC99338; CAC99338.
GeneIDi14825808.
16333908.
985996.
KEGGilmo:lmo1260.
lmoe:BN418_1494.
PATRICi20311637. VBILisMon69206_1295.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF282880 Genomic DNA. Translation: AAK62254.1 .
AL591978 Genomic DNA. Translation: CAC99338.1 .
PIRi AD1232.
RefSeqi NP_464785.1. NC_003210.1.
WP_003723561.1. NC_003210.1.
YP_007603599.1. NC_020557.1.
YP_008296767.1. NC_021837.1.

3D structure databases

ProteinModelPortali Q93Q56.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 169963.lmo1260.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC99338 ; CAC99338 ; CAC99338 .
GeneIDi 14825808.
16333908.
985996.
KEGGi lmo:lmo1260.
lmoe:BN418_1494.
PATRICi 20311637. VBILisMon69206_1295.

Organism-specific databases

GenoListi LMO1260.

Phylogenomic databases

eggNOGi COG0263.
HOGENOMi HOG000246368.
KOi K00931.
OMAi DIHYRQA.
OrthoDBi EOG6PGK7G.
PhylomeDBi Q93Q56.

Enzyme and pathway databases

UniPathwayi UPA00098 ; UER00359 .
BioCyci LMON169963:LMO1260-MONOMER.

Family and domain databases

Gene3Di 3.40.1160.10. 1 hit.
HAMAPi MF_00456. ProB.
InterProi IPR001048. Asp/Glu/Uridylate_kinase.
IPR001057. Glu/AcGlu_kinase.
IPR011529. Glu_5kinase.
IPR005715. Glu_5kinase/COase_Synthase.
IPR019797. Glutamate_5-kinase_CS.
[Graphical view ]
Pfami PF00696. AA_kinase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000729. GK. 1 hit.
PRINTSi PR00474. GLU5KINASE.
SUPFAMi SSF53633. SSF53633. 1 hit.
TIGRFAMsi TIGR01027. proB. 1 hit.
PROSITEi PS00902. GLUTAMATE_5_KINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and disruption of the proBA Locus in Listeria monocytogenes: role of proline biosynthesis in salt tolerance and murine infection."
    Sleator R.D., Gahan C.G.M., Hill C.
    Appl. Environ. Microbiol. 67:2571-2577(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-679 / EGD-e.

Entry informationi

Entry nameiPROB_LISMO
AccessioniPrimary (citable) accession number: Q93Q56
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3