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Protein

Monofunctional glycosyltransferase

Gene

mgt

Organism
Staphylococcus aureus (strain NCTC 8325)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the biosynthesis of cell wall peptidoglycan. Responsible for the elongation of the glycan strands using lipid-linked disaccharide-pentapeptide as the substrate.1 Publication

Enzyme regulationi

Activity increases 3-fold at pH 6.1. Inhibited by moenomycin A.1 Publication

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-15458.
SAUR93061:GIWJ-1962-MONOMER.
UniPathwayiUPA00219.

Protein family/group databases

CAZyiGT51. Glycosyltransferase Family 51.

Names & Taxonomyi

Protein namesi
Recommended name:
Monofunctional glycosyltransferase (EC:2.4.-.-)
Short name:
MGT
Alternative name(s):
Peptidoglycan TGase
Gene namesi
Name:mgt
Ordered Locus Names:SAOUHSC_02012
OrganismiStaphylococcus aureus (strain NCTC 8325)
Taxonomic identifieri93061 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000008816 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei46 – 6621HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 269269Monofunctional glycosyltransferasePRO_0000083152Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi93061.SAOUHSC_02012.

Structurei

3D structure databases

ProteinModelPortaliQ93Q23.
SMRiQ93Q23. Positions 61-269.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 51 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105BZ4. Bacteria.
COG0744. LUCA.
HOGENOMiHOG000288116.
KOiK04478.
OMAiGSDQYTI.

Family and domain databases

HAMAPiMF_01434. MGT. 1 hit.
InterProiIPR001264. Glyco_trans_51.
IPR023346. Lysozyme-like_dom.
IPR022978. Monofunct_glyco_trans.
[Graphical view]
PfamiPF00912. Transgly. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.

Sequencei

Sequence statusi: Complete.

Q93Q23-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRSDRYSNS NEHFEHMKHE PHYNTYYQPV GKPPKKKKSK RILLKILLTI
60 70 80 90 100
LIIIALFIGI MYFLSTRDNV DELRKIENKS SFVSADNMPE YVKGAFISME
110 120 130 140 150
DERFYNHHGF DLKGTTRALF STISDRDVQG GSTITQQVVK NYFYDNDRSF
160 170 180 190 200
TRKVKELFVA HRVEKQYNKN EILSFYLNNI YFGDNQYTLE GAANHYFGTT
210 220 230 240 250
VNKNSTTMSH ITVLQSAILA SKVNAPSVYN INNMSENFTQ RVSTNLEKMK
260
QQNYINETQY QQAMSQLNR
Length:269
Mass (Da):31,460
Last modified:July 11, 2006 - v2
Checksum:iC0F65B9F5CAB8761
GO

Sequence cautioni

The sequence AAA18515 differs from that shown. Reason: Erroneous termination at position 150. Translated as Phe. May be due to a cloning artifact.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti257 – 2582Missing in AAK83040 (PubMed:11466281).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF287468 Genomic DNA. Translation: AAK83040.1.
L19300 Unassigned DNA. Translation: AAA18515.1. Sequence problems.
CP000253 Genomic DNA. Translation: ABD31068.1.
RefSeqiYP_500509.1. NC_007795.1.

Genome annotation databases

EnsemblBacteriaiABD31068; ABD31068; SAOUHSC_02012.
GeneIDi3920466.
KEGGisao:SAOUHSC_02012.
PATRICi19581411. VBIStaAur99865_1827.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF287468 Genomic DNA. Translation: AAK83040.1.
L19300 Unassigned DNA. Translation: AAA18515.1. Sequence problems.
CP000253 Genomic DNA. Translation: ABD31068.1.
RefSeqiYP_500509.1. NC_007795.1.

3D structure databases

ProteinModelPortaliQ93Q23.
SMRiQ93Q23. Positions 61-269.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi93061.SAOUHSC_02012.

Protein family/group databases

CAZyiGT51. Glycosyltransferase Family 51.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABD31068; ABD31068; SAOUHSC_02012.
GeneIDi3920466.
KEGGisao:SAOUHSC_02012.
PATRICi19581411. VBIStaAur99865_1827.

Phylogenomic databases

eggNOGiENOG4105BZ4. Bacteria.
COG0744. LUCA.
HOGENOMiHOG000288116.
KOiK04478.
OMAiGSDQYTI.

Enzyme and pathway databases

UniPathwayiUPA00219.
BioCyciMetaCyc:MONOMER-15458.
SAUR93061:GIWJ-1962-MONOMER.

Family and domain databases

HAMAPiMF_01434. MGT. 1 hit.
InterProiIPR001264. Glyco_trans_51.
IPR023346. Lysozyme-like_dom.
IPR022978. Monofunct_glyco_trans.
[Graphical view]
PfamiPF00912. Transgly. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMGT_STAA8
AccessioniPrimary (citable) accession number: Q93Q23
Secondary accession number(s): Q2G2G8, Q53720
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: July 11, 2006
Last modified: September 7, 2016
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.